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ARMC9 Gene

protein-coding   GIFtS: 48

GC02P223905
armadillo repeat containing 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
armadillo repeat containing 91 2     Melanoma/melanocyte-specific tumor antigen KU-MEL-12 3
ARM1 2     NS212 3
KU-MEL-11 2     armadillo/beta-catenin-like repeats2
FLJ125841 2     lisH domain-containing protein ARMC92
KIAA18681 3     melanoma/melanocyte specific protein KU-MEL-12

External Ids:    HGNC: 207301   Entrez Gene: 802102   Ensembl: ENSG000001359317   UniProtKB: Q7Z3E53   

Export aliases for ARMC9 gene to outside databases

Previous GC identifers: GC02P231889 GC02P231771 GC02P232064


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARMC9 gene promoter:
         GATA-1   GATA-2   TBP   GATA-3   CUTL1   HNF-4alpha2   SRF   TFIID   FOXC1   FOXD3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ARMC9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ARMC9 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

ARMC9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMC9 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223905:  view genomic region     (about GC identifiers)

Start:
223,905,381 bp from pter
End:
224,051,159 bp from pter
Size:
145,779 bases
Orientation:
plus strand

1 alternative location:
Chr2+ 232,063,260-232,239,548     
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ARMC9_HUMAN, Q7Z3E5 (See protein sequence)
Recommended Name: LisH domain-containing protein ARMC9  
Size: 817 amino acids; 91762 Da
Sequence caution: Sequence=BAB14153.1; Type=Erroneous initiation;
Secondary accessions: Q53TI3 Q6P162 Q7L594 Q86WG2 Q96JF9 Q9H9R8
Alternative splicing: 2 isoforms:  Q7Z3E5-1   Q7Z3E5-2   

Explore the universe of human proteins at neXtProt for ARMC9: NX_Q7Z3E5 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_079415.3  

    ENSEMBL proteins: 
    ENSP00000258417 ENSP00000387391 ENSP00000407146 ENSP00000392086 ENSP00000413932 ENSP00000411778 
    ENSP00000388527 ENSP00000352781 


    Human Recombinant Proteins 
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    Uscn ELISAs and CLIAs for ARMC9 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARMC9 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011989 ARM-like
     IPR006594 LisH_dimerisation
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q7Z3E5

    ProtoNet protein and cluster: Q7Z3E5

    1 Blocks protein family: IPB006594 Lissencephaly type-1-like homology motif

    UniProtKB/Swiss-Prot: ARMC9_HUMAN, Q7Z3E5
    Similarity: Contains 1 LisH domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ARMC9
    Sigma-Aldrich shRNA for ARMC9
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ARMC9
    OriGene shRNA RFP (see all 2): ARMC9
    OriGene basic RS shRNA (see all 2): ARMC9
    OriGene siRNA (see all 2): ARMC9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ARMC9 
    miRNA:Sigma-Aldrich microRNA Mimics for ARMC9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ARMC9 
    Search SABiosciences for Assays for microRNAs that regulate ARMC9

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ARMC9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ARMC9
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ARMC9
    Browse 3'-UTR reporter clones for miRNA target validation 
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    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ARMC9 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488 binding IEA--
    About this table

    ARMC9 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ARMC9 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARMC9

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARMC9


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ARMC9
    Sigma-Aldrich shRNA for ARMC9
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ARMC9
    OriGene shRNA RFP (see all 2): ARMC9
    OriGene basic RS shRNA (see all 2): ARMC9
    OriGene siRNA (see all 2): ARMC9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ARMC9 
    miRNA: Sigma-Aldrich microRNA Mimics for ARMC9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ARMC9 
    Search SABiosciences for Assays for microRNAs that regulate ARMC9
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ARMC9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ARMC9
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ARMC9
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ARMC9 
    Primers: OriGene genome-wide validated SYBR primer pairs: ARMC9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ARMC9: PPH57746A

    REFSEQ mRNAs for ARMC9 gene: 

    NM_025139.3  

    Additional cDNA sequence: 

    AB058771.1 AK022646.1 AK309395.1 AY219922.1 AY929062.1 BC004514.2 BC017229.2 BC065271.1 
    BX537956.1 CR608697.1 

    14 DOTS entries:

    DT.87015163  DT.95210377  DT.86857823  DT.40207557  DT.105733  DT.401546  DT.100638454  DT.97858546 
    DT.120993262  DT.209017  DT.40129282  DT.421997  DT.100782611  DT.99993407 

    24/117 AceView cDNA sequences (see all 117):

    BM685292 BM990717 BQ423528 BM723527 BM988551 AB058771 AI741507 AI274627 
    AI342531 CN479949 BM835538 BX111921 AA309729 BC017229 CR608697 CA427360 
    Z38862 AI018174 BX103854 BC004514 BU183424 BG764906 BM563736 BF525768 

    highest scoring ESTs for ARMC9:

    AL534959 BG027609 BM685292 BM930775 BM990541 BX103854 CA427360 CB305674 CN479949 N39824 

    Unigene Cluster for ARMC9:

    Armadillo repeat containing 9
    Hs.471610  [show with all ESTs]
    Unigene Representative Sequence: AB058771


    GeneLoc Exon Structure

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000349938(uc002vrq.3 uc002vrp.3) ENST00000482392 ENST00000440107
    ENST00000483477(uc002vrr.1) ENST00000469789 ENST00000444285 ENST00000436339
    ENST00000467698 ENST00000424740 ENST00000446447 ENST00000481520 ENST00000428662
    ENST00000486787 ENST00000488821 ENST00000359743

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ARMC9 expression in normal and diseased human tissues

    1  / 2  / 3

    11 probe-sets matching ARMC9 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    50727_at2, 3 U95-B 1 1.00 1.00 0.95 0.54 N39824 0.80 1.00 0.91 1
    72926_at2, 3 U95-D 1 1.00 1.00 0.89 1.33 AI638332 0.60 1.00 0.82 1
    42681_at2, 3 U95-B 1 0.69 1.00 0.18 1.16 AA158623 0.60 1.00 0.82 1
    219636_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_025139 0.60 1.00 0.82 1
    219637_at2, 3 U133-A 1 0.91 1.00 -- -- NM_025139 0.60 1.00 0.82 1
    220754_at2, 3 U133-A 1 0.55 1.00 -- -- NM_024720 0.20 1.00 0.72 1
    235938_at2, 3 U133-B 1 0.46 1.00 -- -- AI018174 0.20 1.00 0.72 1
    219636_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    219637_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    220754_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    235938_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    ARMC9 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ARMC9 gene expression
    ARMC9 gene electronic northern expression
    ARMC9 gene sage expression
    About these images

    CGAP SAGE TAG: ACCAACACGG

    SOURCE GeneReport for Unigene cluster: Hs.471610

    UniProtKB/Swiss-Prot: ARMC9_HUMAN, Q7Z3E5
    Tissue specificity: Strongly expressed in most melanomas and melanocytes. Weakly expressed in the testis

    Primers: OriGene genome-wide validated SYBR primer pairs: ARMC9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ARMC9: PPH57746A
        SABiosciences Custom PCR Arrays for ARMC9 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ARMC9 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ARMC91   -- armadillo repeat containing 9 89.81(n)
    91.51(a)
    477407  XM_534602.2  XP_534602.2 
    cow
    (Bos taurus)
    ARMC91   -- armadillo repeat containing 9 89.51(n)
    90.96(a)
    536462  NM_001046418.1  NP_001039883.1 
    mouse
    (Mus musculus)
    Armc91 , 5 1 (43.94 cM)5
    armadillo repeat containing 91, 5 87.32(n)1
    92.33(a)1
    787951  NM_030184.21  NP_084460.11 
     AI5950885  AK0144505  (see all 25)
    chicken
    (Gallus gallus)
    ARMC91   -- armadillo repeat containing 9 75.54(n)
    79.88(a)
    424929  XM_422737.2  XP_422737.2 
    zebrafish
    (Danio rerio)
    AL918635.12   --   -- 75.2(n)  AL918635.1 
    About this table        Species with no ortholog for ARMC9

    ENSEMBL Gene Tree for ARMC9 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ARMC9
         1 Indel: 45961
    QIAGEN SeqTarget long-range PCR primers for resequencing ARMC9 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARMC9 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ARMC9 (3 documents)

    Export disorders and mutations for ARMC9 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/17 PubMed articles for ARMC9 gene, integrated from 7 sources (see all 17):
    (articles sorted by number of sources associating them with ARMC9)
    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Tumor antigens isolated from a patient with vitiligo and T-cell- infiltrated melanoma. (PubMed id 11691810)1, 2 Kiniwa Y.... Kawakami Y. (2001)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80210 HGNC: 20730 AceView: FLJ12584 Ensembl:ENSG00000135931 euGenes: HUgn80210
    ECgene: ARMC9 H-InvDB: ARMC9

    (According to HUGE)
    About This Section
    HUGE: KIAA1868

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ARMC9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ARMC9 gene:
    Search GeneIP for patents involving ARMC9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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    About This Section

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     Regulatory tfbs in ARMC9 promoter
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     ELISAs and CLIAs for ARMC9
           

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