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AMBRA1 Gene

protein-coding GIFtS: 45

GC11M046124

autophagy/beclin-1 regulator 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
autophagy/beclin-1 regulator 1¹ ²		MGC33725²
KIAA1736¹ ² ³ ⁵		WD repeat domain 94²
WDR94¹ ²		activating molecule in BECN1-regulated autophagy protein 1²
DCAF3¹ ²		activating molecule in beclin-1-regulated autophagy²
FLJ20294¹ ²		DDB1 and CUL4 associated factor 3²

External Ids:	HGNC: 25990¹	Entrez Gene: 55626²	Ensembl: ENSG00000110497⁷	UniProtKB: Q9C0C7³

Export aliases for AMBRA1 gene to outside databases

Previous GC identifer: GC11M046375

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AMRA1_HUMAN, Q9C0C7

Function: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein

turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for AMBRA1
Other transcription factors

Search SABiosciences Chromatin IP Primers for AMBRA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for AMBRA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2

AMBRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMBRA1 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M046124: view genomic region (about GC identifiers)

Start:	46,124,699 bp from pter
End:	46,319,406 bp from pter
Size:	194,708 bases
Orientation:	minus strand

1 alternative location:

Chr11- 46,417,964-46,612,914

RefSeq DNA sequence:

NC_000011.9 NT_009237.18

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: AMRA1_HUMAN, Q9C0C7 (See protein sequence)

Recommended Name: Activating molecule in BECN1-regulated autophagy protein 1

Size: 1298 amino acids; 142507 Da

Subunit: Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3 (By similarity)

Subcellular location: Cytoplasmic vesicle, autophagosome (By similarity)

Sequence caution: Sequence=BAA91067.1; Type=Frameshift; Positions=682; Sequence=BAB14457.1; Type=Erroneous initiation;

Sequence=BAB21827.1; Type=Erroneous initiation;

Secondary accessions: A6XN33 Q86XD6 Q9H8Z0 Q9NXE7

Alternative splicing: 5 isoforms: Q9C0C7-1 Q9C0C7-2 Q9C0C7-3 Q9C0C7-4 Q9C0C7-5

Explore the universe of human proteins at neXtProt for AMBRA1: NX_Q9C0C7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060219.2

ENSEMBL proteins:

ENSP00000410899 ENSP00000318313 ENSP00000401937 ENSP00000318247 ENSP00000415327 ENSP00000298834

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: AMBRA1
	GenScript Custom Purified and Recombinant Proteins Services for AMBRA1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	17589504
GO:0005776	autophagic vacuole	IEA	--
GO:0031410	cytoplasmic vesicle	IEA	--

About this table

AMBRA1 for ontologies About GeneDecksing

Antibodies for AMBRA1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals Antibodies for AMBRA1
	Browse antibodies at Epitomics

Assays for AMBRA1:

	Browse Kits and Assays available from Millipore
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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for AMBRA1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AMBRA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AMBRA1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR019782 WD40_repeat_2

IPR019775 WD40_repeat_CS

IPR011046 WD40_repeat-like_dom

IPR019781 WD40_repeat_sg

IPR001680 WD40_repeat

Graphical View of Domain Structure for InterPro Entry Q9C0C7

ProtoNet protein and cluster: Q9C0C7

UniProtKB/Swiss-Prot: AMRA1_HUMAN, Q9C0C7

Similarity: Contains 3 WD repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: AMRA1_HUMAN, Q9C0C7

Function: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein

turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for AMBRA1 Sigma-Aldrich shRNA for AMBRA1
		OriGene 29mer shRNA kits in GFP-retroviral vector: AMBRA1 OriGene shRNA RFP: AMBRA1 OriGene basic RS shRNA: AMBRA1 OriGene siRNA: AMBRA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of AMBRA1

miRNA:		Sigma-Aldrich microRNA Mimics for AMBRA1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of AMBRA1
		6 SABiosciences Assays for microRNAs that regulate AMBRA1:
		hsa-miR-9 hsa-miR-23b hsa-miR-631 hsa-miR-23a hsa-miR-7 hsa-miR-1272

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: AMBRA1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: AMBRA1 OriGene untagged cDNA clones in CMV expression vector: AMBRA1 OriGene 3'-UTR clone: AMBRA1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: AMBRA1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for AMBRA1

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

About this table

AMBRA1 for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ambra1):

cellular

embryogenesis

lethality-prenatal/perinatal

nervous system

AMBRA1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Pathway-Focused PCR Array including AMBRA1: PAHS-084A

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AMBRA1

5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006914	autophagy	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007399	nervous system development	IEA	--
GO:0008285	negative regulation of cell proliferation	--	--
GO:0009790	embryo development	--	--

About this table

AMBRA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AMBRA1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for AMBRA1 Sigma-Aldrich shRNA for AMBRA1
		OriGene 29mer shRNA kits in GFP-retroviral vector: AMBRA1 OriGene shRNA RFP: AMBRA1 OriGene basic RS shRNA: AMBRA1 OriGene siRNA: AMBRA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of AMBRA1

miRNA:		Sigma-Aldrich microRNA Mimics for AMBRA1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of AMBRA1
		6 SABiosciences Assays for microRNAs that regulate AMBRA1:
		hsa-miR-9 hsa-miR-23b hsa-miR-631 hsa-miR-23a hsa-miR-7 hsa-miR-1272

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: AMBRA1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: AMBRA1 OriGene untagged cDNA clones in CMV expression vector: AMBRA1 OriGene 3'-UTR Clone: AMBRA1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: AMBRA1

Primers:		OriGene genome-wide validated SYBR primer pairs: AMBRA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for AMBRA1: PPH17960A

REFSEQ mRNAs for AMBRA1 gene:

NM_017749.2

Additional cDNA sequence:

AB051523.1 AK000301.1 AK023197.1 AK057896.1 AK302808.1 AK304530.1 AL137611.1 AL834190.1

BC045609.1 CR590663.1 DQ870924.1

16 DOTS entries:

DT.100779368 DT.95338415 DT.107951 DT.95165030 DT.100779367 DT.102841099 DT.75108941 DT.120731309

DT.120731310 DT.91890877 DT.100829056 DT.120731190 DT.120731304 DT.40221669 DT.439523 DT.95259299

24/110 AceView cDNA sequences (see all 110):

AL137611 CR590663 BU171968 BC045609 CA306509 BU527699 BP353292 CB216101

AK057896 BP352652 AL834190 BU956025 NM_017749 AU159538 BM472696 AI699895

BM904226 AI791940 CB149054 BM699885 BU159882 BU737623 BX281628 AI359466

Unigene Cluster for AMBRA1:

Autophagy/beclin-1 regulator 1

Hs.654644 [show with all ESTs]

Unigene Representative Sequence: AK302808

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AMBRA1 (see all 6)

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^	21	^
SP1:																															-						-
SP2:							-																				-				-						-
SP3:							-																						-		-						-
SP4:
SP5:																																																	-

ExUns:	22a	·	22b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for AMBRA1
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000426438 ENST00000314845 ENST00000452566 ENST00000314823(uc010rgt.1 uc001ncu.1 uc001ncv.2 uc001ncw.2)

ENST00000458649(uc009ylc.1 uc010rgu.1 uc001ncx.2) ENST00000298834

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

AMBRA1 expression in normal and diseased human tissues

¹ / ²

8 probe-sets matching AMBRA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
52731_at²	U95-B	1	1.00	1.00	0.89	1.23	--	--	--	--	--
67932_at²	U95-D	1	0.50	1.00	0.27	0.77	--	--	--	--	--
219141_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
52731_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
234237_s_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
219141_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
52731_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234237_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

AMBRA1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

AMBRA1 gene electronic northern expression

About these images

CGAP SAGE TAG: CCCCTCAAAA

SOURCE GeneReport for Unigene cluster: Hs.654644

Primers:		OriGene genome-wide validated SYBR primer pairs: AMBRA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for AMBRA1: PPH17960A

SABiosciences Expression via Pathway-Focused PCR Array including AMBRA1: PAHS-084A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AMBRA1 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AMBRA1¹	--	autophagy/beclin-1 regulator 1	93.43(n) 96.6(a)	483634 XM_540754.2 XP_540754.2
chimpanzee (Pan troglodytes)	AMBRA1¹	--	autophagy/beclin-1 regulator 1	99.72(n) 99.92(a)	451154 XM_001163429.1 XP_001163429.1
cow (Bos taurus)	AMBRA1¹	--	autophagy/beclin-1 regulator 1	91(n) 95.03(a)	520828 XM_599078.3 XP_599078.3
rat (Rattus norvegicus)	Nyw1¹	--	ischemia related factor NYW-1	90.2(n) 94.45(a)	59319 XM_001073596.1 XP_001073596.1
mouse (Mus musculus)	Ambra1⁵	2 (50.63 cM)	autophagy/beclin 1 regulator 1	--	CJ150588

About this table Species with no ortholog for AMBRA1

ENSEMBL Gene Tree for AMBRA1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs13264^1,2	--	46450293(-)	`GGTGCC/TGACAA`	1	--	int¹		1		MN	184
rs713120^1,2	C	46550600(-)	`ATTGTA/GATAAT`	1	--	int¹		0	--	--	--	--
rs756343^1,2	C,F,	46550276(-)	`TAAAAG/TTGTAC`	1	--	int¹		3		NA EA	162
rs870242^1,2	C,A	46517982(+)	`CATCAT/CGGGTC`	1	--	int¹		4		NS EA	416
rs901997^1,2	C,F	46526904(+)	`CTGTAG/TAGGGA`	1	--	int¹		5		MN NS EA	602
rs901999^1,2	C,F,A,H,	46426424(+)	`CTAACA/CAAGAA`	1	--	int¹		15		EA NA NS WA	544
rs931402^1,2	H	46453593(+)	`tatttA/Tttttt`	1	--	int¹		4		NS EA	418
rs967754^1,2	C,F,A,H,	46436789(-)	`TTGAGT/CGGTCT`	1	--	int¹		18		NA EA NS WA	836
rs1052395^1,2	--	46450302(-)	`GTGCCA/CCCTGG`	1	--	int¹		0	--	--	--	--
rs1140566^1,2	--	46450319(+)	`CCGTCC/TGTAGG`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for AMBRA1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AMBRA1: --

QIAGEN SeqTarget long-range PCR primers for resequencing AMBRA1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AMBRA1 for disorders About GeneDecksing

OMIM: 611359

Export disorders and mutations for AMBRA1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/16 PubMed articles for AMBRA1 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with AMBRA1)

Ambra1 regulates autophagy and development of the nervous system. (PubMed id 17589504)^{1, 2, 3} Fimia G.M....Cecconi F. (2007)
A novel role for autophagy in neurodevelopment. (PubMed id 17622796)^{1, 3} Cecconi F....Piacentini M. (2007)
Autophagy: a new regulator of development. (PubMed id 17603510)^{1, 3} Le Bot N. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{1, 2} Nagase T.... Ohara O. (2000)
Association of IFIH1 and other autoimmunity risk alle les with selective IgA deficiency. (PubMed id 20694011)¹ Ferreira R.C....HammarstrAPm L. (2010)
The dynamic interaction of AMBRA1 with the dynein mot or complex regulates mammalian autophagy. (PubMed id 20921139)¹ Di Bartolomeo S....Fimia G.M. (2010 Oct 4)
Network organization of the human autophagy system. (PubMed id 20562859)¹ Behrends C....Harper J.W. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55626	HGNC: 25990	AceView: FLJ20294	Ensembl:ENSG00000110497	euGenes: HUgn55626
ECgene: AMBRA1	H-InvDB: AMBRA1

(According to HUGE)
About This Section

HUGE: KIAA1736

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for AMBRA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for AMBRA1 gene:
Search GeneIP for patents involving AMBRA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Predesigned and custom siRNAs for AMBRA1		Antibodies for AMBRA1
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Tagged/untagged cDNA clones
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	Lysates
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	siRNA
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	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of AMBRA1
	SeqTarget long-range PCR primers for resequencing AMBRA1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for AMBRA1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of AMBRA1

	GenScript Custom Purified and Recombinant Proteins Services for AMBRA1		GenScript cDNA clones with any tag delivered in your preferred vector for AMBRA1
	GenScript Custom Assay Services for AMBRA1		GenScript Custom Superior Antibodies Services for AMBRA1
	GenScript Custom overexpressing Cell Line Services for AMBRA1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for AMBRA1
	Search Chromatin IP Primers for AMBRA1
	RT² qPCR Primer Assay for AMBRA1
	Search GNC Networks for AMBRA1
	Assays for microRNAs that regulate AMBRA1
	SABiosciences PCR Arrays including AMBRA1

Search Tocris compounds for AMBRA1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for AMBRA1

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for AMBRA1

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

AMBRA1 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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AMBRA1 Gene

protein-coding GIFtS: 45

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Export list of displayed genes

AMBRA1 Gene

protein-coding GIFtS: 45

Aliases & Descriptionsfor AMBRA1 gene

Summariesfor AMBRA1 gene

Genomic Viewsfor AMBRA1 gene

Proteinsfor AMBRA1 gene

Protein Domains/Familiesfor AMBRA1 gene

Gene Functionfor AMBRA1 gene

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Expression for AMBRA1 gene

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External Searches for AMBRA1 gene

Genome Databases showing AMBRA1 gene

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Specialized Databases showing AMBRA1 gene

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Aliases &
Descriptions
for AMBRA1 gene

Summaries
for AMBRA1 gene

Genomic Views
for AMBRA1 gene

Proteins
for AMBRA1 gene

Protein Domains/
Families
for AMBRA1 gene

Gene Function
for AMBRA1 gene

Pathways & Interactions
for AMBRA1 gene

Drugs & Compounds
for AMBRA1 gene

Transcripts
for AMBRA1 gene

Expression
for AMBRA1 gene

Orthologs
for AMBRA1 gene

Paralogs
for AMBRA1 gene

Genomic Variants
for AMBRA1 gene

Disorders & Mutations
for AMBRA1 gene

Medical News
for AMBRA1 gene

Publications
for AMBRA1 gene

Intellectual Property
for AMBRA1 gene

Products
for AMBRA1 gene