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ADAMTS8 Gene

protein-coding   GIFtS: 52

GC11M126229
ADAM metallopeptidase with thrombospondin type 1 motif, 8
(Previous names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ADAM metallopeptidase with thrombospondin type 1 motif, 81 2     ADAMTS-82 3
METH21 2 3 5     ADAM-TS 82 3
ADAM-TS81 2 3     METH-82 3
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin
type 1 motif, 81 2
     A disintegrin and metalloproteinase with thrombospondin motifs 82
FLJ417121 2     EC 3.4.24.-3
METH-22 3     

External Ids:    HGNC: 2241   Entrez Gene: 110952   Ensembl: ENSG000001349177   UniProtKB: Q9UP793   

Export aliases for ADAMTS8 gene to outside databases

Previous GC identifers: GC11M132275 GC11M131787 GC11M130308 GC11M129812 GC11M129780


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS8:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of the family share several distinct protein modules, including a propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of
this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded
by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been
mapped in the vicinity of this gene, most notably lung neoplasms. (provided by RefSeq)

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
Function: Has anti-angiogenic properties

Gene Wiki entry for ADAMTS8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTS8 gene promoter:
         ATF   MIF-1   NF-kappaB2   NF-kappaB   NF-kappaB1   GR-alpha   ER-alpha   MyoD   C/EBPalpha   POU2F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ADAMTS8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ADAMTS8 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q25

ADAMTS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS8 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M126229:  view genomic region     (about GC identifiers)

Start:
126,229,030 bp from pter
End:
126,252,351 bp from pter
Size:
23,322 bases
Orientation:
minus strand

1 alternative location:
Chr11- 130,274,820-130,298,539     
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79 (See protein sequence)
Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 8 precursor  
Size: 889 amino acids; 96460 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q9NZS0

Explore the universe of human proteins at neXtProt for ADAMTS8: NX_Q9UP79 

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_008968.4  

    ENSEMBL proteins: 
    ENSP00000405370 ENSP00000257359 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ADAMTS8
    GenScript Custom Purified and Recombinant Proteins Services for ADAMTS8 
    Novus Biologicals Protein for ADAMTS8
    Novus Biologicals Lysate for ADAMTS8
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix IEA--
    GO:0031012 extracellular matrix ----
    About this table

    ADAMTS8 for ontologies           About GeneDecksing



    Antibodies for ADAMTS8: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ADAMTS8
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ADAMTS8 
    Novus Biologicals Antibody for ADAMTS8
    Browse antibodies at Epitomics

    Assays for ADAMTS8: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAMTS8 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ADAMTS8 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ADAMTS8 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000884 Thrombospondin_1_rpt
     IPR013273 Peptidase_M12B_ADAM-TS
     IPR010294 ADAM_spacer1
     IPR001590 Peptidase_M12B
     IPR013277 Pept_M12B_ADAM-TS8

    Graphical View of Domain Structure for InterPro Entry Q9UP79

    ProtoNet protein and cluster: Q9UP79

    5 Blocks protein families:
    IPB000884 Thrombospondin
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB008085 Thrombospondin type 1 repeat signature
    IPB010294 ADAM-TS Spacer 1


    UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
    Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular
    matrix
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain
    Similarity: Contains 2 TSP type-1 domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
    Function: Has anti-angiogenic properties
    Enzyme Number (IUBMB): EC 3.4.24.- 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADAMTS8
    Sigma-Aldrich shRNA Panels and shRNA for ADAMTS8
    OriGene 29mer shRNA kits in GFP-retroviral vector: ADAMTS8
    OriGene shRNA RFP: ADAMTS8
    OriGene basic RS shRNA: ADAMTS8
    OriGene siRNA: ADAMTS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAMTS8 
    miRNA:Sigma-Aldrich microRNA Mimics for ADAMTS8
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAMTS8 
    8/12 SABiosciences Assays for microRNAs that regulate ADAMTS8 (see all 12):
    hsa-miR-203 hsa-miR-98 hsa-let-7d hsa-let-7c hsa-miR-519c-3p hsa-let-7i hsa-miR-519a hsa-let-7g

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ADAMTS8
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ADAMTS8
    OriGene untagged cDNA clones in CMV expression vector: ADAMTS8
    OriGene 3'-UTR clone: ADAMTS8 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ADAMTS8 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ADAMTS8 

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222 metalloendopeptidase activity IEA--
    GO:0005178 integrin binding TAS10438512
    GO:0008201 heparin binding IEA--
    GO:0008233 peptidase activity IEA--
    GO:0008237 metallopeptidase activity TAS10438512
    About this table

    ADAMTS8 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including ADAMTS8: PAHS-013A 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTS8

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508 proteolysis IEA--
    GO:0008285 negative regulation of cell proliferation TAS10438512
    About this table

    ADAMTS8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTS8


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADAMTS8
    Sigma-Aldrich shRNA Panels and shRNA for ADAMTS8
    OriGene 29mer shRNA kits in GFP-retroviral vector: ADAMTS8
    OriGene shRNA RFP: ADAMTS8
    OriGene basic RS shRNA: ADAMTS8
    OriGene siRNA: ADAMTS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAMTS8 
    miRNA: Sigma-Aldrich microRNA Mimics for ADAMTS8
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAMTS8 
    8/12 SABiosciences Assays for microRNAs that regulate ADAMTS8 (see all 12):
    hsa-miR-203 hsa-miR-98 hsa-let-7d hsa-let-7c hsa-miR-519c-3p hsa-let-7i hsa-miR-519a hsa-let-7g
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ADAMTS8
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ADAMTS8
    OriGene untagged cDNA clones in CMV expression vector: ADAMTS8
    OriGene 3'-UTR Clone: ADAMTS8 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ADAMTS8 
    Primers: OriGene genome-wide validated SYBR primer pairs: ADAMTS8
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ADAMTS8: PPH01150A

    REFSEQ mRNAs for ADAMTS8 gene: 

    NM_007037.4  

    Additional cDNA sequence: 

    AB209717.1 AF060153.1 AF175283.1 AK123706.1 BC089435.1 BC113874.1 BC114624.1 

    8 DOTS entries:

    DT.120727753  DT.102826821  DT.91753837  DT.101980577  DT.106087  DT.120727736  DT.106086  DT.100845050 

    24/68 AceView cDNA sequences (see all 68):

    CA440574 AA350802 CO248849 AK123706 BF221873 BM988619 BQ013052 CO398765 
    AI811557 CO393893 CF126031 AI138443 BM726460 CO246413 CF125500 AA693573 
    AI291502 CO249109 CO247431 BF033017 AF175283 AW137467 BM701548 CO246112 

    highest scoring ESTs for ADAMTS8:

    AF060153 AI400905 AA350802 AA635657 AF175283 AI378857 AI674956 AI969885 AW137467 BF033017 

    Unigene Cluster for ADAMTS8:

    ADAM metallopeptidase with thrombospondin type 1 motif, 8
    Hs.271605  [show with all ESTs]
    Unigene Representative Sequence: AF060153


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS8

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                      -     -                       -               
    SP2:                          -     -     -     -     -     -     -     -     -         
    SP3:                                                                    -               
    SP4:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for ADAMTS8
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414575 ENST00000257359(uc001qgf.2 uc001qgg.3)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ADAMTS8 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching ADAMTS8 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    88879_at2, 3 U95-E 1 1.00 1.00 0.85 1.14 AI378857 0.60 1.00 0.82 1
    85346_at2, 3 U95-E 1 0.75 1.00 0.34 0.87 AI400905 0.80 1.00 0.91 1
    235649_at2, 3 U133-B 1 1.00 1.00 -- -- AW207389 0.40 1.00 0.76 1
    220677_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_007037 0.60 1.00 0.82 1
    220676_at2, 3 U133-A 1 0.64 1.00 -- -- NM_007037 0.60 1.00 0.82 1
    235649_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    220677_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    220676_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    ADAMTS8 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ADAMTS8 gene expression
    ADAMTS8 gene electronic northern expression
    ADAMTS8 gene sage expression
    About these images

    CGAP SAGE TAG: TTCTCAGGCT

    SOURCE GeneReport for Unigene cluster: Hs.271605

    UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79
    Tissue specificity: Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and
    fetal brain and kidney

    Primers: OriGene genome-wide validated SYBR primer pairs: ADAMTS8
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ADAMTS8: PPH01150A
        SABiosciences Expression via Pathway-Focused PCR Array including ADAMTS8: PAHS-013A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ADAMTS8 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ADAMTS81   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 99.06(n)
    98.87(a)
    466852  XM_522252.2  XP_522252.2 
    cow
    (Bos taurus)
    ADAMTS81   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 82.9(n)
    76.9(a)
    512544  XM_590083.3  XP_590083.3 
    rat
    (Rattus norvegicus)
    Adamts81   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 82.24(n)
    78.92(a)
    300475  XM_235977.4  XP_235977.4 
    mouse
    (Mus musculus)
    Adamts81 , 5 9 (16.49 cM)5
    a disintegrin-like and metallopeptidase (reprolysin more1, 5 83.61(n)1
    81.55(a)1
    308061  NM_013906.21  NP_038934.21 
     AA8555325  AF1752825  (see all 8)
    chicken
    (Gallus gallus)
    ADAMTS81   -- ADAM metallopeptidase with thrombospondin type 1 motif, more 76.5(n)
    76.74(a)
    769222  XM_001232456.1  XP_001232457.1 
    About this table        Species with no ortholog for ADAMTS8

    ENSEMBL Gene Tree for ADAMTS8 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ADAMTS8 gene
    ADAMTS42  ADAMTS152  ADAMTS12  ADAMTS92  ADAMTS202  

    ADAMTS8 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/289 NCBI SNPs in ADAMTS8 are shown (see all 289)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs7653861,2
    C,F,A,H,130289608(+) TCTACC/TGGACG 1 -- int123Minor allele frequency- T:0.10NS EA NA WA 1020
    rs7653871,2
    --130289235(+) TCTCAA/GGGCCC 1 -- int10--------
    rs9030241,2
    C,F,A,130298447(-) GGGCAA/GGGGCG 1 -- ut511Minor allele frequency- G:0.49MN 184
    rs10212061,2
    C,F,130276810(+) TTGCTC/TTTCTT 1 -- int114Minor allele frequency- T:0.05NA EA WA 601
    rs15523301,2
    C,F,A,H,130293894(+) TTGTCA/GCGTAA 1 -- int123Minor allele frequency- G:0.37NS EA NA WA 2986
    rs20032101,2
    --130295776(+) caggcG/Ttgagc 1 -- int10--------
    rs20032111,2
    C130295787(+) caccgC/Tgcccg 1 -- int10--------
    rs20100821,2
    C,130300526(-) AACTGC/GTACTG 1 -- ng511Minor allele frequency- G:0.01NA 72
    rs21012901,2
    --130289699(+) AAGTTC/TTGAGC 1 -- int10--------
    rs21315351,2
    C,F,A,130281488(+) CATCTA/GCCACG 2 A V ref1 mis1 ese323Minor allele frequency- G:0.23EA NA NS WA 2868
    About this table

    HapMap Linkage Disequilibrium images for ADAMTS8 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ADAMTS8
         1 CNV: 3869

    QIAGEN SeqTarget long-range PCR primers for resequencing ADAMTS8 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADAMTS8 for disorders           About GeneDecksing

    OMIM: 605175

    Human Genome Epidemiology (HuGE) Navigator: ADAMTS8 (1 document)

    Export disorders and mutations for ADAMTS8 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/14 PubMed articles for ADAMTS8 gene, integrated from 7 sources (see all 14):
    (articles sorted by number of sources associating them with ADAMTS8)
    1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PubMed id 10438512)1, 2, 3, 7 Vazquez F.... Iruela-Arispe M.L. (1999)
    2. ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. (PubMed id 10610729)1, 2, 7 Georgiadis K.E.... Apte S.S. (1999)
    3. METH-2 silencing and promoter hypermethylation in NSCLC. (PubMed id 15328519)1, 7 Dunn J.R....Liloglou T. (2004)
    4. ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PubMed id 15296936)1, 7 Collins-Racie L.A....LaVallie E.R. (2004)
    5. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1 Joslyn G....White R.L. (2010)
    6. ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. (PubMed id 17606262)1 Wagsater D....Eriksson P. (2008)
    7. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)2 Yu L.-R.... Veenstra T.D. (2007)
    8. ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. (PubMed id 16152618)1 Porter S....Edwards D.R. (2006)
    9. Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. (PubMed id 16570050)1 Dunn J.R....Walker C. (2006)
    10. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11095 HGNC: 224 AceView: ADAMTS8 Ensembl:ENSG00000134917 euGenes: HUgn11095
    ECgene: ADAMTS8 H-InvDB: ADAMTS8

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for ADAMTS8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for ADAMTS8 gene:
    Search GeneIP for patents involving ADAMTS8

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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     ELISAs and CLIAs for ADAMTS8
           

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