ADAM21P1 Gene
pseudogene GIFtS : 29
GC14M050880
ADAM metallopeptidase domain 21 pseudogene 1 (Previous names: a disintegrin and metalloproteinase domain 21 pseudogene, ADAM metallopeptidase domain 21 pseudogene )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: ADAM21P )
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Aliases & Descriptionsfor ADAM21P1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions ADAM metallopeptidase domain 21 pseudogene 11 2 a disintegrin and metalloproteinase domain 21 pseudogene1 ADAM metallopeptidase domain 21 pseudogene1 ADAM21P2 EC 3.4.24.-3 ADAM 213
Export aliases for ADAM21P1 gene to outside databases Previous GC identifer: GC14M070713
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Summariesfor ADAM21P1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8 Function : May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functionsassociated with establishing and maintaining gradients of ions or nutrients
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Genomic Viewsfor ADAM21P1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for ADAM21P1 Other transcription factors Search SABiosciences Chromatin IP Primers for ADAM21P1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q24.2 Ensembl cytogenetic band: 14q24.2 HGNC cytogenetic band: 14q24.2 ADAM21P1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M050880: view genomic region
(about GC identifiers )
Start:
70,712,470 bp from pter
End:
70,714,518 bp from pter
Size:
2,049 bases
Orientation:
minus strand
1 alternative location : Chr 14+ 70,924,217-70,926,622
RefSeq DNA sequence: NC_000014.8 NT_026437.12
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Proteinsfor ADAM21P1 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8 (See
protein sequence )Recommended Name: Disintegrin and metalloproteinase domain-containing protein 21 precursor Size : 722 amino acids; 80834 Da
Cofactor : Binds 1 zinc ion per subunit (Potential)
Subcellular location : Membrane; Single-pass type I membrane protein
Miscellaneous : May be the functional equivalent of ADAM 1/fertilin alpha which is a pseudogene in human
Secondary accessions : O43507 Q2VPC6 Q32MR0Explore the universe of human proteins at neXtProt for ADAM21P1: NX_Q9UKJ8 Post-translational modifications:
Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated1
ENSEMBL proteins: ENSP00000267499 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
-- -- GO:0016021 integral to membrane
-- --
About this table
ADAM21P1 for ontologies About GeneDecksing Antibodies for ADAM21P1: Assays for ADAM21P1:
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Protein
Domains/ Familiesfor ADAM21P1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ADAM21P1 for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q9UKJ8 ProtoNet protein and cluster: Q9UKJ8
3 Blocks protein families : IPB001762 Disintegrin IPB002870 Metalloendopeptidase M12B IPB006586 ADAM UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8 Domain : A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrinreceptor and thus could mediate sperm/egg binding Domain : The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusionDomain : The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme Similarity : Contains 1 disintegrin domainSimilarity : Contains 1 EGF-like domainSimilarity : Contains 1 peptidase M12B domain
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Gene Functionfor ADAM21P1 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: ADA21_HUMAN, Q9UKJ8 Function : May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functionsassociated with establishing and maintaining gradients of ions or nutrients Enzyme Number (IUBMB): EC 3.4.24.-
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
About this table
ADAM21P1 for ontologies About GeneDecksing
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Pathways & Interactionsfor ADAM21P1 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for ADAM21P1 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAM21P1 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006508 proteolysis
-- -- GO:0007338 single fertilization
-- --
About this table
ADAM21P1 for ontologies About GeneDecksing
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Drugs & Compoundsfor ADAM21P1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for ADAM21P1
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Transcriptsfor ADAM21P1 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section Additional cDNA sequence: DQ202398.1
1 DOTS entry : DT.120762321 Unigene Cluster for ADAM21P1:
ADAM metallopeptidase domain 21 pseudogene 1 Hs.712468 Unigene Representative Sequence: DQ202398 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000267499 (uc001xmd.2 )
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Expression for ADAM21P1 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section ADAM21P1 expression in normal and diseased human tissues 1 Data from GNF BioGPS About these images
About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.712468 SABiosciences Custom PCR Arrays for ADAM21P1
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Orthologsfor ADAM21P1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section ENSEMBL Gene Tree for ADAM21P1 (if available)
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Paralogsfor ADAM21P1 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for ADAM21P1 gene ADAM29 2 ENSG00000235812 2 ADAM32 2 ADAM20 2 ADAM9 2 ADAM18 2 ADAM30 2 ADAM2 2
ADAM21P1 for paralogs About GeneDecksing Pseudogenes 1 related pseudogene
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Genomic Variantsfor ADAM21P1 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
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Disorders & Mutationsfor ADAM21P1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Medical Newsfor ADAM21P1 gene (Possibly Related Articles in
Doctor's Guide )
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Publicationsfor ADAM21P1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 5 PubMed articles for ADAM21P1 gene integrated from 7 sources : (articles sorted by number of sources associating them with ADAM21P1) The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PubMed id 10524237) 1 , 2 Poindexter K....Cerretti D.P. (1999) TCR variable gene involvement in chromosome inversion between 14q11 and 14q24 in adult T-cell leukemia. (PubMed id 16520872) 1 Haider S....Isobe M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 2 Heilig R.... Weissenbach J. (2003) ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. (PubMed id 9469942) 2 Hooft van Huijsduijnen R. (1998)
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External Searches for ADAM21P1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ADAM21P1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ADAM21P1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ADAM21P1 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ADAM21P1 gene: Search GeneIP for patents involving ADAM21P1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ADAM21P1 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
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Aliases for ADAM21P1
Databases for ADAM21P1
Disorders for ADAM21P1
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Expression for ADAM21P1
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Genomic Views for ADAM21P1
Intellectual Property for ADAM21P1
Medical News for ADAM21P1
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Products for ADAM21P1
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