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Aliases & Descriptionsfor AMIGO1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions adhesion molecule with Ig-like domain 11 2 amphoterin-induced gene and ORF2 AMIGO1 2 3 amphoterin-induced protein 12 KIAA11631 3 ALI23 AMIGO-12 3 Alivin-23 alivin-22
Export aliases for AMIGO1 gene to outside databases Previous GC identifers: GC01M109763 GC01M109848 GC01M110046
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Summariesfor AMIGO1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: AMGO1_HUMAN, Q86WK6 Function : Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved infasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity)
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Genomic Viewsfor AMIGO1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AMIGO1 gene promoter: Cart-1 FOXO4 C/EBPalpha CHOP-10 SRF GATA-1 POU3F1 Meis-1 Nkx2-2 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for AMIGO1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3 AMIGO1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M107942: view genomic region
(about GC identifiers )
Start:
107,942,365 bp from pter
End:
107,945,255 bp from pter
Size:
2,891 bases
Orientation:
minus strand
1 alternative location : Chr 1- 110,046,797-110,052,360
RefSeq DNA sequence: NC_000001.10 NT_032977.9
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Proteinsfor AMIGO1 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: AMGO1_HUMAN, Q86WK6 (See
protein sequence )Recommended Name: Amphoterin-induced protein 1 precursor Size : 493 amino acids; 55239 Da
Subunit : Binds itself as well as AMIGO2 and AMIGO3 (By similarity)
Subcellular location : Membrane; Single-pass type I membrane protein (Potential). Cell projection, axon (By similarity).Note=Associated with axons of neuronal cells (By similarity)
Secondary accessions : B4DIM3 Q8IW71 Q9ULQ7Explore the universe of human proteins at neXtProt for AMIGO1: NX_Q86WK6 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_065754.2 ENSEMBL proteins: ENSP00000358880 ENSP00000358878 Human Recombinant Proteins 4 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
AMIGO1 for ontologies About GeneDecksing Antibodies for AMIGO1: Assays for AMIGO1:
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Protein
Domains/ Familiesfor AMIGO1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
AMIGO1 for domains About GeneDecksing 5/8 InterPro domains/families (see all 8 ):
Graphical View of Domain Structure for InterPro Entry Q86WK6 ProtoNet protein and cluster: Q86WK6
3 Blocks protein families : IPB000483 Cysteine-rich flanking region IPB001611 Leucine-rich repeat signature IPB003599 Immunoglobulin subtype UniProtKB/Swiss-Prot: AMGO1_HUMAN, Q86WK6 Similarity : Belongs to the immunoglobulin superfamily. AMIGO familySimilarity : Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity : Contains 6 LRR (leucine-rich) repeats
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Gene Functionfor AMIGO1 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: AMGO1_HUMAN, Q86WK6 Function : Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved infasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity)
1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IEA --
About this table
AMIGO1 for ontologies About GeneDecksing
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Pathways & Interactionsfor AMIGO1 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for AMIGO1 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMIGO1 5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10 ):
About this table
AMIGO1 for ontologies About GeneDecksing
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Drugs & Compoundsfor AMIGO1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for AMIGO1
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Transcriptsfor AMIGO1 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for AMIGO1 gene: NM_020703.2
Additional cDNA sequence: AB032989.1 AK295678.1 AY237007.1 BC040879.1
1 DOTS entry : DT.315590
24/97 AceView cDNA sequences (see all 97 ):
CA393641 BE465139 BG056176 BM714965 F03441 BQ636819 BU742472 BI831752 AW205224 AI565242 BU674353 BU628240 AI183455 AI392736 AB032989 AW135785 BE348609 BC040879 AY237007 BM313558 AA195739 H37785 BX415700 CD673013
highest scoring ESTs for AMIGO1 :AA001423 AI392736 BC040879 BM804916 AA001481 AA195703 AA195739 AA256827 AA351971 AA365416 Unigene Cluster for AMIGO1:
Adhesion molecule with Ig-like domain 1 Hs.726479 [show with all ESTs ] Unigene Representative Sequence: AB032989 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000369864 (uc001dxx.3 ) ENST00000369862
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Expression for AMIGO1 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section AMIGO1 expression in normal and diseased human tissues 1 / 2 / 3
4 probe-sets matching AMIGO1 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
66423_at2 , 3
U95-C
1
0.69
1.00
0.97
0.86
AI392736
0.80
1.00
0.91
1
53734_at2 , 3
U95-B
1
0.38
1.00
0.95
1.14
AA001423
0.80
1.00
0.91
1
226718_at2 , 3
U133-B
1
0.27
1.00
--
--
AA001423
0.80
1.00
0.91
1
226718_at2
U133Plus2
1
0.27
1.00
--
--
--
--
--
--
--
About this table
AMIGO1 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TCTCCCAGGA SOURCE GeneReport for Unigene cluster: Hs.726479 SABiosciences Custom PCR Arrays for AMIGO1
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Orthologsfor AMIGO1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for AMIGO1 gene from 5/6 species (see all 6 )
About this table Species with no ortholog for AMIGO1 ENSEMBL Gene Tree for AMIGO1 (if available)
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Paralogsfor AMIGO1 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for AMIGO1 gene AMIGO2 2 AMIGO3 2
AMIGO1 for paralogs About GeneDecksing
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Genomic Variantsfor AMIGO1 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 1 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for AMIGO1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for AMIGO1: --
QIAGEN SeqTarget long-range PCR primers for resequencing AMIGO1
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Disorders & Mutationsfor AMIGO1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Medical Newsfor AMIGO1 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor AMIGO1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 9 PubMed articles for AMIGO1 gene integrated from 7 sources : (articles sorted by number of sources associating them with AMIGO1) AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PubMed id 12629050) 1 , 2 , 3, 7 Kuja-Panula J....Rauvala H. (2003) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461) 1 , 2 Hirosawa M.... Ohara O. (1999) New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146) 1 KAPttgen A....Fox C.S. (2010) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for AMIGO1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing AMIGO1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing AMIGO1 gene
(According to HUGE )
About This Section
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Specialized Databases showing AMIGO1 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for AMIGO1 gene: Search GeneIP for patents involving AMIGO1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AMIGO1 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for AMIGO1
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