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AEBP1 Gene

protein-coding   GIFtS: 53

GC07P044029
AE binding protein 1
(Previous name: AE-binding protein 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
AE binding protein 11 2     adipocyte enhancer binding protein 12
ACLP1 2 3     adipocyte enhancer-binding protein 12
AE-binding protein 11 2 3     FLJ336122
Aortic carboxypeptidase-like protein2 3     

External Ids:    HGNC: 3031   Entrez Gene: 1652   Ensembl: ENSG000001066247   UniProtKB: Q8IUX73   

Export aliases for AEBP1 gene to outside databases

Previous GC identifers: GC07P043790 GC07P043850 GC07P043884 GC07P043917 GC07P044110 GC07P044143


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AEBP1:
The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This
protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the
adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the
regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of
DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular
smooth muscle cells. (provided by RefSeq)

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and
reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by
promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage
inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AEBP1 gene promoter:
         NF-kappaB1   PPAR-gamma2   PPAR-gamma1   NF-kappaB   SRF   p53   Sp1   Arnt   AhR   E4BP4   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for AEBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for AEBP1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p

AEBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AEBP1 gene location

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P044029:  view genomic region     (about GC identifiers)

Start:
44,029,222 bp from pter
End:
44,039,425 bp from pter
Size:
10,204 bases
Orientation:
plus strand

1 alternative location:
Chr7+ 44,143,960-44,154,161     
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NT_079592.2  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7 (See protein sequence)
Recommended Name: Adipocyte enhancer-binding protein 1 precursor  
Size: 1158 amino acids; 130929 Da
Subunit: Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By
similarity). Binds to DNA in vitro (By similarity)
Subcellular location: Isoform 1: Secreted (By similarity)
Subcellular location: Isoform 2: Cytoplasm (Probable). Nucleus (Probable)
Caution: This protein has lost active site residues and zinc-binding sites and so is unlikely to be catalytically
active
Sequence caution: Sequence=BAD92981.1; Type=Erroneous initiation;
Secondary accessions: Q14113 Q59ER7 Q6ZSC7 Q7KZ79
Alternative splicing: 2 isoforms:  Q8IUX7-1   Q8IUX7-2   

Explore the universe of human proteins at neXtProt for AEBP1: NX_Q8IUX7 

Post-translational modifications:

  • Phosphorylated by MAPK1 in vitro (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001120.3  

    ENSEMBL proteins: 
    ENSP00000397241 ENSP00000400530 ENSP00000411277 ENSP00000400660 ENSP00000401758 ENSP00000410349 
    ENSP00000398878 ENSP00000416568 ENSP00000223357 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for AEBP1 
    Novus Biologicals Protein for AEBP1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005615 extracellular space IDA--
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0031012colocalizes with extracellular matrix IDA--
    About this table

    AEBP1 for ontologies           About GeneDecksing



    Antibodies for AEBP1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for AEBP1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for AEBP1 
    Novus Biologicals Antibodies for AEBP1
    Browse antibodies at Epitomics

    Assays for AEBP1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AEBP1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for AEBP1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    AEBP1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008969 CarboxyPept-like_regulatory
     IPR014766 CarboxyPept_regulatory_dom
     IPR008979 Galactose-bd-like
     IPR000834 Peptidase_M14
     IPR000421 Coagulation_factor_5/8-type_C

    Graphical View of Domain Structure for InterPro Entry Q8IUX7

    ProtoNet protein and cluster: Q8IUX7

    1 Blocks protein family: IPB000421 Coagulation factor 5/8 type C domain (FA58C)

    UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
    Similarity: Belongs to the peptidase M14 family
    Similarity: Contains 1 F5/8 type C domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
    Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and
    reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by
    promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage
    inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for AEBP1
    Sigma-Aldrich shRNA for AEBP1
    OriGene 29mer shRNA kits in GFP-retroviral vector: AEBP1
    OriGene shRNA RFP: AEBP1
    OriGene basic RS shRNA: AEBP1
    OriGene siRNA: AEBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of AEBP1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of AEBP1 
    Search SABiosciences for Assays for microRNAs that regulate AEBP1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: AEBP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: AEBP1
    OriGene untagged cDNA clones in CMV expression vector: AEBP1
    OriGene 3'-UTR clone: AEBP1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: AEBP1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for AEBP1 

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0003700 sequence-specific DNA binding transcription factor activity TAS8920928
    GO:0003714 transcription corepressor activity IEA--
    GO:0004180 carboxypeptidase activity TAS8920928
    GO:0004181 metallocarboxypeptidase activity IEA--
    About this table

    AEBP1 for ontologies           About GeneDecksing

    Animal Models: 13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Aebp1):

    adipose tissuebehavior/neurologicalcellulardigestive/alimentaryendocrine/exocrine gland
    growth/sizehomeostasis/metabolismlethality-prenatal/perinatallife span-post-weaning/aginglimbs/digits/tail
    liver/biliary systemreproductive systemskin/coat/nails

    AEBP1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including AEBP1: PAHS-030A 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AEBP1

    1 Interacting protein for AEBP1 (Q8IUX72) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --Q9WMX22MINT-7049166
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501 skeletal system development TAS8920928
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0006508 proteolysis IEA--
    GO:0007155 cell adhesion IEA--
    GO:0007517 muscle organ development TAS9624159
    About this table

    AEBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    AEBP1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AEBP1
    1 Novoseek chemical compound relationship for AEBP1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 7.39 3 2017183 (2), 11161801 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for AEBP1
    Sigma-Aldrich shRNA for AEBP1
    OriGene 29mer shRNA kits in GFP-retroviral vector: AEBP1
    OriGene shRNA RFP: AEBP1
    OriGene basic RS shRNA: AEBP1
    OriGene siRNA: AEBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of AEBP1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of AEBP1 
    Search SABiosciences for Assays for microRNAs that regulate AEBP1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: AEBP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: AEBP1
    OriGene untagged cDNA clones in CMV expression vector: AEBP1
    OriGene 3'-UTR Clone: AEBP1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: AEBP1 
    Primers: OriGene genome-wide validated SYBR primer pairs: AEBP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for AEBP1: PPH00456A

    REFSEQ mRNAs for AEBP1 gene: 

    NM_001129.3  

    Additional cDNA sequence: 

    AB209744.1 AF053944.1 AK090931.1 AK127541.1 AK296001.1 BC038588.1 CR598691.1 D86479.1 

    19 DOTS entries:

    DT.416578  DT.97788359  DT.100663759  DT.91991375  DT.95253095  DT.100663761  DT.121045041  DT.121044993 
    DT.100663769  DT.91775044  DT.121044991  DT.121044999  DT.92021856  DT.95128411  DT.97799728  DT.121044979 
    DT.40224206  DT.95105014  DT.99981427 

    24/308 AceView cDNA sequences (see all 308):

    BF341089 CF125153 AW057582 CA393424 AL040503 AW471279 CR598691 AA993064 
    BM672693 AI914522 AA976886 AI913043 AA595306 BF344552 BQ183397 BQ231970 
    BC038588 CB268388 BF724960 BP377809 CN482343 BQ897584 BP349662 BF338201 

    highest scoring ESTs for AEBP1:

    AF053944 AA077291 AA077339 AA295483 AA431924 AA443526 AA443710 AA477377 AA477882 AA481466 

    Unigene Cluster for AEBP1:

    AE binding protein 1
    Hs.439463  [show with all ESTs]
    Unigene Representative Sequence: NM_001129


    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for AEBP1 (see all 17)

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b · 13c ^ 14a ·
    SP1:                                                                                                        -     -     -                                       
    SP2:                                                  -                                                     -     -     -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                  -                       -     -                       -     -     -                                       

    ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23
    SP1:        -                                         -     -                                                         
    SP2:                                                                                                                  
    SP3:                                                  -     -                                                         
    SP4:                                                        -                 -                                       
    SP5:                                                                                                                  

    About this scheme

    ECgene alternative splicing isoforms for AEBP1
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434445 ENST00000454218 ENST00000455443 ENST00000453052 ENST00000449162
    ENST00000413907(uc003tkd.2) ENST00000450684(uc003tkc.3) ENST00000431035
    ENST00000223357(uc003tkb.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    AEBP1 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching AEBP1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39069_at2, 3 U95-A 1 0.88 1.00 1.00 1.00 AF053944 1.00 1.00 1.00 1
    201792_at2, 3 U133-A 1 0.91 1.00 -- -- NM_001129 0.60 1.00 0.82 1
    201792_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    AEBP1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    AEBP1 gene expression
    AEBP1 gene electronic northern expression
    AEBP1 gene sage expression
    About these images

    CGAP SAGE TAG: ACTGGGACCT

    SOURCE GeneReport for Unigene cluster: Hs.439463

    Expression variation in blood from EXPOLDB for AEBP1

    UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7
    Tissue specificity: Expressed in osteoblast and visceral fat

    Primers: OriGene genome-wide validated SYBR primer pairs: AEBP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for AEBP1: PPH00456A
        SABiosciences Expression via Pathway-Focused PCR Array including AEBP1: PAHS-030A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for AEBP1 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    rat
    (Rattus norvegicus)
    Aebp11   -- AE binding protein 1 84.12(n)
    86.35(a)
    305494  XM_223583.4  XP_223583.4 
    mouse
    (Mus musculus)
    Aebp11 , 5 11 (3.88 cM)5
    AE binding protein 11, 5 83.9(n)1
    85.5(a)1
    115681  NM_009636.11  NP_033766.11 
     AA1620395  AF0539435  (see all 42)
    zebrafish
    (Danio rerio)
    LOC7933081   -- similar to adipocyte enhancer binding protein 1 58.55(n)
    54.34(a)
    793308  XM_001920851.1  XP_001920886.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Omy.25042   -- Oncorhynchus mykiss transcribed sequence with weak more 76.14(n)  BX855966.1 
    About this table        Species with no ortholog for AEBP1

    ENSEMBL Gene Tree for AEBP1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for AEBP1 gene
    CPZ2  CPE2  CPXM22  CPN12  CPD2  CPM2  CPXM12  

    AEBP1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/111 NCBI SNPs in AEBP1 are shown (see all 111)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs139281,2
    C,F,A,44153780(+) AGGAGA/GAAGAG 2 K E ref1 mis1 trp312Minor allele frequency- G:0.42MN NS EA NA WA 816
    rs8761181,2
    C,F,A,H,44143074(-) GTGCAC/ACTTGG 1 -- ng514Minor allele frequency- A:0.13MN NA EA WA 346
    rs8761191,2
    C,A,44142823(-) TGCAGA/GGGCAG 1 -- ng516Minor allele frequency- G:0.38MN NA EA WA 398
    rs15584691,2
    C,F,A,44145910(-) TGAGCG/ATAGGG 1 -- int1105Minor allele frequency- A:0.32NS MN EA PA EU CA WA NA 8286
    rs20144531,2
    C,F,O,A,44142792(-) TCTGCG/AGGGTT 1 -- ng5111Minor allele frequency- A:0.29MN NS EA NA WA 2310
    rs20750711,2
    C,F,A,H,44148388(-) AGGACG/AGGAGA 1 -- int15Minor allele frequency- A:0.29EA NA 1434
    rs20750721,2
    C,F,H,44144866(-) GAGTGG/TTCCCA 1 -- int12Minor allele frequency- T:0.09NA WA 74
    rs22396141,2
    C,A,44143124(-) CAGAAG/AGCAGG 1 -- ng5110Minor allele frequency- A:0.48EA NA WA 1902
    rs25371871,2
    --44148047(-) AAAAGC/GCCTCG 1 -- int10--------
    rs25371881,2
    C,F,A,44147485(-) AGGGGG/TCTCTG 2 T P mis1 ref1 ese34Minor allele frequency- T:0.43NA WA 78
    About this table

    HapMap Linkage Disequilibrium images for AEBP1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for AEBP1
         2 CNVs: 4532 31342

    Search QIAGEN SeqTarget long-range PCR primers for resequencing for AEBP1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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    AEBP1 for disorders           About GeneDecksing

    OMIM: 602981

    3 Novoseek disease relationships for AEBP1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 25 6 16461908 (1), 20396415 (1), 20419060 (1)
    immunodeficiency 11 3 2022670 (1), 11161801 (1), 2302185 (1)
    cancer 0 1 17202411 (1)
    About this table

    1 PharmGKB disease relationship for AEBP1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table


    Export disorders and mutations for AEBP1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/34 PubMed articles for AEBP1 gene, integrated from 7 sources (see all 34):
    (articles sorted by number of sources associating them with AEBP1)
    1. A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line. (PubMed id 8920928)1, 2, 3, 7 Ohno I....Okubo K. (1996)
    2. Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. (PubMed id 9624159)1, 2, 7 Layne M.D.... Lee M.-E. (1998)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. (PubMed id 19179605)1, 7 Schissel S.L....Layne M.D. (2009)
    6. PPARgamma1 and LXRalpha face a new regulator of macro phage cholesterol homeostasis and inflammatory responsiveness, AEBP1. (PubMed id 20419060)1, 7 Majdalawieh A. and Ro H.S. (2010)
    7. Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: stimulation of enzymic activity by its target DNA. (PubMed id 10510298)1, 7 Muise A.M. and Ro H.S. (1999)
    8. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    9. The role of AEBP1 in sex-specific diet-induced obesit y. (PubMed id 16307171)1 Zhang L....Ro H.S. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 165 HGNC: 303 AceView: AEBP1 Ensembl:ENSG00000106624 euGenes: HUgn165
    ECgene: AEBP1 H-InvDB: AEBP1

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for AEBP1 gene:
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