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BAG3 Gene

protein-coding   GIFtS: 60

GC10P115040
BCL2-associated athanogene 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for BAG3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
BCL2-associated athanogene 31 2     BCL2-binding athanogene 32
Docking protein CAIR-12 3     MGC1043072
Bcl-2-associated athanogene 32 3     CAIR-12
Bcl-2-binding protein Bis2 3     BAG family molecular chaperone regulator 32
BAG-32 3     BAG-family molecular chaperone regulator-32
BIS2 3     

External Ids:    HGNC: 9391   Entrez Gene: 95312   Ensembl: ENSG000001519297   UniProtKB: O958173   

Export aliases for BAG3 gene to outside databases

Previous GC identifers: GC10P120329 GC10P120654 GC10P121542 GC10P121075 GC10P121400


Summaries
for BAG3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BAG3:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG
proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal
regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the
C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro
and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone
activity in a Hip-repressible manner. (provided by RefSeq)

UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity

Gene Wiki entry for BAG3

Genomic Views
for BAG3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BAG3 gene promoter:
         AP-1   p53   GR-alpha   GR-beta   AREB6   NF-kappaB1   NF-kappaB   NF-E2 p45   NF-E2   ATF6   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for BAG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2-q26.2   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q25.2-q26.2

BAG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAG3 gene location

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P115040:  view genomic region     (about GC identifiers)

Start:
 115,040,288 bp from pter
End:
 115,066,931 bp from pter
Size:
 26,644 bases
Orientation:
 plus strand

1 alternative location:
Chr10+ 121,410,882-121,437,331     
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  

Proteins
for BAG3 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 3  
Size: 575 amino acids; 61595 Da
Subunit: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma
Secondary accessions: A8K5L8 Q3B763 Q9NT20 Q9P120

Explore the universe of human proteins at neXtProt for BAG3: NX_O95817 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_004272.2  

    ENSEMBL proteins: 
    ENSP00000410036 ENSP00000358081 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for BAG3 
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for BAG3

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829 cytosol IDA10597216
    About this table

    BAG3 for ontologies           About GeneDecksing



    Antibodies for BAG3: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BAG3
    Browse R&D Systems for Antibodies
    OriGene Antibodies: BAG3
    GenScript Custom Superior Antibodies Services for BAG3 
    Epitomics antibodies for BAG3

    Assays for BAG3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BAG3 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BAG3 

    Protein Domains/
    Families
    for BAG3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BAG3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003103 Apoptosis_reg_Bcl-2_prot_BAG
     IPR001202 WW_Rsp5_WWP

    Graphical View of Domain Structure for InterPro Entry O95817

    ProtoNet protein and cluster: O95817

    1 Blocks protein family: IPB003103 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817
    Similarity: Contains 1 BAG domain
    Similarity: Contains 2 WW domains


    Gene Function
    for BAG3 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817
    Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for BAG3
    Sigma-Aldrich shRNA Panels and shRNA for BAG3
    OriGene 29mer shRNA kits in GFP-retroviral vector: BAG3
    OriGene shRNA RFP: BAG3
    OriGene basic RS shRNA: BAG3
    OriGene siRNA: BAG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BAG3 
    miRNA:Sigma-Aldrich microRNA Mimics for BAG3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BAG3 
    3 SABiosciences Assays for microRNAs that regulate BAG3:
    hsa-miR-548d-3p hsa-miR-891b hsa-miR-129-3p

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: BAG3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: BAG3
    OriGene untagged cDNA clones in CMV expression vector (see all 2): BAG3
    OriGene 3'-UTR clone: BAG3 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: BAG3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for BAG3 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IEA--
    About this table

    BAG3 for ontologies           About GeneDecksing

    Animal Models: 11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Bag3):

    adipose tissuecardiovascular systemgrowth/sizehematopoietic systemhomeostasis/metabolism
    immune systemlethality-postnatalliver/biliary systemmuscleno phenotypic analysis
    respiratory system

    BAG3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BAG3 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Arrays including BAG3 (see all 4): PAHS-012A PAHS-016A  

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BAG3

    4 Interacting proteins for BAG3 (O958172 ENSP000003580813) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081072, ENSP000003648023MINT-7264704 STRING: ENSP00000364802
    SQSTM1Q135012MINT-7264716 MINT-7264745 MINT-7264704
    HSPA1BP081072
    HSPB8ENSP000002819383STRING: ENSP00000281938
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457 protein folding NAS9873016
    GO:0006915 apoptosis ----
    GO:0006916 anti-apoptosis NAS10597216
    GO:0043066 negative regulation of apoptosis ----
    About this table

    BAG3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BAG3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BAG3


    Transcripts
    for BAG3 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for BAG3
    Sigma-Aldrich shRNA Panels and shRNA for BAG3
    OriGene 29mer shRNA kits in GFP-retroviral vector: BAG3
    OriGene shRNA RFP: BAG3
    OriGene basic RS shRNA: BAG3
    OriGene siRNA: BAG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BAG3 
    miRNA: Sigma-Aldrich microRNA Mimics for BAG3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BAG3 
    3 SABiosciences Assays for microRNAs that regulate BAG3:
    hsa-miR-548d-3p hsa-miR-891b hsa-miR-129-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: BAG3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: BAG3
    OriGene untagged cDNA clones in CMV expression vector (see all 2): BAG3
    OriGene 3'-UTR Clone: BAG3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: BAG3 
    Primers: OriGene genome-wide validated SYBR primer pairs: BAG3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BAG3: PPH01036A

    REFSEQ mRNAs for BAG3 gene: 

    NM_004281.3  

    Additional cDNA sequence: 

    AF071218.2 AF095193.2 AF127139.1 AK222800.1 AK291333.1 AK313026.1 AL137582.1 BC006418.1 
    BC014656.1 BC107786.1 

    10 DOTS entries:

    DT.218171  DT.100794105  DT.100794103  DT.95151661  DT.100794107  DT.95151971  DT.100663675  DT.91646179 
    DT.92438542  DT.99998637 

    24/297 AceView cDNA sequences (see all 297):

    BI518668 AI766969 AA865662 BU727464 BE409341 BM550204 AA034925 BM800951 
    AI380810 BM675383 CF243159 BU733542 AL137582 AA633832 BU509596 BU948817 
    BF593187 AI587080 CA426385 AA588774 BU621949 AA280559 CN484409 AI261757 

    highest scoring ESTs for BAG3:

    H10530 AA034933 AA040866 AA043135 AA101635 AA101636 AA121931 AA121949 AA150669 AA150793 

    Unigene Cluster for BAG3:

    BCL2-associated athanogene 3
    Hs.523309  [show with all ESTs]
    Unigene Representative Sequence: NM_004281


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BAG3

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:              -     -                                 
    SP2:              -     -                                 
    SP3:                                                      

    About this scheme

    ECgene alternative splicing isoforms for BAG3
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450186 ENST00000369085(uc001lel.2 uc001lem.2)

    Expression
    for BAG3 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    BAG3 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching BAG3 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    48971_at2, 3 U95-C 1 0.94 1.00 1.00 1.00 H10530 1.00 1.00 1.00 1
    217911_s_at2, 3 U133-A 1 0.91 1.00 -- -- NM_004281 0.60 1.00 0.82 1
    217911_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    BAG3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    BAG3 gene expression
    BAG3 gene electronic northern expression
    BAG3 gene sage expression
    About these images

    CGAP SAGE TAG: CATTTCAGAG

    SOURCE GeneReport for Unigene cluster: Hs.523309
    Primers: OriGene genome-wide validated SYBR primer pairs: BAG3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BAG3: PPH01036A
        SABiosciences Expression via Pathway-Focused PCR Arrays including BAG3 (see all 4): PAHS-012A PAHS-016A  


    Orthologs
    for BAG3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for BAG3 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 BAG31   -- BCL2-associated athanogene 3 86.35(n)
    85.19(a)    		 486916  XM_544046.2  XP_544046.2 
    chimpanzee
    (Pan troglodytes)    		 BAG31   -- BCL2-associated athanogene 3 99.42(n)
    98.96(a)    		 450778  XM_508072.2  XP_508072.2 
    cow
    (Bos taurus)    		 BAG31   -- BCL2-associated athanogene 3 85.7(n)
    86.34(a)    		 782633  XM_001250897.1  XP_001250898.1 
    rat
    (Rattus norvegicus)    		 Bag31   -- Bcl2-associated athanogene 3 86.34(n)
    86.51(a)    		 293524  NM_001011936.1  NP_001011936.1 
    mouse
    (Mus musculus)    		 Bag31 , 5 7 (70.26 cM)5
    		 BCL2-associated athanogene 31, 5 85.87(n)1
    85.64(a)1    		 298101  NM_013863.41  NP_038891.41 
     AA4072785  AB0415835  (see all 23)
    About this table        Species with no ortholog for BAG3

    ENSEMBL Gene Tree for BAG3 (if available)

    Paralogs
    for BAG3 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for BAG3 gene
    BAG42  BAG52  

    BAG3 for paralogs           About GeneDecksing



    Genomic Variants
    for BAG3 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/333 NCBI SNPs in BAG3 are shown (see all 333)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs89461,2
    		C,F,O,A,H,121437012(+) TGTTTG/CAGAAG 1 -- ut31 ese327Minor allele frequency- C:0.40MN NS EA NA WA 2278
    rs1255851,2
    		C,A121420554(+) gagccA/Gagatc 1 -- int13Minor allele frequency- G:0.33NA WA 6
    rs1719091,2
    		C,A121422439(+) ggagaA/Gtggcg 1 -- int13Minor allele frequency- G:0.17NA WA 6
    rs1719101,2
    		C,F,A,H,121425336(+) ACCCCG/ACCAGA 1 -- int117Minor allele frequency- A:0.34NS EA NA WA 1038
    rs1855041,2
    		C,121422449(+) gtgaaC/Tgcggg 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1962941,2
    		C,F,A,H,121435955(+) AATATC/ATTTTT 1 -- int18Minor allele frequency- A:0.35NA EA WA 220
    rs1962951,2
    		C,F,A,H,121436362(+) AAGGTG/ACAGGG 2 /V ref1 syn1 ese317Minor allele frequency- A:0.43MN EA NA NS WA 2382
    rs1963161,2
    		C,F,O,A,H,121423759(+) GGGCAC/AATTTT 1 -- int196Minor allele frequency- A:0.48NS MN EA PA EU CA WA NA 4834
    rs1963171,2
    		F,H121423867(+) ATGCAA/GTGCAC 1 -- int14Minor allele frequency- G:0.01NS EA 420
    rs1963181,2
    		C,F,A,121425502(+) CTGACC/TGTCTC 1 -- int113Minor allele frequency- T:0.24NS EA NA WA 1018
    About this table

    HapMap Linkage Disequilibrium images for BAG3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BAG3: --

    QIAGEN SeqTarget long-range PCR primers for resequencing BAG3 

    Disorders & Mutations
    for BAG3 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BAG3 for disorders           About GeneDecksing

    OMIM: 603883   disorders: 612954  

    UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817

  • Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) [MIM:612954]. A neuromuscular
    • disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy,
    severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level,
    muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small,
    dense granules, or larger hyaline masses, or amorphous material

    5 Novoseek disease relationships for BAG3 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 33.3 1 17493862 (1)
    leukemia 13.4 2 17493862 (1), 17164298 (1)
    cancer 7.8 5 17996194 (2), 19179333 (1), 17493862 (1), 11513873 (1)
    tumors 4.74 4 17164298 (2), 11513873 (1), 17996194 (1)
    necrosis 0 1 11513873 (1)
    About this table

    GeneTests: BAG3
    Myofibrillar Myopathy

    Locus Specific Mutation Databases (LSDB): BAG3
    Human Gene Mutation Database (HGMD): BAG3
    Human Genome Epidemiology (HuGE) Navigator: BAG3 (7 documents)

    Export disorders and mutations for BAG3 gene to outside databases

    Medical News
    for BAG3 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for BAG3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/82 PubMed articles for BAG3 gene, integrated from 7 sources (see all 82):
    (articles sorted by number of sources associating them with BAG3)
    1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 3, 7 Takayama S.... Reed J.C. (1999)
    2. Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. (PubMed id 10597216)1, 2, 7 Lee J.H....Tsujimoto Y. (1999)
    3. Mutation in BAG3 causes severe dominant childhood muscular dystrophy. (PubMed id 19085932)1, 2 Selcen D....Engel A.G. (2009)
    4. HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy. (PubMed id 18094623)1, 3 Carra S....Landry J. (2008)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    8. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1, 2 Tao W.A.... Aebersold R. (2005)
    9. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for BAG3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing BAG3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9531 HGNC: 939 AceView: BAG3 Ensembl:ENSG00000151929 euGenes: HUgn9531
    ECgene: BAG3 H-InvDB: BAG3

    Other Databases showing BAG3 gene

    (According to HUGE)
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    Specialized Databases showing BAG3 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for BAG3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BAG3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Search GeneIP for patents involving BAG3

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