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ADAMTS8 Gene

protein-coding GIFtS: 52

GC11M126229

ADAM metallopeptidase with thrombospondin type 1 motif, 8
(Previous names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
ADAM metallopeptidase with thrombospondin type 1 motif, 8¹ ²		ADAMTS-8² ³
METH2¹ ² ³ ⁵		ADAM-TS 8² ³
ADAM-TS8¹ ² ³		METH-8² ³
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8¹ ²		A disintegrin and metalloproteinase with thrombospondin motifs 8²
FLJ41712¹ ²		EC 3.4.24.-³
METH-2² ³

External Ids:	HGNC: 224¹	Entrez Gene: 11095²	Ensembl: ENSG00000134917⁷	UniProtKB: Q9UP79³

Export aliases for ADAMTS8 gene to outside databases

Previous GC identifers: GC11M132275 GC11M131787 GC11M130308 GC11M129812 GC11M129780

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADAMTS8:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein

family. Members of the family share several distinct protein modules, including a propeptide region, a

metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of

this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded

by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been

mapped in the vicinity of this gene, most notably lung neoplasms. (provided by RefSeq)

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79

Function: Has anti-angiogenic properties

Gene Wiki entry for ADAMTS8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADAMTS8 gene promoter:
         ATF   MIF-1   NF-kappaB2   NF-kappaB   NF-kappaB1   GR-alpha   ER-alpha   MyoD   C/EBPalpha   POU2F1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ADAMTS8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ADAMTS8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q25

ADAMTS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTS8 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M126229: view genomic region (about GC identifiers)

Start:	126,229,030 bp from pter
End:	126,252,351 bp from pter
Size:	23,322 bases
Orientation:	minus strand

1 alternative location:

Chr11- 130,274,820-130,298,539

RefSeq DNA sequence:

NC_000011.9 NT_033899.8

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79 (See protein sequence)

Recommended Name: A disintegrin and metalloproteinase with thrombospondin motifs 8 precursor

Size: 889 amino acids; 96460 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: Q9NZS0

Explore the universe of human proteins at neXtProt for ADAMTS8: NX_Q9UP79

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_008968.4

ENSEMBL proteins:

ENSP00000405370 ENSP00000257359

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ADAMTS8
	GenScript Custom Purified and Recombinant Proteins Services for ADAMTS8
	Novus Biologicals Protein for ADAMTS8
	Novus Biologicals Lysate for ADAMTS8
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0031012	extracellular matrix	--	--

About this table

ADAMTS8 for ontologies About GeneDecksing

Antibodies for ADAMTS8:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ADAMTS8
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for ADAMTS8
	Novus Biologicals Antibody for ADAMTS8
	Browse antibodies at Epitomics

Assays for ADAMTS8:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADAMTS8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADAMTS8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADAMTS8 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000884 Thrombospondin_1_rpt

IPR013273 Peptidase_M12B_ADAM-TS

IPR010294 ADAM_spacer1

IPR001590 Peptidase_M12B

IPR013277 Pept_M12B_ADAM-TS8

Graphical View of Domain Structure for InterPro Entry Q9UP79

ProtoNet protein and cluster: Q9UP79

5 Blocks protein families:

IPB000884 Thrombospondin

IPB001762 Disintegrin

IPB002870 Metalloendopeptidase M12B

IPB008085 Thrombospondin type 1 repeat signature

IPB010294 ADAM-TS Spacer 1

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular

matrix

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 peptidase M12B domain

Similarity: Contains 2 TSP type-1 domains

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79

Function: Has anti-angiogenic properties

Enzyme Number (IUBMB): EC 3.4.24.-

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADAMTS8 Sigma-Aldrich shRNA Panels and shRNA for ADAMTS8
		OriGene 29mer shRNA kits in GFP-retroviral vector: ADAMTS8 OriGene shRNA RFP: ADAMTS8 OriGene basic RS shRNA: ADAMTS8 OriGene siRNA: ADAMTS8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAMTS8

miRNA:		Sigma-Aldrich microRNA Mimics for ADAMTS8 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAMTS8
		8/12 SABiosciences Assays for microRNAs that regulate ADAMTS8 (see all 12):
		hsa-miR-203 hsa-miR-98 hsa-let-7d hsa-let-7c hsa-miR-519c-3p hsa-let-7i hsa-miR-519a hsa-let-7g

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ADAMTS8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ADAMTS8 OriGene untagged cDNA clones in CMV expression vector: ADAMTS8 OriGene 3'-UTR clone: ADAMTS8 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ADAMTS8
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ADAMTS8

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005178	integrin binding	TAS	10438512
GO:0008201	heparin binding	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0008237	metallopeptidase activity	TAS	10438512

About this table

ADAMTS8 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Pathway-Focused PCR Array including ADAMTS8: PAHS-013A

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADAMTS8

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0008285	negative regulation of cell proliferation	TAS	10438512

About this table

ADAMTS8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADAMTS8

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADAMTS8 Sigma-Aldrich shRNA Panels and shRNA for ADAMTS8
		OriGene 29mer shRNA kits in GFP-retroviral vector: ADAMTS8 OriGene shRNA RFP: ADAMTS8 OriGene basic RS shRNA: ADAMTS8 OriGene siRNA: ADAMTS8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAMTS8

miRNA:		Sigma-Aldrich microRNA Mimics for ADAMTS8 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAMTS8
		8/12 SABiosciences Assays for microRNAs that regulate ADAMTS8 (see all 12):
		hsa-miR-203 hsa-miR-98 hsa-let-7d hsa-let-7c hsa-miR-519c-3p hsa-let-7i hsa-miR-519a hsa-let-7g

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ADAMTS8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ADAMTS8 OriGene untagged cDNA clones in CMV expression vector: ADAMTS8 OriGene 3'-UTR Clone: ADAMTS8 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ADAMTS8

Primers:		OriGene genome-wide validated SYBR primer pairs: ADAMTS8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ADAMTS8: PPH01150A

REFSEQ mRNAs for ADAMTS8 gene:

NM_007037.4

Additional cDNA sequence:

AB209717.1 AF060153.1 AF175283.1 AK123706.1 BC089435.1 BC113874.1 BC114624.1

8 DOTS entries:

DT.120727753 DT.102826821 DT.91753837 DT.101980577 DT.106087 DT.120727736 DT.106086 DT.100845050

24/68 AceView cDNA sequences (see all 68):

CA440574 AA350802 CO248849 AK123706 BF221873 BM988619 BQ013052 CO398765

AI811557 CO393893 CF126031 AI138443 BM726460 CO246413 CF125500 AA693573

AI291502 CO249109 CO247431 BF033017 AF175283 AW137467 BM701548 CO246112

highest scoring ESTs for ADAMTS8:

AF060153 AI400905 AA350802 AA635657 AF175283 AI378857 AI674956 AI969885 AW137467 BF033017

Unigene Cluster for ADAMTS8:

ADAM metallopeptidase with thrombospondin type 1 motif, 8

Hs.271605 [show with all ESTs]

Unigene Representative Sequence: AF060153

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS8

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9	^	10
SP1:													-		-								-
SP2:									-		-		-		-		-		-		-		-		-
SP3:																							-
SP4:

About this scheme

ECgene alternative splicing isoforms for ADAMTS8
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000414575 ENST00000257359(uc001qgf.2 uc001qgg.3)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ADAMTS8 expression in normal and diseased human tissues

¹ / ² / ³

8 probe-sets matching ADAMTS8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
88879_at²^{, 3}	U95-E	1	1.00	1.00	0.85	1.14	AI378857	0.60	1.00	0.82	1
85346_at²^{, 3}	U95-E	1	0.75	1.00	0.34	0.87	AI400905	0.80	1.00	0.91	1
235649_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW207389	0.40	1.00	0.76	1
220677_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007037	0.60	1.00	0.82	1
220676_at²^{, 3}	U133-A	1	0.64	1.00	--	--	NM_007037	0.60	1.00	0.82	1
235649_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220677_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220676_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table

ADAMTS8 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ADAMTS8 gene electronic northern expression

About these images

CGAP SAGE TAG: TTCTCAGGCT

SOURCE GeneReport for Unigene cluster: Hs.271605

UniProtKB/Swiss-Prot: ATS8_HUMAN, Q9UP79

Tissue specificity: Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and

fetal brain and kidney

Primers:		OriGene genome-wide validated SYBR primer pairs: ADAMTS8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ADAMTS8: PPH01150A

SABiosciences Expression via Pathway-Focused PCR Array including ADAMTS8: PAHS-013A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADAMTS8 gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ADAMTS8¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	99.06(n) 98.87(a)	466852 XM_522252.2 XP_522252.2
cow (Bos taurus)	ADAMTS8¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	82.9(n) 76.9(a)	512544 XM_590083.3 XP_590083.3
rat (Rattus norvegicus)	Adamts8¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	82.24(n) 78.92(a)	300475 XM_235977.4 XP_235977.4
mouse (Mus musculus)	Adamts8^{1 , 5}	9 (16.49 cM)⁵	a disintegrin-like and metallopeptidase (reprolysin more^{1, 5}	83.61(n)¹ 81.55(a)¹	30806¹ NM_013906.2¹ NP_038934.2¹ AA855532⁵ AF175282⁵ (see all 8)
chicken (Gallus gallus)	ADAMTS8¹	--	ADAM metallopeptidase with thrombospondin type 1 motif, more	76.5(n) 76.74(a)	769222 XM_001232456.1 XP_001232457.1

About this table Species with no ortholog for ADAMTS8

ENSEMBL Gene Tree for ADAMTS8 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADAMTS8 gene

ADAMTS4² ADAMTS15² ADAMTS1² ADAMTS9² ADAMTS20²

ADAMTS8 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs765386^1,2	C,F,A,H,	130289608(+)	`TCTACC/TGGACG`	1	--	int¹		23		NS EA NA WA	1020
rs765387^1,2	--	130289235(+)	`TCTCAA/GGGCCC`	1	--	int¹		0	--	--	--	--
rs903024^1,2	C,F,A,	130298447(-)	`GGGCAA/GGGGCG`	1	--	ut5¹		1		MN	184
rs1021206^1,2	C,F,	130276810(+)	`TTGCTC/TTTCTT`	1	--	int¹		14		NA EA WA	601
rs1552330^1,2	C,F,A,H,	130293894(+)	`TTGTCA/GCGTAA`	1	--	int¹		23		NS EA NA WA	2986
rs2003210^1,2	--	130295776(+)	`caggcG/Ttgagc`	1	--	int¹		0	--	--	--	--
rs2003211^1,2	C	130295787(+)	`caccgC/Tgcccg`	1	--	int¹		0	--	--	--	--
rs2010082^1,2	C,	130300526(-)	`AACTGC/GTACTG`	1	--	ng5¹		1		NA	72
rs2101290^1,2	--	130289699(+)	`AAGTTC/TTGAGC`	1	--	int¹		0	--	--	--	--
rs2131535^1,2	C,F,A,	130281488(+)	`CATCTA/GCCACG`	2	A V	ref¹ mis¹ ese³		23		EA NA NS WA	2868

About this table

HapMap Linkage Disequilibrium images for ADAMTS8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ADAMTS8
1 CNV: 3869

QIAGEN SeqTarget long-range PCR primers for resequencing ADAMTS8

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADAMTS8 for disorders About GeneDecksing

OMIM: 605175

Human Genome Epidemiology (HuGE) Navigator: ADAMTS8 (1 document)

Export disorders and mutations for ADAMTS8 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/14 PubMed articles for ADAMTS8 gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with ADAMTS8)

METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PubMed id 10438512)^{1, 2, 3, 7} Vazquez F.... Iruela-Arispe M.L. (1999)
ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. (PubMed id 10610729)^{1, 2, 7} Georgiadis K.E.... Apte S.S. (1999)
METH-2 silencing and promoter hypermethylation in NSCLC. (PubMed id 15328519)^{1, 7} Dunn J.R....Liloglou T. (2004)
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PubMed id 15296936)^{1, 7} Collins-Racie L.A....LaVallie E.R. (2004)
Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)¹ Joslyn G....White R.L. (2010)
ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. (PubMed id 17606262)¹ Wagsater D....Eriksson P. (2008)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)² Yu L.-R.... Veenstra T.D. (2007)
ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. (PubMed id 16152618)¹ Porter S....Edwards D.R. (2006)
Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. (PubMed id 16570050)¹ Dunn J.R....Walker C. (2006)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11095	HGNC: 224	AceView: ADAMTS8	Ensembl:ENSG00000134917	euGenes: HUgn11095
ECgene: ADAMTS8	H-InvDB: ADAMTS8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ADAMTS8	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ADAMTS8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for ADAMTS8 gene:
Search GeneIP for patents involving ADAMTS8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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	Predesigned and custom siRNAs for ADAMTS8		Antibodies for ADAMTS8
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADAMTS8
	SeqTarget long-range PCR primers for resequencing ADAMTS8
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ADAMTS8
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADAMTS8

	GenScript Custom Purified and Recombinant Proteins Services for ADAMTS8		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ADAMTS8
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	GenScript Custom overexpressing Cell Line Services for ADAMTS8		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in ADAMTS8 promoter
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ELISAs and CLIAs for ADAMTS8

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

ADAMTS8 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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ADAMTS8 Gene

protein-coding GIFtS: 52

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ADAMTS8 Gene

protein-coding GIFtS: 52

Aliases & Descriptionsfor ADAMTS8 gene

Summariesfor ADAMTS8 gene

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Protein Domains/Familiesfor ADAMTS8 gene

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Aliases &
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for ADAMTS8 gene

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for ADAMTS8 gene

Genomic Views
for ADAMTS8 gene

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for ADAMTS8 gene

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Families
for ADAMTS8 gene

Gene Function
for ADAMTS8 gene

Pathways & Interactions
for ADAMTS8 gene

Drugs & Compounds
for ADAMTS8 gene

Transcripts
for ADAMTS8 gene

Expression
for ADAMTS8 gene

Orthologs
for ADAMTS8 gene

Paralogs
for ADAMTS8 gene

Genomic Variants
for ADAMTS8 gene

Disorders & Mutations
for ADAMTS8 gene

Medical News
for ADAMTS8 gene

Publications
for ADAMTS8 gene

Intellectual Property
for ADAMTS8 gene

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for ADAMTS8 gene