Aliases &
Descriptions
for AP1S1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| adaptor-related protein complex 1, sigma 1 subunit1 2 | | Sigma-adaptin 1A2 3 | | AP191 2 3 5 | | HA1 19 kDa subunit2 3 | | CLAPS12 3 5 | | OTTHUMP000002114692 | | WUGSC:H_DJ0747G18.21 2 | | sigma1A-adaptin2 | | SIGMA1A1 2 | | clathrin-associated/assembly/adaptor protein, small 1 (19kD)2 | | Sigma 1a subunit of AP-1 clathrin2 3 | | AP-1 complex subunit sigma-1A2 | | Golgi adaptor HA1/AP1 adaptin sigma-1A subunit2 3 | | FLJ924362 | | Adapter-related protein complex 1 sigma-1A subunit2 3 | | OTTHUMP000002114682 | | Adaptor protein complex AP-1 sigma-1A subunit2 3 | | sigma1A subunit of AP-1 clathrin adaptor complex2 | | Clathrin assembly protein complex 1 sigma-1A small chain2 3 | | Sigma1A-adaptin3 | | Clathrin coat assembly protein AP192 3 | | |
Export aliases for AP1S1 gene to outside databasesPrevious GC identifers: GC07P099281 GC07P100344 GC07P100357 GC07P100391 GC07P100584 GC07P100797 |
Summaries
for AP1S1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AP1S1:
The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors incoated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well asbeta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located atthe Golgi vesicle. (provided by RefSeq)
UniProtKB/Swiss-Prot: AP1S1_HUMAN, P61966Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in thelate-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin tomembranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules
Gene Wiki entry for AP1S1 |
Genomic Views
for AP1S1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AP1S1 gene promoter:
STAT3 CREB deltaCREB RFX1 STAT1beta STAT1 NRSF form 2 STAT1alpha NRSF form 1 Bach2
Other transcription factors
Search SABiosciences Chromatin IP Primers for AP1S1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for AP1S1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC chromosome: 7AP1S1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P095390: view genomic region
(about GC identifiers)
Start:
|
95,390,854 bp from pter |
End:
|
95,397,722 bp from pter |
Size:
|
6,869 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+ 100,797,678-100,804,877 |
RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079596.2
|
Proteins
for AP1S1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: AP1S1_HUMAN, P61966 (See
protein sequence)Recommended Name: AP-1 complex subunit sigma-1A Size: 158 amino acids; 18733 Da
Subunit: Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-typesubunit AP1S1 or AP1S2 or AP1S3)
Subcellular location: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles locatedat the Golgi complex
Sequence caution: Sequence=AAD45829.1; Type=Erroneous initiation;
Secondary accessions: B2R5D8 P82267 Q00382 Q53YA7 Q9BTN4 Q9UDW9Alternative splicing: 2 isoforms: P61966-1, Q00382-1 P61966-2, Q00382-2 Explore the universe of human proteins at neXtProt for AP1S1: NX_P61966
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001274.1
ENSEMBL proteins: ENSP00000336666 ENSP00000410780 ENSP00000399902
Human Recombinant Proteins
5/11 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 11): About this table
AP1S1 for ontologies About GeneDecksing
Antibodies for AP1S1:
Assays for AP1S1: |
Protein
Domains/
Families
for AP1S1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AP1S1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P61966ProtoNet protein and cluster: P61966 1 Blocks protein family: IPB000804 Clathrin adaptor complex
UniProtKB/Swiss-Prot: AP1S1_HUMAN, P61966Similarity: Belongs to the adaptor complexes small subunit family |
Gene Function
for AP1S1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: AP1S1_HUMAN, P61966Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in thelate-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin tomembranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo moleculesInduction: Up-regulated in response to enterovirus 71 (EV71) infection
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
AP1S1 for ontologies About GeneDecksing
|
Pathways & Interactions
for AP1S1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
AP1S1 for pathways About GeneDecksing
1  Millipore Pathway for AP1S1
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for AP1S1
1  Kegg Pathway (Kegg details for AP1S1):
SABiosciences Pathway-Focused PCR Array including AP1S1: PAHS-004A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for AP1S1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AP1S1
5/33 Interacting proteins for AP1S1 (ENSP000003366663 P619661) via UniProtKB, MINT, and/or STRING (see all 33)About this table
5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9): About this table
AP1S1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AP1S1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for AP1S1
|
Transcripts
for AP1S1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for AP1S1 gene: NM_001283.3 Additional cDNA sequence: AB015319.1 AK312151.1 BC003561.1 BC127718.1 BT006779.1 CR592205.1 CR599373.1 CR601876.1 CR608060.1 9 DOTS entries: DT.100679961 DT.92435189 DT.100794186 DT.443952 DT.121126401 DT.121126515 DT.121126523 DT.92435185 DT.92015495 24/218 AceView cDNA sequences (see all 218): CK431081 BM712868 BF795469 CD518188 BI858603 CF453700 CB106935 BQ221339 BM449513 CF128366 BX115238 CR592205 CR599373 CR601876 BQ639310 CR608060 BU166473 AW732891 NM_001283 BI856945 BM673727 BM745224 BG674285 BQ436867
 highest scoring ESTs for AP1S1:AA010346 AA010347 AA011675 AA011712 AA205622 AA235726 AA311393 AA317054 AA356155 AA399361 Unigene Cluster for AP1S1: Adaptor-related protein complex 1, sigma 1 subunit Hs.489365 [show with all ESTs]Unigene Representative Sequence: NM_001283
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000337619(uc003uxv.3) ENST00000443943 ENST00000429457
|
Expression
for AP1S1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| AP1S1 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching AP1S1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 36498_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
0.98 |
0.97 |
AI936759 |
0.60 |
1.00 |
0.82 |
1 |
| 72897_at*2, 3
|
U95-D |
1 |
-- |
-- |
-0.24 |
1.05 |
AA601662 |
0.40 |
1.00 |
0.76 |
1 |
| 205196_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_001283 |
0.60 |
1.00 |
0.82 |
1 |
| 205195_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_001283 |
0.60 |
1.00 |
0.82 |
1 |
| 209635_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
BC003561 |
0.80 |
1.00 |
0.91 |
1 |
| 205196_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 205195_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 209635_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
AP1S1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CAGGTTGTCC
SOURCE GeneReport for Unigene cluster: Hs.489365
Expression variation in blood from EXPOLDB for AP1S1 UniProtKB/Swiss-Prot: AP1S1_HUMAN, P61966Tissue specificity: Widely expressed
SABiosciences Expression via Pathway-Focused PCR Array including AP1S1: PAHS-004A
|
Orthologs
for AP1S1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AP1S1 gene from 5/10 species (see all 10)
About this table Species with no ortholog for AP1S1
ENSEMBL Gene Tree for AP1S1 (if available) |
Paralogs
for AP1S1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for AP1S1 gene
- AP4S12 AP1S32 AP2S12 AP1S22
AP1S1 for paralogs About GeneDecksing
|
Genomic Variants
for AP1S1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for AP1S1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for AP1S1
2 CNVs: 8576 5245 | | QIAGEN SeqTarget long-range PCR primers for resequencing AP1S1 |
|
Disorders & Mutations
for AP1S1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AP1S1 for disorders About GeneDecksing
OMIM: 603531
Human Gene Mutation Database (HGMD): AP1S1
Export disorders and mutations for AP1S1 gene to outside databases
|
Medical News
for AP1S1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for AP1S1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/33 PubMed articles for AP1S1 gene, integrated from 7 sources (see all 33):
(articles sorted by number of sources associating them with AP1S1)- Identification and characterization of novel clathrin adaptor-related proteins. (PubMed id 9733768)1, 2, 3 Takatsu H.... Nakayama K. (1998)
- Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). (PubMed id 9653655)1, 3 Peyrard M.... Dumanski J.P. (1998)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord. (PubMed id 19057675)1 Montpetit A....Cossette P. (2008)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment. (PubMed id 16253302)1 Coleman S.H....Guatelli J.C. (2006)
|
External Searches for AP1S1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AP1S1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AP1S1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AP1S1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AP1S1 gene:
Search GeneIP for patents involving AP1S1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AP1S1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for AP1S1 |
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