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Aliases & Descriptionsfor AWAT2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions acyl-CoA wax alcohol acyltransferase 21 2 DC42 3 MFAT1 2 3 diacylglycerol O-acyltransferase 2-like 41 Diacylglycerol O-acyltransferase 2-like protein 42 3 OTTHUMP000002172802 Multifunctional O-acyltransferase2 3 Wax synthase3 Diacylglycerol O-acyltransferase candidate 42 3 hDC43 Long-chain-alcohol O-fatty-acyltransferase 22 3 hWS3 DGAT2L42 3 EC 2.3.1.753 WS2 3
Export aliases for AWAT2 gene to outside databases Previous GC identifer: GC0XM069178
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Summariesfor AWAT2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for AWAT2 : This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. (provided by RefSeq) UniProtKB/Swiss-Prot: AWAT2_HUMAN, Q6E213 Function : Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids toproduce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo
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Genomic Viewsfor AWAT2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for AWAT2 Other transcription factors Search SABiosciences Chromatin IP Primers for AWAT2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1 AWAT2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM063081: view genomic region
(about GC identifiers )
Start:
63,081,194 bp from pter
End:
63,090,585 bp from pter
Size:
9,392 bases
Orientation:
minus strand
1 alternative location : Chr X- 69,260,392-69,269,788
RefSeq DNA sequence: NC_000023.10 NT_011669.17
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Proteinsfor AWAT2 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: AWAT2_HUMAN, Q6E213 (See
protein sequence )Recommended Name: Acyl-CoA wax alcohol acyltransferase 2 Size : 333 amino acids; 38094 Da
Subcellular location : Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions : Q6IEE3 Q6P437Explore the universe of human proteins at neXtProt for AWAT2: NX_Q6E213
REFSEQ proteins: NP_001002254.1 ENSEMBL proteins: ENSP00000421172 ENSP00000427523 Human Recombinant Proteins 4 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
AWAT2 for ontologies About GeneDecksing Antibodies for AWAT2: Assays for AWAT2:
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Protein
Domains/ Familiesfor AWAT2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
AWAT2 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6E213 ProtoNet protein and cluster: Q6E213
UniProtKB/Swiss-Prot: AWAT2_HUMAN, Q6E213 Similarity : Belongs to the diacylglycerol acyltransferase family
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Gene Functionfor AWAT2 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: AWAT2_HUMAN, Q6E213 Function : Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids toproduce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo Catalytic activity : Acyl-CoA + a long-chain alcohol = CoA + a long-chain esterBiophysicochemical properties : Kinetic parameters: Vmax=1232 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate;Enzyme Number (IUBMB): EC 2.3.1.75
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008415 acyltransferase activity
IEA -- GO:0016740 transferase activity
IEA -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
-- -- GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity
IEA --
About this table
AWAT2 for ontologies About GeneDecksing
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Pathways & Interactionsfor AWAT2 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
AWAT2 for pathways About GeneDecksing 1 Kegg Pathway (Kegg details for AWAT2) : SABiosciences Custom Pathway-Focused PCR Arrays for AWAT2 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AWAT2 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008610 lipid biosynthetic process
IEA -- GO:0010025 wax biosynthetic process
IEA --
About this table
AWAT2 for ontologies About GeneDecksing
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Drugs & Compoundsfor AWAT2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for AWAT2
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Transcriptsfor AWAT2 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for AWAT2 gene: NM_001002254.1
Additional cDNA sequence: AY605053.1 BC063698.1
2 DOTS entries : DT.406619 DT.95358368
14 AceView cDNA sequences :
BX096548 BG743254 BC063698 AA629135 NM_001002254 AY605053 BG740651 BX110378 AA252887 BG742848 BG743236 AA253425 BG674003 AA969335 Unigene Cluster for AWAT2:
Acyl-CoA wax alcohol acyltransferase 2 Hs.661507 [show with all ESTs ] Unigene Representative Sequence: NM_001002254 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for AWAT2 ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b SP1 :             -   -   -               SP2 :             -                   SP3 :             -   -   -               SP4 :                               SP5 :                              
About this scheme ECgene alternative splicing isoforms for AWAT2 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000276101 (uc004dxt.1 ) ENST00000443056 ENST00000440401
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Expression for AWAT2 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section AWAT2 expression in normal and diseased human tissues 1 / 2
1 probe-set matching AWAT2 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
68168_at2
U95-E
1
0.50
1.00
1.00
1.00
--
--
--
--
--
About this table
AWAT2 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.661507 UniProtKB/Swiss-Prot: AWAT2_HUMAN, Q6E213 Tissue specificity : Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highlyexpressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas
SABiosciences Custom PCR Arrays for AWAT2
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Orthologsfor AWAT2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for AWAT2 gene from 5 species
About this table Species with no ortholog for AWAT2 ENSEMBL Gene Tree for AWAT2 (if available)
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Paralogsfor AWAT2 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for AWAT2 gene MOGAT3 2 DGAT2L7 2 DGAT2 2 MOGAT1 2 DGAT2L6 2 MOGAT2 2 AWAT1 2
AWAT2 for paralogs About GeneDecksing
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Genomic Variantsfor AWAT2 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr X pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for AWAT2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for AWAT2: --
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Disorders & Mutationsfor AWAT2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Medical Newsfor AWAT2 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor AWAT2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 7 PubMed articles for AWAT2 gene integrated from 7 sources : (articles sorted by number of sources associating them with AWAT2) Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. (PubMed id 15671038) 1 , 2 , 3 Turkish A.R.... Sturley S.L. (2005) A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. (PubMed id 16106050) 1 , 2 , 3 Yen C.-L.E.... Farese R.V. Jr. (2005) Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677) 1 , 2 , 3 Winter A....Fries R. (2003) Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. (PubMed id 15220349) 1 , 2 Cheng J.B. and Russell D.W. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Comparative genomics and proteomics of vertebrate dia cylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT). (PubMed id 20374941) 1 , 7 Holmes R.S. (2010) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for AWAT2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing AWAT2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing AWAT2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing AWAT2 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for AWAT2 gene: Search GeneIP for patents involving AWAT2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AWAT2 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for AWAT2
ELISAs and CLIAs for AWAT2
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