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ACSS1 Gene

protein-coding   GIFtS: 53

GC20M024986
acyl-CoA synthetase short-chain family member 1
(Previous name: acetyl-Coenzyme A synthetase 2 (AMP forming)-like )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ACAS2L)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
acyl-CoA synthetase short-chain family member 11 2 3     acetyl-coenzyme A synthetase 2-like, mitochondrial2
acetyl-Coenzyme A synthetase 2 (AMP forming)-like1 2     FLJ456592
AceCS2L1 2     Acetyl-CoA synthetase 23
MGC338431 2     KIAA18463
Acetate--CoA ligase 22 3     EC 6.2.1.13
ACAS2L2 3     AceCS23
dJ568C11.31     

External Ids:    HGNC: 160911   Entrez Gene: 845322   Ensembl: ENSG000001549307   UniProtKB: Q9NUB13   

Export aliases for ACSS1 gene to outside databases

Previous GC identifer: GC20M024935


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACSS1:
An acetyl-CoA synthetase found in the mitochondrial matrix has been characterized in both cow and mouse. It is
primarily a cardiac enzyme which produces acetyl-CoA mainly for the oxidation of acetate. The protein encoded by this
gene is structurally similar to the cow and mouse proteins and therefore may serve a similar function in humans.
(provided by RefSeq)

UniProtKB/Swiss-Prot: ACS2L_HUMAN, Q9NUB1
Function: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for
energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used
for oxidation through the tricarboxylic cycle to produce ATP and CO(2)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACSS1 gene promoter:
         AREB6   MEF-2A   ATF6   NF-E2   NF-E2 p45   c-Jun   AP-1   c-Fos   JunB   Fra-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ACSS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ACSS1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.23-p11.21   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.23-p11.21

ACSS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSS1 gene location

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M024986:  view genomic region     (about GC identifiers)

Start:
24,943,710 bp from pter
End:
25,039,616 bp from pter
Size:
95,907 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ACS2L_HUMAN, Q9NUB1 (See protein sequence)
Recommended Name: Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor  
Size: 689 amino acids; 74857 Da
Subunit: Interacts with SIRT3
Subcellular location: Mitochondrion matrix
Sequence caution: Sequence=BAB55390.1; Type=Erroneous initiation; Sequence=BAC03853.1; Type=Frameshift; Positions=250;
Sequence=BAC03853.1; Type=Miscellaneous discrepancy; Note=Sequencing errors;
PDB structures from and Proteopedia :
3GLR (3D)    3GLT (3D)    3GLU (3D)    
Secondary accessions: Q5TF42 Q8IV99 Q8N234 Q96JI1 Q96JX6 Q9NU28
Alternative splicing: 2 isoforms:  Q9NUB1-1   Q9NUB1-2   

Explore the universe of human proteins at neXtProt for ACSS1: NX_Q9NUB1 

Post-translational modifications:

  • Reversibly acetylated on Lys-642. The acetyl-CoA synthase activity is inhibited by acetylation and activated by
  • deacetylation1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_115890.2  

    ENSEMBL proteins: 
    ENSP00000365916 ENSP00000388793 ENSP00000365917 ENSP00000316924 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for ACSS1 
    Novus Biologicals Lysate for ACSS1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739 mitochondrion IEA--
    GO:0005759 mitochondrial matrix IDA16788062
    About this table

    ACSS1 for ontologies           About GeneDecksing



    Antibodies for ACSS1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ACSS1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ACSS1 
    Novus Biologicals Antibody for ACSS1
    Browse antibodies at Epitomics

    Assays for ACSS1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACSS1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ACSS1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACSS1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR020845 AMP-binding_CS
     IPR011904 Ac_CoA_lig
     IPR000873 AMP-dep_Synth/Lig

    Graphical View of Domain Structure for InterPro Entry Q9NUB1

    ProtoNet protein and cluster: Q9NUB1

    1 Blocks protein family: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACS2L_HUMAN, Q9NUB1
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ACS2L_HUMAN, Q9NUB1
    Function: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for
    energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used
    for oxidation through the tricarboxylic cycle to produce ATP and CO(2)
    Catalytic activity: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
    Enzyme regulation: Inhibited by acetylation at Lys-642 and activated by deacetylation
    Enzyme Number (IUBMB): EC 6.2.1.1 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ACSS1
    Sigma-Aldrich shRNA for ACSS1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ACSS1
    OriGene shRNA RFP (see all 2): ACSS1
    OriGene basic RS shRNA (see all 2): ACSS1
    OriGene siRNA: ACSS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ACSS1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ACSS1 
    1 SABiosciences Assays for microRNA that regulate ACSS1:
    hsa-miR-548n

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ACSS1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ACSS1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ACSS1
    OriGene 3'-UTR clone: ACSS1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: ACSS1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ACSS1 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003824 catalytic activity ----
    GO:0003987 acetate-CoA ligase activity IDA16788062
    GO:0005515 protein binding IPI19535340
    GO:0005524 ATP binding IEA--
    About this table

    ACSS1 for ontologies           About GeneDecksing

    Animal Models: 5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Acss1):

    behavior/neurologicalcellulargrowth/sizehomeostasis/metabolismlife span-post-weaning/aging

    ACSS1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ACSS1 for pathways           About GeneDecksing

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  ACSS1
        Pyruvate Metabolism
    Glycolysis/Gluconeogenesis
    Propanoate Metabolism

    5 Kegg Pathways  (Kegg details for ACSS1):
        hsa00010 Glycolysis / Gluconeogenesis
    hsa00620 Pyruvate metabolism
    hsa00640 Propanoate metabolism
    hsa01100 Metabolic pathways
    hsa01120 Microbial metabolism in diverse environments

        SABiosciences Custom Pathway-Focused PCR Arrays for ACSS1 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ACSS1
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACSS1

    5/34 Interacting proteins for ACSS1 (ENSP000003169243) via UniProtKB, MINT, and/or STRING (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACAT1ENSP000002658383STRING: ENSP00000265838
    ACAT2ENSP000003560153STRING: ENSP00000356015
    ACLYENSP000002537923STRING: ENSP00000253792
    ACSS2ENSP000003638253STRING: ENSP00000363825
    ALDH6A1ENSP000003425643STRING: ENSP00000342564
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006069 ethanol oxidation TAS--
    GO:0006085 acetyl-CoA biosynthetic process IDA16788062
    GO:0006805 xenobiotic metabolic process TAS--
    GO:0008152 metabolic process ----
    About this table

    ACSS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACSS1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ACSS1
    Sigma-Aldrich shRNA for ACSS1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ACSS1
    OriGene shRNA RFP (see all 2): ACSS1
    OriGene basic RS shRNA (see all 2): ACSS1
    OriGene siRNA: ACSS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ACSS1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ACSS1 
    1 SABiosciences Assays for microRNA that regulate ACSS1:
    hsa-miR-548n
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ACSS1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ACSS1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ACSS1
    OriGene 3'-UTR Clone: ACSS1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: ACSS1 
    Primers: OriGene genome-wide validated SYBR primer pairs: ACSS1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ACSS1: PPH07489A

    REFSEQ mRNAs for ACSS1 gene: 

    NM_032501.2  

    Additional cDNA sequence: 

    AB058749.1 AK027817.1 AK090851.1 AK092295.1 AK125058.1 AK125923.1 AK127566.1 AK296306.1 
    AK314440.1 AL832939.1 AL833041.1 BC032076.1 BC039261.1 BC044588.1 BC055008.1 BC114612.1 
    CR593620.1 CR616020.1 CR624354.1 

    21 DOTS entries:

    DT.441489  DT.100036403  DT.100710053  DT.101977443  DT.100789155  DT.100789153  DT.91919704  DT.91941783 
    DT.320002  DT.120832524  DT.91662654  DT.120832547  DT.120832552  DT.120832558  DT.120832561  DT.120832563 
    DT.120832593  DT.120832607  DT.120832621  DT.92439525  DT.80100506 

    24/209 AceView cDNA sequences (see all 209):

    BF514433 BU740271 AI241110 BE041281 BX641221 AI086481 BM727197 AK024424 
    BF930930 BE855412 BQ366261 AI168487 CR616020 BQ773698 AI356425 AW675715 
    AK027817 AK125923 AW025667 BE293600 AW242634 AA912043 AI832144 CK299554 

    highest scoring ESTs for ACSS1:

    AA418301 AA418343 AI356425 AI499835 AI684951 AI762466 AI983417 AL832939 AW007194 AW024994 

    Unigene Cluster for ACSS1:

    Acyl-CoA synthetase short-chain family member 1
    Hs.529353  [show with all ESTs]
    Unigene Representative Sequence: AK125058


    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for ACSS1 (see all 18)

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a ·
    SP1:                          -           -     -     -                       -                             -                 -                 -     -         
    SP2:                          -           -     -     -                       -                             -                 -                 -     -         
    SP3:                                                                          -                             -                 -                 -     -         
    SP4:                          -           -     -     -                       -                             -                 -                 -     -         
    SP5:                                                                                                        -                 -                                 

    ExUns: 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d · 20e ^ 21 ^ 22
    SP1:                    -           -     -     -           -     -     -                                             
    SP2:                    -           -     -     -           -     -     -                                             
    SP3:                    -           -     -     -           -     -     -                                             
    SP4:              -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP5:                                                                                                                  

    About this scheme

    ECgene alternative splicing isoforms for ACSS1
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376726 ENST00000484396 ENST00000432802(uc002wub.2 uc002wuc.2)
    ENST00000376727(uc010gdc.2) ENST00000323482(uc002wud.1 uc002wua.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ACSS1 expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching ACSS1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    64918_at2, 3 U95-C 1 1.00 1.00 0.96 0.95 AI684951 0.80 1.00 0.91 1
    48752_s_at2, 3 U95-B 1 1.00 1.00 0.93 1.05 AI983417 0.80 1.00 0.91 1
    224882_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --
    234801_s_at2, 3 U133-B 1 0.46 1.00 -- -- AK024424 0.40 1.00 0.76 1
    234483_at*2, 3 U133-B NULL 0.00 0.00 -- -- AK024424 0.40 1.00 0.76 1
    234484_s_at*2, 3 U133-B NULL 0.00 0.00 -- -- AK024424 0.40 1.00 0.76 1
    224882_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    234801_s_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    234483_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    234484_s_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    About this table

    ACSS1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ACSS1 gene expression
    ACSS1 gene electronic northern expression
    ACSS1 gene sage expression
    About these images

    CGAP SAGE TAG: GTCCCGGGCA

    SOURCE GeneReport for Unigene cluster: Hs.529353
    Primers: OriGene genome-wide validated SYBR primer pairs: ACSS1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ACSS1: PPH07489A
        SABiosciences Custom PCR Arrays for ACSS1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ACSS1 gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ACSS11   -- acyl-CoA synthetase short-chain family member 1 86.53(n)
    89.67(a)
    477002  XM_534200.2  XP_534200.2 
    chimpanzee
    (Pan troglodytes)
    ACSS11   -- acyl-CoA synthetase short-chain family member 1 99.42(n)
    99.42(a)
    469905  XM_001149851.1  XP_001149851.1 
    cow
    (Bos taurus)
    ACSS11   -- acyl-CoA synthetase short-chain family member 1 84.1(n)
    85.19(a)
    282873  NM_174746.2  NP_777171.1 
    rat
    (Rattus norvegicus)
    Acss11   -- acyl-CoA synthetase short-chain family member 1 84.61(n)
    87.06(a)
    296259  XM_215897.4  XP_215897.4 
    mouse
    (Mus musculus)
    Acss11 , 5 2 (74.74 cM)5
    acyl-CoA synthetase short-chain family member 11, 5 84.46(n)1
    88.09(a)1
    687381  NM_080575.11  NP_542142.11 
     AB0467425  AI7889785  (see all 17)
    About this table        Species with no ortholog for ACSS1

    ENSEMBL Gene Tree for ACSS1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ACSS1 gene
    ENSG000002282822  C10orf1292  ACSM52  ACSM32  ACSS22  ACSM2A2  ACSM12  ACSM42  
    ACSS32  ACSM2B2  

    ACSS1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/552 NCBI SNPs in ACSS1 are shown (see all 552)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs36461,2
    C,A,25038839(+) CCTTCG/CGCCAC 1 -- ut51 ese31Minor allele frequency- C:0.00WA 2
    rs7617201,2
    C,F,A,25026066(+) GTCACG/AGTGGG 1 -- int113Minor allele frequency- A:0.13NA MN NS EA 1260
    rs9105261,2
    C,F,A,25026893(+) TTAGAG/AACAGA 1 -- int1 ese315Minor allele frequency- A:0.13NS EA NA WA 1050
    rs9105271,2
    C,F,A,25027078(+) TCCCAT/CGGGCA 1 -- int1 ese315Minor allele frequency- C:0.42NS EA NA 976
    rs10078811,2
    C,F,A,25014385(+) GCTCAA/GCTTGG 1 -- int114Minor allele frequency- N:0.00NS EA NA WA 888
    rs10152781,2
    C,A,H,25002519(+) CAGCAG/ACTGAG 1 -- int112Minor allele frequency- A:0.04NA EA MN WA 514
    rs19601901,2
    C,F,A,25026565(+) ttattT/Attatt 1 -- int15Minor allele frequency- A:0.35WA NA 60
    rs19854851,2
    C,F,H25015492(+) agctaC/Tcacca 1 -- int115Minor allele frequency- T:0.03NS EA NA WA 570
    rs20247401,2
    --25023080(+) CCACGA/CCTCAC 1 -- int10--------
    rs21443711,2
    C,F,A,H,25020047(+) GTTCaT/Cttttt 1 -- int116Minor allele frequency- C:0.46NS EA NA 1016
    About this table

    HapMap Linkage Disequilibrium images for ACSS1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACSS1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ACSS1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACSS1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ACSS1 (5 documents)

    Export disorders and mutations for ACSS1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/20 PubMed articles for ACSS1 gene, integrated from 7 sources (see all 20):
    (articles sorted by number of sources associating them with ACSS1)
    1. Crystal structures of human SIRT3 displaying substrate-induced conformational changes. (PubMed id 19535340)1, 2, 7 Jin L.... Perni R.B. (2009)
    2. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. (PubMed id 16788062)1, 2, 7 Schwer B.... Verdin E. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    7. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84532 HGNC: 16091 AceView: ACAS2L Ensembl:ENSG00000154930 euGenes: HUgn84532
    ECgene: ACSS1 Kegg: 84532 H-InvDB: ACSS1

    (According to HUGE)
    About This Section
    HUGE: KIAA1846

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ACSS1 gene:
    Search GeneIP for patents involving ACSS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in ACSS1 promoter
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     ELISAs and CLIAs for ACSS1
           

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