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ADAM19 Gene

protein-coding   GIFtS: 59

GC05M151992
ADAM metallopeptidase domain 19
(Previous name: a disintegrin and metalloproteinase domain 19 (meltrin beta) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ADAM metallopeptidase domain 191 2     disintegrin and metalloproteinase domain-containing protein 192
MLTNB1 2 3 5     meltrin-beta2
a disintegrin and metalloproteinase domain 19 (meltrin beta)1 2     meltrin beta2
Metalloprotease and disintegrin dendritic antigen marker2 3     Meltrin-beta3
MADDAM2 3     EC 3.4.24.-3
ADAM 192 3     

External Ids:    HGNC: 1971   Entrez Gene: 87282   Ensembl: ENSG000001350747   UniProtKB: Q9H0133   

Export aliases for ADAM19 gene to outside databases

Previous GC identifers: GC05M156953 GC05M157455 GC05M156839 GC05M156885 GC05M156836


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAM19:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are
membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of
biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,
and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell
differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal
physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix
interactions, and signal transduction. (provided by RefSeq)

UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in
neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May
be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)

Gene Wiki entry for ADAM19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM19 gene promoter:
         STAT5A   RSRFC4   AREB6   c-Rel   STAT3   NF-kappaB   NF-kappaB1   NF-kappaB2   RelA   MEF-2A   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ADAM19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ADAM19 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

ADAM19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM19 gene location

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M151992:  view genomic region     (about GC identifiers)

Start:
151,992,608 bp from pter
End:
152,091,078 bp from pter
Size:
98,471 bases
Orientation:
minus strand

1 alternative location:
Chr5- 156,822,542-157,002,783     
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 19 precursor  
Size: 955 amino acids; 104997 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with SH3PXD2A
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9BZL5 Q9UHP2
Alternative splicing: 2 isoforms:  Q9H013-1   Q9H013-2   

Explore the universe of human proteins at neXtProt for ADAM19: NX_Q9H013 

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_150377.1  

    ENSEMBL proteins: 
    ENSP00000410266 ENSP00000414088 ENSP00000257527 ENSP00000377588 ENSP00000428654 ENSP00000431027 
    ENSP00000428376 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ADAM19
    GenScript Custom Purified and Recombinant Proteins Services for ADAM19 
    Novus Biologicals Lysate for ADAM19
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    ADAM19 for ontologies           About GeneDecksing



    Antibodies for ADAM19: 
    Millipore Mono- and Polyclonal Antibodies for the study of ADAM19
    Sigma-Aldrich Antibodies for ADAM19
    R&D Systems Antibodies for ADAM19
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ADAM19 
    Browse antibodies at Epitomics

    Assays for ADAM19: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAM19 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ADAM19 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ADAM19 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR006586 ADAM_Cys-rich
     IPR000742 EGF_3
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B

    Graphical View of Domain Structure for InterPro Entry Q9H013

    ProtoNet protein and cluster: Q9H013

    3 Blocks protein families:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
    Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in
    neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May
    be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)
    Induction: By 1,25(OH)2VD3 in monocytes
    Enzyme Number (IUBMB): EC 3.4.24.- 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADAM19
    Sigma-Aldrich shRNA for ADAM19
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ADAM19
    OriGene shRNA RFP (see all 2): ADAM19
    OriGene basic RS shRNA (see all 2): ADAM19
    OriGene siRNA (see all 2): ADAM19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAM19 
    miRNA:Sigma-Aldrich microRNA Mimics for ADAM19
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAM19 
    8/22 SABiosciences Assays for microRNAs that regulate ADAM19 (see all 22):
    hsa-miR-30c hsa-miR-576-3p hsa-miR-146b-3p hsa-miR-25 hsa-miR-30d hsa-miR-1297 hsa-miR-30a hsa-miR-124

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ADAM19
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ADAM19
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ADAM19
    OriGene 3'-UTR clone: ADAM19 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ADAM19 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ADAM19 

    Genatlas biochemistry entry for ADAM19:
    a disintegrin and metalloprotease (active) domain 19,membrane anchored cell surface adhesion protein,predominantly
    expressed in bone,heart,lung,also expressed in somatic tissuesl,involved in myotube formation and putatively in
    osteoblast differentiation

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222 metalloendopeptidase activity IEA--
    GO:0005515 protein binding ----
    GO:0008233 peptidase activity IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0017124 SH3 domain binding IEA--
    About this table

    ADAM19 for ontologies           About GeneDecksing

    Animal Models: 8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adam19):

    cardiovascular systemendocrine/exocrine glandhomeostasis/metabolismlethality-postnatallethality-prenatal/perinatal
    life span-post-weaning/agingmuscleskeleton

    ADAM19 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ADAM19 for pathways           About GeneDecksing

    1 Millipore Pathway for ADAM19
        Metalloproteases in connective tissue degradation

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  ADAM19
        Axonal Guidance Signaling

        SABiosciences Custom Pathway-Focused PCR Arrays for ADAM19 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ADAM19
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM19

    3 Interacting proteins for ADAM19 (Q9H0132) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI2Q9NYB92MINT-50919 MINT-50918
    ESF1Q9H5012MINT-51038
    --P629882MINT-51039
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508 proteolysis IEA--
    GO:0006509 membrane protein ectodomain proteolysis ----
    GO:0007507 heart development ----
    About this table

    ADAM19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM19


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADAM19
    Sigma-Aldrich shRNA for ADAM19
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ADAM19
    OriGene shRNA RFP (see all 2): ADAM19
    OriGene basic RS shRNA (see all 2): ADAM19
    OriGene siRNA (see all 2): ADAM19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAM19 
    miRNA: Sigma-Aldrich microRNA Mimics for ADAM19
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAM19 
    8/22 SABiosciences Assays for microRNAs that regulate ADAM19 (see all 22):
    hsa-miR-30c hsa-miR-576-3p hsa-miR-146b-3p hsa-miR-25 hsa-miR-30d hsa-miR-1297 hsa-miR-30a hsa-miR-124
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ADAM19
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ADAM19
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ADAM19
    OriGene 3'-UTR Clone: ADAM19 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ADAM19 
    Primers: OriGene genome-wide validated SYBR primer pairs: ADAM19
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ADAM19: PPH05578A

    REFSEQ mRNAs for ADAM19 gene: 

    NM_033274.3  

    Additional cDNA sequence: 

    AF134707.1 AF311317.1 AF326918.1 AK093535.1 AK308182.1 AL049415.1 BC024214.2 BC033132.1 
    Y13786.2 

    9 DOTS entries:

    DT.213222  DT.95170801  DT.86842185  DT.92424141  DT.40253624  DT.91879845  DT.95170800  DT.95339040 
    DT.97861713 

    24/112 AceView cDNA sequences (see all 112):

    BU194499 BG057680 AA832347 BE389727 BE502479 BE674636 AW195100 BU166620 
    BC024214 AA937792 BF059166 BC033132 BQ017560 AA167289 W00799 AI422731 
    AI681576 AA375767 AA167288 BQ775611 AF311317 CN483705 AI638530 N69991 

    highest scoring ESTs for ADAM19:

    AF311317 AF326918 AK091464 AL049415 BF899863 CF125633 Y13786 AA476621 AA832347 AA937792 

    Unigene Cluster for ADAM19:

    ADAM metallopeptidase domain 19
    Hs.483944  [show with all ESTs]
    Unigene Representative Sequence: NM_033274


    GeneLoc Exon Structure

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432888(uc011ddr.1) ENST00000430702 ENST00000257527 ENST00000519752
    ENST00000394020(uc003lww.1 uc003lwy.2 uc003lwz.2) ENST00000517905
    ENST00000517374 ENST00000517951

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ADAM19 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching ADAM19 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33812_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 AL049415 0.80 1.00 0.91 1
    209765_at2, 3 U133-A 1 0.82 1.00 -- -- Y13786 0.80 1.00 0.91 1
    221128_at2, 3 U133-A 1 0.73 1.00 -- -- NM_023038 0.60 1.00 0.82 1
    209765_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    221128_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    ADAM19 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ADAM19 gene expression
    ADAM19 gene electronic northern expression
    ADAM19 gene sage expression
    About these images

    CGAP SAGE TAG: GTGCCTTTTT

    SOURCE GeneReport for Unigene cluster: Hs.483944

    Expression variation in blood from EXPOLDB for ADAM19

    UniProtKB/Swiss-Prot: ADA19_HUMAN, Q9H013
    Tissue specificity: Expressed in many normal organ tissues and several cancer cell lines

    Primers: OriGene genome-wide validated SYBR primer pairs: ADAM19
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ADAM19: PPH05578A
        SABiosciences Custom PCR Arrays for ADAM19 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ADAM19 gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ADAM191   -- ADAM metallopeptidase domain 19 (meltrin beta) 88.45(n)
    89.01(a)
    489156  XM_546274.2  XP_546274.2 
    chimpanzee
    (Pan troglodytes)
    ADAM191   -- ADAM metallopeptidase domain 19 (meltrin beta) 99.55(n)
    99.37(a)
    735763  XM_001137686.1  XP_001137686.1 
    cow
    (Bos taurus)
    ADAM191   -- ADAM metallopeptidase domain 19 (meltrin beta) 88.78(n)
    89.42(a)
    510907  NM_001075475.1  NP_001068943.1 
    rat
    (Rattus norvegicus)
    Adam191   -- a disintegrin and metallopeptidase domain 19 (meltrin more 84.2(n)
    83.87(a)
    303068  XM_220328.4  XP_220328.4 
    mouse
    (Mus musculus)
    Adam191 , 5 11 (27.54 cM)5
    a disintegrin and metallopeptidase domain 19 (meltrin more1, 5 84.19(n)1
    83.21(a)1
    114921  NM_009616.31  NP_033746.11 
     AA7262235  AB0960935  (see all 18)
    About this table        Species with no ortholog for ADAM19

    ENSEMBL Gene Tree for ADAM19 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ADAM19 gene
    ADAM72  ADAM122  ADAM152  ADAM332  ADAM282  

    ADAM19 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/74 NCBI SNPs in ADAM19 are shown (see all 74)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs104041,2
    C,F,A,156904633(-) GGAACA/GCCAAC 1 -- ut31 ese320Minor allele frequency- T:0.05MN NS NA EU EA WA 1480
    rs9497991,2
    C,156904781(-) AAGTCT/CCTCCC 1 -- ut31 ese31Minor allele frequency- C:0.00MN 184
    rs9498001,2
    F,156904634(-) GGGAAC/TGCCAA 1 -- ut31 ese35Minor allele frequency- T:0.01MN NS EA 596
    rs10616911,2
    --156904975(-) ctttcA/Ggcctt 1 -- ut310--------
    rs11387501,2
    --156904965(-) tgctgA/Gcttct 1 -- ut311Minor allele frequency- G:0.00MN 184
    rs14227951,2
    C,F,O,A,156936364(-) TTCTCA/GGTTGG 4 S G ref1 mis1 ese334Minor allele frequency- N:0.00MN EA NA EU NS WA 3934
    rs22877491,2
    C,F,O,156918850(+) CATGGC/TCATTG 4 D G mis1 ref121Minor allele frequency- T:0.05EA NA EU NS 2872
    rs22877501,2
    H156923939(+) TAGGTG/AAGGCA 4 /L ref1 syn1 ese35Minor allele frequency- A:0.01EA NS 1914
    rs38225851,2
    C,F,A,156906986(+) GCCCCG/AAGTCT 1 -- ut3117Minor allele frequency- A:0.44NA EU NS EA 812
    rs44449521,2
    H156904985(+) ggaaTC/TTATGG 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    About this table

    HapMap Linkage Disequilibrium images for ADAM19 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ADAM19
         2 CNVs: 3583 62447

    QIAGEN SeqTarget long-range PCR primers for resequencing ADAM19 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADAM19 for disorders           About GeneDecksing

    OMIM: 603640

    3 Novoseek disease relationships for ADAM19 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 28.3 1 16827870 (1)
    renal disease 11.4 8 16900093 (5), 16827870 (3)
    tumors 0 7 16772875 (3), 19601835 (1), 16827870 (1)
    About this table

    Human Gene Mutation Database (HGMD): ADAM19
    Human Genome Epidemiology (HuGE) Navigator: ADAM19 (5 documents)

    Export disorders and mutations for ADAM19 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/44 PubMed articles for ADAM19 gene, integrated from 7 sources (see all 44):
    (articles sorted by number of sources associating them with ADAM19)
    1. Molecular cloning and characterization of a human metalloprotease disintegrin a novel marker for dendritic cell differentiation. (PubMed id 10887142)1, 2, 7 Fritsche J....Kreutz M. (2000)
    2. Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. (PubMed id 9806848)1, 3, 7 Hirohata S....Apte S.S. (1998)
    3. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta. (PubMed id 11162584)1, 2, 7 Wei P.... Sang Q.-X.A. (2001)
    4. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. (PubMed id 12615925)1, 2 Abram C.L....Courtneidge S.A. (2003)
    5. Upregulation of ADAM19 in chronic allograft nephropathy. (PubMed id 16827870)1, 7 Melenhorst W.B....van Goor H. (2006)
    6. Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer. (PubMed id 18714391)1, 7 Chan M.W....Lin H.J. (2008)
    7. Epigenetic regulation of the dendritic cell-marker gene ADAM19. (PubMed id 15896713)1, 7 Ehrnsperger A....Kreutz M. (2005)
    8. Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. (PubMed id 12463424)1, 7 Huang L....Li C. (2002)
    9. Inhibitory antibodies against endopeptidase activity of human adamalysin 19. (PubMed id 11708814)1, 7 Zhao Y.G....Sang Q.X. (2001)
    10. ADAM19 autolysis is activated by LPS and promotes non -classical secretion of cysteine-rich protein 2. (PubMed id 20460109)1 Tanabe C....Ishiura S. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8728 HGNC: 197 AceView: ADAM19 Ensembl:ENSG00000135074 euGenes: HUgn8728
    ECgene: ADAM19 H-InvDB: ADAM19

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