Aliases &
Descriptions
for AIF1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| allograft inflammatory factor 1-like1 2 | | MGC294662 | | IBA21 2 3 | | ionized calcium binding adapter molecule 22 | | FLJ127831 2 | | OTTHUMP000000223902 | | Ionized calcium-binding adapter molecule 22 3 | | OTTHUMP000000223872 | | C9orf582 3 | | OTTHUMP000000223882 | | chromosome 9 open reading frame 581 | | |
Export aliases for AIF1L gene to outside databasesPrevious GC identifers: GC09P132962 GC09P133971 |
Summaries
for AIF1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AIF1L_HUMAN, Q9BQI0Function: Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium forfunction
Gene Wiki entry for AIF1L (C9orf58) |
Genomic Views
for AIF1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for AIF1L
Other transcription factors
Search SABiosciences Chromatin IP Primers for AIF1L
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for AIF1L  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.13-q34.3 Ensembl cytogenetic band: 9q34.12 HGNC cytogenetic band: 9q34.13-q34.3AIF1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P103462: view genomic region
(about GC identifiers)
Start:
|
103,462,597 bp from pter |
End:
|
103,489,133 bp from pter |
Size:
|
26,537 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr9+ 133,971,912-133,998,539 |
RefSeq DNA sequence:- NC_000009.11 NT_035014.4
|
Proteins
for AIF1L gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: AIF1L_HUMAN, Q9BQI0 (See
protein sequence)Recommended Name: Allograft inflammatory factor 1-like Size: 150 amino acids; 17068 Da
Subunit: Homodimer (Potential). Monomer
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein;Cytoplasmic side. Note=Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invadingbacteria
PDB structures from  and Proteopedia  :2VTG (3D)
Secondary accessions: B2RBC4 Q6ZR40 Q8NAX7 Q8WU47 Q9H9G0Alternative splicing: 4 isoforms: Q9BQI0-1 Q9BQI0-2 Q9BQI0-3 Q9BQI0-4 Explore the universe of human proteins at neXtProt for AIF1L: NX_Q9BQI0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_001172024.1 NP_001172025.1 NP_113614.1
ENSEMBL proteins: ENSP00000361375 ENSP00000361388 ENSP00000361372 ENSP00000361376 ENSP00000361371 ENSP00000361393 ENSP00000361386 ENSP00000361383 ENSP00000361374 ENSP00000247291
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
AIF1L for ontologies About GeneDecksing
Antibodies for AIF1L:
Assays for AIF1L: |
Protein
Domains/
Families
for AIF1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AIF1L for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BQI0ProtoNet protein and cluster: Q9BQI0 UniProtKB/Swiss-Prot: AIF1L_HUMAN, Q9BQI0Similarity: Contains 2 EF-hand domains |
Gene Function
for AIF1L gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: AIF1L_HUMAN, Q9BQI0Function: Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium forfunction
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
AIF1L for ontologies About GeneDecksing
|
Pathways & Interactions
for AIF1L gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for AIF1L
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AIF1L
1 Interacting protein for AIF1L (Q9BQI02) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds
for AIF1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for AIF1L
|
Transcripts
for AIF1L gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for AIF1L gene (3 alternative transcripts): NM_001185095.1 NM_001185096.1 NM_031426.3 Additional cDNA sequence: AK022845.1 AK027181.1 AK057789.1 AK091912.1 AK128526.1 AK300473.1 AK314600.1 AL136566.1 AL833896.1 AY359067.1 BC009826.2 BC021253.2 CR601218.1 18 DOTS entries: DT.447855 DT.99994868 DT.92017556 DT.100027260 DT.99982473 DT.100792729 DT.121188365 DT.91817513 DT.95141278 DT.121188297 DT.40200881 DT.92015681 DT.100695306 DT.100792728 DT.121188305 DT.121188316 DT.121188320 DT.100724856 24/272 AceView cDNA sequences (see all 272): BP361202 Z45215 T12552 BF589149 BP362284 AA349627 CR601218 BP375194 CD559010 T12612 AA349673 BP348419 CD633153 BP348584 AA359971 AW169332 AI885408 NM_001002260 CD514425 Z40943 CB265746 T31713 F04100 BP338824 Unigene Cluster for AIF1L: Allograft inflammatory factor 1-like Hs.4944 [show with all ESTs]Unigene Representative Sequence: NM_001185095
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for AIF1L (see all 13)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11 |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | - | | - | | | | |
| SP4: | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for AIF1L
12 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372301 ENST00000372314(uc004cac.1) ENST00000372298 ENST00000372302
ENST00000372297 ENST00000372319 ENST00000372312 ENST00000478257 ENST00000372309(uc004cab.1 uc004cad.1 uc004cae.1 uc011mce.1)
ENST00000472942 ENST00000372300 ENST00000247291
|
Expression
for AIF1L gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| AIF1L expression in normal and diseased human tissues
1 / 2 6 probe-sets matching AIF1L gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 52986_at2
|
U95-B |
1 |
0.94 |
1.00 |
0.99 |
1.25 |
-- |
-- |
-- |
-- |
-- |
| 44606_at2
|
U95-B |
1 |
0.94 |
1.00 |
0.99 |
0.75 |
-- |
-- |
-- |
-- |
-- |
| 223075_s_at2
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 223074_s_at2
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 223075_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 223074_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
AIF1L for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGAGTGTGCG
SOURCE GeneReport for Unigene cluster: Hs.4944
SABiosciences Custom PCR Arrays for AIF1L
|
Orthologs
for AIF1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AIF1L gene from 5/8 species (see all 8)
About this table Species with no ortholog for AIF1L
ENSEMBL Gene Tree for AIF1L (if available) |
Paralogs
for AIF1L gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for AIF1L gene
- AIF12
AIF1L for paralogs About GeneDecksing
|
Genomic Variants
for AIF1L gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 9 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for AIF1L (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AIF1L
1 CNV: 3782 | | QIAGEN SeqTarget long-range PCR primers for resequencing AIF1L |
|
Disorders & Mutations
for AIF1L gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AIF1L for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: AIF1L (1 document)
Export disorders and mutations for AIF1L gene to outside databases
|
Medical News
for AIF1L gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for AIF1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/15 PubMed articles for AIF1L gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with AIF1L)- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Structural and functional characterization of human Iba proteins. (PubMed id 18699778)1, 2, 7 Schulze J.O....Bussow K. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for AIF1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AIF1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AIF1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AIF1L gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AIF1L gene:
Search GeneIP for patents involving AIF1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AIF1L gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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