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ANXA11 Gene

protein-coding   GIFtS: 62

GC10M075758
annexin A11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ANX11)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
annexin A111 2     CAP502
ANX112 3 5     OTTHUMP000000199572
Calcyclin-associated annexin 502 3     autoantigen, 56-kD2
Annexin XI2 3     OTTHUMP000000199582
56 kDa autoantigen2 3     annexin-112
CAP-502 3     Annexin-113

External Ids:    HGNC: 5351   Entrez Gene: 3112   Ensembl: ENSG000001223597   UniProtKB: P509953   

Export aliases for ANXA11 gene to outside databases

Previous GC identifers: GC10M080871 GC10M081136 GC10M082046 GC10M081579 GC10M081904


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANXA11:
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins
have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent
phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various
autoimmune diseases. Transcript variants encoding the same isoform have been identified. (provided by RefSeq)

UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995
Function: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation
and completion of the terminal phase of cytokinesis

Gene Wiki entry for ANXA11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANXA11 gene promoter:
         Arnt   AhR   MEF-2A   Sox9   FOXO1a   AP-1   MZF-1   POU2F1   c-Rel   Bach1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ANXA11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ANXA11 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q22.3   HGNC cytogenetic band: 10q22.3

ANXA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANXA11 gene location

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M075758:  view genomic region     (about GC identifiers)

Start:
75,758,329 bp from pter
End:
75,808,559 bp from pter
Size:
50,231 bases
Orientation:
minus strand

1 alternative location:
Chr10- 81,910,645-81,965,433     
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995 (See protein sequence)
Recommended Name: Annexin A11  
Size: 505 amino acids; 54390 Da
Subunit: Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with
KIF23 during cytokinesis
Subcellular location: Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle.
Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By
similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope,
with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent

Explore the universe of human proteins at neXtProt for ANXA11: NX_P50995 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001148.1  NP_665875.1  NP_665876.1  


    ENSEMBL proteins: 
    ENSP00000410826 ENSP00000353827 ENSP00000361308 ENSP00000414642 ENSP00000405009 ENSP00000265447 
    ENSP00000361293 ENSP00000398610 ENSP00000361305 ENSP00000404412 ENSP00000391296 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): ANXA11
    OriGene Protein Over-expression Lysate (see all 2): ANXA11
    GenScript Custom Purified and Recombinant Proteins Services for ANXA11 
    Novus Biologicals Proteins for ANXA11
    Novus Biologicals Lysates for ANXA11
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/11 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 11):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005635 nuclear envelope NAS12577318
    GO:0005654 nucleoplasm NAS12577318
    GO:0005737 cytoplasm IDA12601007
    GO:0005819 spindle IDA15197175
    About this table

    ANXA11 for ontologies           About GeneDecksing



    Antibodies for ANXA11: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ANXA11
    R&D Systems Antibodies for ANXA11 (Annexin A11)
    OriGene Antibodies: ANXA11
    GenScript Custom Superior Antibodies Services for ANXA11 
    Novus Biologicals Antibodies for ANXA11
    Epitomics antibodies for ANXA11

    Assays for ANXA11: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANXA11 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ANXA11 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANXA11 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008157 AnnexinXI
     IPR018502 Annexin_repeat
     IPR001464 Annexin
     IPR018252 Annexin_repeat_CS

    Graphical View of Domain Structure for InterPro Entry P50995

    ProtoNet protein and cluster: P50995

    1 Blocks protein family: IPB001464 Annexin

    UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995
    Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
    Similarity: Belongs to the annexin family
    Similarity: Contains 4 annexin repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ANX11_HUMAN, P50995
    Function: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation
    and completion of the terminal phase of cytokinesis

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ANXA11
    Sigma-Aldrich shRNA for ANXA11
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ANXA11
    OriGene shRNA RFP (see all 3): ANXA11
    OriGene basic RS shRNA (see all 3): ANXA11
    OriGene siRNA (see all 3): ANXA11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ANXA11 
    miRNA:Sigma-Aldrich microRNA Mimics for ANXA11
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ANXA11 
    3 SABiosciences Assays for microRNAs that regulate ANXA11:
    hsa-miR-146b-3p hsa-miR-124 hsa-miR-506

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ANXA11
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ANXA11
    OriGene untagged cDNA clones in CMV expression vector (see all 3): ANXA11
    OriGene 3'-UTR clone (see all 3): ANXA11 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): ANXA11 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ANXA11 

    Genatlas biochemistry entry for ANXA11:
    annexin A11,calcium and phospholipid binding protein,two alternatively spliced isoforms

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509 calcium ion binding IEA--
    GO:0005515 protein binding IPI18256029
    GO:0005544 calcium-dependent phospholipid binding IEA--
    GO:0048155 S100 alpha binding IPI19724273
    GO:0048306 calcium-dependent protein binding IPI12445460
    About this table

    ANXA11 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including ANXA11: PAHS-016A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANXA11

    5/543 Interacting proteins for ANXA11 (ENSP000003538273 P509951, 2) via UniProtKB, MINT, and/or STRING (see all 543)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDCD6O753401EBI-715243,EBI-352915
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    ACTL6AO960192MINT-7947479
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909 phagocytosis IEP9188810
    GO:0007049 cell cycle IEA--
    GO:0007109 cytokinesis, completion of separation IMP15197175
    GO:0051301 cell division IEA--
    GO:0051592 response to calcium ion IDA12601007
    About this table

    ANXA11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ANXA11 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANXA11
    2 Novoseek chemical compound relationships for ANXA11 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 34.8 3 1299619 (1), 7508441 (1)
    calcium 9.68 7 9188810 (3), 12805373 (2), 8639854 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ANXA11
    Sigma-Aldrich shRNA for ANXA11
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ANXA11
    OriGene shRNA RFP (see all 3): ANXA11
    OriGene basic RS shRNA (see all 3): ANXA11
    OriGene siRNA (see all 3): ANXA11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ANXA11 
    miRNA: Sigma-Aldrich microRNA Mimics for ANXA11
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ANXA11 
    3 SABiosciences Assays for microRNAs that regulate ANXA11:
    hsa-miR-146b-3p hsa-miR-124 hsa-miR-506
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ANXA11
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ANXA11
    OriGene untagged cDNA clones in CMV expression vector (see all 3): ANXA11
    OriGene 3'-UTR Clone (see all 3): ANXA11 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): ANXA11 
    Primers: OriGene genome-wide validated SYBR primer pairs: ANXA11
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ANXA11: PPH06949A

    REFSEQ mRNAs for ANXA11 gene (3 alternative transcripts): 

    NM_001157.2  NM_145868.1  NM_145869.1  

    Additional cDNA sequence: 

    AB209770.1 AJ278463.1 AJ278464.1 AJ278465.1 AK000567.1 AK056107.1 AK126287.1 AK222918.1 
    AK298362.1 AK300509.1 AK301047.1 AL357617.1 BC007564.2 BT019934.1 CR450323.1 CR591981.1 
    CR592506.1 CR604152.1 CR606218.1 CR621013.1 L19605.1 

    24/39 DOTS entries (see all 39):

    DT.449904  DT.75182037  DT.100849032  DT.95208551  DT.100849034  DT.100849033  DT.100849011  DT.100697284 
    DT.121246178  DT.92458913  DT.92458908  DT.121246149  DT.121246156  DT.101985389  DT.95373951  DT.97860541 
    DT.91870206  DT.100849009  DT.121246298  DT.100849014  DT.100849028  DT.100849030  DT.91656372  DT.91732204 

    24/816 AceView cDNA sequences (see all 816):

    AL550520 CA434409 BM833229 BQ064069 AI005052 H81555 BP431159 BG391087 
    AI474506 AW843849 BF969970 AI478734 AW850073 AA363111 CB119882 AI027231 
    AA985520 AI597954 AI744824 CR450323 AK056107 AA617811 AA314524 AI564321 

    highest scoring ESTs for ANXA11:

    L19605 AA406017 AI750414 AI923271 AJ278464 AJ278465 AK000567 AK056107 AU099319 AU122096 

    Unigene Cluster for ANXA11:

    Annexin A11
    Hs.530291  [show with all ESTs]
    Unigene Representative Sequence: NM_145869


    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for ANXA11 (see all 20)

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
    SP1:                          -     -     -     -     -     -     -     -                       -           -     -                                             
    SP2:                          -     -     -     -     -     -     -     -     -     -           -           -     -                                             
    SP3:                          -     -     -     -     -     -     -     -     -     -     -     -           -     -                                             
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                          -     -     -     -     -     -     -     -     -     -     -     -           -     -                 -     -     -               

    ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
    SP1:              -                       -                                                         
    SP2:              -                       -                                                         
    SP3:              -                       -                                                         
    SP4:  -     -     -     -                 -                                                         
    SP5:              -                                                                                 

    About this scheme

    ECgene alternative splicing isoforms for ANXA11
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475974 ENST00000474545 ENST00000424188 ENST00000360615 ENST00000372234(uc010qlx.1 uc001kbu.1)
    ENST00000463657 ENST00000437799 ENST00000447489 ENST00000265447 ENST00000481805
    ENST00000372219 ENST00000438331(uc001kbq.1 uc001kbr.1 uc001kbs.1 uc001kbt.1 uc010qly.1 uc009xsq.1)
    ENST00000372231 ENST00000422982 ENST00000445524 ENST00000463340

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ANXA11 expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching ANXA11 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36637_at2, 3 U95-A 1 1.00 1.00 0.72 1.08 L19605 1.00 1.00 1.00 1
    80049_at2, 3 U95-E 1 0.81 1.00 0.78 0.79 AI811019 0.20 1.00 0.72 1
    43449_at2, 3 U95-B 1 0.75 1.00 0.88 0.85 AI185063 0.40 1.00 0.76 1
    55664_at2, 3 U95-C 1 0.50 1.00 0.90 1.30 AI923271 0.80 1.00 0.91 1
    206200_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001157 0.60 1.00 0.82 1
    214783_s_at2, 3 U133-A 1 0.91 1.00 -- -- BG177920 0.60 1.00 0.82 1
    228727_at2, 3 U133-B 1 0.82 1.00 -- -- BF969970 0.20 1.00 0.72 1
    206200_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    214783_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    228727_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    ANXA11 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ANXA11 gene expression
    ANXA11 gene electronic northern expression
    ANXA11 gene sage expression
    About these images

    CGAP SAGE TAG: GTGTCTCGCA

    SOURCE GeneReport for Unigene cluster: Hs.530291

    Expression variation in blood from EXPOLDB for ANXA11

    Primers: OriGene genome-wide validated SYBR primer pairs: ANXA11
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ANXA11: PPH06949A
        SABiosciences Expression via Pathway-Focused PCR Array including ANXA11: PAHS-016A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ANXA11 gene from 5/13 species (see all 13)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ANXA111   -- annexin A11 90.21(n)
    93.85(a)
    479259  XM_536401.2  XP_536401.2 
    chimpanzee
    (Pan troglodytes)
    ANXA111   -- annexin A11 98.51(n)
    98.11(a)
    450553  XM_507872.2  XP_507872.2 
    cow
    (Bos taurus)
    ANXA111   -- annexin A11 86.99(n)
    89.13(a)
    282142  NM_174502.2  NP_776927.1 
    rat
    (Rattus norvegicus)
    Anxa111   -- annexin A11 88.27(n)
    93.64(a)
    290527  NM_001011918.1  NP_001011918.1 
    mouse
    (Mus musculus)
    Anxa111 , 5 14 (15.06 cM)5
    annexin A111, 5 89.07(n)1
    93.44(a)1
    117441  NM_013469.11  NP_038497.11 
     AJ2897595  AJ2897695  (see all 16)
    About this table        Species with no ortholog for ANXA11

    ENSEMBL Gene Tree for ANXA11 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ANXA11 gene
    ANXA62  ANXA8L22  ANXA52  ANXA8L12  ANXA92  ANXA42  ANXA132  ANXA82  

    ANXA11 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/593 NCBI SNPs in ANXA11 are shown (see all 593)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs7349651,2
    --81961770(-) TCTGGG/AATCTC 2 -- int12Minor allele frequency- A:0.00NA 164
    rs10495501,2
    C,F,A,H,81926702(-) GGAGTC/TGCTCC 4 R C ref1 mis1 ese321Minor allele frequency- G:0.01MN EA NA NS WA 2814
    rs10792421,2
    C,F,81917708(+) TGCACG/ATGGAA 2 -- int114Minor allele frequency- A:0.46NS EA NA WA 2108
    rs18029321,2
    C,F81917486(-) TTCGCA/GTCATG 4 I V ref1 mis16Minor allele frequency- G:0.01NA NS EA 478
    rs18029341,2
    --81915528(-) TCTAAA/CAAATC 2 -- ut310--------
    rs18029351,2
    --81930604(-) GATAAC/TGTGGC 4 N ref1 syn10--------
    rs22284271,2
    C,F,81926718(-) ATCATC/TGACTG 4 I syn1 ref18Minor allele frequency- G:0.03MN NA 260
    rs22295541,2
    C,F,81927059(-) AAGCCG/AAGGCA 4 /Q /R mis1 ref1 ese314Minor allele frequency- A:0.02MN NA NS EA 1094
    rs22295551,2
    H81915484(-) TTAGGC/TCTGTC 2 -- ut31 ese35Minor allele frequency- T:0.00MN NS EA 464
    rs22365561,2
    C,F,A,H,81932790(-) GAGGCA/GCCAGC 2 -- int116Minor allele frequency- G:0.47EA NS NA WA 1592
    About this table

    HapMap Linkage Disequilibrium images for ANXA11 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ANXA11: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ANXA11 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANXA11 for disorders           About GeneDecksing

    OMIM: 602572

    6 Novoseek disease relationships for ANXA11 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerosis systemic 34.2 1 7699691 (1)
    autoimmune diseases 32 8 11035417 (3), 7699691 (3), 12805373 (1)
    lupus erythematosus systemic 28.3 1 7699691 (1)
    rheumatoid arthritis 17.9 1 7699691 (1)
    tumors 0 4 17982121 (2), 19422301 (1), 19484149 (1)
    cancer 0 1 17982121 (1)
    About this table

    Human Gene Mutation Database (HGMD): ANXA11
    Human Genome Epidemiology (HuGE) Navigator: ANXA11 (5 documents)

    Export disorders and mutations for ANXA11 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/51 PubMed articles for ANXA11 gene, integrated from 7 sources (see all 51):
    (articles sorted by number of sources associating them with ANXA11)
    1. The 56K autoantigen is identical to human annexin XI. (PubMed id 7508441)1, 2, 3, 7 Misaki Y.... van Venrooij W.J. (1994)
    2. Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. (PubMed id 12805373)1, 2, 7 Farnaes L. and Ditzel H.J. (2003)
    3. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. (PubMed id 11883939)1, 2, 7 Satoh H.... Maki M. (2002)
    4. Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms. (PubMed id 11013079)1, 2, 7 Bances P....Fernandez M.-P. (2000)
    5. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. (PubMed id 9503022)1, 3, 7 Morgan R.O....Fernandez M.P. (1998)
    6. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PubMed id 18256029)1, 2, 7 Shibata H....Maki M. (2008)
    7. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    8. Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. (PubMed id 15197175)1, 2 Tomas A.... Moss S.E. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope. (PubMed id 12601007)1, 2 Tomas A. and Moss S.E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 311 HGNC: 535 AceView: ANXA11 Ensembl:ENSG00000122359 euGenes: HUgn311
    ECgene: ANXA11 H-InvDB: ANXA11

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ANXA11 gene:
    Search GeneIP for patents involving ANXA11

    GeneCards and IP:
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