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ADAM21P1 Gene

pseudogene   GIFtS: 29

GC14M050880
ADAM metallopeptidase domain 21 pseudogene 1
(Previous names: a disintegrin and metalloproteinase domain 21 pseudogene, ADAM metallopeptidase domain 21 pseudogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ADAM21P)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ADAM metallopeptidase domain 21 pseudogene 11 2
a disintegrin and metalloproteinase domain 21 pseudogene1
ADAM metallopeptidase domain 21 pseudogene1
ADAM21P2
EC 3.4.24.-3
ADAM 213

External Ids:    HGNC: 198221   Entrez Gene: 1452412   Ensembl: ENSG000001399857   UniProtKB: Q9UKJ83   

Export aliases for ADAM21P1 gene to outside databases

Previous GC identifer: GC14M070713


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8
Function: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions
associated with establishing and maintaining gradients of ions or nutrients


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ADAM21P1
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ADAM21P1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.2

ADAM21P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM21P1 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M050880:  view genomic region     (about GC identifiers)

Start:
70,712,470 bp from pter
End:
70,714,518 bp from pter
Size:
2,049 bases
Orientation:
minus strand

1 alternative location:
Chr14+ 70,924,217-70,926,622     
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 21 precursor  
Size: 722 amino acids; 80834 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Subcellular location: Membrane; Single-pass type I membrane protein
Miscellaneous: May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human
Secondary accessions: O43507 Q2VPC6 Q32MR0

Explore the universe of human proteins at neXtProt for ADAM21P1: NX_Q9UKJ8 

Post-translational modifications:

  • Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated1




  • ENSEMBL proteins: 
    ENSP00000267499 


    Human Recombinant Proteins 
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    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane ----
    GO:0016021 integral to membrane ----
    About this table

    ADAM21P1 for ontologies           About GeneDecksing



    Antibodies for ADAM21P1: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ADAM21P1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR006586 ADAM_Cys-rich
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B
     IPR013032 EGF-like_reg_CS

    Graphical View of Domain Structure for InterPro Entry Q9UKJ8

    ProtoNet protein and cluster: Q9UKJ8

    3 Blocks protein families:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8
    Domain: A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin
    receptor and thus could mediate sperm/egg binding
    Domain: The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the
    enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8
    Function: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions
    associated with establishing and maintaining gradients of ions or nutrients
    Enzyme Number (IUBMB): EC 3.4.24.- 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    miRNA:Browse microRNA Mimics at Sigma-Aldrich
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAM21P1 
    Search SABiosciences for Assays for microRNAs that regulate ADAM21P1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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    Cell
    Lines:
      
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    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222 metalloendopeptidase activity ----
    GO:0008233 peptidase activity ----
    GO:0008237 metallopeptidase activity ----
    GO:0008270 zinc ion binding ----
    GO:0046872 metal ion binding ----
    About this table

    ADAM21P1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ADAM21P1 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM21P1

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508 proteolysis ----
    GO:0007338 single fertilization ----
    About this table

    ADAM21P1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM21P1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Browse siRNA at Sigma-Aldrich
    Browse shRNA at Sigma-Aldrich
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAM21P1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAM21P1 
    Search SABiosciences for Assays for microRNAs that regulate ADAM21P1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    Browse 3'-UTR reporter clones for miRNA target validation 
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    Primers: OriGene genome-wide validated SYBR primer pairs: ADAM21P1
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for ADAM21P1

    Additional cDNA sequence: DQ202398.1 

    1 DOTS entry:

    DT.120762321 

    Unigene Cluster for ADAM21P1:

    ADAM metallopeptidase domain 21 pseudogene 1
    Hs.712468
    Unigene Representative Sequence: DQ202398


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000267499(uc001xmd.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ADAM21P1 expression in normal and diseased human tissues

    1 Data from GNF BioGPS
        About these images

    ADAM21P1 gene expression
    ADAM21P1 gene electronic northern expression
    ADAM21P1 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.712468
    Primers: OriGene genome-wide validated SYBR primer pairs: ADAM21P1
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for ADAM21P1
        SABiosciences Custom PCR Arrays for ADAM21P1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    ENSEMBL Gene Tree for ADAM21P1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ADAM21P1 gene
    ADAM292  ENSG000002358122  ADAM322  ADAM202  ADAM92  ADAM182  ADAM302  ADAM22  

    ADAM21P1 for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section
    Search QIAGEN SeqTarget long-range PCR primers for resequencing for ADAM21P1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    5 PubMed articles for ADAM21P1 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with ADAM21P1)
    1. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PubMed id 10524237)1, 2 Poindexter K....Cerretti D.P. (1999)
    2. TCR variable gene involvement in chromosome inversion between 14q11 and 14q24 in adult T-cell leukemia. (PubMed id 16520872)1 Haider S....Isobe M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
    5. ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. (PubMed id 9469942)2 Hooft van Huijsduijnen R. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 145241 HGNC: 19822 Ensembl:ENSG00000139985 euGenes: HUgn145241 ECgene: ADAM21P1
    H-InvDB: ADAM21P1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ADAM21P1 gene:
    Search GeneIP for patents involving ADAM21P1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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