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ASMT Gene

protein-coding   GIFtS: 51

GC0XP001674
acetylserotonin O-methyltransferase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
acetylserotonin O-methyltransferase1 2 3     acetylserotonin methyltransferase (Y chromosome)2
HIOMT1 2 3 5     hydroxyindole O-methyltransferase2
ASMTY1 2     acetylserotonin N-methyltransferase2
HIOMTY1 2     EC 2.1.1.43

External Ids:    HGNC: 7501   Entrez Gene: 4382   Ensembl: ENSG000001964337   UniProtKB: P465973   

Export aliases for ASMT gene to outside databases

Previous GC identifers: GC0XP001185 GC0XP001125 GC0XP001294 GC0XP001359 GC0XP001356 GC0YP001758 GC0XP001758


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASMT:
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end
of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of
melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this
gene. (provided by RefSeq)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASMT gene promoter:
         p53   NF-kappaB   NF-kappaB1   RelA   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ASMT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3 or Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3 and Yp11.3

ASMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASMT gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP001674:  view genomic region     (about GC identifiers)

Start:
1,714,348 bp from pter
End:
1,761,974 bp from pter
Size:
47,627 bases
Orientation:
plus strand

1 alternative location:
ChrY+ 1,664,348-1,711,974     

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597 (See protein sequence)
Recommended Name: Hydroxyindole O-methyltransferase  
Size: 345 amino acids; 38453 Da
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Secondary accessions: B2RC33 Q16598 Q5JQ72 Q5JQ73
Alternative splicing: 3 isoforms:  P46597-1   P46597-2   P46597-3   

Explore the universe of human proteins at neXtProt for ASMT: NX_P46597 

REFSEQ proteins (3 alternative transcripts): 
NP_001164509.1  NP_001164510.1  NP_004034.2  


ENSEMBL proteins: 
ENSP00000370631 ENSP00000392053 ENSP00000370627 ENSP00000370639 


Human Recombinant Proteins 
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Browse OriGene Protein Over-expression Lysates
GenScript Custom Purified and Recombinant Proteins Services for ASMT 
Novus Biologicals Proteins for ASMT
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005829 cytosol EXP7989373
About this table

ASMT for ontologies           About GeneDecksing



Antibodies for ASMT: 
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Browse antibodies at Epitomics

Assays for ASMT: 
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Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for ASMT 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ASMT for domains           About GeneDecksing

3 InterPro domains/families:
 IPR016461 O-MeTrfase_COMT_euk
 IPR011991 WHTH_trsnscrt_rep_DNA-bd
 IPR001077 O_MeTrfase_2

Graphical View of Domain Structure for InterPro Entry P46597

ProtoNet protein and cluster: P46597

1 Blocks protein family: IPB001077 O-methyltransferase

UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597
Similarity: Belongs to the methyltransferase superfamily


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597
Catalytic activity: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine +
N-acetyl-5-methoxytryptamine
Enzyme Number (IUBMB): EC 2.1.1.4 

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ASMT
Sigma-Aldrich shRNA for ASMT
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ASMT
OriGene shRNA RFP (see all 4): ASMT
OriGene basic RS shRNA (see all 4): ASMT
OriGene siRNA (see all 4): ASMT
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ASMT 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ASMT 
Search SABiosciences for Assays for microRNAs that regulate ASMT

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ASMT
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ASMT
OriGene untagged cDNA clones in CMV expression vector (see all 2): ASMT
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ASMT 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for ASMT 

Genatlas biochemistry entry for ASMT:
methyltransferase,hydroxyindole-O,catalyzing the final step of melatonin synthesis,expressed in the pineal gland

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008171 O-methyltransferase activity TAS8397829
GO:0008172 S-methyltransferase activity EXP7989373
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity ----
GO:0016740 transferase activity IEA--
GO:0017096 acetylserotonin O-methyltransferase activity IEA--
About this table

ASMT for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


ASMT for pathways           About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  ASMT
    Tryptophan Metabolism

2 Kegg Pathways  (Kegg details for ASMT):
    hsa00380 Tryptophan metabolism
hsa01100 Metabolic pathways

UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597
Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2

    SABiosciences Pathway-Focused PCR Array including ASMT: PAHS-069A 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ASMT
    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASMT

5/38 Interacting proteins for ASMT (ENSP000003706393) via UniProtKB, MINT, and/or STRING (see all 38)

InteractantInteraction Details
GeneCardExternal ID(s)
AANATENSP000002506153STRING: ENSP00000250615
ALDH1B1ENSP000003669273STRING: ENSP00000366927
ALDH2ENSP000002617333STRING: ENSP00000261733
ALDH3A1ENSP000003345903STRING: ENSP00000334590
ALDH3A2ENSP000003457743STRING: ENSP00000345774
About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006412 translation TAS8397829
GO:0030187 melatonin biosynthetic process IEA--
GO:0042446 hormone biosynthetic process TAS--
About this table

ASMT for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

ASMT for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Enzo Life Sciences drugs & compounds for ASMT

Browse Tocris compounds for ASMT
7 Novoseek chemical compound relationships for ASMT gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
arylalkylamine 90.6 8 10338362 (1), 16150106 (1), 20377855 (1), 10496148 (1) (see all 8)
melatonin 84.2 66 20377855 (3), 10801305 (3), 10338362 (2), 10496148 (2) (see all 31)
dbc-amp 43 9 10496148 (4), 2162375 (1)
cyclic amp 38.2 2 2054606 (1), 10496148 (1)
butyrate 31.9 10 10496148 (5), 2162375 (1)
5-hydroxytryptamine 25.1 1 14675129 (1)
oligonucleotide 6.09 2 8397829 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ASMT
Sigma-Aldrich shRNA for ASMT
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ASMT
OriGene shRNA RFP (see all 4): ASMT
OriGene basic RS shRNA (see all 4): ASMT
OriGene siRNA (see all 4): ASMT
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ASMT 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ASMT 
Search SABiosciences for Assays for microRNAs that regulate ASMT
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ASMT
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ASMT
OriGene untagged cDNA clones in CMV expression vector (see all 2): ASMT
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for ASMT 
Primers: OriGene genome-wide validated SYBR primer pairs: ASMT
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ASMT: PPH13405A

REFSEQ mRNAs for ASMT gene (3 alternative transcripts): 

NM_001171038.1  NM_001171039.1  NM_004043.2  

24/301 AceView cDNA sequences (see all 301):

AW978405 AI217889 AA975839 AI129402 BE646344 BM510017 BQ433141 NM_004043 
AI083532 U11090 BX105929 CR620922 AI189957 AL041971 AI885136 AI433949 
BQ930425 NM_005088 U11091 AI143357 AI810064 BE858964 AA768174 BC028151 

highest scoring ESTs for ASMT:

U11098 AA719545 AI631730 AI825554 AW003492 BC001620 BE251419 BE778984 BE782544 BF057067 


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ASMT

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1:                                      -                       -     -                     
SP2:                                      -           -     -     -     -                     
SP3:                                            -     -     -                                 
SP4:                                                                                          

About this scheme

ECgene alternative splicing isoforms for ASMT
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000381233 ENST00000432523 ENST00000381229 ENST00000381241(uc004cqd.2 uc010ncy.2 uc004cqe.2)


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ASMT expression in normal and diseased human tissues

1  / 2  / 3

5 probe-sets matching ASMT gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
35447_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U11098 0.20 1.00 0.72 1
206779_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004043 0.40 0.50 0.45 1
210551_s_at2, 3 U133-A 1 0.91 1.00 -- -- BC001620 0.60 0.62 0.61 1
206779_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
210551_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
About this table

ASMT for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
ASMT gene expression
ASMT gene electronic northern expression
ASMT gene sage expression
About these images

CGAP SAGE TAG: --

Expression variation in blood from EXPOLDB for ASMT

UniProtKB/Swiss-Prot: HIOM_HUMAN, P46597
Tissue specificity: Most abundant in pineal gland, less in retina and brain, not in pigment epithelium

Primers: OriGene genome-wide validated SYBR primer pairs: ASMT
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for ASMT: PPH13405A
    SABiosciences Expression via Pathway-Focused PCR Array including ASMT: PAHS-069A 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ASMT gene from 5/6 species (see all 6)
Organism Gene Locus Description Human
Similarity
NCBI accessions
rat
(Rattus norvegicus)
Asmt1   -- acetylserotonin O-methyltransferase 59.48(n)
51.5(a)
246281  NM_144759.1  NP_653360.1 
chicken
(Gallus gallus)
ASMT1   -- acetylserotonin O-methyltransferase 62.51(n)
57.1(a)
396286  NM_205343.1  NP_990674.1 
zebrafish
(Danio rerio)
zgc:1718851   -- zgc:171885 61.11(n)
51.82(a)
100141344  NM_001114909.1  NP_001108381.1 
tropical clawed frog
(Silurana tropicalis)
Str.84922   -- Transcribed sequence with weak similarity to protein more 71(n)  CF591017.1 
thale cress
(Arabidopsis thaliana)
ATOMT11   -- ATOMT1 (O-METHYLTRANSFERASE 1) 41.97(n)
28.52(a)
835504  NM_124796.3  NP_200227.1 
About this table        Species with no ortholog for ASMT

ENSEMBL Gene Tree for ASMT (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for ASMT gene
ASMTL2  

ASMT for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for ASMT
     11 CNVs: 97147 73910 83261 83259 73908 73909 96390 83898 83899 83260 83258
     3 Indels: 47793 47791 47792
QIAGEN SeqTarget long-range PCR primers for resequencing ASMT 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ASMT for disorders           About GeneDecksing

OMIM: 300015

5 Novoseek disease relationships for ASMT gene

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pineocytoma 82.4 6 10831155 (4), 16825954 (1)
pineal tumors 79.6 2 10831155 (1)
pineoblastoma 79.2 6 10831155 (4), 16825954 (1)
retinoblastoma 58.6 5 10496148 (2), 8842389 (1), 2162375 (1), 8574683 (1)
tumors 0 6 10831155 (2), 20418777 (1)
About this table

Locus Specific Mutation Databases (LSDB): ASMT
Human Gene Mutation Database (HGMD): ASMT
Human Genome Epidemiology (HuGE) Navigator: ASMT (3 documents)

Export disorders and mutations for ASMT gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/48 PubMed articles for ASMT gene, integrated from 7 sources (see all 48):
(articles sorted by number of sources associating them with ASMT)
  1. Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. (PubMed id 8397829)1, 2, 3, 7 Donohue S.J.... Klein D.C. (1993)
  2. Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. (PubMed id 7989373)1, 2, 3, 7 Rodriguez I.R....Chader G.J. (1994)
  3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Mutation screening of melatonin-related genes in pati ents with autism spectrum disorders. (PubMed id 20377855)1, 7 Jonsson L....Melke J. (2010)
  6. Single-nucleotide polymorphisms and mRNA expression f or melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. (PubMed id 20433639)1, 7 GaA8ecki P....Karbownik-LewiA8ska M. (2010)
  7. Expression of hydroxyindole-O-methyltransferase enzym e in the human central nervous system and in pineal parenchymal cell tumors. (PubMed id 20418777)1, 7 Fukuda T....Saito S. (2010)
  8. Localization of the hydroxyindole-O-methyltransferase gene to the pseudoautosomal region: implications for mapping of psychiatric disorders. (PubMed id 8098975)1, 7 Yi H....McBride O.W. (1993)
  9. Linkage and candidate gene studies of autism spectrum disorders in European populations. (PubMed id 20442744)1 Holt R....Monaco A.P. (2010)
  10. Abnormal melatonin synthesis in autism spectrum disorders. (PubMed id 17505466)1 Melke J....Bourgeron T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 438 HGNC: 750 AceView: ASMT.1 Ensembl:ENSG00000196433 euGenes: HUgn438
ECgene: ASMT Kegg: 438 H-InvDB: ASMT

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
Wikipedia http://en.wikipedia.org/wiki/5-hydroxyindole-O-methyltransferase

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for ASMT gene:
Search GeneIP for patents involving ASMT

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 Predesigned and custom siRNAs for ASMT Browse antibodies at Sigma-Aldrich
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 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
 Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
 Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 3' UTR Clones for miRNA Target Studies
 miRNA Expression Plasmids

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ASMT
 SeqTarget long-range PCR primers for resequencing ASMT
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ASMT
 GenScript Custom Purified and Recombinant Proteins Services for ASMT GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ASMT
 GenScript Custom Assay Services for ASMT GenScript Superior Antibodies for ASMT
 GenScript Custom overexpressing Cell Line Services for ASMT CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in ASMT promoter
 Search Chromatin IP Primers for ASMT
 RT2 qPCR Primer Assay for ASMT
 Search GNC Networks for ASMT
 Search for Assays for microRNAs that regulate ASMT
 SABiosciences PCR Arrays including ASMT
 Search Tocris compounds for ASMT
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Drugs for ASMT
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 Antibodies for ASMT
 Proteins for ASMT
 Browse antibodies at Epitomics
 Browse ProSpec Recombinant Proteins

 ELISAs and CLIAs for ASMT
       

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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