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ACP1 Gene

protein-coding   GIFtS: 68

GC02P000254
acid phosphatase 1, soluble
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
acid phosphatase 1, soluble1 2     acid phosphatase of erythrocyte2
Low molecular weight cytosolic acid phosphatase2 3     OTTHUMP000001999142
Adipocyte acid phosphatase2 3     protein tyrosine phosphatase2
Red cell acid phosphatase 12 3     OTTHUMP000001999152
LMW-PTP2 3     MGC34992
LMW-PTPase2 3     MGC1110302
cytoplasmic phosphotyrosyl protein phosphatase2     EC 3.1.3.483
low molecular weight phosphotyrosine protein phosphatase2     EC 3.1.3.23
HAAP2     

External Ids:    HGNC: 1221   Entrez Gene: 522   Ensembl: ENSG000001437277   UniProtKB: P246663   

Export aliases for ACP1 gene to outside databases

Previous GC identifer: GC02P000258


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACP1:
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid
phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and
orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is
genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes.
Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in
allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been
identified for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
Isoform 3 does not possess phosphatase activity

Gene Wiki entry for ACP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACP1 gene promoter:
         p53   STAT5B   STAT3   NF-1   FOXJ2 (long isoform)   Nkx3-1 v3   Nkx3-1 v4   Nkx3-1 v2   Nkx3-1 v1   Nkx3-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ACP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ACP1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25

ACP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACP1 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P000254:  view genomic region     (about GC identifiers)

Start:
261,431 bp from pter
End:
278,283 bp from pter
Size:
16,853 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.11  NT_022221.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666 (See protein sequence)
Recommended Name: Low molecular weight phosphotyrosine protein phosphatase  
Size: 158 amino acids; 18042 Da
Subunit: Isoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for isoforms 2 or 3
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :
1XWW (3D)    5PNT (3D)    
Secondary accessions: A8K1L9 P24667 Q16035 Q16036 Q16725 Q3KQX8 Q53RU0
Alternative splicing: 3 isoforms:  P24666-1   P24666-2, P24667-1   P24666-3   (The ratio of isoform 1 to isoform 2 is 2:1 in allele A, 4:1 in allele B and 1:4 in allele C)

Explore the universe of human proteins at neXtProt for ACP1: NX_P24666 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001035739.1  NP_004291.1  NP_009030.1  


    ENSEMBL proteins: 
    ENSP00000272067 ENSP00000384184 ENSP00000385404 ENSP00000408373 ENSP00000410331 ENSP00000389681 
    ENSP00000411121 ENSP00000384307 ENSP00000272065 ENSP00000408596 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant ACP1 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): ACP1
    OriGene Protein Over-expression Lysate (see all 2): ACP1
    GenScript Custom Purified and Recombinant Proteins Services for ACP1 
    Novus Biologicals Proteins for ACP1
    Novus Biologicals Lysate for ACP1
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ACP1

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625 soluble fraction TAS1587862
    GO:0005634 nucleus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    GO:0019717 synaptosome ----
    About this table

    ACP1 for ontologies           About GeneDecksing



    Antibodies for ACP1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ACP1
    R&D Systems Antibodies for ACP1 (LMW-PTP/ACP1)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ACP1 
    Novus Biologicals Antibodies for ACP1
    Browse antibodies at Epitomics

    Assays for ACP1: 
    Browse Kits and Assays available from Millipore
    Sigma-Aldrich ELISAs for ACP1
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACP1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ACP1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACP1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000106 Tyr_phospatase/Ars_reductase
     IPR017867 Tyr_phospatase_low_mol_wt
     IPR002115 Tyr_Pase_low_mol_wt_mml

    Graphical View of Domain Structure for InterPro Entry P24666

    ProtoNet protein and cluster: P24666

    2 Blocks protein families:
    IPB000106 LMW phosphotyrosine protein phosphatase signature
    IPB002115 Mammalian LMW phosphotyrosine protein phosphatase signature


    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
    Isoform 3 does not possess phosphatase activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate
    Enzyme regulation: Inhibited by sulfhydryl reagents
    Enzyme Numbers (IUBMB): EC 3.1.3.48  EC 3.1.3.2 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ACP1
    Sigma-Aldrich shRNA Panels and shRNA for ACP1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): ACP1
    OriGene shRNA RFP (see all 6): ACP1
    OriGene basic RS shRNA (see all 6): ACP1
    OriGene siRNA (see all 5): ACP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ACP1 
    miRNA:Sigma-Aldrich microRNA Mimics for ACP1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ACP1 
    Search SABiosciences for Assays for microRNAs that regulate ACP1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ACP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ACP1
    OriGene untagged cDNA clones in CMV expression vector (see all 7): ACP1
    OriGene 3'-UTR clone (see all 3): ACP1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ACP1 
    Sino Biological Human cDNA Clone for ACP1

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ACP1 

    Genatlas biochemistry entry for ACP1:
    phosphatase acid,red cell

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003993 acid phosphatase activity IEA--
    GO:0004725 protein tyrosine phosphatase activity ----
    GO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA--
    GO:0016787 hydrolase activity IEA--
    GO:0016791 phosphatase activity ----
    About this table

    ACP1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ACP1 for pathways           About GeneDecksing

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  ACP1
        Riboflavin Metabolism
    PDGF Signaling
    Ephrin Receptor Signaling

    3 Kegg Pathways  (Kegg details for ACP1):
        hsa00740 Riboflavin metabolism
    hsa01120 Microbial metabolism in diverse environments
    hsa04520 Adherens junction

        SABiosciences Pathway-Focused PCR Array including ACP1: PAHS-045A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ACP1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACP1

    5/17 Interacting proteins for ACP1 (ENSP000002720673 P246661) via UniProtKB, MINT, and/or STRING (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACP1P246661EBI-717701,EBI-717701
    ENPP1ENSP000003509643STRING: ENSP00000350964
    ENPP3ENSP000003502653STRING: ENSP00000350265
    PDGFRBENSP000002617993STRING: ENSP00000261799
    PON1ENSP000002223813STRING: ENSP00000222381
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470 protein dephosphorylation IEA--
    About this table

    ACP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ACP1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACP1
    10/116 Novoseek chemical compound relationships for ACP1 gene (see all 116)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 94.6 3576 16039061 (12), 15477998 (6), 10980198 (5), 8258363 (5) (see all 99)
    phosphotyrosine 91.9 211 7679612 (5), 2134890 (3), 8620937 (3), 7686722 (3) (see all 99)
    sodium orthovanadate 88.7 78 10230815 (2), 11507066 (2), 8186375 (1), 8014198 (1) (see all 66)
    vanadate 88.1 139 11980490 (4), 2154464 (3), 9878539 (2), 10439081 (2) (see all 99)
    phenylarsine oxide 82.6 54 8581996 (2), 7738000 (2), 1423640 (2), 9341756 (2) (see all 31)
    raytide 80.3 5 1318316 (1), 7684610 (1), 8256510 (1)
    p-nitrophenyl phosphate 76.9 8 8127855 (2), 2134890 (1), 19414171 (1), 7528537 (1) (see all 7)
    dephostatin 75.7 9 8557604 (4), 8226312 (1), 20130847 (1)
    bpv(phen) 71.2 3 16039061 (1), 11792460 (1)
    benzylphosphonic acid 70 2 9458714 (1), 9106619 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ACP1
    Sigma-Aldrich shRNA Panels and shRNA for ACP1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): ACP1
    OriGene shRNA RFP (see all 6): ACP1
    OriGene basic RS shRNA (see all 6): ACP1
    OriGene siRNA (see all 5): ACP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ACP1 
    miRNA: Sigma-Aldrich microRNA Mimics for ACP1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ACP1 
    Search SABiosciences for Assays for microRNAs that regulate ACP1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ACP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ACP1
    OriGene untagged cDNA clones in CMV expression vector (see all 7): ACP1
    OriGene 3'-UTR Clone (see all 3): ACP1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ACP1 
    Primers: OriGene genome-wide validated SYBR primer pairs: ACP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ACP1: PPH00008A

    REFSEQ mRNAs for ACP1 gene (3 alternative transcripts): 

    NM_001040649.2  NM_004300.3  NM_007099.3  

    Additional cDNA sequence: 

    AB209838.1 AK289934.1 AK291861.1 BC007422.2 BC106011.1 BT007136.1 CR591454.1 CR597555.1 
    CR599434.1 CR607431.1 CR609595.1 CR609802.1 CR613475.1 CR624312.1 M83653.1 M83654.1 
    M87545.1 S62884.1 Y16846.1 

    20 DOTS entries:

    DT.100842980  DT.99931855  DT.100030203  DT.454219  DT.100842972  DT.100842978  DT.119141  DT.121013711 
    DT.100742580  DT.95256266  DT.100842976  DT.100842982  DT.119140  DT.95256302  DT.121013776  DT.121013819 
    DT.91759792  DT.95256278  DT.121417499  DT.99984839 

    24/473 AceView cDNA sequences (see all 473):

    BX481618 BI253868 AW951882 CR597555 CB105331 AU117562 BM770461 CB243083 
    CR607431 AA568474 R51820 NM_007099 R87733 CB162319 BI439004 CB144180 
    BU539875 AA120890 BG056276 AI167367 AI141086 CD675878 BM980953 BF001721 

    highest scoring ESTs for ACP1:

    AA037447 AA037448 AA056583 AA115242 AA130244 AA130248 AA205145 AA467733 AA467801 AA479138 

    Unigene Cluster for ACP1:

    Acid phosphatase 1, soluble
    Hs.558296  [show with all ESTs]
    Unigene Representative Sequence: NM_004300


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ACP1 (see all 9)

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
    SP1:                                -                 -                 -     -     -                                                         
    SP2:                                -     -           -           -     -           -                                                         
    SP3:                                -     -           -     -     -     -           -                                                         
    SP4:                                -     -           -                 -     -     -                                                         
    SP5:                                      -           -                 -     -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for ACP1
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272067(uc002qwg.2 uc002qwh.2) ENST00000405364 ENST00000407983(uc002qwd.2)
    ENST00000449425 ENST00000480874 ENST00000413140 ENST00000442386 ENST00000484464
    ENST00000463831 ENST00000453390 ENST00000405233(uc002qwe.3) ENST00000484125
    ENST00000272065(uc002qwf.2) ENST00000439645

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ACP1 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching ACP1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36611_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 U25849 0.20 1.00 0.72 1
    201629_s_at2, 3 U133-A 2 1.00 0.95 -- -- BE872974 0.80 1.00 0.91 1
    201630_s_at2, 3 U133-A 1 0.91 1.00 -- -- NM_004300 0.60 1.00 0.82 1
    215227_x_at2, 3 U133-A 1 0.91 1.00 -- -- BG035989 0.80 1.00 0.91 1
    201629_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    201630_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    215227_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    1554808_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    ACP1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ACP1 gene expression
    ACP1 gene electronic northern expression
    ACP1 gene sage expression
    About these images

    CGAP SAGE TAG: AATATTTCAA

    SOURCE GeneReport for Unigene cluster: Hs.558296

    Expression variation in blood from EXPOLDB for ACP1

    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Tissue specificity: T-lymphocytes express only isoform 2

    Primers: OriGene genome-wide validated SYBR primer pairs: ACP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ACP1: PPH00008A
        SABiosciences Expression via Pathway-Focused PCR Array including ACP1: PAHS-045A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ACP1 gene from 5/18 species (see all 18)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ACP11   -- acid phosphatase 1, soluble 100(n)
    100(a)
    458990  XM_001149653.1  XP_001149653.1 
    cow
    (Bos taurus)
    ACP11   -- acid phosphatase 1, soluble 91.03(n)
    94.87(a)
    280977  NM_173978.2  NP_776403.1 
    rat
    (Rattus norvegicus)
    Acp11   -- acid phosphatase 1, soluble 79.54(n)
    81.01(a)
    24161  NM_021262.2  NP_067085.1 
    mouse
    (Mus musculus)
    Acp11 , 5 12 (13.00 cM)5
    acid phosphatase 1, soluble1, 5 80.17(n)1
    81.01(a)1
    114311  NM_021330.31  NP_067305.21 
     AA0001995  AI4274685  (see all 35)
    chicken
    (Gallus gallus)
    ACP11   -- acid phosphatase 1, soluble 72.36(n)
    74.05(a)
    421909  NM_001039291.1  NP_001034380.1 
    About this table        Species with no ortholog for ACP1

    ENSEMBL Gene Tree for ACP1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Pseudogenes
    3 related pseudogenes



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    UniProtKB/Swiss-Prot: PPAC_HUMAN, P24666
    Polymorphism: ACP1 is genetically polymorphic. Three common alleles are known in Caucasians: ACP1*A, ACP1*B and ACP1*C.
    They give rise to six different phenotypes. Each allele appears to encode two electrophoretically different isozymes,
    F and S, which are produced in allele-specific ratios. The sequence shown is that of allele ACP1*B and allele ACP1*C


    10/143 NCBI SNPs in ACP1 are shown (see all 143)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs68551,2
    C,F,A,H,277995(+) GAAAGA/GAGGAC 2 -- ut31 trp316Minor allele frequency- G:0.15MN NS EA NA WA 1504
    rs125031,2
    H277951(+) GCTCCC/AATCTG 2 -- ut31 ese35Minor allele frequency- A:0.00MN NS EA 598
    rs148141,2
    --278000(+) AAGGAC/AACTTG 2 -- ut31 ese31Minor allele frequency- A:0.00MN 184
    rs11306121,2
    --272048(+) GTAGAC/TAGCGC 5 D ref1 syn1 int10--------
    rs11306131,2
    --272058(+) CGGCAA/GCTTCC 5 T A int1 ref1 mis10--------
    rs11306141,2
    --272087(+) CCCCCA/TGACTA 5 P syn1 ref1 int1 ese30--------
    rs11306151,2
    --272095(+) CTACCA/GAGGGC 5 Q R int1 mis1 ref1 ese30--------
    rs11306161,2
    --272098(+) CCGAGA/GGCAGA 5 E G mis1 ref1 int1 ese30--------
    rs11306181,2
    --272101(+) AGGGCA/TGAGCT 5 Q L int1 ref1 mis1 ese30--------
    rs11306191,2
    --272109(+) GCTGCA/CTGAAG 5 M L ref1 mis1 int1 ese30--------
    About this table

    HapMap Linkage Disequilibrium images for ACP1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ACP1
         2 CNVs: 2360 3341

    QIAGEN SeqTarget long-range PCR primers for resequencing ACP1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACP1 for disorders           About GeneDecksing

    OMIM: 171500

    10/90 Novoseek disease relationships for ACP1 gene (see all 90)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noonan syndrome 70 11 15240615 (2), 12161469 (2), 16208280 (1), 19541608 (1) (see all 9)
    bubonic plague 60.8 7 1723471 (1), 14609321 (1), 8052312 (1), 7803389 (1) (see all 5)
    centronuclear myopathy 49.8 2 10900271 (1), 11056007 (1)
    lafora disease 45 6 9771710 (1), 16134145 (1), 14643920 (1), 17010495 (1) (see all 5)
    insulin resistance 40.4 32 18925540 (4), 15271787 (2), 7769120 (2), 7535776 (1) (see all 21)
    autoimmunity 36.4 6 17608818 (1), 11826758 (1), 18303998 (1), 18416318 (1) (see all 6)
    leopard syndrome 36.1 1 16208280 (1)
    favism 34.7 2 8522318 (1), 9116311 (1)
    diabetes autoimmune 32.7 2 18056891 (1)
    immune disorder 32.6 2 18490013 (1), 19246900 (1)
    About this table

    Genetic Association Database (GAD): ACP1
    Human Genome Epidemiology (HuGE) Navigator: ACP1 (38 documents)

    Export disorders and mutations for ACP1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/1466 PubMed articles for ACP1 gene, integrated from 7 sources (see all 1466):
    (articles sorted by number of sources associating them with ACP1)
    1. Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. (PubMed id 12640337)1, 4, 7 Meloni G....Bottini E. (2003)
    2. Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms. (PubMed id 15281007)1, 4, 7 Bottini N....Bottini E. (2004)
    3. Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women. (PubMed id 12409270)1, 4, 7 Bottini N....Comings D.E. (2002)
    4. Genetic polymorphism and TH1/TH2 orientation. (PubMed id 16224193)1, 4, 7 Bottini N....Bottini E. (2005)
    5. [Genetic predisposition to development of toxic liver cirrhosis caused by alcohol] (PubMed id 11436564)1, 4, 7 Spitsyn V.A....Afanas'eva I.S. (2001)
    6. Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex. (PubMed id 15586390)1, 4, 7 Bottini N....Bottini E. (2005)
    7. [Genetic polymorphism of erythrocytic enzymes in Yakut populations] (PubMed id 11963573)1, 4, 7 Tarskaia L.A....Spitsin V.A. (2002)
    8. The genetics of signal transduction and the effect of smoking on intrauterine growth. (PubMed id 11369750)1, 4, 7 Bottini E....Lucarini N. (2001)
    9. Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. (PubMed id 9705307)1, 2, 7 Zhang M.... van Etten R.L. (1998)
    10. Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase. (PubMed id 1304913)1, 2, 7 Shekels L.L.... Bernlohr D.A. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 52 HGNC: 122 AceView: ACP1 Ensembl:ENSG00000143727 euGenes: HUgn52
    ECgene: ACP1 Kegg: 52 H-InvDB: ACP1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ACP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ACP1 gene:
    Search GeneIP for patents involving ACP1

    GeneCards and IP:
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