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ABCC4 Gene

protein-coding   GIFtS: 62

GC13M076269
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ATP-binding cassette, sub-family C (CFTR/MRP), member 41 2     ATP-binding cassette sub-family C member 42 3
MRP41 2 3 5     MRP/cMOAT-related ABC transporter2 3
MOAT-B1 2 3     canalicular multispecific organic anion transporter (ABC superfamily)2
MOATB1 2 5     multidrug resistance-associated protein 42
EST1702051 2     bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)2
Multi-specific organic anion transporter B2 3     multispecific organic anion transporter B2

External Ids:    HGNC: 551   Entrez Gene: 102572   Ensembl: ENSG000001252577   UniProtKB: O154393   

Export aliases for ABCC4 gene to outside databases

Previous GC identifers: GC13M094033 GC13M090059 GC13M094508 GC13M093370 GC13M094470 GC13M095672


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABCC4:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven
distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily
which is involved in multi-drug resistance. The specific function of this protein has not yet been determined;
however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.
Alternative splicing results in multiple splice variants encoding different isoforms. (provided by RefSeq)

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
Function: May be an organic anion pump relevant to cellular detoxification


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABCC4 gene promoter:
         Max1   c-Myc   HNF-4alpha2   GR-beta   GR-alpha   Max   COUP-TF1   AhR   Arnt   STAT3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ABCC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ABCC4 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q31

ABCC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABCC4 gene location

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M076269:  view genomic region     (about GC identifiers)

Start:
76,269,792 bp from pter
End:
76,551,747 bp from pter
Size:
281,956 bases
Orientation:
minus strand

1 alternative location:
Chr13- 95,672,083-95,953,687     
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439 (See protein sequence)
Recommended Name: Multidrug resistance-associated protein 4  
Size: 1325 amino acids; 149527 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A9Z1Z7 Q8IZN6 Q8NEW8 Q9Y6J2
Alternative splicing: 2 isoforms:  O15439-1   O15439-2   

Explore the universe of human proteins at neXtProt for ABCC4: NX_O15439 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001098985.1  NP_005836.2  


    ENSEMBL proteins: 
    ENSP00000366084 ENSP00000388657 ENSP00000398562 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for ABCC4 
    Novus Biologicals Proteins for ABCC4
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction IDA15297306
    GO:0005886 plasma membrane IDA15297306
    GO:0016021 integral to membrane IEA--
    GO:0031088 platelet dense granule membrane IDA15297306
    About this table

    ABCC4 for ontologies           About GeneDecksing



    Antibodies for ABCC4: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ABCC4
    Browse R&D Systems for Antibodies
    OriGene Antibodies: ABCC4
    GenScript Custom Superior Antibodies Services for ABCC4 
    Novus Biologicals Antibodies for ABCC4
    Browse antibodies at Epitomics

    Assays for ABCC4: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABCC4 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ABCC4 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ABCC4 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003439 ABC_transporter-like
     IPR001140 ABC_transptr_TM_dom
     IPR009147 CysFib_conduc_TM
     IPR003593 ATPase_AAA+_core
     IPR017940 ABC_transporter_type1

    Graphical View of Domain Structure for InterPro Entry O15439

    ProtoNet protein and cluster: O15439

    UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
    Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily
    Similarity: Contains 2 ABC transmembrane type-1 domains
    Similarity: Contains 2 ABC transporter domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
    Function: May be an organic anion pump relevant to cellular detoxification

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ABCC4
    Sigma-Aldrich shRNA for ABCC4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ABCC4
    OriGene shRNA RFP (see all 2): ABCC4
    OriGene basic RS shRNA (see all 2): ABCC4
    OriGene siRNA (see all 2): ABCC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ABCC4 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ABCC4 
    8/11 SABiosciences Assays for microRNAs that regulate ABCC4 (see all 11):
    hsa-miR-125a-5p hsa-miR-539 hsa-miR-1297 hsa-miR-1270 hsa-miR-124 hsa-miR-620 hsa-miR-125b hsa-miR-891b

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ABCC4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ABCC4
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ABCC4
    OriGene 3'-UTR clone (see all 2): ABCC4 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ABCC4 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ABCC4 

    Genatlas biochemistry entry for ABCC4:
    ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005254 chloride channel activity IEA--
    GO:0005524 ATP binding IEA--
    GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism EXP15297306
    GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity NAS7557451
    About this table

    ABCC4 for ontologies           About GeneDecksing

    Animal Models: 12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Abcc4):

    behavior/neurologicalcardiovascular systemdigestive/alimentarygrowth/sizehematopoietic system
    homeostasis/metabolismimmune systemlife span-post-weaning/agingnervous systemno phenotypic analysis
    renal/urinary systemtouch/vibrissae

    ABCC4 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ABCC4 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  ABCC4
        LPS/IL-1 Mediated Inhibition of RXR Function

    1 Kegg Pathway  (Kegg details for ABCC4):
        hsa02010 ABC transporters

        SABiosciences Pathway-Focused PCR Array including ABCC4: PAHS-070A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ABCC4
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABCC4

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576 platelet degranulation TAS--
    GO:0006810 transport ----
    GO:0006811 ion transport IEA--
    GO:0007596 blood coagulation TAS--
    GO:0008150 biological_process ND--
    About this table

    ABCC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ABCC4 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ABCC4
    10/48 Novoseek chemical compound relationships for ABCC4 gene (see all 48)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mk 571 85.1 4 16132345 (1), 12695538 (1)
    adefovir 83 47 17110501 (5), 19735648 (3), 10470083 (3), 18364470 (2) (see all 12)
    probenecid 75.9 3 15504935 (2), 18930752 (1)
    sulfinpyrazone 74.3 1 15504935 (1)
    nucleoside monophosphate 69.1 3 15026196 (1), 10470083 (1), 12695538 (1)
    androstane 65.6 2 15004017 (1), 18662272 (1)
    nucleoside 63.1 20 10470083 (2), 12695538 (2), 15827327 (1), 15364914 (1) (see all 11)
    tenofovir 61.7 12 17110501 (4), 17503669 (3), 20149322 (1)
    tenofovir disoproxil fumarate 60 5 17083032 (3), 20149322 (1)
    6 thioguanine 58.7 2 11447229 (1), 12435799 (1)
    About this table

    7 PharmGKB drug compound relationships for ABCC4 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    6-mercaptopurineFA  12435799
    6-thioguanineFA  12435799
    antiviralsFA  GN  12499391
    azidothymidineFA  10470083
    folic acidFA  12036927
    leucovorinFA  12036927
    methotrexatePD  FA  12036927 15630450
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ABCC4
    Sigma-Aldrich shRNA for ABCC4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ABCC4
    OriGene shRNA RFP (see all 2): ABCC4
    OriGene basic RS shRNA (see all 2): ABCC4
    OriGene siRNA (see all 2): ABCC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ABCC4 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ABCC4 
    8/11 SABiosciences Assays for microRNAs that regulate ABCC4 (see all 11):
    hsa-miR-125a-5p hsa-miR-539 hsa-miR-1297 hsa-miR-1270 hsa-miR-124 hsa-miR-620 hsa-miR-125b hsa-miR-891b
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ABCC4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ABCC4
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ABCC4
    OriGene 3'-UTR Clone (see all 2): ABCC4 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ABCC4 
    Primers: OriGene genome-wide validated SYBR primer pairs: ABCC4
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ABCC4: PPH00553A

    REFSEQ mRNAs for ABCC4 gene (2 alternative transcripts): 

    NM_001105515.1  NM_005845.3  

    Additional cDNA sequence: 

    AB208973.1 AF071202.1 AF071203.1 AF339763.1 AF541977.1 AK290317.1 AK296247.1 AK298953.1 
    AK309460.1 AY081219.1 AY133678.1 AY133679.1 AY133680.1 AY207008.1 BC041560.1 BX647118.1 
    U66686.1 U83660.1 

    19 DOTS entries:

    DT.115026  DT.92431917  DT.120783528  DT.99998873  DT.100764438  DT.91729507  DT.100764437  DT.120783477 
    DT.100764439  DT.40310418  DT.100651779  DT.101972277  DT.92431915  DT.97769103  DT.120783530  DT.120783536 
    DT.100810521  DT.120783466  DT.40241131 

    24/125 AceView cDNA sequences (see all 125):

    BX474791 BM556442 BQ889997 W31962 BP382967 AY207008 AA305627 N79659 
    BM462073 AL699662 BE879353 AI248055 BG025276 BM969974 AI420046 BQ069612 
    AI479547 BC041560 AI452594 AA229426 BU186494 CA314196 AI342742 AI240818 

    highest scoring ESTs for ABCC4:

    AF071202 AF541977 AI948503 AY081219 AY133678 AY133679 AY133680 AY207008 BC041560 BQ069612 

    Unigene Cluster for ABCC4:

    ATP-binding cassette, sub-family C (CFTR/MRP), member 4
    Hs.508423  [show with all ESTs]
    Unigene Representative Sequence: NM_005845


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 (see all 9)

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
    SP1:        -     -                                                                                                                             -           -   
    SP2:        -     -                                                                                               -                             -           -   
    SP3:        -     -                                                                                                                                             
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
    SP1:                                      -                                       
    SP2:                                      -                                       
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              

    About this scheme

    ECgene alternative splicing isoforms for ABCC4
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467685 ENST00000376887(uc001vmd.3) ENST00000474158 ENST00000412704(uc010afj.2 uc010afk.2 uc001vmf.2 uc010afl.1 uc010afm.1)
    ENST00000484109 ENST00000471041 ENST00000431522(uc001vme.2 uc010tih.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ABCC4 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching ABCC4 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    34955_at2, 3 U95-A 1 1.00 1.00 0.98 0.80 AF071202 1.00 1.00 1.00 1
    91447_at2, 3 U95-E 1 0.94 1.00 0.95 1.70 AI948503 0.80 1.00 0.91 1
    1931_at2, 3 U95-A 1 0.88 1.00 0.90 0.56 U83660 0.80 1.00 0.91 1
    72602_at2, 3 U95-D 1 0.81 1.00 0.91 1.03 AI452594 0.40 1.00 0.76 1
    203196_at2, 3 U133-A 1 1.00 1.00 -- -- AI948503 0.80 1.00 0.91 1
    1555039_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1554918_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    203196_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    ABCC4 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ABCC4 gene expression
    ABCC4 gene electronic northern expression
    ABCC4 gene sage expression
    About these images

    CGAP SAGE TAG: GTTCGTATTT

    SOURCE GeneReport for Unigene cluster: Hs.508423

    Expression variation in blood from EXPOLDB for ABCC4

    UniProtKB/Swiss-Prot: MRP4_HUMAN, O15439
    Tissue specificity: Widely expressed, with particularly high levels in prostate, but is barely detectable in liver

    Primers: OriGene genome-wide validated SYBR primer pairs: ABCC4
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ABCC4: PPH00553A
        SABiosciences Expression via Pathway-Focused PCR Array including ABCC4: PAHS-070A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ABCC4 gene from 5/12 species (see all 12)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ABCC41   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 86.92(n)
    89.36(a)
    485523  XM_542642.2  XP_542642.2 
    chimpanzee
    (Pan troglodytes)
    ABCC41   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 99.4(n)
    99.62(a)
    452625  XM_001137006.1  XP_001137006.1 
    cow
    (Bos taurus)
    ABCC41   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 86.94(n)
    89.89(a)
    515333  XM_593336.3  XP_593336.2 
    rat
    (Rattus norvegicus)
    Abcc41   -- ATP-binding cassette, sub-family C (CFTR/MRP), member more 81.74(n)
    86.87(a)
    170924  NM_133411.1  NP_596902.1 
    mouse
    (Mus musculus)
    Abcc41 , 5 14 (62.24 cM)5
    ATP-binding cassette, sub-family C (CFTR/MRP), member more1, 5 81.58(n)1
    87.02(a)1
    2392731  NM_001033336.21  NP_001028508.11 
     AK0328025  AK0527785  (see all 10)
    About this table        Species with no ortholog for ABCC4

    ENSEMBL Gene Tree for ABCC4 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ABCC4 gene
    CFTR2  

    ABCC4 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/3838 NCBI SNPs in ABCC4 are shown (see all 3838)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 13 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs37701,2
    C,F,95672237(+) CTATCA/GTTTTA 1 -- ut3110Minor allele frequency- G:0.50MN NA EA WA 676
    rs8688531,2
    C,F,A,H,95955076(-) ATAAAA/GTAAGG 2 -- ng5116Minor allele frequency- G:0.14NA EA NS WA 844
    rs8699511,2
    C,F,O,A,95954210(+) AACGAG/CGGTGC 2 -- ng5116Minor allele frequency- C:0.43MN NS EA NA WA 2502
    rs8700041,2
    C,F,O,A,H,95918063(+) CTTCCG/ATACAG 2 -- int117Minor allele frequency- A:0.21NS EA NA WA 1146
    rs8710511,2
    C,A,95950210(+) aTGATG/TATTAT 2 -- int17Minor allele frequency- T:0.05NA WA 84
    rs8710521,2
    C,F,A,H,95950740(-) ccactT/Ctggac 2 -- int19Minor allele frequency- C:0.49NS EA NA 584
    rs8711751,2
    C,F,A,H,95918965(-) CCCCAT/CTTACT 2 -- int18Minor allele frequency- C:0.12NA EA 401
    rs8737051,2
    C,F,A,95862197(+) GAAAGC/TCTGTA 2 -- int12Minor allele frequency- T:0.06NA EA 160
    rs8737061,2
    C,F,95862387(+) TATGGC/TCAGCA 2 -- int19Minor allele frequency- T:0.13NS EA NA 722
    rs8994941,2
    C,F,O,A,95861804(+) ACTGCG/AATCGC 4 /I syn1 ref116Minor allele frequency- A:0.20NS EA NA WA 2858
    About this table

    HapMap Linkage Disequilibrium images for ABCC4 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ABCC4
         1 CNV: 49276
         3 Indels: 101823 45219 41573

    QIAGEN SeqTarget long-range PCR primers for resequencing ABCC4 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ABCC4 for disorders           About GeneDecksing

    OMIM: 605250

    10/11 Novoseek disease relationships for ABCC4 gene (see all 11)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholestasis 64.9 3 17404579 (2), 15004017 (1)
    breast cancer 39.2 15 17682070 (2), 16393888 (1), 16565357 (1), 10739113 (1) (see all 9)
    cancer 26.9 4 9270026 (1), 16454695 (1), 17943230 (1)
    small cell lung cancer 25.1 2 10100721 (1), 12792791 (1)
    ovarian carcinoma 16.5 1 20005867 (1)
    leukemia 16.5 1 19142964 (1)
    lymphoblastic leukemia acute 11.1 1 12816874 (1)
    immunodeficiency 7.07 4 15105153 (1), 17083032 (1), 10944550 (1)
    virus infection 0 1 15105153 (1)
    cancer lung 0 3 11477564 (2)
    About this table

    2 PharmGKB disease relationships for ABCC4 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    HIVFA  10470083
    Leukemia, Lymphocytic, Acute, L1PD  15630450
    About this table

    Human Gene Mutation Database (HGMD): ABCC4
    Human Genome Epidemiology (HuGE) Navigator: ABCC4 (18 documents)

    Export disorders and mutations for ABCC4 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/190 PubMed articles for ABCC4 gene, integrated from 7 sources (see all 190):
    (articles sorted by number of sources associating them with ABCC4)
    1. Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons. (PubMed id 12499391)1, 5, 7 Lamba J.K....Schuetz J.D. (2003)
    2. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. (PubMed id 10470083)1, 5, 7 Schuetz J.D....Fridland A. (1999)
    3. Isolation of MOAT-B, a widely expressed multidrug resistance- associated protein/canalicular multispecific organic anion transporter-related transporter. (PubMed id 9661885)1, 2, 3 Lee K.... Kruh G.D. (1998)
    4. Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. (PubMed id 12105214)1, 2, 7 Adachi M.... Schuetz J. (2002)
    5. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (PubMed id 9270026)1, 2, 7 Kool M.... Borst P. (1997)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. (PubMed id 12435799)5, 7 Wielinga P.R....Borst P. (2002)
    8. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PubMed id 8894702)1, 3 Allikmets R....Dean M. (1996)
    9. The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. (PubMed id 18364470)1, 7 Abla N....Kroetz D.L. (2008)
    10. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PubMed id 12695538)1, 7 Reid G....Borst P. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10257 HGNC: 55 AceView: ABCC4 Ensembl:ENSG00000125257 euGenes: HUgn10257
    ECgene: ABCC4 Kegg: 10257 H-InvDB: ABCC4

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ABCC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for ABCC4 gene:
    Search GeneIP for patents involving ABCC4

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