Aliases &
Descriptions
for BAGE2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| B melanoma antigen family, member 21 2 | | CT2.21 2 3 | | Cancer/testis antigen 2.22 3 | | B melanoma antigen 22 | | cancer/testis antigen family 2, member 22 |
Export aliases for BAGE2 gene to outside databasesPrevious GC identifers: GC21U990099 GC21M010043 GC21M010072 |
Summaries
for BAGE2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BAGE2_HUMAN, Q86Y30Function: Unknown. Candidate gene encoding tumor antigens
|
Genomic Views
for BAGE2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
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|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BAGE2
Other transcription factors
Search SABiosciences Chromatin IP Primers for BAGE2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21p Ensembl cytogenetic band: 21p11.1 HGNC cytogenetic band: 21pBAGE2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M010996: view genomic region
(about GC identifiers)
Start:
|
10,996,026 bp from pter |
End:
|
11,098,980 bp from pter |
Size:
|
102,955 bases |
Orientation:
|
minus strand |
|
Proteins
for BAGE2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: BAGE2_HUMAN, Q86Y30 (See
protein sequence)Recommended Name: B melanoma antigen 2 precursor Size: 109 amino acids; 12114 Da
Subcellular location: Secreted (Potential)
Miscellaneous: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE familywas expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genesthat map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered inthe juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21
Secondary accessions: A8K925 Q08ER0Explore the universe of human proteins at neXtProt for BAGE2: NX_Q86Y30
REFSEQ proteins: NP_872288.2
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
About this table
BAGE2 for ontologies About GeneDecksing
Antibodies for BAGE2:
Assays for BAGE2: |
Protein
Domains/
Families
for BAGE2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BAGE2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86Y30ProtoNet protein and cluster: Q86Y30 1 Blocks protein family: IPB012530 B melanoma antigen
UniProtKB/Swiss-Prot: BAGE2_HUMAN, Q86Y30Similarity: Belongs to the BAGE family |
Gene Function
for BAGE2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: BAGE2_HUMAN, Q86Y30Function: Unknown. Candidate gene encoding tumor antigens
|
Pathways & Interactions
for BAGE2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for BAGE2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BAGE2
|
Drugs & Compounds
for BAGE2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for BAGE2
|
Transcripts
for BAGE2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for BAGE2 gene: NM_182482.2
 highest scoring ESTs for BAGE2:AI075803 CD359687 NM_182481 NM_182482
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000474011 ENST00000470054(uc002yit.1 uc002yiu.1 uc002yiv.1 uc002yix.2)
ENST00000496773(uc002yiw.1)
|
Expression
for BAGE2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| BAGE2 expression in normal and diseased human tissues
Data from GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: BAGE2_HUMAN, Q86Y30Tissue specificity: Not expressed in normal tissues except in testis. Expressed in 22% of melanomas, in bladder andlung carcinomas
SABiosciences Custom PCR Arrays for BAGE2
|
Orthologs
for BAGE2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for BAGE2 (if available) |
Paralogs
for BAGE2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for BAGE2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 27 variations for BAGE2
15/26 CNVs (see all 26): 23086 79305 61955 59034 23321 35942 73597 3224 22515 32434 7328 22855 90682 73600 5156
1 Indel: 40470 | | QIAGEN SeqTarget long-range PCR primers for resequencing BAGE2 |
|
Disorders & Mutations
for BAGE2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for BAGE2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for BAGE2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
9 PubMed articles for BAGE2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with BAGE2)- New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PubMed id 12461691)1, 2, 3 Ruault M....De Sario A. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- BAGE genes generated by juxtacentromeric reshuffling in the Hominidae lineage are under selective pressure. (PubMed id 12676563)1, 2 Ruault M....De Sario A. (2003)
- Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. (PubMed id 12909339)1, 7 Brun M.-E.... De Sario A. (2003)
- Gene dosage change of TPTE and BAGE2 and breakpoint analysis in Robertsonian Down syndrome. (PubMed id 18074101)1 Shaw S.W....Hsieh F.J. (2008)
- The diploid genome sequence of an individual human. (PubMed id 17803354)1 Levy S....Venter J.C. (2007)
- Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21. (PubMed id 16963709)1 Grunau C....De Sario A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for BAGE2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing BAGE2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BAGE2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAGE2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for BAGE2 gene:
Search GeneIP for patents involving BAGE2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BAGE2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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