Aliases &
Descriptions
for AEBP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| AE binding protein 11 2 | | adipocyte enhancer binding protein 12 | | ACLP1 2 3 | | adipocyte enhancer-binding protein 12 | | AE-binding protein 11 2 3 | | FLJ336122 | | Aortic carboxypeptidase-like protein2 3 | | |
Export aliases for AEBP1 gene to outside databasesPrevious GC identifers: GC07P043790 GC07P043850 GC07P043884 GC07P043917 GC07P044110 GC07P044143 |
Summaries
for AEBP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AEBP1:
The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. Thisprotein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of theadipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of theregulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding ofDNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascularsmooth muscle cells. (provided by RefSeq)
UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation andreduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages bypromoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophageinflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity)
|
Genomic Views
for AEBP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AEBP1 gene promoter:
NF-kappaB1 PPAR-gamma2 PPAR-gamma1 NF-kappaB SRF p53 Sp1 Arnt AhR E4BP4
Other transcription factors
Search SABiosciences Chromatin IP Primers for AEBP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for AEBP1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7pAEBP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P044029: view genomic region
(about GC identifiers)
Start:
|
44,029,222 bp from pter |
End:
|
44,039,425 bp from pter |
Size:
|
10,204 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+ 44,143,960-44,154,161 |
RefSeq DNA sequence:- NC_000007.13 NT_007819.17 NT_079592.2
|
Proteins
for AEBP1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7 (See
protein sequence)Recommended Name: Adipocyte enhancer-binding protein 1 precursor Size: 1158 amino acids; 130929 Da
Subunit: Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (Bysimilarity). Binds to DNA in vitro (By similarity)
Subcellular location: Isoform 1: Secreted (By similarity)
Subcellular location: Isoform 2: Cytoplasm (Probable). Nucleus (Probable)
Caution: This protein has lost active site residues and zinc-binding sites and so is unlikely to be catalyticallyactive
Sequence caution: Sequence=BAD92981.1; Type=Erroneous initiation;
Secondary accessions: Q14113 Q59ER7 Q6ZSC7 Q7KZ79Alternative splicing: 2 isoforms: Q8IUX7-1 Q8IUX7-2 Explore the universe of human proteins at neXtProt for AEBP1: NX_Q8IUX7
Post-translational modifications:
Phosphorylated by MAPK1 in vitro (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001120.3
ENSEMBL proteins: ENSP00000397241 ENSP00000400530 ENSP00000411277 ENSP00000400660 ENSP00000401758 ENSP00000410349 ENSP00000398878 ENSP00000416568 ENSP00000223357
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
AEBP1 for ontologies About GeneDecksing
Antibodies for AEBP1:
Assays for AEBP1: |
Protein
Domains/
Families
for AEBP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AEBP1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IUX7ProtoNet protein and cluster: Q8IUX7 1 Blocks protein family: IPB000421 Coagulation factor 5/8 type C domain (FA58C)
UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7Similarity: Belongs to the peptidase M14 familySimilarity: Contains 1 F5/8 type C domain |
Gene Function
for AEBP1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7Function: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation andreduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages bypromoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophageinflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity)
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
AEBP1 for ontologies About GeneDecksing
Animal Models: 13 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Aebp1):
AEBP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AEBP1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including AEBP1: PAHS-030A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AEBP1
1 Interacting protein for AEBP1 (Q8IUX72) via UniProtKB, MINT, and/or STRINGAbout this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
AEBP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AEBP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
AEBP1 for compounds About GeneDecksing
 Browse Tocris compounds for AEBP1
1  Novoseek chemical compound relationship for AEBP1 gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
7.39 |
3 |
2017183 (2), 11161801 (1) |
About this table
|
Transcripts
for AEBP1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for AEBP1 gene: NM_001129.3 Additional cDNA sequence: AB209744.1 AF053944.1 AK090931.1 AK127541.1 AK296001.1 BC038588.1 CR598691.1 D86479.1 19 DOTS entries: DT.416578 DT.97788359 DT.100663759 DT.91991375 DT.95253095 DT.100663761 DT.121045041 DT.121044993 DT.100663769 DT.91775044 DT.121044991 DT.121044999 DT.92021856 DT.95128411 DT.97799728 DT.121044979 DT.40224206 DT.95105014 DT.99981427 24/308 AceView cDNA sequences (see all 308): BF341089 CF125153 AW057582 CA393424 AL040503 AW471279 CR598691 AA993064 BM672693 AI914522 AA976886 AI913043 AA595306 BF344552 BQ183397 BQ231970 BC038588 CB268388 BF724960 BP377809 CN482343 BQ897584 BP349662 BF338201
 highest scoring ESTs for AEBP1:AF053944 AA077291 AA077339 AA295483 AA431924 AA443526 AA443710 AA477377 AA477882 AA481466 Unigene Cluster for AEBP1: AE binding protein 1 Hs.439463 [show with all ESTs]Unigene Representative Sequence: NM_001129
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for AEBP1 (see all 17)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | |
| ExUns: | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for AEBP1
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000434445 ENST00000454218 ENST00000455443 ENST00000453052 ENST00000449162
ENST00000413907(uc003tkd.2) ENST00000450684(uc003tkc.3) ENST00000431035
ENST00000223357(uc003tkb.2)
|
Expression
for AEBP1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| AEBP1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching AEBP1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39069_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
1.00 |
1.00 |
AF053944 |
1.00 |
1.00 |
1.00 |
1 |
| 201792_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_001129 |
0.60 |
1.00 |
0.82 |
1 |
| 201792_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
AEBP1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACTGGGACCT
SOURCE GeneReport for Unigene cluster: Hs.439463
Expression variation in blood from EXPOLDB for AEBP1 UniProtKB/Swiss-Prot: AEBP1_HUMAN, Q8IUX7Tissue specificity: Expressed in osteoblast and visceral fat
SABiosciences Expression via Pathway-Focused PCR Array including AEBP1: PAHS-030A
|
Orthologs
for AEBP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AEBP1 gene from 4 species
About this table Species with no ortholog for AEBP1
ENSEMBL Gene Tree for AEBP1 (if available) |
Paralogs
for AEBP1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for AEBP1 gene
- CPZ2 CPE2 CPXM22 CPN12 CPD2 CPM2 CPXM12
AEBP1 for paralogs About GeneDecksing
|
Genomic Variants
for AEBP1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for AEBP1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for AEBP1
2 CNVs: 4532 31342 |
Disorders & Mutations
for AEBP1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AEBP1 for disorders About GeneDecksing
OMIM: 602981
3 Novoseek disease relationships for AEBP1 gene
About this table
1 PharmGKB disease relationship for AEBP1 geneAbout this table
Export disorders and mutations for AEBP1 gene to outside databases
|
Medical News
for AEBP1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for AEBP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/34 PubMed articles for AEBP1 gene, integrated from 7 sources (see all 34):
(articles sorted by number of sources associating them with AEBP1)- A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line. (PubMed id 8920928)1, 2, 3, 7 Ohno I....Okubo K. (1996)
- Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. (PubMed id 9624159)1, 2, 7 Layne M.D.... Lee M.-E. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. (PubMed id 19179605)1, 7 Schissel S.L....Layne M.D. (2009)
- PPARgamma1 and LXRalpha face a new regulator of macro phage cholesterol homeostasis and inflammatory responsiveness, AEBP1. (PubMed id 20419060)1, 7 Majdalawieh A. and Ro H.S. (2010)
- Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: stimulation of enzymic activity by its target DNA. (PubMed id 10510298)1, 7 Muise A.M. and Ro H.S. (1999)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
- The role of AEBP1 in sex-specific diet-induced obesit y. (PubMed id 16307171)1 Zhang L....Ro H.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for AEBP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AEBP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AEBP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AEBP1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AEBP1 gene:
Search GeneIP for patents involving AEBP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AEBP1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for AEBP1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for AEBP1 |
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