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AKAP11 Gene

protein-coding GIFtS: 56

GC13P023649

A kinase (PRKA) anchor protein 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
A kinase (PRKA) anchor protein 11¹ ²		AKAP-11² ³
AKAP220¹ ² ³		A-kinase anchor protein 220 kDa² ³
PRKA11¹ ² ³		A-kinase anchor protein 11²
KIAA0629¹ ² ³		protein kinase A anchoring protein 11²
DKFZp781I12161¹ ²		a kinase anchor protein 220 kDa²
FLJ11304¹ ²		A-kinase anchoring protein, 220kDa²
Protein kinase A-anchoring protein 11² ³		AKAP 220³
hAKAP220² ³

External Ids:	HGNC: 369¹	Entrez Gene: 11215²	Ensembl: ENSG00000023516⁷	UniProtKB: Q9UKA4³

Export aliases for AKAP11 gene to outside databases

Previous GC identifers: GC13P040846 GC13P036832 GC13P041782 GC13P040644 GC13P041744 GC13P042846

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AKAP11:

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of

binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within

the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout

spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in

cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm

function. (provided by RefSeq)

UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4

Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them

Gene Wiki entry for AKAP11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AKAP11 gene promoter:
         GATA-1   Max1   c-Myc   MyoD   Pbx1a   RFX1   USF1   ATF   POU3F1   RORalpha1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for AKAP11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for AKAP11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q

AKAP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AKAP11 gene location

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P023649: view genomic region (about GC identifiers)

Start:	23,649,570 bp from pter
End:	23,700,688 bp from pter
Size:	51,119 bases
Orientation:	plus strand

1 alternative location:

Chr13+ 42,846,289-42,897,396

RefSeq DNA sequence:

NC_000013.10 NT_024524.14

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4 (See protein sequence)

Recommended Name: A-kinase anchor protein 11

Size: 1901 amino acids; 210512 Da

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic in premeiotic pachytene

spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was

found in elongating spermatocytes and mature sperm

Sequence caution: Sequence=BAA92117.1; Type=Erroneous initiation;

Secondary accessions: O75124 Q9NUK7

Explore the universe of human proteins at neXtProt for AKAP11: NX_Q9UKA4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_057332.1

ENSEMBL proteins:

ENSP00000025301

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for AKAP11
	Novus Biologicals Protein for AKAP11
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005815	microtubule organizing center	IEA	--
GO:0005856	cytoskeleton	IEA	--

About this table

AKAP11 for ontologies About GeneDecksing

Antibodies for AKAP11:

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	Browse antibodies at Epitomics

Assays for AKAP11:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for AKAP11
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AKAP11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AKAP11 for domains About GeneDecksing

1 InterPro domain/family:

IPR008382 SPHK1-interactor_AKAP_110

Graphical View of Domain Structure for InterPro Entry Q9UKA4

ProtoNet protein and cluster: Q9UKA4

1 Blocks protein family: IPB008382 A-kinase anchor 110 kDa

UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4

Domain: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein

interactions with a complementary surface on the R-subunit dimer

Similarity: Belongs to the AKAP110 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4

Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for AKAP11 Sigma-Aldrich shRNA Panels and shRNA for AKAP11
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): AKAP11 OriGene shRNA RFP (see all 2): AKAP11 OriGene basic RS shRNA (see all 2): AKAP11 OriGene siRNA (see all 2): AKAP11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of AKAP11

miRNA:		Sigma-Aldrich microRNA Mimics for AKAP11 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of AKAP11
		8/34 SABiosciences Assays for microRNAs that regulate AKAP11 (see all 34):
		hsa-miR-142-5p hsa-miR-323-3p hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-301a hsa-miR-548l hsa-miR-141

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: AKAP11 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: AKAP11 OriGene untagged cDNA clones in CMV expression vector: AKAP11 OriGene 3'-UTR clone: AKAP11 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: AKAP11
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for AKAP11

Genatlas biochemistry entry for AKAP11:

A kinase (PRKA,regulating subunit RIIA) anchor protein 11,expressed in brain,related to rat A kinase anchoring protein

AKAP220

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931
GO:0008157	protein phosphatase 1 binding	TAS	10209101
GO:0051018	protein kinase A binding	TAS	10209101

About this table

AKAP11 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

AKAP11 for pathways About GeneDecksing

1 Millipore Pathway for AKAP11

Signal transduction PKA signaling

3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for AKAP11

	Protein Kinase A Signaling
	cAMP-mediated Signaling
	Cardiac β-adrenergic Signaling

SABiosciences Custom Pathway-Focused PCR Arrays for AKAP11

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for AKAP11

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AKAP11

3 Interacting proteins for AKAP11 (ENSP00000025301³ Q9UKA4¹) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMYD2	Q9NRG4¹	EBI-1049491,EBI-1055671
PRKAR2A	ENSP00000265563³	STRING: ENSP00000265563
PPP1CA	ENSP00000326031³	STRING: ENSP00000326031

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007243	intracellular protein kinase cascade	TAS	10209101

About this table

AKAP11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AKAP11

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for AKAP11 Sigma-Aldrich shRNA Panels and shRNA for AKAP11
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): AKAP11 OriGene shRNA RFP (see all 2): AKAP11 OriGene basic RS shRNA (see all 2): AKAP11 OriGene siRNA (see all 2): AKAP11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of AKAP11

miRNA:		Sigma-Aldrich microRNA Mimics for AKAP11 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of AKAP11
		8/34 SABiosciences Assays for microRNAs that regulate AKAP11 (see all 34):
		hsa-miR-142-5p hsa-miR-323-3p hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-301a hsa-miR-548l hsa-miR-141

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: AKAP11 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: AKAP11 OriGene untagged cDNA clones in CMV expression vector: AKAP11 OriGene 3'-UTR Clone: AKAP11 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: AKAP11

Primers:		OriGene genome-wide validated SYBR primer pairs: AKAP11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for AKAP11: PPH19709A

REFSEQ mRNAs for AKAP11 gene:

NM_016248.2

Additional cDNA sequence:

AB014529.2 AF176555.1 AK002166.1 AK074384.1 CR627087.1

9 DOTS entries:

DT.114752 DT.100023768 DT.100704976 DT.100769091 DT.434994 DT.120776864 DT.120776877 DT.120776881

DT.95223295

24/156 AceView cDNA sequences (see all 156):

AI367927 CB266408 AA112737 AA809424 BU620731 AA837616 BU167169 BP368267

BM460367 BX483248 T32813 BM727557 BM452941 BX283776 AI357298 AA463313

F37180 AK002166 AI039073 BQ228514 BP339922 AA810908 BQ719874 AI573202

highest scoring ESTs for AKAP11:

AA130296 AA215462 AA215463 AA463313 AA478296 AA502379 AA810908 AA811457 AA862480 AA971446

Unigene Cluster for AKAP11:

A kinase (PRKA) anchor protein 11

Hs.105105 [show with all ESTs]

Unigene Representative Sequence: AF176555

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for AKAP11 (see all 9)

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	·	18c
SP1:					-		-
SP2:							-
SP3:							-		-
SP4:																																							-
SP5:

About this scheme

ECgene alternative splicing isoforms for AKAP11
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000025301(uc001uys.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

AKAP11 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching AKAP11 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34657_at²^{, 3}	U95-A	1	1.00	1.00	0.77	1.34	AB014529	0.80	1.00	0.91	1
43903_at²^{, 3}	U95-B	1	0.44	1.00	0.03	0.67	R63925	0.80	1.00	0.91	1
203156_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016248	0.60	1.00	0.82	1
215336_at²^{, 3}	U133-A	1	0.46	1.00	--	--	AK002166	0.40	1.00	0.76	1
203156_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215336_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

About this table

AKAP11 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

AKAP11 gene electronic northern expression

About these images

CGAP SAGE TAG: GTGAATATAT

SOURCE GeneReport for Unigene cluster: Hs.105105

Expression variation in blood from EXPOLDB for AKAP11

UniProtKB/Swiss-Prot: AKA11_HUMAN, Q9UKA4

Tissue specificity: Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal

muscle, pancreas and spleen

Primers:		OriGene genome-wide validated SYBR primer pairs: AKAP11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for AKAP11: PPH19709A

SABiosciences Custom PCR Arrays for AKAP11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AKAP11 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AKAP11¹	--	A kinase (PRKA) anchor protein 11	86.85(n) 82.68(a)	609431 XM_846688.1 XP_851781.1
chimpanzee (Pan troglodytes)	AKAP11¹	--	A kinase (PRKA) anchor protein 11	99.39(n) 98.74(a)	740874 XM_001151723.1 XP_001151723.1
cow (Bos taurus)	AKAP11¹	--	A kinase (PRKA) anchor protein 11	84.57(n) 79.2(a)	533105 XM_612396.3 XP_612396.3
rat (Rattus norvegicus)	Akap11¹	--	A kinase (PRKA) anchor protein 11	81.54(n) 75.29(a)	498549 XM_573823.2 XP_573823.2
mouse (Mus musculus)	Akap11^{1 , 5}	14 (41.46 cM)⁵	A kinase (PRKA) anchor protein 11^{1, 5}	81.85(n)¹ 75.07(a)¹	219181¹ XM_001002157.2¹ XP_001002157.2¹ AA623649⁵ AI180937⁵ (see all 13)

About this table Species with no ortholog for AKAP11

ENSEMBL Gene Tree for AKAP11 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AKAP11 gene

SPHKAP²

AKAP11 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs238313^1,2	F,H	42883173(-)	`ACCCTC/TGCCCC`	1	--	int¹		5	MN NS EA	602
rs238314^1,2	C,F,O,H,	42882762(-)	`TTATAC/TGCAAA`	1	--	int¹		19	NS EA NA WA	1196
rs238315^1,2	C,F,	42881942(-)	`tcttcT/Ggatca`	1	--	int¹		12	MN NS EA NA WA	618
rs238331^1,2	--	42861247(-)	`GATTAG/ACAAAG`	1	--	int¹		1	MN	184
rs238332^1,2	C,H,	42856444(-)	`GGTGTA/TAATAG`	1	--	int¹		8	NA WA	64
rs238336^1,2	F,H	42890444(-)	`CATCAT/GGCCAA`	1	--	int¹		5	MN NS EA	602
rs238337^1,2	C,H,	42870413(+)	`TATGGA/GCAAAA`	1	--	int¹		12	MN NS EA NA WA	608
rs238338^1,2	--	42870341(+)	`GCAGTA/GAAGTG`	1	--	int¹		1	MN	184
rs238339^1,2	C,H,	42868098(+)	`cctcaC/Gaacta`	1	--	int¹		11	NS EA NA WA	424
rs238352^1,2	--	42850811(-)	`AACTTT/CAAGGT`	1	--	int¹		1	MN	184

About this table

HapMap Linkage Disequilibrium images for AKAP11 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AKAP11: --

QIAGEN SeqTarget long-range PCR primers for resequencing AKAP11

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AKAP11 for disorders About GeneDecksing

OMIM: 604696

Export disorders and mutations for AKAP11 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/24 PubMed articles for AKAP11 gene, integrated from 7 sources (see all 24):
(articles sorted by number of sources associating them with AKAP11)

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2, 3} Ishikawa K.... Ohara O. (1998)
Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. (PubMed id 10864471)^{1, 2, 7} Reinton N.... Tasken K. (2000)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. (PubMed id 8621616)^{1, 3} Lester L.B....Scott J.D. (1996)
Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. (PubMed id 11152471)^{1, 7} Schillace R.V....Scott J.D. (2001)
Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. (PubMed id 11823486)^{1, 7} Schillace R.V.... Carr D.W. (2002)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)¹ Rivadeneira F....Uitterlinden A.G. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11215	HGNC: 369	AceView: AKAP11	Ensembl:ENSG00000023516	euGenes: HUgn11215
ECgene: AKAP11	H-InvDB: AKAP11

(According to HUGE)
About This Section

HUGE: KIAA0629

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for AKAP11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for AKAP11 gene:
Search GeneIP for patents involving AKAP11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AKAP11		Antibodies for AKAP11
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AKAP11		microRNA Mimics for AKAP11
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of AKAP11
	SeqTarget long-range PCR primers for resequencing AKAP11
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for AKAP11
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of AKAP11

	GenScript Custom Purified and Recombinant Proteins Services for AKAP11		GenScript cDNA clones with any tag delivered in your preferred vector for AKAP11
	GenScript Custom Assay Services for AKAP11		GenScript Custom Superior Antibodies Services for AKAP11
	GenScript Custom overexpressing Cell Line Services for AKAP11		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search for Antibodies & Assays

	Regulatory tfbs in AKAP11 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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ELISAs and CLIAs for AKAP11

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

AKAP11 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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AKAP11 Gene

protein-coding GIFtS: 56

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AKAP11 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor AKAP11 gene

Summariesfor AKAP11 gene

Genomic Viewsfor AKAP11 gene

Proteinsfor AKAP11 gene

Protein Domains/Familiesfor AKAP11 gene

Gene Functionfor AKAP11 gene

Pathways & Interactionsfor AKAP11 gene

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for AKAP11 gene

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for AKAP11 gene

Genomic Views
for AKAP11 gene

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for AKAP11 gene

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for AKAP11 gene

Gene Function
for AKAP11 gene

Pathways & Interactions
for AKAP11 gene

Drugs & Compounds
for AKAP11 gene

Transcripts
for AKAP11 gene

Expression
for AKAP11 gene

Orthologs
for AKAP11 gene

Paralogs
for AKAP11 gene

Genomic Variants
for AKAP11 gene

Disorders & Mutations
for AKAP11 gene

Medical News
for AKAP11 gene

Publications
for AKAP11 gene

Intellectual Property
for AKAP11 gene

Products
for AKAP11 gene