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ASGR2 Gene

protein-coding GIFtS: 51

GC17M006898

asialoglycoprotein receptor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
asialoglycoprotein receptor 2¹ ²		ASGPR 2² ³
CLEC4H2¹ ² ³		L-H2²
Hepatic lectin H2² ³		asialoglycoprotein receptor H2²
HL-2² ³		ASGP-R²
ASGP-R 2² ³		C-type lectin domain family 4, member H2²
C-type lectin domain family 4 member H2² ³

External Ids:	HGNC: 743¹	Entrez Gene: 433²	Ensembl: ENSG00000161944⁷	UniProtKB: P07307³

Export aliases for ASGR2 gene to outside databases

Previous GC identifers: GC17M007393 GC17M007735 GC17M006949 GC17M007205 GC17M006945 GC17M007004

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASGR2:

This cell surface receptor binds to galactose-terminated glycoproteins. It transports these glycoproteins via a series

of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the

receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene.

(provided by RefSeq)

UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307

Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex

carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units.

After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle,

where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ASGR2 gene promoter:
         C/EBPbeta   RelA   NF-kappaB1   NF-kappaB   MEF-2A   E47   Hlf   C/EBPalpha   deltaCREB   CREB
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ASGR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p

ASGR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASGR2 gene location

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M006898: view genomic region (about GC identifiers)

Start:	6,898,025 bp from pter
End:	6,911,467 bp from pter
Size:	13,443 bases
Orientation:	minus strand

1 alternative location:

Chr17- 7,004,641-7,018,142

RefSeq DNA sequence:

NC_000017.10 NT_010718.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307 (See protein sequence)

Recommended Name: Asialoglycoprotein receptor 2

Size: 311 amino acids; 35092 Da

Subunit: The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2

Subcellular location: Membrane; Single-pass type II membrane protein

Miscellaneous: Calcium is required for ligand binding

Secondary accessions: A6NLV8 A8MT12 O00448 Q03969

Alternative splicing: 3 isoforms: P07307-1 P07307-2 P07307-3

Explore the universe of human proteins at neXtProt for ASGR2: NX_P07307

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001172.1 NP_550434.1 NP_550435.1 NP_550436.1

ENSEMBL proteins:

ENSP00000370329 ENSP00000416949 ENSP00000254850 ENSP00000405844 ENSP00000347140 ENSP00000408409

ENSP00000370339 ENSP00000411881

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ASGR2 OriGene Protein Over-expression Lysate (see all 3): ASGR2
	GenScript Custom Purified and Recombinant Proteins Services for ASGR2
	Novus Biologicals Protein for ASGR2
	Novus Biologicals Lysates for ASGR2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005730	nucleolus	IDA	18029348
GO:0005886	plasma membrane	IDA	18029348
GO:0005925	focal adhesion	IDA	18029348
GO:0016020	membrane	--	--

About this table

ASGR2 for ontologies About GeneDecksing

Antibodies for ASGR2:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ASGR2
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for ASGR2
	Novus Biologicals Antibodies for ASGR2
	Browse antibodies at Epitomics

Assays for ASGR2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ASGR2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ASGR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ASGR2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR005640 Lectin_N

IPR016187 C-type_lectin_fold

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry P07307

ProtoNet protein and cluster: P07307

2 Blocks protein families:

IPB002353 Type II antifreeze protein signature

IPB005640 Hepatic lectin

UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307

Similarity: Contains 1 C-type lectin domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307

Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex

carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units.

After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle,

where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ASGR2 Sigma-Aldrich shRNA for ASGR2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ASGR2 OriGene shRNA RFP (see all 4): ASGR2 OriGene basic RS shRNA (see all 4): ASGR2 OriGene siRNA (see all 4): ASGR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ASGR2

miRNA:		Sigma-Aldrich microRNA Mimics for ASGR2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ASGR2
		Search SABiosciences for Assays for microRNAs that regulate ASGR2

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): ASGR2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): ASGR2 OriGene untagged cDNA clones in CMV expression vector (see all 4): ASGR2 OriGene 3'-UTR clone (see all 2): ASGR2 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: ASGR2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ASGR2

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004873	asialoglycoprotein receptor activity	TAS	3863106
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	11543633
GO:0005529	sugar binding	IEA	--

About this table

ASGR2 for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Asgr2):

hematopoietic system

homeostasis/metabolism

immune system

life span-post-weaning/aging

ASGR2 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for ASGR2

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ASGR2

1 Interacting protein for ASGR2 (P07307¹) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LASS2	Q96G23¹	EBI-1172636,EBI-1057080

About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	IEA	--
GO:0007166	cell surface receptor linked signaling pathway	TAS	3863106
GO:0009100	glycoprotein metabolic process	IEA	--
GO:0031647	regulation of protein stability	IEA	--
GO:0055088	lipid homeostasis	IEA	--

About this table

ASGR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

ASGR2 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ASGR2
10/12 Novoseek chemical compound relationships for ASGR2 gene (see all 12)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pvla	87.3	9	11444822 (3), 14586135 (1), 16004427 (1), 16158256 (1)
galactose	69.8	21	18855599 (2), 9555658 (2), 15885467 (2), 17931643 (1) (see all 15)
sialic acid	42.4	2	17103087 (1), 9989767 (1)
spec-t	36.9	1	14575385 (1)
glycolipid	23.5	2	16254203 (1), 15509179 (1)
doxorubicin	17.1	4	15189276 (1), 11489324 (1), 20403430 (1)
lysine	6.87	2	7873664 (1), 7948096 (1)
ethanol	5.89	5	18336663 (3), 14986823 (1), 18161881 (1)
calcium	0	3	12477859 (1), 7844558 (1)
fatty acid	0	1	8668674 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ASGR2 Sigma-Aldrich shRNA for ASGR2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ASGR2 OriGene shRNA RFP (see all 4): ASGR2 OriGene basic RS shRNA (see all 4): ASGR2 OriGene siRNA (see all 4): ASGR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ASGR2

miRNA:		Sigma-Aldrich microRNA Mimics for ASGR2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ASGR2
		Search SABiosciences for Assays for microRNAs that regulate ASGR2

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): ASGR2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): ASGR2 OriGene untagged cDNA clones in CMV expression vector (see all 4): ASGR2 OriGene 3'-UTR Clone (see all 2): ASGR2 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: ASGR2

Primers:		OriGene genome-wide validated SYBR primer pairs: ASGR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ASGR2: PPH07059A

REFSEQ mRNAs for ASGR2 gene (4 alternative transcripts):

NM_001181.3 NM_080912.2 NM_080913.2 NM_080914.1

Additional cDNA sequence:

AF529374.1 AK303787.1 AK310123.1 BC017251.2 CR594935.1 M11025.1 U97197.1 X55283.1

X55284.1

4 DOTS entries:

DT.91677142 DT.92324210 DT.100755545 DT.95259760

24/65 AceView cDNA sequences (see all 65):

BQ651695 AI635553 CR594935 BC017251 NM_080913 AF529374 BQ647289 BQ648893

CB161601 BI252350 BI253022 BU506758 T27873 U97197 AL532507 NM_080912

M11025 X55284 BQ648417 BV197615 NM_080914 AL564408 BX283340 AW950089

highest scoring ESTs for ASGR2:

BC017251 BI252350 BI772605 BI911666 BM005917 BM561839 BX483468 CB111973 CB115380 M11025

Unigene Cluster for ASGR2:

Asialoglycoprotein receptor 2

Hs.654440 [show with all ESTs]

Unigene Representative Sequence: NM_080912

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ASGR2

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b
SP1:									-				-
SP2:													-
SP3:
SP4:									-
SP5:

About this scheme

ECgene alternative splicing isoforms for ASGR2
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380942 ENST00000456451 ENST00000254850(uc002geq.3 uc010clw.2 uc010vtl.1)

ENST00000446679 ENST00000355035 ENST00000436686 ENST00000380952(uc002gem.1 uc002gen.1 uc002geo.1 uc002gep.3 uc002ger.3)

ENST00000450034(uc010vtk.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ASGR2 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching ASGR2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37799_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X55284	0.80	1.00	0.91	1
206130_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001181	0.60	1.00	0.82	1
206130_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

ASGR2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ASGR2 gene electronic northern expression

About these images

CGAP SAGE TAG: GTCTGCTTCA

SOURCE GeneReport for Unigene cluster: Hs.654440

Expression variation in blood from EXPOLDB for ASGR2

UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307

Tissue specificity: Expressed exclusively in hepatic parenchymal cells

Primers:		OriGene genome-wide validated SYBR primer pairs: ASGR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ASGR2: PPH07059A

SABiosciences Custom PCR Arrays for ASGR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ASGR2 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ASGR2¹	--	asialoglycoprotein receptor 2	99.46(n) 98.69(a)	455238 XM_001168696.1 XP_001168696.1
cow (Bos taurus)	ASGR2¹	--	asialoglycoprotein receptor 2	80.16(n) 72.58(a)	531519 NM_001075952.1 NP_001069420.1
rat (Rattus norvegicus)	Asgr2¹	--	asialoglycoprotein receptor 2	76.11(n) 63.67(a)	29403 NM_017189.2 NP_058885.1
mouse (Mus musculus)	Asgr2^{1 , 5}	11 (42.99 cM)⁵	asialoglycoprotein receptor 2^{1, 5}	75.44(n)¹ 66(a)¹	11890¹ NM_007493.3¹ NP_031519.1¹ BC011197⁵ X53042⁵

About this table Species with no ortholog for ASGR2

ENSEMBL Gene Tree for ASGR2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ASGR2 gene

FCER2² CLEC10A² CD207² ASGR1² CLEC4M² CD209² CLEC4F²

ASGR2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs167536^1,2	C,	7015364(-)	`tccccC/TcTCTC`	4	--	int¹ trp³		0	--	--	--	--
rs190087^1,2	C,F,	7015109(-)	`cgtgtA/C/Tgacct`	4	--	int¹		4		NA	8
rs314233^1,2	C,F,A,	7008258(-)	`gagtgC/Taatgg`	4	--	int¹		5		MN NA	376
rs314234^1,2	C,F	7007864(-)	`tctccC/Tgagta`	4	--	int¹		4		MN NA	190
rs314235^1,2	--	7014791(-)	`tcaccA/Gtgtta`	4	--	int¹		0	--	--	--	--
rs314236^1,2	C,A,H,	7014367(-)	`tgctcT/Cgggat`	4	--	int¹		7		NA EA WA	220
rs314237^1,2	C,F,A,H,	7014235(-)	`tcctgT/Gcctgt`	4	--	int¹		8		NA EA WA	220
rs314238^1,2	C,F,A,H,	7014191(-)	`gtgatT/Cggagg`	4	--	int¹		8		NA EA WA	220
rs314239^1,2	C,F,A,H,	7013365(-)	`TGGGTC/TGGGGG`	4	--	int¹		13		NS EA NA WA	1054
rs367953^1,2	C,F,A	7016984(+)	`acaagA/Ttacac`	4	--	int¹		6		NS EA NA WA	302

About this table

HapMap Linkage Disequilibrium images for ASGR2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ASGR2: --

QIAGEN SeqTarget long-range PCR primers for resequencing ASGR2

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ASGR2 for disorders About GeneDecksing

OMIM: 108361

10/21 Novoseek disease relationships for ASGR2 gene (see all 21)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis autoimmune	61.6	6	19576873 (2), 8590155 (1), 15890353 (1), 7508490 (1) (see all 5)
hepatitis chronic active	57	3	1979365 (1), 1532926 (1), 12002624 (1)
hepatitis chronic	53.8	2	7508490 (1), 1955777 (1)
other liver diseases	51.8	1	16396634 (1)
liver diseases	42	5	1532926 (2), 15890353 (1), 1955777 (1), 8301043 (1)
hepatocellular carcinoma	41.9	7	10075085 (2), 16396634 (1), 10507763 (1), 20403430 (1) (see all 6)
liver damage	41.8	1	16920400 (1)
liver mass	40	1	9935069 (1)
autoimmune response	34.6	1	1955777 (1)
liver cirrhosis	29.5	1	12297928 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: ASGR2 (1 document)

Export disorders and mutations for ASGR2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/134 PubMed articles for ASGR2 gene, integrated from 7 sources (see all 134):
(articles sorted by number of sources associating them with ASGR2)

Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. (PubMed id 3863106)^{1, 2, 3} Spiess M. and Lodish H.F. (1985)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)^{1, 2} Pan H....Gu J.-R. (2001)
Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver. (PubMed id 1371982)^{1, 2} Paietta E.... Racevskis J. (1992)
H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid. (PubMed id 12089159)^{1, 7} Saxena A....Weigel P.H. (2002)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulat ion by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes . (PubMed id 19520807)¹ SA...Hoffmeister K.M. (2009)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 433	HGNC: 743	AceView: ASGR2	Ensembl:ENSG00000161944	euGenes: HUgn433
ECgene: ASGR2	H-InvDB: ASGR2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_216

Intellectual Property for ASGR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for ASGR2 gene:
Search GeneIP for patents involving ASGR2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

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Search for Antibodies & Assays

	Regulatory tfbs in ASGR2 promoter
	Search Chromatin IP Primers for ASGR2
	RT² qPCR Primer Assay for ASGR2
	Search GNC Networks for ASGR2
	Search for Assays for microRNAs that regulate ASGR2
	SABiosciences Custom PCR Arrays for ASGR2

Search Tocris compounds for ASGR2

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Browse antibodies at Epitomics

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ELISAs and CLIAs for ASGR2

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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