Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



ARHGAP21 Gene

protein-coding   GIFtS: 48

GC10M024534
Rho GTPase activating protein 21
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
Rho GTPase activating protein 211 2     OTTHUMP000000193212
ARHGAP101 2 3     Rho-GTPase activating protein 102
KIAA14241 3 5     DKFZp761L04242
Rho-type GTPase-activating protein 212 3     rho GTPase-activating protein 212
Rho GTPase-activating protein 102 3     FLJ901082
FLJ333232     

External Ids:    HGNC: 237251   Entrez Gene: 575842   Ensembl: ENSG000001078637   UniProtKB: Q5T5U33   

Export aliases for ARHGAP21 gene to outside databases

Previous GC identifers: GC10M024876 GC10M024912


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP21:
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3
complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 (PubMed
15793564)).(supplied by OMIM)

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may
control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGAP21 gene promoter:
         Chx10   Hlf   E4BP4   POU2F2 (Oct-2.1)   POU2F2   POU2F2B   Oct-B1   POU2F2C   oct-B2   oct-B3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ARHGAP21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ARHGAP21 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1|10p12.3   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.31

ARHGAP21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP21 gene location

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M024534:  view genomic region     (about GC identifiers)

Start:
24,534,090 bp from pter
End:
24,673,492 bp from pter
Size:
139,403 bases
Orientation:
minus strand

1 alternative location:
Chr10- 24,872,538-25,012,597     
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3 (See protein sequence)
Recommended Name: Rho GTPase-activating protein 21  
Size: 1957 amino acids; 217331 Da
Subunit: Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle
membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on
interaction with GTP-bound ARF1
Miscellaneous: Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers
Miscellaneous: Required for In1A-dependent entry of Listeria monocytogenes into cells
PDB structures from and Proteopedia :
2DHJ (3D)    2J59 (3D)    2YUY (3D)    
Secondary accessions: Q0VF98 Q7Z3P7 Q8N3A2 Q8NI19 Q8TBV5 Q9P2C3
Alternative splicing: 2 isoforms:  Q5T5U3-1   Q5T5U3-3   

Explore the universe of human proteins at neXtProt for ARHGAP21: NX_Q5T5U3 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_065875.3  

    ENSEMBL proteins: 
    ENSP00000388873 ENSP00000405018 ENSP00000389940 ENSP00000408073 ENSP00000379709 ENSP00000365592 
    ENSP00000365604 ENSP00000402761 ENSP00000400566 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for ARHGAP21 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139 Golgi membrane IEA--
    GO:0005622 intracellular IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005794 Golgi apparatus IEA--
    GO:0005856 cytoskeleton IEA--
    About this table

    ARHGAP21 for ontologies           About GeneDecksing



    Antibodies for ARHGAP21: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ARHGAP21
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ARHGAP21 
    Browse antibodies at Epitomics

    Assays for ARHGAP21: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGAP21 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ARHGAP21 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARHGAP21 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_type
     IPR001478 PDZ/DHR/GLGF
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q5T5U3

    ProtoNet protein and cluster: Q5T5U3

    2 Blocks protein families:
    IPB000198 RhoGAP domain
    IPB001605 Spectrin pleckstrin homology domain signature


    UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rho-GAP domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
    Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may
    control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions
    Induction: Up-regulated upon cell differentiation

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ARHGAP21
    Sigma-Aldrich shRNA for ARHGAP21
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ARHGAP21
    OriGene shRNA RFP (see all 3): ARHGAP21
    OriGene basic RS shRNA (see all 3): ARHGAP21
    OriGene siRNA: ARHGAP21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ARHGAP21 
    miRNA:Sigma-Aldrich microRNA Mimics for ARHGAP21
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ARHGAP21 
    8/10 SABiosciences Assays for microRNAs that regulate ARHGAP21 (see all 10):
    hsa-miR-148b hsa-miR-183 hsa-miR-548e hsa-miR-888 hsa-miR-548a-3p hsa-miR-152 hsa-miR-199a-5p hsa-miR-194

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ARHGAP21
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ARHGAP21
    OriGene untagged cDNA clones in CMV expression vector: ARHGAP21
    OriGene 3'-UTR clone: ARHGAP21 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ARHGAP21 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ARHGAP21 

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096 GTPase activator activity IEA--
    GO:0005515 protein binding IPI--
    About this table

    ARHGAP21 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ARHGAP21 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGAP21

    4 Interacting proteins for ARHGAP21 (Q5T5U31, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1DP296921EBI-1642518,EBI-358607
    SFNP319472MINT-3974844
    YWHAZP631042MINT-3295618
    --P840782MINT-4788426 MINT-4788412 MINT-4788399
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction IEA--
    About this table

    ARHGAP21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGAP21


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ARHGAP21
    Sigma-Aldrich shRNA for ARHGAP21
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ARHGAP21
    OriGene shRNA RFP (see all 3): ARHGAP21
    OriGene basic RS shRNA (see all 3): ARHGAP21
    OriGene siRNA: ARHGAP21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ARHGAP21 
    miRNA: Sigma-Aldrich microRNA Mimics for ARHGAP21
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ARHGAP21 
    8/10 SABiosciences Assays for microRNAs that regulate ARHGAP21 (see all 10):
    hsa-miR-148b hsa-miR-183 hsa-miR-548e hsa-miR-888 hsa-miR-548a-3p hsa-miR-152 hsa-miR-199a-5p hsa-miR-194
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ARHGAP21
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ARHGAP21
    OriGene untagged cDNA clones in CMV expression vector: ARHGAP21
    OriGene 3'-UTR Clone: ARHGAP21 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ARHGAP21 
    Primers: OriGene genome-wide validated SYBR primer pairs: ARHGAP21
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ARHGAP21: PPH19678A

    REFSEQ mRNAs for ARHGAP21 gene: 

    NM_020824.3  

    Additional cDNA sequence: 

    AB037845.2 AF480466.1 AK090642.1 AK295649.1 AK297278.1 AK307604.1 AL834495.1 BC022931.1 
    BC118915.2 

    18 DOTS entries:

    DT.444446  DT.99962095  DT.91952775  DT.121291442  DT.121343937  DT.91897476  DT.121343936  DT.92419733 
    DT.121291398  DT.121364000  DT.40273675  DT.100710705  DT.95207218  DT.99938162  DT.100656762  DT.121291470 
    DT.121306615  DT.453753 

    24/242 AceView cDNA sequences (see all 242):

    BE856005 BM719318 AI373662 BQ959956 AW001808 BG152506 H71148 CF144610 
    AL701494 AW338526 BE550507 CF144649 AW593794 BM562264 AI160830 BQ574876 
    AA599905 AA587458 AA973435 AA236188 BQ027782 BP349812 AA527538 BM683250 

    highest scoring ESTs for ARHGAP21:

    AF480466 AV709499 AV727505 W26091 AA130257 AA134110 AA451811 AA527538 AA554611 AA568361 

    Unigene Cluster for ARHGAP21:

    Rho GTPase activating protein 21
    Hs.524195  [show with all ESTs]
    Unigene Representative Sequence: NM_020824


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP21 (see all 8)

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:        -     -                 -                                   -     -                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                -                                   -     -     -                                                                           
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29
    SP1:                    -                 -               
    SP2:                    -                 -               
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      

    About this scheme

    ECgene alternative splicing isoforms for ARHGAP21
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000472150 ENST00000477137 ENST00000445703 ENST00000446003(uc009xkl.1)
    ENST00000476067 ENST00000418033 ENST00000447364 ENST00000396432 ENST00000376410
    ENST00000486374 ENST00000320481(uc010qdb.1 uc001isb.2 uc010qdc.1 uc001isc.1)
    ENST00000477190 ENST00000483114 ENST00000482792 ENST00000476499(uc001isd.1)
    ENST00000418325 ENST00000416305 ENST00000493154

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ARHGAP21 expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching ARHGAP21 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    80095_at2, 3 U95-D 1 1.00 1.00 0.38 1.17 AI271326 0.40 1.00 0.76 1
    77357_at2, 3 U95-D 2 1.00 0.97 0.94 0.79 AA974102 0.60 1.00 0.82 1
    52927_at2, 3 U95-B 1 0.94 1.00 0.97 1.02 W26091 0.80 0.88 0.84 1
    72552_at2, 3 U95-D 1 0.81 1.00 0.78 1.00 AI082290 0.60 1.00 0.82 1
    74818_at2, 3 U95-E 2 0.69 0.86 0.97 1.04 AI034337 0.80 0.83 0.82 1
    241701_at2, 3 U133-B 1 1.00 1.00 -- -- BF369489 0.20 0.50 0.38 1
    224764_at2, 3 U133-B 1 1.00 1.00 -- -- AB037845 0.60 1.00 0.82 1
    241701_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    224764_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    ARHGAP21 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ARHGAP21 gene expression
    ARHGAP21 gene electronic northern expression
    ARHGAP21 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.524195

    UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3
    Tissue specificity: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta

    Primers: OriGene genome-wide validated SYBR primer pairs: ARHGAP21
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ARHGAP21: PPH19678A
        SABiosciences Custom PCR Arrays for ARHGAP21 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ARHGAP21 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ARHGAP211   -- Rho GTPase activating protein 21 99.52(n)
    99.49(a)
    450355  XM_507699.2  XP_507699.2 
    cow
    (Bos taurus)
    ARHGAP211   -- Rho GTPase activating protein 21 84.63(n)
    86.87(a)
    538584  XM_581232.3  XP_581232.3 
    rat
    (Rattus norvegicus)
    Arhgap211   -- Rho GTPase activating protein 21 83.07(n)
    86.73(a)
    307178  XM_225628.4  XP_225628.4 
    mouse
    (Mus musculus)
    Arhgap211 , 5 2 (14.60 cM)5
    Rho GTPase activating protein 211, 5 83.89(n)1
    87.24(a)1
    714351  NM_001081364.11  NP_001074833.11 
     AA4164585  AI1552735  (see all 19)
    chicken
    (Gallus gallus)
    ARHGAP211   -- Rho GTPase activating protein 21 75.06(n)
    74.87(a)
    420500  XM_418602.2  XP_418602.2 
    About this table        Species with no ortholog for ARHGAP21

    ENSEMBL Gene Tree for ARHGAP21 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ARHGAP21 gene
    ARHGAP52  ENSG000002146272  GRLF12  ENSG000001674332  IGHV3OR16-62  ARHGAP232  

    ARHGAP21 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1058 NCBI SNPs in ARHGAP21 are shown (see all 1058)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs103271,2
    F24872990(+) ACTGTA/GTTTTT 1 -- ut311Minor allele frequency- G:0.38MN 184
    rs11278911,2
    C24873560(-) ACGACA/CGACAC 2 T syn1 ref1 ese30--------
    rs11278931,2
    C,F,A,H,24873369(-) AGGCAA/C/GTAAAG 3 N T S mis1 ref16MN NS EA NA 602
    rs11278991,2
    --24873129(-) TAGTTA/GTATAC 1 -- ut310--------
    rs11279011,2
    F24873111(-) CAAGGT/CATTTG 1 -- ut311Minor allele frequency- C:0.08MN 184
    rs11279301,2
    --24872629(-) TAATTC/TTGCAT 1 -- ut31 ese30--------
    rs11338971,2
    F24874438(-) CTGCTA/GCATAC 2 T A ref1 mis1 ese31Minor allele frequency- G:0.33MN 184
    rs11430501,2
    C24874391(-) GTGCAA/GTCCGT 2 Q ref1 syn10--------
    rs11430511,2
    F24874386(-) ATCCGT/CGGCAG 2 /A /V mis1 ref1 ese31Minor allele frequency- C:0.43MN 184
    rs11430521,2
    --24874358(-) GCAGAT/CGACGA 2 /D syn1 ref1 ese31Minor allele frequency- C:0.00MN 184
    About this table

    HapMap Linkage Disequilibrium images for ARHGAP21 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARHGAP21: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ARHGAP21 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARHGAP21 for disorders           About GeneDecksing

    OMIM: 609870

    Human Genome Epidemiology (HuGE) Navigator: ARHGAP21 (1 document)

    Export disorders and mutations for ARHGAP21 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/25 PubMed articles for ARHGAP21 gene, integrated from 7 sources (see all 25):
    (articles sorted by number of sources associating them with ARHGAP21)
    1. ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. (PubMed id 12056806)1, 2, 3 Basseres D.S.... Saad S.T.O. (2002)
    2. Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PubMed id 17347647)1, 2 Menetrey J.... Houdusse A. (2007)
    3. Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. (PubMed id 15793564)1, 2 Dubois T.... Chavrier P. (2005)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    5. Characterization of human ARHGAP10 gene in silico. (PubMed id 15375573)2, 7 Katoh M. and Katoh M. (2004)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    7. ARHGAP21 modulates FAK activity and impairs glioblastoma cell migration. (PubMed id 19268501)1 Bigarella C.L....Saad S.T. (2009)
    8. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57584 HGNC: 23725 AceView: ARHGAP21 Ensembl:ENSG00000107863 euGenes: HUgn57584
    ECgene: ARHGAP21 H-InvDB: ARHGAP21

    (According to HUGE)
    About This Section
    HUGE: KIAA1424

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ARHGAP21 gene:
    Search GeneIP for patents involving ARHGAP21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for ARHGAP21 Antibodies for ARHGAP21
     Super-pooled esiRNAs for ARHGAP21 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ARHGAP21 microRNA Mimics for ARHGAP21
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ARHGAP21
     SeqTarget long-range PCR primers for resequencing ARHGAP21
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ARHGAP21
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ARHGAP21
     GenScript Custom Purified and Recombinant Proteins Services for ARHGAP21 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ARHGAP21
     GenScript Custom Assay Services for ARHGAP21 GenScript Custom Superior Antibodies Services for ARHGAP21
     GenScript Custom overexpressing Cell Line Services for ARHGAP21 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARHGAP21 promoter
     Search Chromatin IP Primers for ARHGAP21
     RT2 qPCR Primer Assay for ARHGAP21
     Search GNC Networks for ARHGAP21
     Assays for microRNAs that regulate ARHGAP21
     SABiosciences Custom PCR Arrays for ARHGAP21
     Search Tocris compounds for ARHGAP21
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for ARHGAP21
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    ARHGAP21 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4