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ALKBH8 Gene

protein-coding GIFtS: 45

GC11M103298

alkB, alkylation repair homolog 8 (E. coli)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
alkB, alkylation repair homolog 8 (E. coli)¹ ²		AlkB homologue 8²
ABH8² ³ ⁵		FLJ38204²
MGC10235¹ ²		OTTHUMP00000211286²
Probable alpha-ketoglutarate-dependent dioxygenase ABH8² ³		OTTHUMP00000211287²
S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8² ³		EC 2.1.1.-³
alkylated DNA repair protein alkB homolog 8²		EC 1.14.11.-³

External Ids:	HGNC: 25189¹	Entrez Gene: 91801²	Ensembl: ENSG00000137760⁷	UniProtKB: Q96BT7³

Export aliases for ALKBH8 gene to outside databases

Previous GC identifers: GC11M106879 GC11M107373

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ALKB8_HUMAN, Q96BT7

Function: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position

of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble

position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind

tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and

angiogenesis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ALKBH8 gene promoter:
         C/EBPalpha   CHOP-10   FOXD1   POU3F2   FOXJ2 (long isoform)   SREBP-1a   SREBP-1b   SREBP-1c   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ALKBH8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3

ALKBH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH8 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M103298: view genomic region (about GC identifiers)

Start:	103,298,990 bp from pter
End:	103,361,859 bp from pter
Size:	62,870 bases
Orientation:	minus strand

1 alternative location:

Chr11- 107,373,452-107,436,461

RefSeq DNA sequence:

NC_000011.9 NT_033899.8

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ALKB8_HUMAN, Q96BT7 (See protein sequence)

Recommended Name: Alkylated DNA repair protein alkB homolog 8

Size: 664 amino acids; 75208 Da

Subunit: Interacts with TRMT112

Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic

PDB structures from and Proteopedia :

2CQ2 (3D)

Secondary accessions: B1Q2M0 B4DEF6 Q8N989

Alternative splicing: 4 isoforms: Q96BT7-1 Q96BT7-2 Q96BT7-3 Q96BT7-4

Explore the universe of human proteins at neXtProt for ALKBH8: NX_Q96BT7

REFSEQ proteins: NP_620130.2

ENSEMBL proteins:

ENSP00000410820 ENSP00000376812 ENSP00000374219 ENSP00000397673 ENSP00000260318 ENSP00000391225

ENSP00000415885

Human Recombinant Proteins

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	GenScript Custom Purified and Recombinant Proteins Services for ALKBH8
	Novus Biologicals Protein for ALKBH8
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IDA	--
GO:0005840	ribosome	--	--

About this table

ALKBH8 for ontologies About GeneDecksing

Antibodies for ALKBH8:

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	Sigma-Aldrich Antibodies for ALKBH8
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	Browse antibodies at Epitomics

Assays for ALKBH8:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ALKBH8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ALKBH8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ALKBH8 for domains About GeneDecksing

4 InterPro domains/families:

IPR012677 Nucleotide-bd_a/b_plait

IPR013216 Methyltransf_11

IPR005123 Oxoglutarate/Fe-dep_oxygenase

IPR015095 AlkB_hom8_N

Graphical View of Domain Structure for InterPro Entry Q96BT7

ProtoNet protein and cluster: Q96BT7

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB001014 Ribosomal L23 protein

UniProtKB/Swiss-Prot: ALKB8_HUMAN, Q96BT7

Similarity: Belongs to the alkB family

Similarity: Contains 1 Fe2OG dioxygenase domain

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ALKB8_HUMAN, Q96BT7

Function: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position

of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble

position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind

tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and

angiogenesis

Induction: Up-regulated after DNA damage. Induction is mediated via ATM

Enzyme Numbers (IUBMB): EC 1.14.11.- EC 2.1.1.-

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ALKBH8 Sigma-Aldrich shRNA for ALKBH8
		OriGene 29mer shRNA kits in GFP-retroviral vector: ALKBH8 OriGene shRNA RFP: ALKBH8 OriGene basic RS shRNA: ALKBH8 OriGene siRNA: ALKBH8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ALKBH8

miRNA:		Sigma-Aldrich microRNA Mimics for ALKBH8 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ALKBH8
		1 SABiosciences Assays for microRNA that regulate ALKBH8:
		hsa-miR-432

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ALKBH8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ALKBH8 OriGene untagged cDNA clones in CMV expression vector (see all 2): ALKBH8 OriGene 3'-UTR clone: ALKBH8 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ALKBH8
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ALKBH8

5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	IEA	--
GO:0003735	structural constituent of ribosome	--	--
GO:0005515	protein binding	IPI	--

About this table

ALKBH8 for ontologies About GeneDecksing

Animal Models: 1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Alkbh8):

normal

ALKBH8 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ALKBH8

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ALKBH8

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006412	translation	--	--
GO:0006974	response to DNA damage stimulus	IDA	--
GO:0008152	metabolic process	--	--
GO:0030488	tRNA methylation	IDA	--
GO:0055114	oxidation-reduction process	IEA	--

About this table

ALKBH8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ALKBH8

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ALKBH8 Sigma-Aldrich shRNA for ALKBH8
		OriGene 29mer shRNA kits in GFP-retroviral vector: ALKBH8 OriGene shRNA RFP: ALKBH8 OriGene basic RS shRNA: ALKBH8 OriGene siRNA: ALKBH8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ALKBH8

miRNA:		Sigma-Aldrich microRNA Mimics for ALKBH8 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ALKBH8
		1 SABiosciences Assays for microRNA that regulate ALKBH8:
		hsa-miR-432

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ALKBH8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ALKBH8 OriGene untagged cDNA clones in CMV expression vector (see all 2): ALKBH8 OriGene 3'-UTR Clone: ALKBH8 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ALKBH8

Primers:		OriGene genome-wide validated SYBR primer pairs: ALKBH8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ALKBH8: PPH10472A

REFSEQ mRNAs for ALKBH8 gene:

NM_138775.2

Additional cDNA sequence:

AB218768.1 AF086489.1 AK095523.1 AK293603.1 AK298800.1 AK304413.1 BC015183.1 BX649085.1

5 DOTS entries:

DT.100016636 DT.108954 DT.40305950 DT.108955 DT.120738863

24/51 AceView cDNA sequences (see all 51):

BM054901 CK904381 AA411920 AA393087 BC015183 BX109798 AA313350 AA262405

BG574178 AA806370 BM753257 BQ010516 AF086489 NM_138775 BM054706 BX956410

AI925740 AA337166 BE887937 CD172200 CB958294 BG573506 CA444499 BX472466

highest scoring ESTs for ALKBH8:

AA313350 AI925740 BC015183 BE887937 BG255644 AA336257 AA337166 AA411920 AF086489 AI590659

Unigene Cluster for ALKBH8:

AlkB, alkylation repair homolog 8 (E. coli)

Hs.503763 [show with all ESTs]

Unigene Representative Sequence: NM_138775

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH8

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b
SP1:																									-		-
SP2:
SP3:
SP4:					-

About this scheme

ECgene alternative splicing isoforms for ALKBH8
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000449781(uc001pjl.2) ENST00000393100 ENST00000389568 ENST00000417449(uc009yxp.2)

ENST00000260318 ENST00000429370 ENST00000428149(uc001pjk.2 uc010rvq.1 uc010rvr.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ALKBH8 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching ALKBH8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
87116_at²^{, 3}	U95-E	2	1.00	0.97	0.81	0.97	AI925740	0.80	1.00	0.91	1
54389_at²^{, 3}	U95-C	1	0.81	1.00	0.95	1.03	AI590659	0.60	1.00	0.82	1
235713_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF242537	0.40	1.00	0.76	1
235610_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AI590659	0.60	1.00	0.82	1
235713_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235610_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

ALKBH8 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ALKBH8 gene electronic northern expression

About these images

CGAP SAGE TAG: CCAATAAATT

SOURCE GeneReport for Unigene cluster: Hs.503763

UniProtKB/Swiss-Prot: ALKB8_HUMAN, Q96BT7

Tissue specificity: Widely expressed, with highest expression in spleen, followed by pancreas and lung

Primers:		OriGene genome-wide validated SYBR primer pairs: ALKBH8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ALKBH8: PPH10472A

SABiosciences Custom PCR Arrays for ALKBH8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALKBH8 gene from 5/16 species (see all 16)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALKBH8¹	--	alkB, alkylation repair homolog 8 (E. coli)	89.8(n) 87.93(a)	489424 XM_546542.2 XP_546542.2
chimpanzee (Pan troglodytes)	ALKBH8¹	--	alkB, alkylation repair homolog 8 (E. coli)	99.28(n) 98.28(a)	466772 XM_001137322.1 XP_001137322.1
rat (Rattus norvegicus)	Alkbh8¹	--	alkB, alkylation repair homolog 8 (E. coli)	82.47(n) 77.16(a)	366783 XM_345766.3 XP_345767.3
mouse (Mus musculus)	Alkbh8^{1 , 5}	9 (2.02 cM)⁵	alkB, alkylation repair homolog 8 (E. coli)^{1, 5}	81.9(n)¹ 76.29(a)¹	67667¹ NM_026303.1¹ NP_080579.1¹ AA756131⁵ AK016188⁵ (see all 20)
chicken (Gallus gallus)	ALKBH8¹	--	alkB, alkylation repair homolog 8 (E. coli)	71.59(n) 63.48(a)	418972 XM_417166.2 XP_417166.2

About this table Species with no ortholog for ALKBH8

ENSEMBL Gene Tree for ALKBH8 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALKBH8 gene

ENSG00000250305²

ALKBH8 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs471668^1,2	C,F,A,H,	107415947(+)	`GTGGTT/ATAAAG`	1	--	int¹		13		NA EA WA	366
rs475574^1,2		107429897(+)	`cacgaC/Ttgtga`	1	--	int¹		0	--	--	--	--
rs477206^1,2	C,F,A,H,	107387656(-)	`cctccT/Cacctc`	1	--	int¹		7		NA WA	18
rs477390^1,2	C,A	107387726(+)	`gcctgA/Ggcaac`	1	--	int¹		6		NA WA	12
rs478404^1,2	H	107430244(+)	`TTTCTT/GGCTAC`	1	--	int¹ trp³		5		MN NS EA	570
rs478625^1,2	C,F,	107402219(+)	`gagaaA/Tctctt`	1	--	int¹		5		NS EA WA	458
rs479193^1,2	C,F,O,A,	107430300(+)	`GAAAGA/C/TGATGA`	1	--	int¹		7		MN NS NA EA WA	470
rs484178^1,2	C,A,	107413574(+)	`gaggcT/Cgcagt`	1	--	int¹		6		NA WA	12
rs487086^1,2	--	107390200(+)	`GAAAAC/TCAGAC`	1	--	int¹		0	--	--	--	--
rs487101^1,2	--	107413909(+)	`aatacA/Caaaat`	1	--	int¹		1		MN	184

About this table

HapMap Linkage Disequilibrium images for ALKBH8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ALKBH8: --

QIAGEN SeqTarget long-range PCR primers for resequencing ALKBH8

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ALKBH8 for disorders About GeneDecksing

OMIM: 613306

Export disorders and mutations for ALKBH8 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

8 PubMed articles for ALKBH8 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ALKBH8)

A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression. (PubMed id 19293182)^{1, 2, 7} Shimada K.... Konishi N. (2009)
Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. (PubMed id 20308323)^{1, 2} Fu D.... Samson L.D. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Expression and sub-cellular localization of human ABH family molecules. (PubMed id 17979886)² Tsujikawa K....Yamamoto H. (2007)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 91801	HGNC: 25189	AceView: LOC91801	Ensembl:ENSG00000137760	euGenes: HUgn91801
ECgene: ALKBH8	H-InvDB: ALKBH8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for ALKBH8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for ALKBH8 gene:
Search GeneIP for patents involving ALKBH8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALKBH8		Antibodies for ALKBH8
	Super-pooled esiRNAs for ALKBH8		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALKBH8		microRNA Mimics for ALKBH8
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
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	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ALKBH8
	SeqTarget long-range PCR primers for resequencing ALKBH8
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ALKBH8

	GenScript Custom Purified and Recombinant Proteins Services for ALKBH8		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ALKBH8
	GenScript Custom Assay Services for ALKBH8		GenScript Custom Superior Antibodies Services for ALKBH8
	GenScript Custom overexpressing Cell Line Services for ALKBH8		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ALKBH8 promoter
	Search Chromatin IP Primers for ALKBH8
	RT² qPCR Primer Assay for ALKBH8
	Search GNC Networks for ALKBH8
	Assays for microRNAs that regulate ALKBH8
	SABiosciences Custom PCR Arrays for ALKBH8

Search Tocris compounds for ALKBH8

	Browse Sino Biological Proteins and Antibodies
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	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Proteins for ALKBH8

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for ALKBH8

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

ALKBH8 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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ALKBH8 Gene

protein-coding GIFtS: 45

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Export list of displayed genes

ALKBH8 Gene

protein-coding GIFtS: 45

Aliases & Descriptionsfor ALKBH8 gene

Summariesfor ALKBH8 gene

Genomic Viewsfor ALKBH8 gene

Proteinsfor ALKBH8 gene

Protein Domains/Familiesfor ALKBH8 gene

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Pathways & Interactionsfor ALKBH8 gene

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Expression for ALKBH8 gene

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Publicationsfor ALKBH8 gene

External Searches for ALKBH8 gene

Genome Databases showing ALKBH8 gene

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Specialized Databases showing ALKBH8 gene

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Aliases &
Descriptions
for ALKBH8 gene

Summaries
for ALKBH8 gene

Genomic Views
for ALKBH8 gene

Proteins
for ALKBH8 gene

Protein Domains/
Families
for ALKBH8 gene

Gene Function
for ALKBH8 gene

Pathways & Interactions
for ALKBH8 gene

Drugs & Compounds
for ALKBH8 gene

Transcripts
for ALKBH8 gene

Expression
for ALKBH8 gene

Orthologs
for ALKBH8 gene

Paralogs
for ALKBH8 gene

Genomic Variants
for ALKBH8 gene

Disorders & Mutations
for ALKBH8 gene

Medical News
for ALKBH8 gene

Publications
for ALKBH8 gene

Intellectual Property
for ALKBH8 gene

Products
for ALKBH8 gene