Aliases &
Descriptions
for ADAM19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ADAM metallopeptidase domain 191 2 | | disintegrin and metalloproteinase domain-containing protein 192 | | MLTNB1 2 3 5 | | meltrin-beta2 | | a disintegrin and metalloproteinase domain 19 (meltrin beta)1 2 | | meltrin beta2 | | Metalloprotease and disintegrin dendritic antigen marker2 3 | | Meltrin-beta3 | | MADDAM2 3 | | EC 3.4.24.-3 | | ADAM 192 3 | | |
Export aliases for ADAM19 gene to outside databasesPrevious GC identifers: GC05M156953 GC05M157455 GC05M156839 GC05M156885 GC05M156836 |
Summaries
for ADAM19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADAM19:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family aremembrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety ofbiological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic celldifferentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normalphysiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrixinteractions, and signal transduction. (provided by RefSeq)
UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved inneurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. Maybe involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)
Gene Wiki entry for ADAM19 |
Genomic Views
for ADAM19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAM19 gene promoter:
STAT5A RSRFC4 AREB6 c-Rel STAT3 NF-kappaB NF-kappaB1 NF-kappaB2 RelA MEF-2A
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAM19
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ADAM19  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q33.3ADAM19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M151992: view genomic region
(about GC identifiers)
Start:
|
151,992,608 bp from pter |
End:
|
152,091,078 bp from pter |
Size:
|
98,471 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr5- 156,822,542-157,002,783 |
RefSeq DNA sequence:- NC_000005.9 NT_023133.13
|
Proteins
for ADAM19 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013 (See
protein sequence)Recommended Name: Disintegrin and metalloproteinase domain-containing protein 19 precursor Size: 955 amino acids; 104997 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with SH3PXD2A
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9BZL5 Q9UHP2Alternative splicing: 2 isoforms: Q9H013-1 Q9H013-2 Explore the universe of human proteins at neXtProt for ADAM19: NX_Q9H013
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_150377.1
ENSEMBL proteins: ENSP00000410266 ENSP00000414088 ENSP00000257527 ENSP00000377588 ENSP00000428654 ENSP00000431027 ENSP00000428376
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
ADAM19 for ontologies About GeneDecksing
Antibodies for ADAM19:
Assays for ADAM19: |
Protein
Domains/
Families
for ADAM19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAM19 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9H013ProtoNet protein and cluster: Q9H013 3 Blocks protein families: IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB006586 ADAM
UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzymeSimilarity: Contains 1 disintegrin domainSimilarity: Contains 1 EGF-like domainSimilarity: Contains 1 peptidase M12B domain |
Gene Function
for ADAM19 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved inneurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. Maybe involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)Induction: By 1,25(OH)2VD3 in monocytesEnzyme Number (IUBMB): EC 3.4.24.-
Genatlas biochemistry entry for ADAM19:a disintegrin and metalloprotease (active) domain 19,membrane anchored cell surface adhesion protein,predominantlyexpressed in bone,heart,lung,also expressed in somatic tissuesl,involved in myotube formation and putatively inosteoblast differentiation5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
ADAM19 for ontologies About GeneDecksing
Animal Models: 8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Adam19):
ADAM19 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ADAM19 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
ADAM19 for pathways About GeneDecksing
1  Millipore Pathway for ADAM19
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for ADAM19
SABiosciences Custom Pathway-Focused PCR Arrays for ADAM19
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ADAM19
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM19
3 Interacting proteins for ADAM19 (Q9H0132) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0006509 | membrane protein ectodomain proteolysis |
-- | -- | | GO:0007507 | heart development |
-- | -- |
About this table
ADAM19 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADAM19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ADAM19
|
Transcripts
for ADAM19 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ADAM19 gene: NM_033274.3 Additional cDNA sequence: AF134707.1 AF311317.1 AF326918.1 AK093535.1 AK308182.1 AL049415.1 BC024214.2 BC033132.1 Y13786.2 9 DOTS entries: DT.213222 DT.95170801 DT.86842185 DT.92424141 DT.40253624 DT.91879845 DT.95170800 DT.95339040 DT.97861713 24/112 AceView cDNA sequences (see all 112): BU194499 BG057680 AA832347 BE389727 BE502479 BE674636 AW195100 BU166620 BC024214 AA937792 BF059166 BC033132 BQ017560 AA167289 W00799 AI422731 AI681576 AA375767 AA167288 BQ775611 AF311317 CN483705 AI638530 N69991
 highest scoring ESTs for ADAM19:AF311317 AF326918 AK091464 AL049415 BF899863 CF125633 Y13786 AA476621 AA832347 AA937792 Unigene Cluster for ADAM19: ADAM metallopeptidase domain 19 Hs.483944 [show with all ESTs]Unigene Representative Sequence: NM_033274
GeneLoc Exon Structure
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432888(uc011ddr.1) ENST00000430702 ENST00000257527 ENST00000519752
ENST00000394020(uc003lww.1 uc003lwy.2 uc003lwz.2) ENST00000517905
ENST00000517374 ENST00000517951
|
Expression
for ADAM19 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ADAM19 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching ADAM19 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33812_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AL049415 |
0.80 |
1.00 |
0.91 |
1 |
| 209765_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
Y13786 |
0.80 |
1.00 |
0.91 |
1 |
| 221128_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
NM_023038 |
0.60 |
1.00 |
0.82 |
1 |
| 209765_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 221128_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ADAM19 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTGCCTTTTT
SOURCE GeneReport for Unigene cluster: Hs.483944
Expression variation in blood from EXPOLDB for ADAM19 UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013Tissue specificity: Expressed in many normal organ tissues and several cancer cell lines
SABiosciences Custom PCR Arrays for ADAM19
|
Orthologs
for ADAM19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ADAM19 gene from 5/11 species (see all 11)
About this table Species with no ortholog for ADAM19
ENSEMBL Gene Tree for ADAM19 (if available) |
Paralogs
for ADAM19 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ADAM19 gene
- ADAM72 ADAM122 ADAM152 ADAM332 ADAM282
ADAM19 for paralogs About GeneDecksing
|
Genomic Variants
for ADAM19 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 5 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ADAM19 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ADAM19
2 CNVs: 3583 62447 | | QIAGEN SeqTarget long-range PCR primers for resequencing ADAM19 |
|
Disorders & Mutations
for ADAM19 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADAM19 for disorders About GeneDecksing
OMIM: 603640
3  Novoseek disease relationships for ADAM19 gene
About this table
Human Gene Mutation Database (HGMD): ADAM19
Human Genome Epidemiology (HuGE) Navigator: ADAM19 (5 documents)
Export disorders and mutations for ADAM19 gene to outside databases
|
Medical News
for ADAM19 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ADAM19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/44 PubMed articles for ADAM19 gene, integrated from 7 sources (see all 44):
(articles sorted by number of sources associating them with ADAM19)- Molecular cloning and characterization of a human metalloprotease disintegrin a novel marker for dendritic cell differentiation. (PubMed id 10887142)1, 2, 7 Fritsche J....Kreutz M. (2000)
- Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. (PubMed id 9806848)1, 3, 7 Hirohata S....Apte S.S. (1998)
- Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta. (PubMed id 11162584)1, 2, 7 Wei P.... Sang Q.-X.A. (2001)
- The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. (PubMed id 12615925)1, 2 Abram C.L....Courtneidge S.A. (2003)
- Upregulation of ADAM19 in chronic allograft nephropathy. (PubMed id 16827870)1, 7 Melenhorst W.B....van Goor H. (2006)
- Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer. (PubMed id 18714391)1, 7 Chan M.W....Lin H.J. (2008)
- Epigenetic regulation of the dendritic cell-marker gene ADAM19. (PubMed id 15896713)1, 7 Ehrnsperger A....Kreutz M. (2005)
- Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. (PubMed id 12463424)1, 7 Huang L....Li C. (2002)
- Inhibitory antibodies against endopeptidase activity of human adamalysin 19. (PubMed id 11708814)1, 7 Zhao Y.G....Sang Q.X. (2001)
- ADAM19 autolysis is activated by LPS and promotes non -classical secretion of cysteine-rich protein 2. (PubMed id 20460109)1 Tanabe C....Ishiura S. (2010)
|
External Searches for ADAM19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADAM19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAM19 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAM19 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ADAM19 gene:
Search GeneIP for patents involving ADAM19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAM19 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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