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ACTR2 Gene

protein-coding   GIFtS: 55

GC02P065189
ARP2 actin-related protein 2 homolog (yeast)
(Previous names: ARP2 (actin-related protein 2, yeast) homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ARP2 actin-related protein 2 homolog (yeast)1 2
ARP21 2 3
Actin-like protein 22 3
ARP2 (actin-related protein 2, yeast) homolog1
actin-related protein 22

External Ids:    HGNC: 1691   Entrez Gene: 100972   Ensembl: ENSG000001380717   UniProtKB: P611603   

Export aliases for ACTR2 gene to outside databases

Previous GC identifers: GC02P065588 GC02P065412 GC02P065429 GC02P065366 GC02P065308 GC02P065454


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACTR2:
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major
constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and
motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160
Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin
polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched
actin networks. Seems to contact the pointed end of the daughter actin filament

Gene Wiki entry for ACTR2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACTR2 gene promoter:
         p53   Elk-1   Pbx1a   NF-E2 p45   NF-E2   CREB   deltaCREB   c-Jun   c-Fos   AP-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ACTR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ACTR2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

ACTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR2 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P065189:  view genomic region     (about GC identifiers)

Start:
65,189,074 bp from pter
End:
65,232,629 bp from pter
Size:
43,556 bases
Orientation:
plus strand

1 alternative location:
Chr2+ 65,454,887-65,498,387     
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160 (See protein sequence)
Recommended Name: Actin-related protein 2  
Size: 394 amino acids; 44761 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC
Subcellular location: Cytoplasm, cytoskeleton. Cell projection
Secondary accessions: B2RCP5 O15142 Q96C82

Explore the universe of human proteins at neXtProt for ACTR2: NX_P61160 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001005386.1  NP_005713.1  


    ENSEMBL proteins: 
    ENSP00000260641 ENSP00000367220 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): ACTR2
    GenScript Custom Purified and Recombinant Proteins Services for ACTR2 
    Novus Biologicals Protein for ACTR2
    Novus Biologicals Lysates for ACTR2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005885 Arp2/3 protein complex TAS9230079
    GO:0015629 actin cytoskeleton TAS9230079
    GO:0042995 cell projection IEA--
    About this table

    ACTR2 for ontologies           About GeneDecksing



    Antibodies for ACTR2: 
    Millipore Mono- and Polyclonal Antibodies for the study of ACTR2
    Sigma-Aldrich Antibody Arrays and Antibodies for ACTR2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ACTR2  (ARP2)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ACTR2 
    Novus Biologicals Antibodies for ACTR2
    Epitomics antibodies for ACTR2

    Assays for ACTR2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACTR2 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACTR2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020902 Actin/actin-like_CS
     IPR004000 Actin-like

    Graphical View of Domain Structure for InterPro Entry P61160

    ProtoNet protein and cluster: P61160

    UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160
    Similarity: Belongs to the actin family. ARP2 subfamily


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160
    Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin
    polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched
    actin networks. Seems to contact the pointed end of the daughter actin filament

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ACTR2
    Sigma-Aldrich shRNA for ACTR2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ACTR2
    OriGene shRNA RFP (see all 2): ACTR2
    OriGene basic RS shRNA (see all 2): ACTR2
    OriGene siRNA (see all 2): ACTR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ACTR2 
    miRNA:Sigma-Aldrich microRNA Mimics for ACTR2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ACTR2 
    8/13 SABiosciences Assays for microRNAs that regulate ACTR2 (see all 13):
    hsa-miR-495 hsa-miR-922 hsa-miR-15a hsa-miR-561 hsa-miR-503 hsa-miR-497 hsa-miR-103 hsa-miR-182

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ACTR2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ACTR2
    OriGene untagged cDNA clones in CMV expression vector (see all 3): ACTR2
    OriGene 3'-UTR clone (see all 2): ACTR2 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ACTR2 
    Sino Biological Human cDNA Clone for ACTR2

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ACTR2 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003779 actin binding IEA--
    GO:0005515 protein binding IPI17353931
    GO:0005524 ATP binding IEA--
    About this table

    ACTR2 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ACTR2 for pathways           About GeneDecksing

    5/13 Millipore Pathways for ACTR2 (see all 13)
        Cytoskeleton remodeling Integrin outside-in signaling
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Immune response Role of DAP12 receptors in NK cells

    5/12 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  ACTR2 (see all 12)
        Clathrin-mediated Endocytosis Signaling
    RhoA Signaling
    fMLP Signaling in Neutrophils
    Cdc42 Signaling
    Rac Signaling

        SABiosciences Pathway-Focused PCR Arrays including ACTR2: PAHS-040A PAHS-088A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ACTR2
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACTR2

    5/771 Interacting proteins for ACTR2 (ENSP000003672203 P611601, 2) via UniProtKB, MINT, and/or STRING (see all 771)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTR3BQ9P1U11EBI-353580,EBI-1047175
    BAK1Q166111EBI-353580,EBI-519866
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    ABCF3Q9NUQ82MINT-7945693 MINT-7947479
    ACTBP607092MINT-7945693 MINT-7947479
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928 cellular component movement TAS9230079
    About this table

    ACTR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ACTR2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACTR2
    1 Novoseek chemical compound relationship for ACTR2 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 4.2 5 11752435 (3), 17251352 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ACTR2
    Sigma-Aldrich shRNA for ACTR2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ACTR2
    OriGene shRNA RFP (see all 2): ACTR2
    OriGene basic RS shRNA (see all 2): ACTR2
    OriGene siRNA (see all 2): ACTR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ACTR2 
    miRNA: Sigma-Aldrich microRNA Mimics for ACTR2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ACTR2 
    8/13 SABiosciences Assays for microRNAs that regulate ACTR2 (see all 13):
    hsa-miR-495 hsa-miR-922 hsa-miR-15a hsa-miR-561 hsa-miR-503 hsa-miR-497 hsa-miR-103 hsa-miR-182
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ACTR2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ACTR2
    OriGene untagged cDNA clones in CMV expression vector (see all 3): ACTR2
    OriGene 3'-UTR Clone (see all 2): ACTR2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ACTR2 
    Primers: OriGene genome-wide validated SYBR primer pairs: ACTR2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ACTR2: PPH02650A

    REFSEQ mRNAs for ACTR2 gene (2 alternative transcripts): 

    NM_001005386.2  NM_005722.3  

    Additional cDNA sequence: 

    AB462501.1 AF006082.1 AK025051.1 AK295157.1 AK301634.1 AK315205.1 AL049356.1 BC014546.1 
    BC036253.1 BX649080.1 CR593126.1 

    24/29 DOTS entries (see all 29):

    DT.101961003  DT.95156078  DT.75189376  DT.100877083  DT.100877089  DT.95245735  DT.100877085  DT.100877084 
    DT.97801854  DT.95074926  DT.121011729  DT.100877090  DT.97791493  DT.99926655  DT.100877081  DT.120826962 
    DT.121011721  DT.121011735  DT.121011742  DT.121011911  DT.121011966  DT.121493112  DT.92454903  DT.97760126 

    24/845 AceView cDNA sequences (see all 845):

    AI922125 BU186139 BU629480 BP346190 N33321 BX506549 AA042888 N36158 
    BX956354 AI753490 AL538895 BM708911 AA047331 AU099224 BX957065 BM053007 
    AW500116 AI473477 AI817508 AU131915 AA886678 W69469 BU429333 AI753315 

    highest scoring ESTs for ACTR2:

    AF006082 AA007317 AA021093 AA026823 AA026955 AA034103 AA064957 AA075106 AA089505 AA134171 

    Unigene Cluster for ACTR2:

    ARP2 actin-related protein 2 homolog (yeast)
    Hs.643727  [show with all ESTs]
    Unigene Representative Sequence: NM_001005386


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260641(uc010yqf.1 uc002sdp.2 uc002sdq.2 uc010yqg.1)
    ENST00000377982 ENST00000471552 ENST00000476840

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ACTR2 expression in normal and diseased human tissues

    1  / 2  / 3

    12 probe-sets matching ACTR2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35734_at2, 3 U95-A 1 1.00 1.00 0.97 0.92 AI935551 0.80 1.00 0.91 1
    35733_at2, 3 U95-A 1 0.75 1.00 0.99 1.08 AF006082 1.00 1.00 1.00 1
    200729_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005722 0.60 1.00 0.82 1
    200727_s_at2, 3 U133-A 1 1.00 1.00 -- -- AA699583 0.80 1.00 0.91 1
    200728_at2 U133-A 1 0.91 1.00 -- -- -- -- -- -- --
    234210_x_at*2, 3 U133-B 1 0.36 1.00 -- -- AK025051 0.20 1.00 0.72 1
    200729_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    200727_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1554390_s_at2 U133Plus2 3 1.00 0.80 -- -- -- -- -- -- --
    1558015_s_at2 U133Plus2 3 1.00 0.76 -- -- -- -- -- -- --
    200728_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    234210_x_at*2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    About this table

    ACTR2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ACTR2 gene expression
    ACTR2 gene electronic northern expression
    ACTR2 gene sage expression
    About these images

    CGAP SAGE TAG: AAATACTTCA

    SOURCE GeneReport for Unigene cluster: Hs.643727

    Expression variation in blood from EXPOLDB for ACTR2

    Primers: OriGene genome-wide validated SYBR primer pairs: ACTR2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ACTR2: PPH02650A
        SABiosciences Expression via Pathway-Focused PCR Arrays including ACTR2: PAHS-040A PAHS-088A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ACTR2 gene from 5/22 species (see all 22)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ACTR21   -- ARP2 actin-related protein 2 homolog (yeast) 94.99(n)
    100(a)
    481396  XM_847614.1  XP_852707.1 
    chimpanzee
    (Pan troglodytes)
    ACTR21   -- ARP2 actin-related protein 2 homolog (yeast) 99.83(n)
    100(a)
    746973  XM_001155450.1  XP_001155450.1 
    cow
    (Bos taurus)
    ACTR21   -- ARP2 actin-related protein 2 homolog (yeast) 93.82(n)
    100(a)
    538486  XM_580624.3  XP_580624.3 
    rat
    (Rattus norvegicus)
    Actr21   -- ARP2 actin-related protein 2 homolog (yeast) 90.78(n)
    99.75(a)
    289820  NM_001009268.1  NP_001009268.1 
    mouse
    (Mus musculus)
    Actr21 , 5 11 (12.88 cM)5
    ARP2 actin-related protein 2 homolog (yeast)1, 5 92.3(n)1
    100(a)1
    667131  NM_146243.11  NP_666355.11 
     AA4097825  AA7917425  (see all 22)
    About this table        Species with no ortholog for ACTR2

    ENSEMBL Gene Tree for ACTR2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ACTR2 gene
    ACTL82  C20orf1342  

    ACTR2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/488 NCBI SNPs in ACTR2 are shown (see all 488)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs72461,2
    C65497634(+) TCTTAC/TATAAA 2 -- ut31 ese33Minor allele frequency- T:0.50MN NA 374
    rs72471,2
    C,F,A,H,65498340(+) ATGAAA/GTACTT 2 -- ut316Minor allele frequency- G:0.29MN NA EA WA 586
    rs87711,2
    C65496075(-) TCTATG/ATAGGG 2 -- ut31 ese34Minor allele frequency- A:0.26MN NA 376
    rs101161,2
    C,H,65496729(-) TAATTT/CGAATT 2 -- ut316Minor allele frequency- C:0.22MN NA WA 196
    rs107171,2
    --65498295(-) TCAAGA/CTACTT 2 -- ut31 ese30--------
    rs114241,2
    C,F,O,A,H,65496018(+) GGAAGC/GTTTGT 2 -- ut3113Minor allele frequency- G:0.49MN NA NS EA 942
    rs116981,2
    C,F,A,H,65497262(+) GAAAAA/GTAAAA 2 -- ut315Minor allele frequency- G:0.29MN NA 378
    rs125601,2
    C,F,A,65496187(+) TAGTCA/GTAGTC 2 -- ut31 ese313Minor allele frequency- G:0.41MN NS EA NA 2438
    rs125611,2
    C65497941(-) AAAATC/TATAAA 2 -- ut311Minor allele frequency- T:0.50WA 2
    rs138121,2
    C,F,A65497682(-) CTACAT/CACGCG 2 -- ut31 ese313Minor allele frequency- C:0.07EA NA MN 536
    About this table

    HapMap Linkage Disequilibrium images for ACTR2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACTR2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ACTR2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACTR2 for disorders           About GeneDecksing

    OMIM: 604221

    4 Novoseek disease relationships for ACTR2 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 79 4 16638851 (2), 11598103 (1), 17277766 (1)
    metastasis 0.743 8 17459058 (4), 16638851 (2)
    tumors 0 4 14990971 (3), 16638851 (1)
    cancer 0 6 17459058 (3), 16638851 (3)
    About this table


    Export disorders and mutations for ACTR2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/87 PubMed articles for ACTR2 gene, integrated from 7 sources (see all 87):
    (articles sorted by number of sources associating them with ACTR2)
    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (2001)
    4. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. (PubMed id 9000076)1, 2 Welch M.D.... Mitchison T.J. (1997)
    5. Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung. (PubMed id 16638851)1, 7 Semba S....Mukai K. (2006)
    6. Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma. (PubMed id 17459058)1, 7 Iwaya K....Mukai K. (2007)
    7. Actin-related protein (Arp2) inserts into artificial lipid membranes. (PubMed id 12468383)1, 7 Goldmann W.H. and Isenberg G. (2002)
    8. Interaction of cortactin and N-WASp with Arp2/3 complex. (PubMed id 12176354)1, 7 Weaver A.M....Cooper J.A. (2002)
    9. Involvement of Arp2/3 complex in MCP-1-induced chemotaxis. (PubMed id 16004967)1, 7 Mukai Y....Mukai K. (2005)
    10. The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle. (PubMed id 15834156)1, 7 Tang D.D....Gunst S.J. (2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10097 HGNC: 169 AceView: ACTR2 Ensembl:ENSG00000138071 euGenes: HUgn10097
    ECgene: ACTR2 H-InvDB: ACTR2

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    (Patent information from GeneIP,
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