Aliases &
Descriptions
for AHCTF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| AT hook containing transcription factor 11 2 | | MST1082 | | ELYS1 2 3 5 | | OTTHUMP000000384192 | | Putative AT-hook-containing transcription factor 12 3 | | ELYS transcription factor-like protein TMBS622 | | Embryonic large molecule derived from yolk sac2 3 | | DKFZp434N0932 | | TMBS622 3 | | ELYS transcription factor like protein TMBS622 | | protein ELYS2 | | Protein MEL-283 | | OTTHUMP000000384182 | | |
Export aliases for AHCTF1 gene to outside databasesPrevious GC identifers: GC01M243329 GC01M245069 GC01M247002 |
Summaries
for AHCTF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ELYS_HUMAN, Q8WYP5Function: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nucleiform at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplexof the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore duringmitosis and for the completion of cytokinesis
Gene Wiki entry for AHCTF1 |
Genomic Views
for AHCTF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AHCTF1 gene promoter:
E4BP4 Hlf Nkx6-1 Cart-1 STAT3 FOXC1 RORalpha1 MIF-1 STAT1 STAT1beta
Other transcription factors
Search SABiosciences Chromatin IP Primers for AHCTF1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for AHCTF1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44AHCTF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M217396: view genomic region
(about GC identifiers)
Start:
|
217,396,102 bp from pter |
End:
|
217,488,405 bp from pter |
Size:
|
92,304 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr1- 247,002,400-247,095,499 |
RefSeq DNA sequence:- NC_000001.10 NT_167186.1
|
Proteins
for AHCTF1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ELYS_HUMAN, Q8WYP5 (See
protein sequence)Recommended Name: Protein ELYS Size: 2266 amino acids; 252498 Da
Subunit: Associates with the Nup107-160 subcomplex of the NPC
Subcellular location: Cytoplasm (By similarity). Nucleus matrix (By similarity). Chromosome, centromere, kinetochore.Nucleus, nucleoplasm. Nucleus, nuclear pore complex. Note=Localizes to the nuclear pore complex (NPC) throughoutinterphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107-160 subcomplex of theNPC. Localizes to the periphery of chromatin from late anaphase
Sequence caution: Sequence=AAN65622.1; Type=Frameshift; Positions=Several; Sequence=AAQ13621.1; Type=Erroneousinitiation;
Secondary accessions: A6NGM0 A8MSG9 A8MZ86 Q7Z4E3 Q8IZA4 Q96EH9 Q9Y4Q6Alternative splicing: 2 isoforms: Q8WYP5-1 Q8WYP5-2 Explore the universe of human proteins at neXtProt for AHCTF1: NX_Q8WYP5
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056261.4
ENSEMBL proteins: ENSP00000283201 ENSP00000355465 ENSP00000417115 ENSP00000418007 ENSP00000375705 ENSP00000394728 ENSP00000355464 ENSP00000354780
Human Recombinant Proteins
5/11 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 11): About this table
AHCTF1 for ontologies About GeneDecksing
Antibodies for AHCTF1:
Assays for AHCTF1: |
Protein
Domains/
Families
for AHCTF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AHCTF1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WYP5ProtoNet protein and cluster: Q8WYP5 UniProtKB/Swiss-Prot: ELYS_HUMAN, Q8WYP5Similarity: Belongs to the ELYS familySimilarity: Contains 1 A.T hook DNA-binding domain |
Gene Function
for AHCTF1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ELYS_HUMAN, Q8WYP5Function: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nucleiform at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplexof the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore duringmitosis and for the completion of cytokinesis
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- |
About this table
AHCTF1 for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ahctf1):
AHCTF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AHCTF1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for AHCTF1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AHCTF1
5/83 Interacting proteins for AHCTF1 (ENSP000002832013 Q8WYP52) via UniProtKB, MINT, and/or STRING (see all 83)About this table
5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10): About this table
AHCTF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AHCTF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for AHCTF1
|
Transcripts
for AHCTF1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for AHCTF1 gene: NM_015446.4 Additional cDNA sequence: AB059277.1 AK057394.1 AK122844.1 17 DOTS entries: DT.100722077 DT.455576 DT.100782663 DT.100782662 DT.121003283 DT.213897 DT.100782667 DT.91754159 DT.121003264 DT.213896 DT.91768609 DT.100735543 DT.100782664 DT.100782665 DT.121421286 DT.92045421 DT.95270397 24/208 AceView cDNA sequences (see all 208): BM561545 AI678529 AA761156 AW440376 BM467863 AI374620 BC012307 AA748759 BF062340 AL041058 AA635850 CA749031 AW630710 AW627377 BM711248 AL522811 AK122844 AI699728 AV703690 AK095398 AI400688 BC047361 BM968234 AL080144
 highest scoring ESTs for AHCTF1:AI374620 AY157619 AA433921 AA434605 AA634114 AB059277 AF173978 AI122864 AI138934 AI351410 Unigene Clusters for AHCTF1: AT hook containing transcription factor 1 Hs.300887 [show with all ESTs], Hs.470435 [show with all ESTs]Unigene Representative Sequences: NM_015446, AB059277
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AHCTF1 (see all 6)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for AHCTF1
11 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283201 ENST00000326225(uc001ibw.1 uc001ibu.1 uc001ibv.1)
ENST00000478568 ENST00000498601 ENST00000391829 ENST00000483900 ENST00000428671
ENST00000477526 ENST00000366508 ENST00000470300(uc009xgs.1) ENST00000361182
|
Expression
for AHCTF1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| AHCTF1 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching AHCTF1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 61864_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.79 |
1.09 |
AI374620 |
0.80 |
1.00 |
0.91 |
1 |
| 35672_at2, 3
|
U95-A |
2 |
1.00 |
0.94 |
0.57 |
0.92 |
AL080144 |
0.60 |
1.00 |
0.82 |
1 |
| 226115_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AI138934 |
0.60 |
1.00 |
0.82 |
1 |
| 214766_s_at2, 3
|
U133-A |
2 |
1.00 |
0.95 |
-- |
-- |
AL080144 |
0.60 |
1.00 |
0.82 |
1 |
| 226115_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 214766_s_at2
|
U133Plus2 |
2 |
1.00 |
0.95 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1560224_at2
|
U133Plus2 |
2 |
1.00 |
0.64 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
AHCTF1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GATGCAACGT TTAGAAGGGT
SOURCE GeneReport for Unigene clusters: Hs.300887 Hs.470435
SABiosciences Custom PCR Arrays for AHCTF1
|
Orthologs
for AHCTF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AHCTF1 gene from 5/9 species (see all 9)
About this table Species with no ortholog for AHCTF1
ENSEMBL Gene Tree for AHCTF1 (if available) |
Paralogs
for AHCTF1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for AHCTF1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for AHCTF1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for AHCTF1
3 CNVs: 6816 39040 97715
3 Indels: 42381 44551 39708 | | QIAGEN SeqTarget long-range PCR primers for resequencing AHCTF1 |
|
Disorders & Mutations
for AHCTF1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AHCTF1 for disorders About GeneDecksing
OMIM: 610853
Export disorders and mutations for AHCTF1 gene to outside databases
|
Medical News
for AHCTF1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for AHCTF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/18 PubMed articles for AHCTF1 gene, integrated from 7 sources (see all 18):
(articles sorted by number of sources associating them with AHCTF1)- Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. (PubMed id 11952839)1, 2, 3 Kimura N.... Taga T. (2002)
- Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)1, 2 Nousiainen M.... Koerner R. (2006)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division. (PubMed id 17098863)1, 2 Rasala B.A.... Forbes D.J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. (PubMed id 19007248)2 Wang B.... Korner R. (2008)
|
External Searches for AHCTF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AHCTF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AHCTF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AHCTF1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AHCTF1 gene:
Search GeneIP for patents involving AHCTF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AHCTF1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for AHCTF1 |
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