Aliases &
Descriptions
for ABP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| amiloride binding protein 1 (amine oxidase (copper-containing))1 2 | | OTTHUMP000002127622 | | AOC11 2 3 | | amiloride-binding protein-12 | | DAO1 2 3 | | OTTHUMP000002127642 | | Diamine oxidase2 3 | | amiloride-sensitive amine oxidase2 | | Kidney amine oxidase2 3 | | amiloride-sensitive amine oxidase [copper-containing]2 | | DAO12 3 | | OTTHUMP000002127632 | | ABP2 3 | | Histaminase3 | | KAO2 3 | | EC 1.4.3.223 | | histaminase2 | | Amiloride-binding protein3 |
Export aliases for ABP1 gene to outside databasesPrevious GC identifers: GC07P148796 GC07P149864 GC07P149941 GC07P149987 GC07P150180 GC07P150521 |
Summaries
for ABP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ABP1:
This gene encodes a membrane glycoprotein that is expressed in many epithelium-rich and/or hematopoietic tissues andoxidatively deaminates putrescine and histamine. The protein may play a role in controlling the level of histamineand/or putrescine in these tissues. It also binds to and is inhibited by amiloride, a diuretic that acts by closingepithelial sodium ion channels. (provided by RefSeq)
UniProtKB/Swiss-Prot: ABP1_HUMAN, P19801Function: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substancesinvolved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possiblyapoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function
|
Genomic Views
for ABP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ABP1 gene promoter:
AP-1 GR-alpha Pax-6 deltaCREB CREB ARP-1 POU2F1 E47 AREB6 c-Rel
Other transcription factors
Search SABiosciences Chromatin IP Primers for ABP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34-q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q34-qterABP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P144361: view genomic region
(about GC identifiers)
Start:
|
144,361,618 bp from pter |
End:
|
144,370,427 bp from pter |
Size:
|
8,810 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+ 150,521,715-150,558,592 |
RefSeq DNA sequence:- NC_000007.13 NT_007914.15 NT_079596.2
|
Proteins
for ABP1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ABP1_HUMAN, P19801 (See
protein sequence)Recommended Name: Amiloride-sensitive amine oxidase [copper-containing] precursor Size: 751 amino acids; 85378 Da
Cofactor: Binds 1 copper ion per subunit (By similarity)
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Cofactor: Contains 1 topaquinone per subunit (By similarity)
Subcellular location: Secreted, extracellular space
Miscellaneous: Inhibited by amiloride in a competitive manner (By similarity)
Sequence caution: Sequence=AAA58358.1; Type=Frameshift; Positions=266, 284, 328, 494, 497, 514, 707, 729;
PDB structures from  and Proteopedia  :3HI7 (3D)
3HIG (3D)
3HII (3D)
3K5T (3D)
3MPH (3D)
Secondary accessions: Q16683 Q16684 Q56II4 Q6GU42Alternative splicing: 2 isoforms: P19801-1 P19801-2 Explore the universe of human proteins at neXtProt for ABP1: NX_P19801
Post-translational modifications:
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue1
REFSEQ proteins: NP_001082.2
ENSEMBL proteins: ENSP00000411613 ENSP00000354193 ENSP00000418328 ENSP00000373621 ENSP00000417317 ENSP00000417392 ENSP00000418557 ENSP00000417051 ENSP00000390254 ENSP00000418614
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ABP1 for ontologies About GeneDecksing
Antibodies for ABP1:
Assays for ABP1: |
Protein
Domains/
Families
for ABP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ABP1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P19801ProtoNet protein and cluster: P19801 1 Blocks protein family: IPB000269 Copper amine oxidase
UniProtKB/Swiss-Prot: ABP1_HUMAN, P19801Similarity: Belongs to the copper/topaquinone oxidase family |
Gene Function
for ABP1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ABP1_HUMAN, P19801Function: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substancesinvolved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possiblyapoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive functionCatalytic activity: Histamine + H(2)O + O(2) = (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2)Enzyme Number (IUBMB): EC 1.4.3.22
Genatlas biochemistry entry for ABP1:amiloride binding protein 1,expressed in kidney5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
ABP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ABP1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
ABP1 for pathways About GeneDecksing
2  Millipore Pathways for ABP1
5/7  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for ABP1 (see all 7)
3  Kegg Pathways (Kegg details for ABP1):
SABiosciences Pathway-Focused PCR Array including ABP1: PAHS-002A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ABP1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ABP1
5/34 Interacting proteins for ABP1 (ENSP000003736213) via UniProtKB, MINT, and/or STRING (see all 34)About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009308 | amine metabolic process |
IEA | -- | | GO:0055114 | oxidation-reduction process |
IEA | -- |
About this table
ABP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ABP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
ABP1 for compounds About GeneDecksing
 Browse Tocris compounds for ABP1
10/48  Novoseek chemical compound relationships for ABP1 gene (see all 48)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hydrazine |
97.2 |
426 |
8645981 (7), 9831324 (7), 2115243 (6), 2121582 (6) (see all 99) |
| histamine |
79.6 |
199 |
18499706 (5), 11603849 (5), 8645981 (4), 17490952 (4) (see all 69) |
| putrescine |
78.7 |
27 |
2124566 (3), 7741045 (2), 9661267 (1), 1417947 (1) (see all 18) |
| tele-methylimidazoleacetic acid |
77.7 |
1 |
8195119 (1) |
| cadaverine |
75.5 |
11 |
19627092 (3), 1417947 (1), 1458548 (1), 17826755 (1) (see all 7) |
| spermidine |
68.2 |
12 |
8348850 (2), 9661267 (1), 2124566 (1), 7882298 (1) (see all 7) |
| tele-methylhistamine |
67.4 |
1 |
17142964 (1) |
| spermine |
66.9 |
12 |
8348850 (2), 9661267 (1), 2124566 (1), 12927050 (1) (see all 8) |
| auxin |
65.2 |
61 |
19777056 (6), 7592943 (5), 17766341 (5), 19669789 (4) (see all 14) |
| amine |
63.9 |
21 |
17142964 (2), 7931266 (1), 8917118 (1), 9405445 (1) (see all 15) |
About this table
|
Transcripts
for ABP1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ABP1 gene: NM_001091.2 Additional cDNA sequence: AK092514.1 AK296638.1 AK307278.1 AK314806.1 BC014093.2 BX648159.1 CR592378.1 CR596790.1 CR598361.1 CR600605.1 CR601090.1 CR602032.1 CR603421.1 CR608165.1 CR610042.1 CR611479.1 CR615931.1 CR615995.1 CR617118.1 CR617395.1 CR618888.1 CR621626.1 CR622987.1 CR624494.1 CR625394.1 CR626724.1 M55602.1 U11862.1 U11863.1 24/30 DOTS entries (see all 30): DT.100851526 DT.216235 DT.95276223 DT.100866765 DT.100863416 DT.95244222 DT.100868947 DT.100653341 DT.95276220 DT.100859438 DT.95276218 DT.100023520 DT.97844407 DT.100640575 DT.100848633 DT.95276231 DT.99937658 DT.92447664 DT.100866194 DT.100867969 DT.121114759 DT.100839669 DT.100852174 DT.100853340 24/392 AceView cDNA sequences (see all 392): BQ326725 CR601090 BG572800 AA078659 CR611479 CR622987 CR602032 CR610042 CR596790 AU135756 CR603421 CR618888 BQ023466 AA604046 AA368561 AA035423 AA368783 BQ022708 BQ022264 BX399363 CR624494 CR626724 CR598361 AU156260
 highest scoring ESTs for ABP1:AA035423 AA088210 AA088634 AA131933 AA132194 AA368451 AA369084 AA369560 AA531201 AA532507 Unigene Cluster for ABP1: Amiloride binding protein 1 (amine oxidase (copper-containing)) Hs.647097 [show with all ESTs]Unigene Representative Sequence: BX648159
GeneLoc Exon Structure
10 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000416793(uc003wia.1) ENST00000360937(uc003whz.1) ENST00000467291
ENST00000388969 ENST00000480582 ENST00000483043 ENST00000460213 ENST00000487631(uc003why.1)
ENST00000437714 ENST00000493429
|
Expression
for ABP1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ABP1 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching ABP1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37186_s_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.99 |
0.83 |
U11863 |
0.80 |
1.00 |
0.91 |
1 |
| 74904_at2, 3
|
U95-D |
1 |
0.69 |
1.00 |
0.99 |
1.18 |
AI984156 |
0.80 |
1.00 |
0.91 |
1 |
| 203559_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_001091 |
0.60 |
1.00 |
0.82 |
1 |
| 203559_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ABP1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCCGACCAGG
SOURCE GeneReport for Unigene cluster: Hs.647097
Expression variation in blood from EXPOLDB for ABP1 UniProtKB/Swiss-Prot: ABP1_HUMAN, P19801Tissue specificity: Placenta and kidney
SABiosciences Expression via Pathway-Focused PCR Array including ABP1: PAHS-002A
|
Orthologs
for ABP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ABP1 gene from 5/7 species (see all 7)
About this table Species with no ortholog for ABP1
ENSEMBL Gene Tree for ABP1 (if available) |
Paralogs
for ABP1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ABP1 gene
- AOC22 AOC32
ABP1 for paralogs About GeneDecksing
|
Genomic Variants
for ABP1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ABP1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ABP1
2 CNVs: 3711 7616 |
Disorders & Mutations
for ABP1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ABP1 for disorders About GeneDecksing
OMIM: 104610
10/30 Novoseek disease relationships for ABP1 gene (see all 30)
About this table
Human Gene Mutation Database (HGMD): ABP1
Human Genome Epidemiology (HuGE) Navigator: ABP1 (6 documents)
Export disorders and mutations for ABP1 gene to outside databases
|
Medical News
for ABP1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ABP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/253 PubMed articles for ABP1 gene, integrated from 7 sources (see all 253):
(articles sorted by number of sources associating them with ABP1)- The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter. (PubMed id 8182053)1, 2, 3, 7 Chassande O.... Lazdunski M. (1994)
- Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues. (PubMed id 8144586)1, 2, 7 Novotny W.F.... Barbry P. (1994)
- Human kidney amiloride-binding protein: cDNA structure and functional expression. (PubMed id 2217167)1, 2, 7 Barbry P....Lazdunski M. (1990)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- cDNA sequences of variant forms of human placenta diamine oxidase. (PubMed id 8595053)1, 2 Zhang X.... McIntire W.S. (1995)
- An environmentally regulated receptor for diamine oxidase modulates human endothelial cell/fibroblast histamine degradative uptake. (PubMed id 8195119)1, 7 Baenziger N.L....Haddock R.C. (1994)
- Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease. (PubMed id 19701972)1, 7 Song W.B....Ma L. (2009)
- Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity. (PubMed id 17700358)1, 7 Ayuso P....Agundez J.A. (2007)
- Wine and headache. (PubMed id 8645981)1, 7 Jarisch R. and Wantke F. (1996)
- Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy. (PubMed id 11603849)1, 7 Brew O.B. and Sullivan M.H. (2001)
|
External Searches for ABP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ABP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ABP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ABP1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/abp1/ |
|
| | |
About This Section
| Patent Information for ABP1 gene:
Search GeneIP for patents involving ABP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ABP1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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