Aliases &
Descriptions
for ASMT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| acetylserotonin O-methyltransferase1 2 3 | | acetylserotonin methyltransferase (Y chromosome)2 | | HIOMT1 2 3 5 | | hydroxyindole O-methyltransferase2 | | ASMTY1 2 | | acetylserotonin N-methyltransferase2 | | HIOMTY1 2 | | EC 2.1.1.43 |
Export aliases for ASMT gene to outside databasesPrevious GC identifers: GC0XP001185 GC0XP001125 GC0XP001294 GC0XP001359 GC0XP001356 GC0YP001758 GC0XP001758 |
Summaries
for ASMT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ASMT:
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the endof the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis ofmelatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for thisgene. (provided by RefSeq)
|
Genomic Views
for ASMT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASMT gene promoter:
p53 NF-kappaB NF-kappaB1 RelA
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASMT
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.3 or Yp11.3 Ensembl cytogenetic band: Xp22.33 HGNC cytogenetic band: Xp22.3 and Yp11.3ASMT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP001674: view genomic region
(about GC identifiers)
Start:
|
1,714,348 bp from pter |
End:
|
1,761,974 bp from pter |
Size:
|
47,627 bases |
Orientation:
|
plus strand |
1 alternative location:
| ChrY+ 1,664,348-1,711,974 |
|
Proteins
for ASMT gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597 (See
protein sequence)Recommended Name: Hydroxyindole O-methyltransferase Size: 345 amino acids; 38453 Da
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Ychromosomes
Secondary accessions: B2RC33 Q16598 Q5JQ72 Q5JQ73Alternative splicing: 3 isoforms: P46597-1 P46597-2 P46597-3 Explore the universe of human proteins at neXtProt for ASMT: NX_P46597
REFSEQ proteins (3 alternative transcripts):
NP_001164509.1 NP_001164510.1 NP_004034.2
ENSEMBL proteins: ENSP00000370631 ENSP00000392053 ENSP00000370627 ENSP00000370639
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): About this table
ASMT for ontologies About GeneDecksing
Antibodies for ASMT:
Assays for ASMT: |
Protein
Domains/
Families
for ASMT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASMT for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P46597ProtoNet protein and cluster: P46597 1 Blocks protein family: IPB001077 O-methyltransferase
UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597Similarity: Belongs to the methyltransferase superfamily |
Gene Function
for ASMT gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597Catalytic activity: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine +N-acetyl-5-methoxytryptamineEnzyme Number (IUBMB): EC 2.1.1.4
Genatlas biochemistry entry for ASMT:methyltransferase,hydroxyindole-O,catalyzing the final step of melatonin synthesis,expressed in the pineal gland5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
ASMT for ontologies About GeneDecksing
|
Pathways & Interactions
for ASMT gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
ASMT for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for ASMT
2  Kegg Pathways (Kegg details for ASMT):
UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2 SABiosciences Pathway-Focused PCR Array including ASMT: PAHS-069A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ASMT
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASMT
5/38 Interacting proteins for ASMT (ENSP000003706393) via UniProtKB, MINT, and/or STRING (see all 38) About this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
ASMT for ontologies About GeneDecksing
|
Drugs & Compounds
for ASMT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
ASMT for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for ASMT |
 Browse Tocris compounds for ASMT
7  Novoseek chemical compound relationships for ASMT gene
About this table
|
Transcripts
for ASMT gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ASMT gene (3 alternative transcripts): NM_001171038.1 NM_001171039.1 NM_004043.2 24/301 AceView cDNA sequences (see all 301): AW978405 AI217889 AA975839 AI129402 BE646344 BM510017 BQ433141 NM_004043 AI083532 U11090 BX105929 CR620922 AI189957 AL041971 AI885136 AI433949 BQ930425 NM_005088 U11091 AI143357 AI810064 BE858964 AA768174 BC028151
 highest scoring ESTs for ASMT:U11098 AA719545 AI631730 AI825554 AW003492 BC001620 BE251419 BE778984 BE782544 BF057067
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ASMT
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for ASMT
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381233 ENST00000432523 ENST00000381229 ENST00000381241(uc004cqd.2 uc010ncy.2 uc004cqe.2)
|
Expression
for ASMT gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ASMT expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching ASMT gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 35447_s_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
U11098 |
0.20 |
1.00 |
0.72 |
1 |
| 206779_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_004043 |
0.40 |
0.50 |
0.45 |
1 |
| 210551_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
BC001620 |
0.60 |
0.62 |
0.61 |
1 |
| 206779_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 210551_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ASMT for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
Expression variation in blood from EXPOLDB for ASMT UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597Tissue specificity: Most abundant in pineal gland, less in retina and brain, not in pigment epithelium
SABiosciences Expression via Pathway-Focused PCR Array including ASMT: PAHS-069A
|
Orthologs
for ASMT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ASMT gene from 5/6 species (see all 6)
About this table Species with no ortholog for ASMT
ENSEMBL Gene Tree for ASMT (if available) |
Paralogs
for ASMT gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ASMT gene
- ASMTL2
ASMT for paralogs About GeneDecksing
|
Genomic Variants
for ASMT gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for ASMT
11 CNVs: 97147 73910 83261 83259 73908 73909 96390 83898 83899 83260 83258
3 Indels: 47793 47791 47792 | | QIAGEN SeqTarget long-range PCR primers for resequencing ASMT |
|
Disorders & Mutations
for ASMT gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASMT for disorders About GeneDecksing
OMIM: 300015
5 Novoseek disease relationships for ASMT gene
About this table
Locus Specific Mutation Databases (LSDB): ASMT
Human Gene Mutation Database (HGMD): ASMT
Human Genome Epidemiology (HuGE) Navigator: ASMT (3 documents)
Export disorders and mutations for ASMT gene to outside databases
|
Medical News
for ASMT gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ASMT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/48 PubMed articles for ASMT gene, integrated from 7 sources (see all 48):
(articles sorted by number of sources associating them with ASMT)- Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. (PubMed id 8397829)1, 2, 3, 7 Donohue S.J.... Klein D.C. (1993)
- Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. (PubMed id 7989373)1, 2, 3, 7 Rodriguez I.R....Chader G.J. (1994)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutation screening of melatonin-related genes in pati ents with autism spectrum disorders. (PubMed id 20377855)1, 7 Jonsson L....Melke J. (2010)
- Single-nucleotide polymorphisms and mRNA expression f or melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. (PubMed id 20433639)1, 7 GaA8ecki P....Karbownik-LewiA8ska M. (2010)
- Expression of hydroxyindole-O-methyltransferase enzym e in the human central nervous system and in pineal parenchymal cell tumors. (PubMed id 20418777)1, 7 Fukuda T....Saito S. (2010)
- Localization of the hydroxyindole-O-methyltransferase gene to the pseudoautosomal region: implications for mapping of psychiatric disorders. (PubMed id 8098975)1, 7 Yi H....McBride O.W. (1993)
- Linkage and candidate gene studies of autism spectrum disorders in European populations. (PubMed id 20442744)1 Holt R....Monaco A.P. (2010)
- Abnormal melatonin synthesis in autism spectrum disorders. (PubMed id 17505466)1 Melke J....Bourgeron T. (2008)
|
External Searches for ASMT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ASMT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASMT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASMT gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/5-hydroxyindole-O-methyltransferase |
|
| | |
About This Section
| Patent Information for ASMT gene:
Search GeneIP for patents involving ASMT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASMT gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for ASMT |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for ASMT |
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