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ARHGAP21 Gene

protein-coding GIFtS: 48

GC10M024534

Rho GTPase activating protein 21
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
Rho GTPase activating protein 21¹ ²		OTTHUMP00000019321²
ARHGAP10¹ ² ³		Rho-GTPase activating protein 10²
KIAA1424¹ ³ ⁵		DKFZp761L0424²
Rho-type GTPase-activating protein 21² ³		rho GTPase-activating protein 21²
Rho GTPase-activating protein 10² ³		FLJ90108²
FLJ33323²

External Ids:	HGNC: 23725¹	Entrez Gene: 57584²	Ensembl: ENSG00000107863⁷	UniProtKB: Q5T5U3³

Export aliases for ARHGAP21 gene to outside databases

Previous GC identifers: GC10M024876 GC10M024912

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGAP21:

ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3

complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 (PubMed

15793564)).(supplied by OMIM)

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3

Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may

control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARHGAP21 gene promoter:
         Chx10   Hlf   E4BP4   POU2F2 (Oct-2.1)   POU2F2   POU2F2B   Oct-B1   POU2F2C   oct-B2   oct-B3
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ARHGAP21

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ARHGAP21

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1|10p12.3 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12.31

ARHGAP21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGAP21 gene location

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M024534: view genomic region (about GC identifiers)

Start:	24,534,090 bp from pter
End:	24,673,492 bp from pter
Size:	139,403 bases
Orientation:	minus strand

1 alternative location:

Chr10- 24,872,538-25,012,597

RefSeq DNA sequence:

NC_000010.10 NT_008705.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3 (See protein sequence)

Recommended Name: Rho GTPase-activating protein 21

Size: 1957 amino acids; 217331 Da

Subunit: Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1

Subcellular location: Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle

membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on

interaction with GTP-bound ARF1

Miscellaneous: Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers

Miscellaneous: Required for In1A-dependent entry of Listeria monocytogenes into cells

PDB structures from and Proteopedia :

2DHJ (3D)

2J59 (3D)

2YUY (3D)

Secondary accessions: Q0VF98 Q7Z3P7 Q8N3A2 Q8NI19 Q8TBV5 Q9P2C3

Alternative splicing: 2 isoforms: Q5T5U3-1 Q5T5U3-3

Explore the universe of human proteins at neXtProt for ARHGAP21: NX_Q5T5U3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_065875.3

ENSEMBL proteins:

ENSP00000388873 ENSP00000405018 ENSP00000389940 ENSP00000408073 ENSP00000379709 ENSP00000365592

ENSP00000365604 ENSP00000402761 ENSP00000400566

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for ARHGAP21
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005856	cytoskeleton	IEA	--

About this table

ARHGAP21 for ontologies About GeneDecksing

Antibodies for ARHGAP21:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ARHGAP21
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for ARHGAP21
	Browse antibodies at Epitomics

Assays for ARHGAP21:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ARHGAP21
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ARHGAP21

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARHGAP21 for domains About GeneDecksing

5 InterPro domains/families:

IPR008936 Rho_GTPase_activation_prot

IPR001849 Pleckstrin_homology

IPR011993 PH_type

IPR001478 PDZ/DHR/GLGF

IPR000198 RhoGAP_dom

Graphical View of Domain Structure for InterPro Entry Q5T5U3

ProtoNet protein and cluster: Q5T5U3

2 Blocks protein families:

IPB000198 RhoGAP domain

IPB001605 Spectrin pleckstrin homology domain signature

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 Rho-GAP domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3

Function: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may

control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions

Induction: Up-regulated upon cell differentiation

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ARHGAP21 Sigma-Aldrich shRNA for ARHGAP21
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ARHGAP21 OriGene shRNA RFP (see all 3): ARHGAP21 OriGene basic RS shRNA (see all 3): ARHGAP21 OriGene siRNA: ARHGAP21
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ARHGAP21

miRNA:		Sigma-Aldrich microRNA Mimics for ARHGAP21 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ARHGAP21
		8/10 SABiosciences Assays for microRNAs that regulate ARHGAP21 (see all 10):
		hsa-miR-148b hsa-miR-183 hsa-miR-548e hsa-miR-888 hsa-miR-548a-3p hsa-miR-152 hsa-miR-199a-5p hsa-miR-194

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ARHGAP21 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ARHGAP21 OriGene untagged cDNA clones in CMV expression vector: ARHGAP21 OriGene 3'-UTR clone: ARHGAP21 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ARHGAP21
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ARHGAP21

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IEA	--
GO:0005515	protein binding	IPI	--

About this table

ARHGAP21 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ARHGAP21

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARHGAP21

4 Interacting proteins for ARHGAP21 (Q5T5U3^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EEF1D	P29692¹	EBI-1642518,EBI-358607
SFN	P31947²	MINT-3974844
YWHAZ	P63104²	MINT-3295618
--	P84078²	MINT-4788426 MINT-4788412 MINT-4788399

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--

About this table

ARHGAP21 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARHGAP21

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ARHGAP21 Sigma-Aldrich shRNA for ARHGAP21
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): ARHGAP21 OriGene shRNA RFP (see all 3): ARHGAP21 OriGene basic RS shRNA (see all 3): ARHGAP21 OriGene siRNA: ARHGAP21
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ARHGAP21

miRNA:		Sigma-Aldrich microRNA Mimics for ARHGAP21 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ARHGAP21
		8/10 SABiosciences Assays for microRNAs that regulate ARHGAP21 (see all 10):
		hsa-miR-148b hsa-miR-183 hsa-miR-548e hsa-miR-888 hsa-miR-548a-3p hsa-miR-152 hsa-miR-199a-5p hsa-miR-194

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ARHGAP21 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ARHGAP21 OriGene untagged cDNA clones in CMV expression vector: ARHGAP21 OriGene 3'-UTR Clone: ARHGAP21 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ARHGAP21

Primers:		OriGene genome-wide validated SYBR primer pairs: ARHGAP21 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ARHGAP21: PPH19678A

REFSEQ mRNAs for ARHGAP21 gene:

NM_020824.3

Additional cDNA sequence:

AB037845.2 AF480466.1 AK090642.1 AK295649.1 AK297278.1 AK307604.1 AL834495.1 BC022931.1

BC118915.2

18 DOTS entries:

DT.444446 DT.99962095 DT.91952775 DT.121291442 DT.121343937 DT.91897476 DT.121343936 DT.92419733

DT.121291398 DT.121364000 DT.40273675 DT.100710705 DT.95207218 DT.99938162 DT.100656762 DT.121291470

DT.121306615 DT.453753

24/242 AceView cDNA sequences (see all 242):

BE856005 BM719318 AI373662 BQ959956 AW001808 BG152506 H71148 CF144610

AL701494 AW338526 BE550507 CF144649 AW593794 BM562264 AI160830 BQ574876

AA599905 AA587458 AA973435 AA236188 BQ027782 BP349812 AA527538 BM683250

highest scoring ESTs for ARHGAP21:

AF480466 AV709499 AV727505 W26091 AA130257 AA134110 AA451811 AA527538 AA554611 AA568361

Unigene Cluster for ARHGAP21:

Rho GTPase activating protein 21

Hs.524195 [show with all ESTs]

Unigene Representative Sequence: NM_020824

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP21 (see all 8)

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:			-		-						-												-		-
SP2:
SP3:											-												-		-		-
SP4:
SP5:					-

ExUns:	23	^	24	^	25a	·	25b	^	26	^	27a	·	27b	^	28	^	29
SP1:							-						-
SP2:							-						-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ARHGAP21
18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000472150 ENST00000477137 ENST00000445703 ENST00000446003(uc009xkl.1)

ENST00000476067 ENST00000418033 ENST00000447364 ENST00000396432 ENST00000376410

ENST00000486374 ENST00000320481(uc010qdb.1 uc001isb.2 uc010qdc.1 uc001isc.1)

ENST00000477190 ENST00000483114 ENST00000482792 ENST00000476499(uc001isd.1)

ENST00000418325 ENST00000416305 ENST00000493154

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ARHGAP21 expression in normal and diseased human tissues

¹ / ² / ³

9 probe-sets matching ARHGAP21 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
80095_at²^{, 3}	U95-D	1	1.00	1.00	0.38	1.17	AI271326	0.40	1.00	0.76	1
77357_at²^{, 3}	U95-D	2	1.00	0.97	0.94	0.79	AA974102	0.60	1.00	0.82	1
52927_at²^{, 3}	U95-B	1	0.94	1.00	0.97	1.02	W26091	0.80	0.88	0.84	1
72552_at²^{, 3}	U95-D	1	0.81	1.00	0.78	1.00	AI082290	0.60	1.00	0.82	1
74818_at²^{, 3}	U95-E	2	0.69	0.86	0.97	1.04	AI034337	0.80	0.83	0.82	1
241701_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF369489	0.20	0.50	0.38	1
224764_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB037845	0.60	1.00	0.82	1
241701_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224764_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

ARHGAP21 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ARHGAP21 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.524195

UniProtKB/Swiss-Prot: RHG21_HUMAN, Q5T5U3

Tissue specificity: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta

Primers:		OriGene genome-wide validated SYBR primer pairs: ARHGAP21 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ARHGAP21: PPH19678A

SABiosciences Custom PCR Arrays for ARHGAP21

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ARHGAP21 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ARHGAP21¹	--	Rho GTPase activating protein 21	99.52(n) 99.49(a)	450355 XM_507699.2 XP_507699.2
cow (Bos taurus)	ARHGAP21¹	--	Rho GTPase activating protein 21	84.63(n) 86.87(a)	538584 XM_581232.3 XP_581232.3
rat (Rattus norvegicus)	Arhgap21¹	--	Rho GTPase activating protein 21	83.07(n) 86.73(a)	307178 XM_225628.4 XP_225628.4
mouse (Mus musculus)	Arhgap21^{1 , 5}	2 (14.60 cM)⁵	Rho GTPase activating protein 21^{1, 5}	83.89(n)¹ 87.24(a)¹	71435¹ NM_001081364.1¹ NP_001074833.1¹ AA416458⁵ AI155273⁵ (see all 19)
chicken (Gallus gallus)	ARHGAP21¹	--	Rho GTPase activating protein 21	75.06(n) 74.87(a)	420500 XM_418602.2 XP_418602.2

About this table Species with no ortholog for ARHGAP21

ENSEMBL Gene Tree for ARHGAP21 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ARHGAP21 gene

ARHGAP5² ENSG00000214627² GRLF1² ENSG00000167433² IGHV3OR16-6² ARHGAP23²

ARHGAP21 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs10327^1,2	F	24872990(+)	`ACTGTA/GTTTTT`	1	--	ut3¹		1		MN	184
rs1127891^1,2	C	24873560(-)	`ACGACA/CGACAC`	2	T	syn¹ ref¹ ese³		0	--	--	--	--
rs1127893^1,2	C,F,A,H,	24873369(-)	`AGGCAA/C/GTAAAG`	3	N T S	mis¹ ref¹		6		MN NS EA NA	602
rs1127899^1,2	--	24873129(-)	`TAGTTA/GTATAC`	1	--	ut3¹		0	--	--	--	--
rs1127901^1,2	F	24873111(-)	`CAAGGT/CATTTG`	1	--	ut3¹		1		MN	184
rs1127930^1,2	--	24872629(-)	`TAATTC/TTGCAT`	1	--	ut3¹ ese³		0	--	--	--	--
rs1133897^1,2	F	24874438(-)	`CTGCTA/GCATAC`	2	T A	ref¹ mis¹ ese³		1		MN	184
rs1143050^1,2	C	24874391(-)	`GTGCAA/GTCCGT`	2	Q	ref¹ syn¹		0	--	--	--	--
rs1143051^1,2	F	24874386(-)	`ATCCGT/CGGCAG`	2	/A /V	mis¹ ref¹ ese³		1		MN	184
rs1143052^1,2	--	24874358(-)	`GCAGAT/CGACGA`	2	/D	syn¹ ref¹ ese³		1		MN	184

About this table

HapMap Linkage Disequilibrium images for ARHGAP21 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARHGAP21: --

QIAGEN SeqTarget long-range PCR primers for resequencing ARHGAP21

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARHGAP21 for disorders About GeneDecksing

OMIM: 609870

Human Genome Epidemiology (HuGE) Navigator: ARHGAP21 (1 document)

Export disorders and mutations for ARHGAP21 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/25 PubMed articles for ARHGAP21 gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with ARHGAP21)

ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. (PubMed id 12056806)^{1, 2, 3} Basseres D.S.... Saad S.T.O. (2002)
Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PubMed id 17347647)^{1, 2} Menetrey J.... Houdusse A. (2007)
Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. (PubMed id 15793564)^{1, 2} Dubois T.... Chavrier P. (2005)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (2000)
Characterization of human ARHGAP10 gene in silico. (PubMed id 15375573)^{2, 7} Katoh M. and Katoh M. (2004)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
ARHGAP21 modulates FAK activity and impairs glioblastoma cell migration. (PubMed id 19268501)¹ Bigarella C.L....Saad S.T. (2009)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)² Cantin G.T....Yates J.R. III (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57584	HGNC: 23725	AceView: ARHGAP21	Ensembl:ENSG00000107863	euGenes: HUgn57584
ECgene: ARHGAP21	H-InvDB: ARHGAP21

(According to HUGE)
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HUGE: KIAA1424

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for ARHGAP21 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for ARHGAP21 gene:
Search GeneIP for patents involving ARHGAP21

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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Search for Antibodies & Assays

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protein-coding GIFtS: 48

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