Aliases &
Descriptions
for ASCC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| activating signal cointegrator 1 complex subunit 31 2 | | dJ467N11.11 | | Helicase, ATP binding 11 2 3 | | RNA helicase family2 | | RNAH1 2 | | B630009I04Rik2 | | ASC1p2001 2 | | DJ467N11.12 | | dJ121G13.41 2 | | MGC260742 | | Trip4 complex subunit p2002 3 | | OTTHUMP000000169052 | | ASC-1 complex subunit p2002 3 | | OTTHUMP000000169042 | | HELIC12 3 | | EC 3.6.4.-3 |
Export aliases for ASCC3 gene to outside databasesPrevious GC identifers: GC06M101063 GC06M100956 |
Summaries
for ASCC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HELC1_HUMAN, Q8N3C0Function: Enhances NF-kappa-B, SRF and AP1 transactivation
Gene Wiki entry for ASCC3 |
Genomic Views
for ASCC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASCC3 gene promoter:
NF-1 IRF-1 GATA-3 GATA-2 GATA-1 CUTL1 MyoD AP-4 RFX1 HNF-4alpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASCC3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ASCC3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q16 Ensembl cytogenetic band: 6q16.3 HGNC cytogenetic band: 6q16ASCC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M098395: view genomic region
(about GC identifiers)
Start:
|
98,395,506 bp from pter |
End:
|
98,771,546 bp from pter |
Size:
|
376,041 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr6- 100,956,070-101,329,248 |
RefSeq DNA sequence:- NC_000006.11 NT_025741.15
|
Proteins
for ASCC3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: HELC1_HUMAN, Q8N3C0 (See
protein sequence)Recommended Name: Activating signal cointegrator 1 complex subunit 3 Size: 2202 amino acids; 251460 Da
Subunit: Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAG45474.1; Type=Frameshift; Positions=2175; Sequence=CAA11679.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=CAA11679.1; Type=Frameshift; Positions=2175;
Secondary accessions: O43738 Q5VTN2 Q9H1I9 Q9NTR0Explore the universe of human proteins at neXtProt for ASCC3: NX_Q8N3C0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_006819.2 NP_071374.1
ENSEMBL proteins: ENSP00000358159 ENSP00000320252 ENSP00000430769 ENSP00000320777 ENSP00000358139
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ASCC3 for ontologies About GeneDecksing
Antibodies for ASCC3:
Assays for ASCC3: |
Protein
Domains/
Families
for ASCC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASCC3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8N3C0ProtoNet protein and cluster: Q8N3C0 UniProtKB/Swiss-Prot: HELC1_HUMAN, Q8N3C0Similarity: Belongs to the helicase familySimilarity: Contains 2 helicase ATP-binding domainsSimilarity: Contains 2 helicase C-terminal domainsSimilarity: Contains 3 SEC63 domains |
Gene Function
for ASCC3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: HELC1_HUMAN, Q8N3C0Function: Enhances NF-kappa-B, SRF and AP1 transactivationEnzyme Number (IUBMB): EC 3.6.4.-
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
ASCC3 for ontologies About GeneDecksing
|
Pathways & Interactions
for ASCC3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ASCC3
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASCC3
5/8 Interacting proteins for ASCC3 (ENSP000003202523 Q8N3C02) via UniProtKB, MINT, and/or STRING (see all 8)About this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045449 | regulation of transcription |
IEA | -- |
About this table
ASCC3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ASCC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ASCC3
|
Transcripts
for ASCC3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ASCC3 gene (2 alternative transcripts): NM_006828.2 NM_022091.3 Additional cDNA sequence: AJ223948.1 AK023189.1 AK299117.1 AK307903.1 AK315197.1 AL834463.1 AY013288.1 BC014358.1 BC026066.1 BC039857.1 BC050681.1 BC125211.1 BC125212.1 BC130038.1 CR936692.1 9 DOTS entries: DT.442902 DT.75101017 DT.100644004 DT.100784229 DT.100784230 DT.121333145 DT.92060157 DT.99927233 DT.121333097 24/167 AceView cDNA sequences (see all 167): CB122307 AL834463 AI889749 AA405505 CB124488 AI674903 BE503088 AI206167 AA039251 BU686034 BU742942 NM_006828 AI659742 AA788717 BM127434 BF431792 BF062402 BP335462 CB161288 NM_022091 AA989030 CK906074 BG941712 N58930
 highest scoring ESTs for ASCC3:AJ223948 BG718109 BQ082002 AA039251 AA156961 AA182699 AA216608 AA216718 AA219556 AA232371 Unigene Cluster for ASCC3: Activating signal cointegrator 1 complex subunit 3 Hs.486031 [show with all ESTs]Unigene Representative Sequence: NM_006828
GeneLoc Exon Structure
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369162(uc010kcv.2) ENST00000518006 ENST00000324696(uc003pqk.2 uc011eai.1 uc003pql.2)
ENST00000522650 ENST00000468245 ENST00000324723 ENST00000369143(uc003pqm.2)
|
Expression
for ASCC3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ASCC3 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching ASCC3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 75511_at2, 3
|
U95-E |
1 |
0.62 |
1.00 |
0.97 |
1.45 |
AI653055 |
0.60 |
1.00 |
0.82 |
1 |
| 36045_at2, 3
|
U95-A |
1 |
0.44 |
1.00 |
0.99 |
0.59 |
AJ223948 |
0.80 |
1.00 |
0.91 |
1 |
| 212815_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
AA156961 |
0.60 |
1.00 |
0.82 |
1 |
| 231269_at2, 3
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
AU153330 |
0.40 |
1.00 |
0.76 |
1 |
| 212815_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 231269_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ASCC3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTTAACTGGG
SOURCE GeneReport for Unigene cluster: Hs.486031
Expression variation in blood from EXPOLDB for ASCC3 UniProtKB/Swiss-Prot: HELC1_HUMAN, Q8N3C0Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for ASCC3
|
Orthologs
for ASCC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ASCC3 gene from 5/18 species (see all 18)
About this table Species with no ortholog for ASCC3
ENSEMBL Gene Tree for ASCC3 (if available) |
Paralogs
for ASCC3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ASCC3 gene
- SNRNP2002 HELQ2 POLQ2
ASCC3 for paralogs About GeneDecksing
|
Genomic Variants
for ASCC3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ASCC3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ASCC3
3 CNVs: 93914 81511 64607
1 Indel: 93915 | | QIAGEN SeqTarget long-range PCR primers for resequencing ASCC3 |
|
Disorders & Mutations
for ASCC3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASCC3 for disorders About GeneDecksing
Human Gene Mutation Database (HGMD): ASCC3
Human Genome Epidemiology (HuGE) Navigator: ASCC3 (5 documents)
Export disorders and mutations for ASCC3 gene to outside databases
|
Medical News
for ASCC3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ASCC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/21 PubMed articles for ASCC3 gene, integrated from 7 sources (see all 21):
(articles sorted by number of sources associating them with ASCC3)- Novel transcription coactivator complex containing activating signal cointegrator 1. (PubMed id 12077347)1, 2 Jung D.-J.... Lee Y.C. (2002)
- Antitumor immunity at work in a melanoma patient. (PubMed id 10218103)1, 3 Coulie P.G....Chiari R. (1999)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1 Liu C.Y....Christiani D.C. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for ASCC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ASCC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASCC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASCC3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ASCC3 gene:
Search GeneIP for patents involving ASCC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASCC3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for ASCC3 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for ASCC3 |
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