Aliases &
Descriptions
for ARHGDIA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| Rho GDP dissociation inhibitor (GDI) alpha1 2 | | GDIA12 3 | | RHOGDI1 2 | | MGC1172482 | | Rho GDI 12 3 | | rho GDP-dissociation inhibitor 12 | | Rho-GDI alpha2 3 | | RHOGDI-12 |
Export aliases for ARHGDIA gene to outside databasesPrevious GC identifers: GC17M079317 GC17M9I0128 GC17M080361 GC17M9I0504 GC17M9I7418 GC17M077419 GC17M079825 |
Summaries
for ARHGDIA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGDIA:
Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guaninenucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interactionwith GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 (PubMed 8262133)).(supplied by OMIM)
UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them,and the subsequent binding of GTP to them (By similarity)
Gene Wiki entry for ARHGDIA |
Genomic Views
for ARHGDIA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGDIA gene promoter:
AP-1 NF-kappaB1 Egr-1 C/EBPalpha MyoD p53 CUTL1 NF-kappaB c-Fos c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGDIA
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ARHGDIA  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3ARHGDIA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M075227: view genomic region
(about GC identifiers)
Start:
|
75,227,385 bp from pter |
End:
|
75,230,633 bp from pter |
Size:
|
3,249 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 79,825,598-79,829,238 |
RefSeq DNA sequence:- NC_000017.10 NT_010663.15
|
Proteins
for ARHGDIA gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565 (See
protein sequence)Recommended Name: Rho GDP-dissociation inhibitor 1 Size: 204 amino acids; 23207 Da
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm
PDB structures from  and Proteopedia  :1CC0 (3D)
1FSO (3D)
1FST (3D)
1FT0 (3D)
1FT3 (3D)
1HH4 (3D)
1KMT (3D)
1QVY (3D)
1RHO (3D)
2BXW (3D)
2JHS (3D)
2JHT (3D)
2JHU (3D)
2JHV (3D)
2JHW (3D)
2JHX (3D)
2JHY (3D)
2JHZ (3D)
2JI0 (3D)
Secondary accessions: B2R5X1 Q6IBM5Explore the universe of human proteins at neXtProt for ARHGDIA: NX_P52565
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_001172006.1 NP_001172007.1 NP_004300.1
ENSEMBL proteins: ENSP00000269321 ENSP00000383556
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ARHGDIA for ontologies About GeneDecksing
Antibodies for ARHGDIA:
Assays for ARHGDIA: |
Protein
Domains/
Families
for ARHGDIA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGDIA for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P52565ProtoNet protein and cluster: P52565 1 Blocks protein family: IPB000406 RHO protein GDP dissociation inhibitor signature
UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565Similarity: Belongs to the Rho GDI family |
Gene Function
for ARHGDIA gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them,and the subsequent binding of GTP to them (By similarity)
Genatlas biochemistry entry for ARHGDIA:Rho GDP-dissociation factor inhibitor (GDI) alpha,aplysia related4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
ARHGDIA for ontologies About GeneDecksing
Animal Models: 9 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Arhgdia):
ARHGDIA for phenotypes About GeneDecksing
|
Pathways & Interactions
for ARHGDIA gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
ARHGDIA for pathways About GeneDecksing
5/7  Millipore Pathways for ARHGDIA (see all 7)
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for ARHGDIA
2  Kegg Pathways (Kegg details for ARHGDIA):  | hsa04722 Neurotrophin signaling pathway | | hsa04962 Vasopressin-regulated water reabsorption |
SABiosciences Custom Pathway-Focused PCR Arrays for ARHGDIA
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ARHGDIA
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGDIA
5/112 Interacting proteins for ARHGDIA (P525651, 2 ENSP000002693213) via UniProtKB, MINT, and/or STRING (see all 112)About this table
5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11): About this table
ARHGDIA for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGDIA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
ARHGDIA for compounds About GeneDecksing
 Browse Tocris compounds for ARHGDIA
2  Novoseek chemical compound relationships for ARHGDIA gene
About this table
|
Transcripts
for ARHGDIA gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ARHGDIA gene (3 alternative transcripts): NM_001185077.1 NM_001185078.1 NM_004309.4 Additional cDNA sequence: AF498926.1 AK293147.1 AK300816.1 AK312347.1 BC005851.2 BC005875.2 BC007630.1 BC008701.3 BC009759.2 BC013846.1 BC016031.1 BC016185.1 BC024258.1 BC027730.2 BC028333.1 BC075827.1 BC106044.1 BT006884.1 CR456777.1 CR590519.1 CR594088.1 CR595053.1 CR597273.1 CR597482.1 CR598667.1 CR599297.1 CR600294.1 CR601042.1 CR603762.1 CR604600.1 CR606983.1 CR609352.1 CR609835.1 CR612591.1 CR612624.1 CR615458.1 CR617872.1 CR617926.1 CR619312.1 CR620401.1 CR620998.1 CR621432.1 CR624264.1 CR624605.1 D13989.1 M97579.1 X69550.1 24/52 DOTS entries (see all 52): DT.97856243 DT.91684644 DT.92471322 DT.100695007 DT.100767630 DT.97856170 DT.100694962 DT.95337225 DT.120995517 DT.95110686 DT.100039713 DT.100039717 DT.100039702 DT.100694992 DT.120995317 DT.100694978 DT.100694994 DT.100637405 DT.100649454 DT.100694986 DT.101985618 DT.120995363 DT.100637549 DT.100694971 24/367 AceView cDNA sequences (see all 367): AI368502 F07681 AA378122 AA578542 BM466416 AI936667 AI090279 CB139605 AI687437 CB528621 BU624345 T28915 BM819949 BQ946940 BC007630 CF455678 BU196600 BQ437686 AI077958 BI822739 BG822035 BU189076 BQ682738 AL563176
 highest scoring ESTs for ARHGDIA:X69550 AA722894 AL536027 AL536066 AL536798 AL538639 AL546412 AL547148 AL548508 AL549202 Unigene Cluster for ARHGDIA: Rho GDP dissociation inhibitor (GDI) alpha Hs.159161 [show with all ESTs]Unigene Representative Sequence: NM_001185077
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIA (see all 11)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | · | 7g | · | 7h | ^ | 8a | · | 8b | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for ARHGDIA
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269321(uc002kjk.1 uc002kbp.2 uc002kbq.2 uc002kbr.2 uc002kbs.1 uc002kbt.1 uc010dig.1)
ENST00000400721
|
Expression
for ARHGDIA gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ARHGDIA expression in normal and diseased human tissues
1 / 2 / 3 9 probe-sets matching ARHGDIA gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 40164_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
X69550 |
1.00 |
0.90 |
0.95 |
1 |
| 201167_x_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
D13989 |
0.60 |
1.00 |
0.82 |
1 |
| 213606_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AI571798 |
0.20 |
1.00 |
0.72 |
1 |
| 211716_x_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
BC005851 |
0.80 |
1.00 |
0.91 |
1 |
| 201168_x_at2, 3
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
NM_004309 |
0.60 |
1.00 |
0.82 |
1 |
| 201167_x_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 213606_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 211716_x_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 201168_x_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ARHGDIA for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGGCCTCCCC
SOURCE GeneReport for Unigene cluster: Hs.159161
Expression variation in blood from EXPOLDB for ARHGDIA SABiosciences Custom PCR Arrays for ARHGDIA
|
Orthologs
for ARHGDIA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ARHGDIA gene from 5/19 species (see all 19)
About this table Species with no ortholog for ARHGDIA
ENSEMBL Gene Tree for ARHGDIA (if available) |
Paralogs
for ARHGDIA gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ARHGDIA gene
- ARHGDIG2 ARHGDIB2
ARHGDIA for paralogs About GeneDecksing
|
Genomic Variants
for ARHGDIA gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ARHGDIA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ARHGDIA
3 CNVs: 30036 73078 5041 | | QIAGEN SeqTarget long-range PCR primers for resequencing ARHGDIA |
|
Disorders & Mutations
for ARHGDIA gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGDIA for disorders About GeneDecksing
OMIM: 601925
Export disorders and mutations for ARHGDIA gene to outside databases
|
Medical News
for ARHGDIA gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ARHGDIA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/67 PubMed articles for ARHGDIA gene, integrated from 7 sources (see all 67):
(articles sorted by number of sources associating them with ARHGDIA)- Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3. (PubMed id 9186513)1, 3 Wagner T....Scherer G. (1997)
- A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. (PubMed id 9195882)1, 2 Keep N.H.... Roberts G.C.K. (1997)
- Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton. (PubMed id 8262133)1, 2 Leffers H.... Celis J.E. (1993)
- Rho GDP dissociation inhibitor alpha expression corre lates with the outcome of CMF treatment in invasive ductal breast cancer. (PubMed id 20043072)1 Ronneburg H....Dittmer J. (2010)
- Gain of miR-151 on chromosome 8q24.3 facilitates tumo ur cell migration and spreading through downregulating RhoGDIA. (PubMed id 20305651)1 Ding J....He X. (2010)
- Regulation of Rho GTPase crosstalk, degradation and a ctivity by RhoGDI1. (PubMed id 20400958)1 Boulter E....Burridge K. (2010)
- Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. (PubMed id 20696765)1 Li X. and Lee A.Y. (2010 Oct 15)
- Sex-specific proteome differences in the anterior cin gulate cortex of schizophrenia. (PubMed id 20381070)1 Martins-de-Souza D....Turck C.W. (2010)
|
External Searches for ARHGDIA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARHGDIA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGDIA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARHGDIA gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ARHGDIA gene:
Search GeneIP for patents involving ARHGDIA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGDIA gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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| | |
 |  |  |  | |
 | Antibodies & Assays for ARHGDIA (RhoGDI) |
| | | | Search Tocris compounds for ARHGDIA |
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