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ADRA1A Gene

protein-coding   GIFtS: 64

GC08M025150
adrenergic, alpha-1A-, receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ADRA1C)
Products    

Aliases &
Descriptions
for ADRA1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
adrenergic, alpha-1A-, receptor1 2     G protein coupled receptor2
ADRA1C2 3 5     adrenergic, alpha-1A-, receptor variant 82
ADRA1L11 2     adrenergic, alpha-1C-, receptor2
Alpha-adrenergic receptor 1c2 3     adrenergic, alpha-1A-, receptor variant 12
Alpha-1A adrenoceptor2 3     adrenergic, alpha -1A-, receptor2
Alpha-1A adrenoreceptor2 3     adrenergic, alpha-1A-, receptor variant 32
Alpha-1C adrenergic receptor2 3     alpha-1A adrenergic receptor2
ALPHA1AAR2     adrenergic, alpha-1A-, receptor variant 52

External Ids:    HGNC: 2771   Entrez Gene: 1482   Ensembl: ENSG000001209077   UniProtKB: P353483   

Export aliases for ADRA1A gene to outside databases

Previous GC identifers: GC08M026378 GC08M027048 GC08M026627 GC08M026661


Summaries
for ADRA1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADRA1A:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate
mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A,
-1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns
of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four
transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding
properties. (provided by RefSeq)

UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348
Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a
phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins

summary for ADRA1A:
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The
adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.
lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in
smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L
based on its low affinity for prazosin. It has been suggested that this subtype may represent a different
conformational state of the alpha1A subtype.

Gene Wiki entry for ADRA1A (Alpha-1A adrenergic receptor)

Genomic Views
for ADRA1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADRA1A gene promoter:
         Meis-1   HOXA9B   AP-1   JunD   c-Fos   c-Jun   JunB   Fra-1   Bach2   NF-E2 p45   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ADRA1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ADRA1A 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

ADRA1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADRA1A gene location

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M025150:  view genomic region     (about GC identifiers)

Start:
 25,150,527 bp from pter
End:
 25,267,740 bp from pter
Size:
 117,214 bases
Orientation:
 minus strand

1 alternative location:
Chr8- 26,605,667-26,724,790     
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  

Proteins
for ADRA1A gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348 (See protein sequence)
Recommended Name: Alpha-1A adrenergic receptor  
Size: 466 amino acids; 51487 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A8K0I3 B0ZBD1 B0ZBD2 B0ZBD4 B0ZBD5 B0ZBD6 B0ZBD8 B0ZBD9 O60451 Q13675 Q13729
Q4VBM7 Q6RUJ4 Q6RUJ5 Q6RUJ7 Q6RUJ8 Q6RUJ9 Q96RE8 Q9UD63 Q9UD67
Alternative splicing: 9 isoforms:  P35348-1   P35348-2   P35348-3   P35348-4   P35348-5   P35348-6   P35348-7   P35348-8   
P35348-9   

Explore the universe of human proteins at neXtProt for ADRA1A: NX_P35348 

Post-translational modifications:

  • Carboxyl-terminal Ser or Thr residues may be phosphorylated (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (4 alternative transcripts): 
    NP_000671.2  NP_150645.2  NP_150646.3  NP_150647.2  


    ENSEMBL proteins: 
    ENSP00000348729 ENSP00000351725 ENSP00000369956 ENSP00000431073 ENSP00000369947 ENSP00000276393 
    ENSP00000346557 ENSP00000430793 ENSP00000369960 ENSP00000369961 ENSP00000430414 ENSP00000369946 
    ENSP00000369955 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant ADRA1A Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for ADRA1A 
    Novus Biologicals Protein for ADRA1A
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction ----
    GO:0005886 plasma membrane TAS--
    GO:0005887 integral to plasma membrane TAS8396931
    GO:0016021 integral to membrane ----
    About this table

    ADRA1A for ontologies           About GeneDecksing



    Antibodies for ADRA1A: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ADRA1A
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ADRA1A 
    Novus Biologicals Antibodies for ADRA1A
    Epitomics antibodies for ADRA1A

    Assays for ADRA1A: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript ADRA1A-overexpressing Cell Line for Assay 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for ADRA1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADRA1A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR002233 Adrnrgc_rcpt
     IPR000276 7TM_GPCR_Rhodpsn
     IPR001004 Adrene_rcpt_A1Cs

    Graphical View of Domain Structure for InterPro Entry P35348

    ProtoNet protein and cluster: P35348

    2 Blocks protein families:
    IPB001004 Alpha-1C adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348
    Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily


    Gene Function
    for ADRA1A gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348
    Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a
    phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADRA1A
    Sigma-Aldrich shRNA Panels and shRNA for ADRA1A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ADRA1A
    OriGene shRNA RFP (see all 4): ADRA1A
    OriGene basic RS shRNA (see all 4): ADRA1A
    OriGene siRNA (see all 4): ADRA1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADRA1A 
    miRNA:Sigma-Aldrich microRNA Mimics for ADRA1A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADRA1A 
    1 SABiosciences Assays for microRNA that regulate ADRA1A:
    hsa-miR-433

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Millipore Clones for the Expression of ADRA1A
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): ADRA1A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): ADRA1A
    OriGene untagged cDNA clones in CMV expression vector (see all 4): ADRA1A
    OriGene 3'-UTR clone (see all 4): ADRA1A 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ADRA1A 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript ADRA1A-overexpressing Cell Line for Assay 

    Genatlas biochemistry entry for ADRA1A:
    adrenergic,alpha-1A,receptor,G protein coupled receptor superfamily,with four alternatively spliced
    isoforms,stimulating,acting through the phosphatidylinositol Ca2+ second messenger system

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity IEA--
    GO:0004935 adrenergic receptor activity IEA--
    GO:0004937 alpha1-adrenergic receptor activity TAS7737411
    About this table

    ADRA1A for ontologies           About GeneDecksing

    Animal Models: 5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Adra1a):

    cardiovascular systemhomeostasis/metabolismlife span-post-weaning/agingmusclerenal/urinary system

    ADRA1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADRA1A gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ADRA1A for pathways           About GeneDecksing

    2 Millipore Pathways for ADRA1A
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors

    4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  ADRA1A
        Î±-Adrenergic Signaling
    AMPK Signaling
    G-Protein Coupled Receptor Signaling
    Cardiac Hypertrophy Signaling

    4 Kegg Pathways  (Kegg details for ADRA1A):
        hsa04020 Calcium signaling pathway
    hsa04080 Neuroactive ligand-receptor interaction
    hsa04270 Vascular smooth muscle contraction
    hsa04970 Salivary secretion

        SABiosciences Pathway-Focused PCR Array including ADRA1A: PAHS-3009A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ADRA1A
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRA1A

    5/10 Interacting proteins for ADRA1A (ENSP000003487293) via UniProtKB, MINT, and/or STRING (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRB2ENSP000003053723STRING: ENSP00000305372
    ADRB3ENSP000003437823STRING: ENSP00000343782
    GNA11ENSP000000784293STRING: ENSP00000078429
    GNA14ENSP000003658073STRING: ENSP00000365807
    GNA15ENSP000002629583STRING: ENSP00000262958
    About this table

    5/30 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 30):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure ----
    GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure ----
    GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine ----
    GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine ----
    GO:0006915 apoptosis TAS10671514
    About this table

    ADRA1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADRA1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ADRA1A for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for ADRA1A:
    Small Molecule - Inhibitor Small Molecule - Antagonist Small Molecule - Agonist
    Enzo Life Sciences drugs & compounds for ADRA1A

    Compounds for ADRA1A available from Tocris Bioscience
    CompoundAction CAS number
    RS 100329 hydrochloride Potent, subtype-selective alpha1A antagonist [232953-52-5]
    RS 17053 hydrochloridealpha1A antagonist[169505-93-5]
    Cirazoline hydrochlorideSelective alpha1 agonist[40600-13-3]
    SNAP 5089Subtype-selective alpha1A antagonist[157066-76-7]
    A 61603 hydrobromidealpha1A agonist[107756-30-9]
    About this table


    3 Novoseek chemical compound relationships for ADRA1A gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prazosin 52.9 1 12782672 (1)
    norepinephrine 14 1 16756025 (1)
    dopamine 0 1 8383880 (1)
    About this table



    Transcripts
    for ADRA1A gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ADRA1A
    Sigma-Aldrich shRNA Panels and shRNA for ADRA1A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ADRA1A
    OriGene shRNA RFP (see all 4): ADRA1A
    OriGene basic RS shRNA (see all 4): ADRA1A
    OriGene siRNA (see all 4): ADRA1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ADRA1A 
    miRNA: Sigma-Aldrich microRNA Mimics for ADRA1A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ADRA1A 
    1 SABiosciences Assays for microRNA that regulate ADRA1A:
    hsa-miR-433
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): ADRA1A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): ADRA1A
    OriGene untagged cDNA clones in CMV expression vector (see all 4): ADRA1A
    OriGene 3'-UTR Clone (see all 4): ADRA1A 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ADRA1A 
    Primers: OriGene genome-wide validated SYBR primer pairs: ADRA1A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ADRA1A: PPH02718A

    REFSEQ mRNAs for ADRA1A gene (4 alternative transcripts): 

    NM_000680.2  NM_033302.2  NM_033303.3  NM_033304.2  

    Additional cDNA sequence: 

    AF013261.1 AF395806.1 AK289548.1 AK311558.1 AY491775.1 AY491776.1 AY491777.1 AY491778.1 
    AY491781.1 BC095512.1 D25235.1 D32201.1 D32202.1 L31774.1 S76001.1 U02569.1 

    8 DOTS entries:

    DT.456038  DT.95193429  DT.95193430  DT.99953072  DT.102825087  DT.87046229  DT.95261826  DT.97798254 

    24 AceView cDNA sequences:

    NM_033302 D32201 L31774 AY491778 NM_033304 AY491780 AA383171 AA312801 
    CF147810 AY491776 S76001 D32202 NM_033303 AY491777 NM_000680 AF013261 
    AY491775 D25235 U02569 AF395806 AA345702 AY491781 AV654179 AW956748 

    highest scoring ESTs for ADRA1A:

    D25235 D32202 AF013261 AF395806 AY491775 AY491776 AY491777 AY491778 CF147810 D32201 

    Unigene Cluster for ADRA1A:

    Adrenergic, alpha-1A-, receptor
    Hs.709175  [show with all ESTs]
    Unigene Representative Sequence: AK289548


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1A

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:              -           -     -         
    SP2:              -           -               
    SP3:              -     -     -     -         
    SP4:                                          
    SP5:              -                           

    About this scheme

    ECgene alternative splicing isoforms for ADRA1A
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518621 ENST00000356368 ENST00000358857 ENST00000380582(uc003xfe.1 uc010lum.1 uc003xff.1)
    ENST00000518810 ENST00000519096 ENST00000380573 ENST00000276393(uc003xfh.1)
    ENST00000354550(uc003xfg.1) ENST00000519229 ENST00000380586(uc003xfc.1)
    ENST00000380587(uc010lul.1 uc003xfd.1) ENST00000521711 ENST00000380572
    ENST00000380581

    Expression
    for ADRA1A gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ADRA1A expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching ADRA1A gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36715_at2, 3 U95-A 1 0.69 1.00 0.32 0.37 D25235 1.00 1.00 1.00 1
    36716_at2, 3 U95-A 1 0.56 1.00 1.00 1.00 D32202 1.00 1.00 1.00 1
    211492_s_at2, 3 U133-A 1 1.00 1.00 -- -- U02569 0.80 1.00 0.91 1
    211490_at2, 3 U133-A 1 0.73 1.00 -- -- AF013261 0.80 1.00 0.91 1
    211491_at2, 3 U133-A 1 0.64 1.00 -- -- D32202 1.00 1.00 1.00 1
    211489_at2, 3 U133-A 1 0.55 1.00 -- -- D32201 0.80 1.00 0.91 1
    211492_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    211490_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    211491_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    211489_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    About this table

    ADRA1A for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ADRA1A gene expression
    ADRA1A gene electronic northern expression
    ADRA1A gene sage expression
    About these images

    CGAP SAGE TAG: CAGCAGTGCT

    SOURCE GeneReport for Unigene cluster: Hs.709175

    Expression variation in blood from EXPOLDB for ADRA1A

    UniProtKB/Swiss-Prot: ADA1A_HUMAN, P35348
    Tissue specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and
    pituitary. Within the prostate, expressed in the apex, base, periurethra and lateral lobe. Isoform 4 is the most
    abundant isoform expressed in the prostate with high levels also detected in liver and heart

    Primers: OriGene genome-wide validated SYBR primer pairs: ADRA1A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ADRA1A: PPH02718A
        SABiosciences Expression via Pathway-Focused PCR Array including ADRA1A: PAHS-3009A 


    Orthologs
    for ADRA1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ADRA1A gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ADRA1A1   -- adrenergic, alpha-1A-, receptor 91.85(n)
    92.92(a)    		 403866  XM_534567.2  XP_534567.2 
    cow
    (Bos taurus)    		 ADRA1A1   -- adrenergic, alpha-1A-, receptor 90.2(n)
    92.06(a)    		 282134  NM_174498.2  NP_776923.1 
    rat
    (Rattus norvegicus)    		 Adra1a1   -- adrenergic, alpha-1A-, receptor 87.55(n)
    92.27(a)    		 29412  NM_017191.1  NP_058887.1 
    mouse
    (Mus musculus)    		 Adra1a1 , 5 14 (34.60 cM)5
    		 adrenergic receptor, alpha 1a1, 5 87.12(n)1
    91.85(a)1    		 115491  NM_013461.31  NP_038489.21 
     AF0314315  AF3620765  (see all 14)
    chicken
    (Gallus gallus)    		 ADRA1A1   -- adrenergic, alpha-1A-, receptor 73.75(n)
    77.25(a)    		 428203  XM_425762.2  XP_425762.2 
    About this table        Species with no ortholog for ADRA1A

    ENSEMBL Gene Tree for ADRA1A (if available)

    Paralogs
    for ADRA1A gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ADRA1A gene
    DRD12  HTR62  DRD52  ADRA1B2  ADRA1D2  HRH22  

    ADRA1A for paralogs           About GeneDecksing



    Genomic Variants
    for ADRA1A gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1511 NCBI SNPs in ADRA1A are shown (see all 1511)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs4711881,2
    		C,F,A,H,26720392(-) AGCCAA/G/TGGATA 3 -- int112NS EA NA WA 522
    rs4721511,2
    		C,F,O,A,26692367(+) AACATA/GCAGAC 3 -- int118Minor allele frequency- G:0.44NS EA NA WA 1218
    rs4728651,2
    		C,F,26698471(+) AGTCAC/TGATAG 3 -- int118Minor allele frequency- T:0.19EA NS NA WA 1732
    rs4766311,2
    		C,F,O,A,H,26706459(+) GTGACT/CCACTT 3 -- int110Minor allele frequency- C:0.40NA EA WA 308
    rs4861791,2
    		C,F,A,H,26723934(-) CTGTCG/ACTTGC 3 -- ng5112Minor allele frequency- A:0.09NS EA NA WA 990
    rs4863541,2
    		C,F,26710290(+) GTTACA/GGTTTA 3 -- int18Minor allele frequency- G:0.23NS EA NA WA 558
    rs4883231,2
    		C,F,O,A,26693973(-) CTTCAC/AGGTGT 3 -- int119Minor allele frequency- A:0.36EA NS NA WA 1238
    rs4897901,2
    		C,F,26716622(-) CAGGGC/TAGGGA 3 -- int1 ese37Minor allele frequency- T:0.13NS EA NA 1052
    rs4922091,2
    		C,A,26711944(-) CCCCCC/GCCCGC 3 -- int1 trp32Minor allele frequency- T:0.25NA WA 4
    rs4943641,2
    		C,F,O,A,H,26720169(-) TGTGCT/CTGCCC 3 -- int122Minor allele frequency- C:0.13EA NS NA WA 1274
    About this table

    HapMap Linkage Disequilibrium images for ADRA1A (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADRA1A: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ADRA1A 

    Disorders & Mutations
    for ADRA1A gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADRA1A for disorders           About GeneDecksing

    OMIM: 104221

    2 Novoseek disease relationships for ADRA1A gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benign prostatic hyperplasia 58.7 4 10843225 (1), 11055359 (1), 16536786 (1), 8183249 (1)
    attention-deficit hyperactivity disorder 24.1 1 11326305 (1)
    About this table

    Human Gene Mutation Database (HGMD): ADRA1A
    Genetic Association Database (GAD): ADRA1A
    Human Genome Epidemiology (HuGE) Navigator: ADRA1A (44 documents)

    Export disorders and mutations for ADRA1A gene to outside databases

    Medical News
    for ADRA1A gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for ADRA1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/114 PubMed articles for ADRA1A gene, integrated from 7 sources (see all 114):
    (articles sorted by number of sources associating them with ADRA1A)
    1. Alpha 1A-adrenergic receptor polymorphism and vascular response. (PubMed id 15179408)1, 2, 4 Sofowora G.G.... Stein C.M. (2004)
    2. Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. (PubMed id 8832064)1, 2, 4 Shibata K....Tsujimoto G. (1996)
    3. Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor. (PubMed id 8396931)1, 2, 7 Hirasawa A....Tsujimoto G. (1993)
    4. Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors. (PubMed id 10493934)1, 2, 7 Coge F.... Canet E. (1999)
    5. The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. (PubMed id 8183249)1, 2, 7 Forray C.... Gluchowski C. (1994)
    6. Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (PubMed id 16043131)1, 4, 7 Clark D.A....Kerwin R.W. (2005)
    7. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PubMed id 15824464)1, 4, 7 Matayoshi T....Kawano Y. (2004)
    8. Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline. (PubMed id 12519093)1, 4, 7 Snapir A....Scheinin M. (2003)
    9. Individual and joint association of alpha1A-adrenergic receptor Arg347Cys polymorphism and plasma irbesartan concentration with blood pressure therapeutic response in Chinese hypertensive subjects. (PubMed id 16153395)1, 4 Jiang S....Wang X. (2005)
    10. A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH. (PubMed id 15136785)1, 4 Klotsman M....Hartmann K.E. (2004)

    External Searches for ADRA1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADRA1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 148 HGNC: 277 AceView: ADRA1A Ensembl:ENSG00000120907 euGenes: HUgn148
    ECgene: ADRA1A Kegg: 148 H-InvDB: ADRA1A

    Other Databases showing ADRA1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADRA1A gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for ADRA1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for ADRA1A gene:
    Search GeneIP for patents involving ADRA1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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