Aliases &
Descriptions
for AZGP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| alpha-2-glycoprotein 1, zinc-binding1 2 | | zinc-alpha-2-glycoprotein2 | | ZAG1 2 3 5 | | OTTHUMP000002103062 | | ZA2G1 2 | | zn-alpha-2-glycoprotein2 | | alpha-2-glycoprotein 1, zinc1 | | Zn-alpha-2-GP3 | | Zn-alpha2-glycoprotein2 | | Zn-alpha-2-glycoprotein3 | | Alpha-2-glycoprotein, zinc2 | | ZNGP13 | | zn-alpha-2-GP2 | | |
Export aliases for AZGP1 gene to outside databasesPrevious GC identifers: GC07M098099 GC07M099161 GC07M099175 GC07M099209 GC07M099402 GC07M099564 |
Summaries
for AZGP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advancedcancers. May bind polyunsaturated fatty acids
Gene Wiki entry for AZGP1 |
Genomic Views
for AZGP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AZGP1 gene promoter:
SREBP-1c SREBP-1b SREBP-1a ARP-1 USF1 LCR-F1 c-Myb PPAR-gamma1 NF-1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for AZGP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1AZGP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M094200: view genomic region
(about GC identifiers)
Start:
|
94,200,047 bp from pter |
End:
|
94,209,434 bp from pter |
Size:
|
9,388 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7- 99,564,343-99,573,780 |
RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079595.2
|
Proteins
for AZGP1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311 (See
protein sequence)Recommended Name: Zinc-alpha-2-glycoprotein precursor Size: 298 amino acids; 34259 Da
Subunit: Interacts with PIP
Subcellular location: Secreted
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=AAA61311.1; Type=Erroneous initiation; Sequence=BAA03123.1; Type=Erroneous initiation;Sequence=BAA14417.1; Type=Erroneous initiation; Sequence=CAA42438.1; Type=Erroneous initiation;
PDB structures from  and Proteopedia  :1T7V (3D)
1T7W (3D)
1T7X (3D)
1T7Y (3D)
1T7Z (3D)
1T80 (3D)
1ZAG (3D)
3ES6 (3D)
Secondary accessions: O60386 Q5XKQ4 Q8N4N0Explore the universe of human proteins at neXtProt for AZGP1: NX_P25311
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001176.1
ENSEMBL proteins: ENSP00000389942 ENSP00000406094 ENSP00000292401 ENSP00000396093
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
AZGP1 for ontologies About GeneDecksing
Antibodies for AZGP1:
Assays for AZGP1: |
Protein
Domains/
Families
for AZGP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AZGP1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P25311ProtoNet protein and cluster: P25311 2 Blocks protein families: IPB001039 MHC class I signature IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain |
Gene Function
for AZGP1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advancedcancers. May bind polyunsaturated fatty acids
Genatlas biochemistry entry for AZGP1:zinc alpha-2-glycoprotein 14 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
AZGP1 for ontologies About GeneDecksing
Animal Models: 1 MGI phenotypic allele  for Azgp1 (no phenotypes)
AZGP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AZGP1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for AZGP1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AZGP1
1 Interacting protein for AZGP1 (ENSP000002924013) via UniProtKB, MINT, and/or STRINGAbout this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
AZGP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AZGP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
AZGP1 for compounds About GeneDecksing
 Browse Tocris compounds for AZGP1
7  Novoseek chemical compound relationships for AZGP1 gene
About this table
|
Transcripts
for AZGP1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for AZGP1 gene: NM_001185.3 Additional cDNA sequence: BC005306.1 BC005908.1 BC014470.1 BC033830.1 D90427.1 M76707.1 X59766.1 9 DOTS entries: DT.454242 DT.95123268 DT.100819191 DT.95275314 DT.100819194 DT.86855291 DT.86855292 DT.92445589 DT.95275316 24/320 AceView cDNA sequences (see all 320): CA946332 CD722298 BM795361 CD722282 T50792 CD723079 CB122300 AU076706 CK431134 CD724111 R97964 H60180 BI860607 CD722018 T29473 BM982830 BX281800 BC038208 AA622995 BC043381 CK430854 CD722869 BC005306 AA916811
 highest scoring ESTs for AZGP1:X59766 AA143598 AA344600 AA345762 AA507153 AA583037 AU099653 AV695243 BC005306 BC005908 Unigene Cluster for AZGP1: Alpha-2-glycoprotein 1, zinc-binding Hs.546239 [show with all ESTs]Unigene Representative Sequence: BC014470
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for AZGP1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 |
|---|
|
| SP1: | | | | | - | | | | - | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for AZGP1
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495765 ENST00000419575 ENST00000483612 ENST00000423052 ENST00000292401(uc003ush.2)
ENST00000477251 ENST00000411734
|
Expression
for AZGP1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| AZGP1 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching AZGP1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 35834_at2, 3
|
U95-A |
2 |
1.00 |
0.97 |
1.00 |
1.00 |
X59766 |
1.00 |
1.00 |
1.00 |
1 |
| 209309_at2, 3
|
U133-A |
2 |
1.00 |
0.95 |
-- |
-- |
D90427 |
0.80 |
1.00 |
0.91 |
1 |
| 217014_s_at2
|
U133-A |
2 |
1.00 |
0.73 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 209309_at2
|
U133Plus2 |
2 |
1.00 |
0.95 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217014_s_at2
|
U133Plus2 |
2 |
1.00 |
0.73 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
AZGP1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGACTCTGGA
SOURCE GeneReport for Unigene cluster: Hs.546239
Expression variation in blood from EXPOLDB for AZGP1 UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311Tissue specificity: Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver
SABiosciences Custom PCR Arrays for AZGP1
|
Orthologs
for AZGP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AZGP1 gene from 5 species
About this table Species with no ortholog for AZGP1
ENSEMBL Gene Tree for AZGP1 (if available) |
Paralogs
for AZGP1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for AZGP1 gene
- ENSG000002045202 MR12 FCGRT2 HFE2 MICB2
AZGP1 for paralogs About GeneDecksing
|
Genomic Variants
for AZGP1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for AZGP1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for AZGP1
4 CNVs: 37533 64900 2104 7658 | | QIAGEN SeqTarget long-range PCR primers for resequencing AZGP1 |
|
Disorders & Mutations
for AZGP1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AZGP1 for disorders About GeneDecksing
OMIM: 194460
9 Novoseek disease relationships for AZGP1 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cysts |
63 |
4 |
9114041 (2), 1828959 (1) |
| breast diseases |
54.7 |
2 |
9114041 (1) |
| breast carcinoma |
44.6 |
6 |
1444749 (2), 8049458 (1), 9114041 (1), 8307568 (1) |
| breast cancer |
10.5 |
2 |
2202419 (1) |
| cancer |
8.4 |
9 |
12190871 (2), 16475792 (1), 15620688 (1), 20198343 (1) (see all 7) |
| prostate cancer |
0.471 |
10 |
11309332 (4), 16598739 (2), 17317883 (2) |
| metastasis |
0 |
2 |
1444749 (1), 16598739 (1) |
| tumors |
0 |
13 |
11309332 (3), 12190871 (2), 2244662 (1), 16598739 (1) (see all 7) |
| melanoma |
0 |
2 |
12190871 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: AZGP1 (1 document)
Export disorders and mutations for AZGP1 gene to outside databases
|
Medical News
for AZGP1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for AZGP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/97 PubMed articles for AZGP1 gene, integrated from 7 sources (see all 97):
(articles sorted by number of sources associating them with AZGP1)- Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene. (PubMed id 2049092)1, 2, 3, 7 Ueyama H.... Ohkubo I. (1991)
- Biochemical characterization and crystalization of human Zn-alpha2- glycoprotein, a soluble class I major histocompatibility complex homolog. (PubMed id 9114041)1, 2, 7 Sanchez L.M.... Bjorkman P.J. (1997)
- Crystallographic studies of ligand binding by Zn-alpha2- glycoprotein. (PubMed id 15477100)1, 2, 7 Delker S.L.... Bjorkman P.J. (2004)
- Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat- depleting factor related to major histocompatibility complex proteins. (PubMed id 11425849)1, 2, 7 Kennedy M.W.... Sanchez L.M. (2001)
- Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules. (PubMed id 10206894)1, 2, 7 Sanchez L.M.... Bjorkman P.J. (1999)
- Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein. (PubMed id 8241150)1, 2, 7 Ueyama H.... Ohkubo I. (1993)
- Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes. (PubMed id 8307568)1, 2, 7 Freije J.P.... Lopez-Otin C. (1993)
- Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues. (PubMed id 1915885)1, 2, 7 Freije J.P.... Lopez-Otin C. (1991)
- Crystal structure of the novel complex formed between zinc alpha2- glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma. (PubMed id 18930737)1, 2 Hassan M.I....Singh T.P. (2008)
- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
|
External Searches for AZGP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AZGP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AZGP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AZGP1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AZGP1 gene:
Search GeneIP for patents involving AZGP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AZGP1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for AZGP1 |
| |  |  |  |  | | | | | | Recombinant Protein for AZGP1 |
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