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ADAM9 Gene

protein-coding   GIFtS: 68

GC08P037387
ADAM metallopeptidase domain 9
(Previous name: a disintegrin and metalloproteinase domain 9 (meltrin gamma) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for ADAM9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
ADAM metallopeptidase domain 91 2     a disintegrin and metalloproteinase domain 9 (meltrin gamma)1
MDC91 2 3 5     OTTHUMP000002164852
MCMP1 2 3 5     disintegrin and metalloproteinase domain-containing protein 92
KIAA00211 2 3     OTTHUMP000002164842
Mltng1 2     ADAM metallopeptidase domain 9 (meltrin gamma)2
Cellular disintegrin-related protein2 3     OTTHUMP000002164812
Myeloma cell metalloproteinase2 3     EC 3.4.24.-3
Metalloprotease/disintegrin/cysteine-rich protein 92 3     Meltrin-gamma3
ADAM 92 3     MLTNG3
CORD92 5     

External Ids:    HGNC: 2161   Entrez Gene: 87542   Ensembl: ENSG000001686157   UniProtKB: Q134433   

Export aliases for ADAM9 gene to outside databases

Previous GC identifers: GC08P038441 GC08P039068 GC08P038595 GC08P038871 GC08P038974 GC08P038975


Summaries
for ADAM9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAM9:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are
membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of
biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,
and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest
deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding
EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene.
(provided by RefSeq)

UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443
Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase
activity for APP

Gene Wiki entry for ADAM9

Genomic Views
for ADAM9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM9 gene promoter:
         NRSF form 2   NRSF form 1   CUTL1   Nkx6-1   deltaCREB   CREB   Arnt   AhR   ATF-2   MRF-2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ADAM9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ADAM9 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.23

ADAM9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM9 gene location

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P037387:  view genomic region     (about GC identifiers)

Start:
 37,387,348 bp from pter
End:
 37,495,887 bp from pter
Size:
 108,540 bases
Orientation:
 plus strand

1 alternative location:
Chr8+ 38,854,388-38,962,663     
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  

Proteins
for ADAM9 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 9 precursor  
Size: 819 amino acids; 90556 Da
Cofactor: Binds 1 zinc ion per subunit (Probable)
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Caution: Has sometimes been referred to as ADAM-12
PDB structures from and Proteopedia :
1M1V (3D)    
Secondary accessions: B7ZLN7 Q10718 Q8NFM6
Alternative splicing: 2 isoforms:  Q13443-1   Q13443-2   

Explore the universe of human proteins at neXtProt for ADAM9: NX_Q13443 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_003807.1  

    ENSEMBL proteins: 
    ENSP00000420257 ENSP00000418437 ENSP00000417066 ENSP00000418737 ENSP00000419446 ENSP00000369249 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    R&D Systems Recombinant & Natural Proteins for ADAM9
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for ADAM9 
    Novus Biologicals Protein for ADAM9
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005615 extracellular space ISS8647900
    GO:0005737 cytoplasm ----
    GO:0005886 plasma membrane IEA--
    GO:0009986 cell surface ISS8647900
    About this table

    ADAM9 for ontologies           About GeneDecksing



    Antibodies for ADAM9: 
    Millipore Mono- and Polyclonal Antibodies for the study of ADAM9
    Sigma-Aldrich Antibodies for ADAM9
    R&D Systems Antibodies for ADAM9
    Cell Signaling Technology (CST) Antibodies for ADAM9 
    Browse OriGene Antibodies
    GenScript Superior Antibodies for ADAM9 
    Novus Biologicals Antibodies for ADAM9
    Browse antibodies at Epitomics

    Assays for ADAM9: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    R&D Systems ELISAs for ADAM9
    GenScript Custom Assay Services for ADAM9 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ADAM9 

    Protein Domains/
    Families
    for ADAM9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAM9 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR006586 ADAM_Cys-rich
     IPR000742 EGF_3
     IPR006210 EGF-like
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin

    Graphical View of Domain Structure for InterPro Entry Q13443

    ProtoNet protein and cluster: Q13443

    4 Blocks protein families:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006210 Type I EGF
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    Gene Function
    for ADAM9 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443
    Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase
    activity for APP
    Enzyme Number (IUBMB): EC 3.4.24.- 

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADAM9
    Sigma-Aldrich shRNA for ADAM9
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): ADAM9
    OriGene shRNA RFP (see all 6): ADAM9
    OriGene basic RS shRNA (see all 6): ADAM9
    OriGene siRNA (see all 5): ADAM9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAM9 
    miRNA:Sigma-Aldrich microRNA Mimics for ADAM9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAM9 
    8/21 SABiosciences Assays for microRNAs that regulate ADAM9 (see all 21):
    hsa-miR-1274a hsa-miR-30c hsa-miR-217 hsa-miR-126 hsa-miR-513a-5p hsa-miR-106a hsa-miR-513c hsa-miR-30d

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ADAM9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ADAM9
    OriGene untagged cDNA clones in CMV expression vector (see all 3): ADAM9
    OriGene 3'-UTR clone: ADAM9 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): ADAM9 
    Sino Biological Human cDNA Clone for ADAM9

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for ADAM9 

    Genatlas biochemistry entry for ADAM9:
    a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion protein,widely
    expressed,also expressed in meyloma cells

    5/11 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 11):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222 metalloendopeptidase activity IDA9920899
    GO:0005080 protein kinase C binding ISS8647900
    GO:0005178 integrin binding IPI17704059
    GO:0005515 protein binding IPI10531379
    GO:0005518 collagen binding IMP15361064
    About this table

    ADAM9 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adam9):

    cardiovascular systemlethality-prenatal/perinatalnormalvision/eye

    ADAM9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADAM9 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ADAM9 for pathways           About GeneDecksing

    1 Millipore Pathway for ADAM9
        Development Endothelin-1/EDNRA transactivation of EGFR

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  ADAM9
        Axonal Guidance Signaling

        SABiosciences Pathway-Focused PCR Array including ADAM9: PAHS-057A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ADAM9
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM9

    3 Interacting proteins for ADAM9 (ENSP000003692493 Q134431, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAD2L2Q9UI951, 2STRING: ENSP00000365860 EBI-77903,EBI-77889 MINT-15197 MINT-15198
    PACSIN3Q9UKS61EBI-77903,EBI-77926
    SH3GL2Q999621EBI-77903,EBI-77938
    About this table

    5/25 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 25):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186 activation of MAPKK activity IDA17704059
    GO:0006508 proteolysis IEA--
    GO:0006509 membrane protein ectodomain proteolysis IDA9920899
    GO:0007155 cell adhesion IMP17704059
    GO:0007160 cell-matrix adhesion IMP15361064
    About this table

    ADAM9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAM9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ADAM9 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM9
    2 Novoseek chemical compound relationships for ADAM9 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxygen 0 2 17018608 (1), 17342749 (1)
    h2o2 0 7 17018608 (4), 17342749 (2)
    About this table



    Transcripts
    for ADAM9 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADAM9
    Sigma-Aldrich shRNA for ADAM9
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): ADAM9
    OriGene shRNA RFP (see all 6): ADAM9
    OriGene basic RS shRNA (see all 6): ADAM9
    OriGene siRNA (see all 5): ADAM9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAM9 
    miRNA: Sigma-Aldrich microRNA Mimics for ADAM9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAM9 
    8/21 SABiosciences Assays for microRNAs that regulate ADAM9 (see all 21):
    hsa-miR-1274a hsa-miR-30c hsa-miR-217 hsa-miR-126 hsa-miR-513a-5p hsa-miR-106a hsa-miR-513c hsa-miR-30d
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ADAM9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ADAM9
    OriGene untagged cDNA clones in CMV expression vector (see all 3): ADAM9
    OriGene 3'-UTR Clone: ADAM9 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): ADAM9 
    Primers: OriGene genome-wide validated SYBR primer pairs: ADAM9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ADAM9: PPH02256A

    REFSEQ mRNAs for ADAM9 gene: 

    NM_003816.2  

    Additional cDNA sequence: 

    AF495383.1 AK293257.1 BC027996.1 BC126406.1 BC143923.1 BC143924.1 CR591969.1 CR601711.1 
    D14665.2 U41766.1 

    13 DOTS entries:

    DT.95290333  DT.100036234  DT.314189  DT.100758569  DT.100806951  DT.91647234  DT.101969807  DT.100818732 
    DT.121475923  DT.121475942  DT.121475966  DT.121475954  DT.91642847 

    24/198 AceView cDNA sequences (see all 198):

    BQ006587 AI383616 BM852524 BQ029957 CD677250 BI856382 H59231 BG163442 
    AF495383 NM_003816 CR601711 CA423541 CB851815 U41766 CB044420 AU133113 
    BM980421 BU156026 CB265379 AI801062 AI499571 BX490480 BM973396 BQ023774 

    highest scoring ESTs for ADAM9:

    U41766 AA065135 AA314599 AA363627 AA373320 AA506729 AA528429 AA584283 AA853771 AA863211 

    Unigene Cluster for ADAM9:

    ADAM metallopeptidase domain 9
    Hs.591852  [show with all ESTs]
    Unigene Representative Sequence: NM_003816


    GeneLoc Exon Structure

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466936(uc003xmo.1) ENST00000481873 ENST00000481513(uc003xmp.2)
    ENST00000481058 ENST00000468065 ENST00000487273 ENST00000379917 ENST00000463437
    ENST00000484143

    Expression
    for ADAM9 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ADAM9 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching ADAM9 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    34761_r_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U41766 1.00 1.00 1.00 1
    202381_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003816 0.60 1.00 0.82 1
    202381_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555326_a_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    1570042_a_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    ADAM9 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ADAM9 gene expression
    ADAM9 gene electronic northern expression
    ADAM9 gene sage expression
    About these images

    CGAP SAGE TAG: TAAAATATTA

    SOURCE GeneReport for Unigene cluster: Hs.591852

    Expression variation in blood from EXPOLDB for ADAM9

    UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443
    Tissue specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart

    Primers: OriGene genome-wide validated SYBR primer pairs: ADAM9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ADAM9: PPH02256A
        SABiosciences Expression via Pathway-Focused PCR Array including ADAM9: PAHS-057A 


    Orthologs
    for ADAM9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ADAM9 gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ADAM91   -- ADAM metallopeptidase domain 9 (meltrin gamma) 92.14(n)
    92.55(a)    		 475579  XM_532798.2  XP_532798.2 
    chimpanzee
    (Pan troglodytes)    		 ADAM91   -- ADAM metallopeptidase domain 9 (meltrin gamma) 99.76(n)
    99.76(a)    		 464129  XM_519719.2  XP_519719.2 
    cow
    (Bos taurus)    		 ADAM91   -- ADAM metallopeptidase domain 9 (meltrin gamma) 87.51(n)
    86.08(a)    		 281600  XM_614306.3  XP_614306.3 
    rat
    (Rattus norvegicus)    		 Adam91   -- ADAM metallopeptidase domain 9 (meltrin gamma) 83.29(n)
    85.29(a)    		 290834  NM_001014772.1  NP_001014772.1 
    mouse
    (Mus musculus)    		 Adam91 , 5 8 (13.70 cM)5
    		 a disintegrin and metallopeptidase domain 9 (meltrin more1, 5 83.5(n)1
    86.27(a)1    		 115021  NM_007404.11  NP_031430.11 
     AA5612435  AK1221885  (see all 18)
    About this table        Species with no ortholog for ADAM9

    ENSEMBL Gene Tree for ADAM9 (if available)

    Paralogs
    for ADAM9 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ADAM9 gene
    ENSG000002358122  ADAM292  ADAM322  ADAM202  ADAM212  ADAM182  ADAM302  ADAM22  

    ADAM9 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAM9 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/897 NCBI SNPs in ADAM9 are shown (see all 897)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs11268501,2
    		--38962372(+) TAAGCA/CCTAAA 2 -- ut310--------
    rs18028841,2
    		--38962338(+) TACTAC/TGGCAG 2 -- ut310--------
    rs32087971,2
    		--38935690(+) TGTTTC/TTCACT 1 -- int11Minor allele frequency- T:0.00MN 184
    rs40758491,2
    		C,F,A,38934583(+) TCTGCC/TGTATT 1 -- int111Minor allele frequency- T:0.46NS EA NA WA 772
    rs41288711,2
    		C38859994(+) CACCAC/TGCCCG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs41288721,2
    		--38860012(+) TTTGTA/GTTTTT 1 -- int10--------
    rs41290951,2
    		C,F,38896721(+) CTGCTG/ACTACT 1 -- int115Minor allele frequency- A:0.22NS EA NA 1136
    rs41303931,2
    		C,F,38940934(-) TCTAAT/CAGCAA 1 -- int110Minor allele frequency- C:0.11NS EA NA WA 552
    rs42840151,2
    		C,F,A,H,38915268(+) ggcccA/Gcctcc 1 -- int15Minor allele frequency- G:0.13NS EA NA 398
    rs43131211,2
    		C,F,A,H,38892921(-) TTCTAA/GGATTA 1 -- int114Minor allele frequency- G:0.14NS NA EA WA 570
    About this table

    HapMap Linkage Disequilibrium images for ADAM9 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ADAM9
         2 Indels: 41837 60697

    QIAGEN SeqTarget long-range PCR primers for resequencing ADAM9 

    Disorders & Mutations
    for ADAM9 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAM9 for disorders           About GeneDecksing

    OMIM: 602713   disorders: 612775  

    UniProtKB/Swiss-Prot: ADAM9_HUMAN, Q13443

  • Defects in ADAM9 are the cause of cone-rod dystrophy type 9 (CORD9) [MIM:612775]. An inherited retinal
    • dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular
    region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity
    and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs
    earlier than in retinitis pigmentosa

    10 Novoseek disease relationships for ADAM9 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 26.6 4 19473694 (1), 18582378 (1), 19146682 (1)
    tumors 24.1 15 14532978 (3), 19505527 (2), 15930291 (1), 16230393 (1) (see all 7)
    prostate cancer 23.6 19 17018608 (6), 18061337 (5), 16230393 (3), 17342749 (2) (see all 5)
    aggressiveness 22.4 2 14997207 (1), 12717386 (1)
    liver metastases 18.4 2 15930291 (1), 12717386 (1)
    cancer 17.5 9 19473694 (2), 19601830 (2), 19408347 (1), 17355265 (1) (see all 6)
    breast carcinoma 7.03 1 12767059 (1)
    cataract 1.74 4 11955914 (3), 14551530 (1)
    necrosis 0.53 4 10527948 (1), 11463349 (1)
    carcinoma 0 7 15930291 (2), 16230393 (2), 12767059 (1), 12717386 (1)
    About this table

    Human Gene Mutation Database (HGMD): ADAM9
    Human Genome Epidemiology (HuGE) Navigator: ADAM9 (1 document)

    Export disorders and mutations for ADAM9 gene to outside databases

    Medical News
    for ADAM9 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for ADAM9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/85 PubMed articles for ADAM9 gene, integrated from 7 sources (see all 85):
    (articles sorted by number of sources associating them with ADAM9)
    1. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PubMed id 8647900)1, 2, 3, 7 Weskamp G.... Blobel C.P. (1996)
    2. Loss of the metalloprotease ADAM9 leads to cone-rod d ystrophy in humans and retinal degeneration in mice. (PubMed id 19409519)1, 2 Parry D.A....Inglehearn C.F. (2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. A secreted form of human ADAM9 has an alpha-secretase activity for APP. (PubMed id 12054541)1, 2 Hotoda N.... Ishiura S. (2002)
    5. Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. (PubMed id 9016778)1, 2 McKie N.... Croucher P.I. (1997)
    6. Cloning of a novel membrane-linked metalloproteinase from human myeloma cells. (PubMed id 8809033)1, 2 McKie N....Croucher P.I. (1996)
    7. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    8. Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix. (PubMed id 19473694)1, 7 Zubel A....Alonso A. (2009)
    9. Oxidative stress induces ADAM9 protein expression in human prostate cancer cells. (PubMed id 17018608)1, 7 Sung S.Y....Chung L.W. (2006)
    10. ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. (PubMed id 14997207)1, 7 Grutzmann R....Pilarsky C. (2004)

    External Searches for ADAM9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ADAM9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8754 HGNC: 216 AceView: ADAM9 Ensembl:ENSG00000168615 euGenes: HUgn8754
    ECgene: ADAM9 H-InvDB: ADAM9

    Other Databases showing ADAM9 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0021

    Specialized Databases showing ADAM9 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ADAM9 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ADAM9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for ADAM9 gene:
    Search GeneIP for patents involving ADAM9

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    Products
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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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