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ARHGDIB Gene

protein-coding   GIFtS: 62

GC12M014864
Rho GDP dissociation inhibitor (GDI) beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: RAP1GN1, GDIA2, GDID4)
Products    

Aliases &
Descriptions
for ARHGDIB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
Rho GDP dissociation inhibitor (GDI) beta1 2     GDIA22 3
Ly-GDI1 2 3     Rho GDI 22 3
GDID42 3 5     D42 5
RhoGDI21 2     rho GDP-dissociation inhibitor 22
Rho-GDI beta2 3     LYGDI2
RAP1GN12 3     

External Ids:    HGNC: 6791   Entrez Gene: 3972   Ensembl: ENSG000001113487   UniProtKB: P525663   

Export aliases for ARHGDIB gene to outside databases

Previous GC identifers: GC12M014834 GC12M015239 GC12M014995 GC12M014986 GC12M015094


Summaries
for ARHGDIB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARHGDIB:
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM
179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization,
and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly
regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine
nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the
rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 (PubMed 8356058)).(supplied by OMIM)

UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566
Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them,
and the subsequent binding of GTP to them

Gene Wiki entry for ARHGDIB

Genomic Views
for ARHGDIB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGDIB gene promoter:
         NF-kappaB1   NF-kappaB   RFX1   TGIF   MEF-2A   PPAR-gamma1   PPAR-gamma2   CP1C   NF-Y   NF-YA   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ARHGDIB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

ARHGDIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGDIB gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014864:  view genomic region     (about GC identifiers)

Start:
 14,864,323 bp from pter
End:
 14,883,946 bp from pter
Size:
 19,624 bases
Orientation:
 minus strand

1 alternative location:
Chr12- 15,094,950-15,114,562     
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  

Proteins
for ARHGDIB gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566 (See protein sequence)
Recommended Name: Rho GDP-dissociation inhibitor 2  
Size: 201 amino acids; 22988 Da
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
1DS6 (3D)    
Secondary accessions: B5BU79

Explore the universe of human proteins at neXtProt for ARHGDIB: NX_P52566 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_001166.3  

    ENSEMBL proteins: 
    ENSP00000228945 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ARHGDIB
    OriGene Protein Over-expression Lysate: ARHGDIB
    GenScript Custom Purified and Recombinant Proteins Services for ARHGDIB 
    Novus Biologicals Protein for ARHGDIB
    Novus Biologicals Lysates for ARHGDIB
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm TAS16130169
    GO:0005829 cytosol TAS--
    GO:0005856 cytoskeleton TAS16130169
    GO:0016023 cytoplasmic membrane-bounded vesicle TAS9113980
    About this table

    ARHGDIB for ontologies           About GeneDecksing



    Antibodies for ARHGDIB: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ARHGDIB
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for ARHGDIB 
    Novus Biologicals Antibodies for ARHGDIB
    Epitomics antibodies for ARHGDIB

    Assays for ARHGDIB: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGDIB 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for ARHGDIB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARHGDIB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR014756 Ig_E-set
     IPR000406 Rho_GDI

    Graphical View of Domain Structure for InterPro Entry P52566

    ProtoNet protein and cluster: P52566

    1 Blocks protein family: IPB000406 RHO protein GDP dissociation inhibitor signature

    UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566
    Similarity: Belongs to the Rho GDI family


    Gene Function
    for ARHGDIB gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566
    Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them,
    and the subsequent binding of GTP to them

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for ARHGDIB
    Sigma-Aldrich shRNA Panels and shRNA for ARHGDIB
    OriGene 29mer shRNA kits in GFP-retroviral vector: ARHGDIB
    OriGene shRNA RFP: ARHGDIB
    OriGene basic RS shRNA: ARHGDIB
    OriGene siRNA: ARHGDIB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ARHGDIB 
    miRNA:Sigma-Aldrich microRNA Mimics for ARHGDIB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ARHGDIB 
    Search SABiosciences for Assays for microRNAs that regulate ARHGDIB

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ARHGDIB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ARHGDIB
    OriGene untagged cDNA clones in CMV expression vector: ARHGDIB
    OriGene 3'-UTR clone: ARHGDIB 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: ARHGDIB 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for ARHGDIB 

    Genatlas biochemistry entry for ARHGDIB:
    Rho GDP-dissociation inhibitor (GDI) beta,aplysia related,preferentially expressed in hematopoietic cells (signal
    transduction)

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005094 Rho GDP-dissociation inhibitor activity IEA--
    GO:0005096 GTPase activator activity IEA--
    GO:0005515 protein binding IEA--
    About this table

    ARHGDIB for ontologies           About GeneDecksing

    Animal Models: 7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Arhgdib):

    endocrine/exocrine glandhematopoietic systemhomeostasis/metabolismimmune systemlethality-prenatal/perinatal
    life span-post-weaning/agingreproductive system

    ARHGDIB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARHGDIB gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ARHGDIB for pathways           About GeneDecksing

    3 Millipore Pathways for ARHGDIB
        G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway
    G-protein signaling Regulation of RAC1 activity

    2 Kegg Pathways  (Kegg details for ARHGDIB):
        hsa04722 Neurotrophin signaling pathway
    hsa04962 Vasopressin-regulated water reabsorption

        SABiosciences Pathway-Focused PCR Arrays including ARHGDIB: PAHS-063A PAHS-088A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGDIB

    5/86 Interacting proteins for ARHGDIB (ENSP000002289453 P525662) via UniProtKB, MINT, and/or STRING (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC2P151532STRING: ENSP00000249071 MINT-16596 MINT-24949
    ABRENSP000003039093STRING: ENSP00000303909
    ARHGDIAENSP000002693213STRING: ENSP00000269321
    ARHGDIGENSP000003724203STRING: ENSP00000372420
    GDI1ENSP000003587563STRING: ENSP00000358756
    About this table

    5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928 cellular component movement TAS16130169
    GO:0006955 immune response TAS8356058
    GO:0007162 negative regulation of cell adhesion TAS9113980
    GO:0007264 small GTPase mediated signal transduction TAS--
    GO:0007266 Rho protein signal transduction TAS8356058
    About this table

    ARHGDIB for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARHGDIB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ARHGDIB for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGDIB
    3 Novoseek chemical compound relationships for ARHGDIB gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 78.1 5 7512369 (1), 15057873 (1), 8356058 (1), 18006811 (1) (see all 5)
    gtp 50.3 1 8356058 (1)
    tyrosine 10.5 2 10664460 (1), 12386169 (1)
    About this table



    Transcripts
    for ARHGDIB gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for ARHGDIB
    Sigma-Aldrich shRNA Panels and shRNA for ARHGDIB
    OriGene 29mer shRNA kits in GFP-retroviral vector: ARHGDIB
    OriGene shRNA RFP: ARHGDIB
    OriGene basic RS shRNA: ARHGDIB
    OriGene siRNA: ARHGDIB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ARHGDIB 
    miRNA: Sigma-Aldrich microRNA Mimics for ARHGDIB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ARHGDIB 
    Search SABiosciences for Assays for microRNAs that regulate ARHGDIB
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ARHGDIB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ARHGDIB
    OriGene untagged cDNA clones in CMV expression vector: ARHGDIB
    OriGene 3'-UTR Clone: ARHGDIB 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: ARHGDIB 
    Primers: OriGene genome-wide validated SYBR primer pairs: ARHGDIB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ARHGDIB: PPH00010A

    REFSEQ mRNAs for ARHGDIB gene: 

    NM_001175.4  

    Additional cDNA sequence: 

    AB451315.1 AB451445.1 AF498927.1 AK125625.1 AK311807.1 BC009200.2 CR590127.1 CR590876.1 
    CR596151.1 CR596642.1 CR605375.1 CR610137.1 CR615019.1 CR616298.1 CR624952.1 L07916.1 
    L20688.1 X69549.1 

    24/35 DOTS entries (see all 35):

    DT.100060471  DT.91847582  DT.91970763  DT.91793426  DT.92361848  DT.100678779  DT.75107035  DT.100678784 
    DT.92380919  DT.97765236  DT.100678782  DT.101967391  DT.95271574  DT.91769961  DT.121189599  DT.91984917 
    DT.100678780  DT.100871202  DT.80101095  DT.91769947  DT.95271572  DT.100049413  DT.121189624  DT.121189654 

    24/1002 AceView cDNA sequences (see all 1002):

    AI819959 AA352794 BU069955 AI193288 BM808661 AA632060 AA766542 BM849963 
    BQ690692 CR624952 BM509156 AL522096 AW075884 CR605375 CR615019 AJ705678 
    CD368069 AW574654 AA699606 AW050463 AA309545 AA369483 AJ713906 AA341535 

    highest scoring ESTs for ARHGDIB:

    X69549 AA220228 AA315743 AA355841 AA356997 AA360280 AA361859 AU098543 AV711917 AV763404 

    Unigene Cluster for ARHGDIB:

    Rho GDP dissociation inhibitor (GDI) beta
    Hs.504877  [show with all ESTs]
    Unigene Representative Sequence: AK125625


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIB (see all 10)

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
    SP1:                                -     -     -     -     -                       -           -                                       
    SP2:                                -     -     -     -     -                       -           -                                       
    SP3:                                -           -     -     -                       -           -                                       
    SP4:                                -     -     -     -     -                       -           -                                       
    SP5:                                -     -     -     -     -                       -           -                                       

    About this scheme

    ECgene alternative splicing isoforms for ARHGDIB
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000228945(uc001rcp.1 uc001rcq.1)

    Expression
    for ARHGDIB gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ARHGDIB expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching ARHGDIB gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1984_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X69549 1.00 1.00 1.00 1
    201288_at2, 3 U133-A 1 0.73 1.00 -- -- NM_001175 0.60 1.00 0.82 1
    1555812_a_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    201288_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    ARHGDIB for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ARHGDIB gene expression
    ARHGDIB gene electronic northern expression
    ARHGDIB gene sage expression
    About these images

    CGAP SAGE TAG: CTGGCGCGAG

    SOURCE GeneReport for Unigene cluster: Hs.504877

    Expression variation in blood from EXPOLDB for ARHGDIB

    Primers: OriGene genome-wide validated SYBR primer pairs: ARHGDIB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ARHGDIB: PPH00010A
        SABiosciences Expression via Pathway-Focused PCR Arrays including ARHGDIB: PAHS-063A PAHS-088A 


    Orthologs
    for ARHGDIB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ARHGDIB gene from 5/12 species (see all 12)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ARHGDIB1   -- Rho GDP dissociation inhibitor (GDI) beta 90.17(n)
    94.5(a)    		 486666  XM_543793.2  XP_543793.1 
    chimpanzee
    (Pan troglodytes)    		 ARHGDIB1   -- Rho GDP dissociation inhibitor (GDI) beta 98.84(n)
    100(a)    		 742002  XM_001158496.1  XP_001158496.1 
    cow
    (Bos taurus)    		 ARHGDIB1   -- Rho GDP dissociation inhibitor (GDI) beta 89(n)
    93.5(a)    		 327676  NM_175797.2  NP_786991.1 
    rat
    (Rattus norvegicus)    		 Arhgdib1   -- Rho, GDP dissociation inhibitor (GDI) beta 84.67(n)
    86(a)    		 362456  NM_001009600.1  NP_001009600.1 
    mouse
    (Mus musculus)    		 Arhgdib1 , 5 6 (66.72 cM)5
    		 Rho, GDP dissociation inhibitor (GDI) beta1, 5 84.17(n)1
    88(a)1    		 118571  NM_007486.21  NP_031512.11 
     AK0025165  AK1697335  (see all 7)
    About this table        Species with no ortholog for ARHGDIB

    ENSEMBL Gene Tree for ARHGDIB (if available)

    Paralogs
    for ARHGDIB gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ARHGDIB gene
    ARHGDIA2  ARHGDIG2  

    ARHGDIB for paralogs           About GeneDecksing



    Genomic Variants
    for ARHGDIB gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/263 NCBI SNPs in ARHGDIB are shown (see all 263)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs9211,2
    		C,F,O,A,15095162(-) AGCAAC/TTAGAG 1 -- ut31 ese326Minor allele frequency- T:0.12MN NA NS EA 2256
    rs47031,2
    		C,F,A,H,15095558(-) CTGGCC/GCGAGG 2 A syn1 ref122Minor allele frequency- G:0.49MN NS EA NA WA 1828
    rs9181241,2
    		C,F,O,A,H,15109571(+) TAATGC/TGGACC 1 -- int119Minor allele frequency- G:0.01MN EA NA NS WA 1048
    rs9181251,2
    		C,F,A,H,15112899(+) ATTAAA/GAAAAC 1 -- int113Minor allele frequency- G:0.18NS EA NA WA 642
    rs10515111,2
    		C15095007(-) GAGACA/CCTGTA 1 -- ut31 ese35Minor allele frequency- C:0.00MN 404
    rs14688901,2
    		C,F,O,A,H,15105318(+) AACTCT/AGAAAA 1 -- int113Minor allele frequency- A:0.18MN NS EA NA WA 822
    rs18039291,2
    		C15095623(-) GCTATG/TGACCT 2 G X ref1 15Minor allele frequency- T:0.00MN 392
    rs18616961,2
    		C,A,H15112916(+) CCAATG/AGCAAG 1 -- int11Minor allele frequency- A:0.25NA 4
    rs18616971,2
    		C,F,15112934(+) ATGCCT/GGCTAG 1 -- int19Minor allele frequency- G:0.01NS EA NA 846
    rs20752651,2
    		C,F,15100683(+) CAGACC/TCAGCT 1 -- int18Minor allele frequency- T:0.15NS NA EA WA 338
    About this table

    HapMap Linkage Disequilibrium images for ARHGDIB (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARHGDIB: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ARHGDIB 

    Disorders & Mutations
    for ARHGDIB gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARHGDIB for disorders           About GeneDecksing

    OMIM: 602843

    1 Novoseek disease relationship for ARHGDIB gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 2 15657050 (1), 18006811 (1)
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    Human Genome Epidemiology (HuGE) Navigator: ARHGDIB (5 documents)

    Export disorders and mutations for ARHGDIB gene to outside databases

    Medical News
    for ARHGDIB gene

    (Possibly Related Articles in Doctor's Guide)
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    		   --

    Publications
    for ARHGDIB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/51 PubMed articles for ARHGDIB gene, integrated from 7 sources (see all 51):
    (articles sorted by number of sources associating them with ARHGDIB)
    1. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. (PubMed id 8434008)1, 2, 3, 7 Lelias J.M.... Lim B. (1993)
    2. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. (PubMed id 8356058)1, 2, 3, 7 Scherle P.... Staudt L.M. (1993)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. (PubMed id 10655614)1, 2 Scheffzek K.... Gierschik P. (2000)
    6. Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton. (PubMed id 8262133)1, 2 Leffers H.... Celis J.E. (1993)
    7. Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database. (PubMed id 2226408)1, 2 Aebersold R. and Leavitt J. (1990)
    8. Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells. (PubMed id 18006811)1, 7 Schunke D....Dittmer J. (2007)
    9. Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways. (PubMed id 12386169)1, 7 Groysman M....Katzav S. (2002)
    10. Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation. (PubMed id 10664460)1, 7 Groysman M....Katzav S. (2000)

    External Searches for ARHGDIB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ARHGDIB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 397 HGNC: 679 AceView: ARHGDIB Ensembl:ENSG00000111348 euGenes: HUgn397
    ECgene: ARHGDIB Kegg: 397 H-InvDB: ARHGDIB

    Other Databases showing ARHGDIB gene

    (According to HUGE)
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    Specialized Databases showing ARHGDIB gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    Intellectual Property
    for ARHGDIB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for ARHGDIB gene:
    Search GeneIP for patents involving ARHGDIB

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