Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern Search by expression pattern


BCL2L1 Gene

protein-coding   GIFtS: 68

GC20M027040
BCL2-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for BCL2L1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
BCL2-like 11 2     BCL-XL/S2
BCLX1 2 3 5     DKFZp781P20922
BCL2L1 2 3     OTTHUMP000000305562
bcl-xL1 2     OTTHUMP000000305552
Bcl-X1 2     OTTHUMP000000305572
bcl-xS1 2     OTTHUMP000000305522
Apoptosis regulator Bcl-X2 3     bcl2-L-12
BCLXL2 5     bcl-2-like protein 12
BCLXS2 5     Bcl2-L-13
OTTHUMP000000305502     

External Ids:    HGNC: 9921   Entrez Gene: 5982   Ensembl: ENSG000001715527   UniProtKB: Q078173   

Export aliases for BCL2L1 gene to outside databases

Previous GC identifers: GC20M030040 GC20M030950 GC20M030997 GC20M029715 GC20M030252


Summaries
for BCL2L1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BCL2L1:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers
and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins
encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer
mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the
production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent
inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been
reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
(provided by RefSeq)

UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817
Function: Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell
death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the
caspase activator, CYC1, from the mitochondrial membrane
Function: Isoform Bcl-X(S) promotes apoptosis

summary for BCL2L1:
Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein
family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as
Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2
proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma
and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members
contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial
and other intracellular membranes.

Gene Wiki entry for BCL2L1 (BCL2-like 1)

Genomic Views
for BCL2L1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL2L1 gene promoter:
         MIF-1   GATA-2   RFX1   CUTL1   p53   POU2F1   Elk-1   HNF-1A   AhR   Arnt   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for BCL2L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for BCL2L1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

BCL2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L1 gene location

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M027040:  view genomic region     (about GC identifiers)

Start:
 27,040,965 bp from pter
End:
 27,099,720 bp from pter
Size:
 58,756 bases
Orientation:
 minus strand

1 alternative location:
Chr20- 30,252,255-30,311,792     
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  

Proteins
for BCL2L1 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817 (See protein sequence)
Recommended Name: Bcl-2-like protein 1  
Size: 233 amino acids; 26049 Da
Subunit: Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not
seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with DMN1L; the interaction
stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and
number of synaptic vesicle clusters (By similarity). Interacts with BAD and BBC3. Interacts (isoform Bcl-X(L)) with
SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Interacts
(isoform Bcl-X(L)) with BAX (isoform Sigma)
Subcellular location: Mitochondrion membrane; Single-pass membrane protein (By similarity). Nucleus membrane;
Single-pass membrane protein; Cytoplasmic side (By similarity). Note=Mitochondrial membranes and perinuclear envelope
(By similarity)
PDB structures from and Proteopedia :
1BXL (3D)    1G5J (3D)    1LXL (3D)    1MAZ (3D)    1R2D (3D)    1R2E (3D)    1R2G (3D)    1R2H (3D)    
1R2I (3D)    1YSG (3D)    1YSI (3D)    1YSN (3D)    2B48 (3D)    2O1Y (3D)    2O2M (3D)    2O2N (3D)    
2P1L (3D)    2PON (3D)    2YXJ (3D)    3CVA (3D)    3FDL (3D)    3FDM (3D)    3INQ (3D)    3IO8 (3D)    
Secondary accessions: Q5CZ89 Q5TE65 Q92976
Alternative splicing: 3 isoforms:  Q07817-1   Q07817-2   Q07817-3   

Explore the universe of human proteins at neXtProt for BCL2L1: NX_Q07817 

Post-translational modifications:

  • Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic
    • activity1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001182.1  NP_612815.1  


    ENSEMBL proteins: 
    ENSP00000365223 ENSP00000365230 ENSP00000406203 ENSP00000411252 ENSP00000390760 ENSP00000302564 
    ENSP00000395545 ENSP00000401173 ENSP00000365228 ENSP00000389688 ENSP00000405563 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for BCL2L1
    R&D Systems Recombinant & Natural Proteins for BCL2L1 (Bcl-xL)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: BCL2L1
    OriGene Protein Over-expression Lysate (see all 2): BCL2L1
    GenScript Custom Purified and Recombinant Proteins Services for BCL2L1 
    Novus Biologicals Protein for BCL2L1
    Novus Biologicals Lysates for BCL2L1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    GO:0005739 mitochondrion IDA12011449
    GO:0005741 mitochondrial outer membrane TAS--
    GO:0005829 cytosol IEA--
    About this table

    BCL2L1 for ontologies           About GeneDecksing



    Antibodies for BCL2L1: 
    Millipore Mono- and Polyclonal Antibodies for the study of BCL2L1
    Sigma-Aldrich Antibody Arrays and Antibodies for BCL2L1
    R&D Systems Antibodies for BCL2L1 (Bcl-x, Bcl-xL)
    Cell Signaling Technology (CST) Antibodies for BCL2L1  (Bcl-XL)
    OriGene Antibodies (see all 3): BCL2L1
    GenScript Custom Superior Antibodies Services for BCL2L1 
    Novus Biologicals Antibodies for BCL2L1
    Epitomics antibodies for BCL2L1

    Assays for BCL2L1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    R&D Systems ELISAs for BCL2L1 (Bcl-xL)
    GenScript Custom Assay Services for BCL2L1 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for BCL2L1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BCL2L1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR020728 Bcl2_BH3_motif_CS
     IPR013279 Apop_reg_BclX
     IPR020717 Bcl2_BH1_motif_CS
     IPR004725 Bcl2_reg
     IPR020726 Bcl2_BH2_motif_CS

    Graphical View of Domain Structure for InterPro Entry Q07817

    ProtoNet protein and cluster: Q07817

    2 Blocks protein families:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB003093 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817
    Domain: The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both
    heterodimerization with other Bcl-2 family members and for repression of cell death
    Similarity: Belongs to the Bcl-2 family


    Gene Function
    for BCL2L1 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817
    Function: Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell
    death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the
    caspase activator, CYC1, from the mitochondrial membrane
    Function: Isoform Bcl-X(S) promotes apoptosis

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for BCL2L1
    Sigma-Aldrich shRNA Panels and shRNA for BCL2L1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): BCL2L1
    OriGene shRNA RFP (see all 2): BCL2L1
    OriGene basic RS shRNA (see all 2): BCL2L1
    OriGene siRNA (see all 2): BCL2L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BCL2L1 
    miRNA:Sigma-Aldrich microRNA Mimics for BCL2L1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BCL2L1 
    6 SABiosciences Assays for microRNAs that regulate BCL2L1:
    hsa-miR-140-5p hsa-miR-513b hsa-miR-1276 hsa-miR-342-5p hsa-miR-184 hsa-miR-342-3p

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): BCL2L1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): BCL2L1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): BCL2L1
    OriGene 3'-UTR clone (see all 2): BCL2L1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): BCL2L1 
    Sino Biological Human cDNA Clone for BCL2L1

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for BCL2L1 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI18250306
    GO:0042802 identical protein binding IPI15131699
    GO:0043027 caspase inhibitor activity IEA--
    GO:0046982 protein heterodimerization activity IEA--
    GO:0051400 BH domain binding IEA--
    About this table

    BCL2L1 for ontologies           About GeneDecksing

    Animal Models: 12 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Bcl2l1):

    behavior/neurologicalcellularendocrine/exocrine glandgrowth/sizehematopoietic system
    homeostasis/metabolismimmune systemlethality-prenatal/perinatalnervous systemreproductive system
    skin/coat/nailstumorigenesis

    BCL2L1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BCL2L1 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    BCL2L1 for pathways           About GeneDecksing

    5/16 Millipore Pathways for BCL2L1 (see all 16)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Immune response IL-22 signaling pathway
    Development Prolactin receptor signaling
    Apoptosis and survival APRIL and BAFF signaling

    5/22 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  BCL2L1 (see all 22)
        IL-15 Signaling
    Huntington's Disease Signaling
    Docosahexaenoic Acid (DHA) Signaling
    PI3K/AKT Signaling
    Small Cell Lung Cancer Signaling

    3 Cell Signaling Technology (CST) Pathways for BCL2L1
        Mitochondrial Control of Apoptosis
    B Cell Receptor Signaling
    Akt/PKB Signaling

    5/8 Kegg Pathways  (Kegg details for BCL2L1) (see all 8):
        hsa04210 Apoptosis
    hsa04630 Jak-STAT signaling pathway
    hsa05014 Amyotrophic lateral sclerosis (ALS)
    hsa05145 Toxoplasmosis
    hsa05200 Pathways in cancer

        SABiosciences Pathway-Focused PCR Arrays including BCL2L1 (see all 16): PAHS-003A PAHS-004A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for BCL2L1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL2L1

    5/64 Interacting proteins for BCL2L1 (ENSP000003652303 Q078171, 2) via UniProtKB, MINT, and/or STRING (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAXQ078121, 2STRING: ENSP00000293288 EBI-78035,EBI-516580 MINT-4980301 MINT-4980319
    BCL2L11O435211, 2STRING: ENSP00000350311 EBI-78035,EBI-526406 MINT-4980301 MINT-4980319
    BAK1Q166111STRING: ENSP00000353878 EBI-78035,EBI-519866
    BBC3Q9BXH11STRING: ENSP00000352999 EBI-78035,EBI-519884
    BIDP559571STRING: ENSP00000318822 EBI-78035,EBI-519672
    About this table

    5/34 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 34):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541 ovarian follicle development IEA--
    GO:0001666 response to hypoxia IEA--
    GO:0001701 in utero embryonic development IEA--
    GO:0001836 release of cytochrome c from mitochondria IDA9843949
    GO:0006915 apoptosis TAS--
    About this table

    BCL2L1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BCL2L1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    BCL2L1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Enzo Life Sciences drugs & compounds for BCL2L1

    Compounds for BCL2L1 available from Tocris Bioscience
    CompoundAction CAS number
    2,3-DCPE hydrochloride Selectively induces cancer cell apoptosis[418788-90-6]
    GossypolPro-apoptotic; downregulates Bcl-2 and Bcl-XL[303-45-7]
    HA14-1Bcl-2 inhibitor. Induces apoptosis[65673-63-4]
    About this table


    10/148 Novoseek chemical compound relationships for BCL2L1 gene (see all 148)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 74.7 32 20051518 (2), 19366803 (1), 16273296 (1), 18418772 (1) (see all 19)
    adpribose 64.6 13 11205313 (1), 14520473 (1), 14966908 (1), 15176047 (1) (see all 12)
    etoposide 64.5 33 10620629 (3), 12553012 (2), 10839193 (2), 9242554 (1) (see all 25)
    gossypol 61.7 35 15657350 (4), 16258364 (4), 16020667 (3), 15657349 (3) (see all 10)
    sp 600125 60.8 3 18281123 (1), 19747539 (1)
    bortezomib 60.4 11 18594829 (2), 20051518 (2), 19372569 (1), 15767553 (1) (see all 9)
    paclitaxel 60.1 81 10516758 (6), 16080463 (5), 18281549 (4), 8853905 (4) (see all 36)
    dutp 59.4 9 20410588 (1), 15182618 (1), 15671112 (1), 11485911 (1) (see all 7)
    doxorubicin 58.5 47 19502069 (3), 17923112 (2), 15893350 (2), 17140381 (2) (see all 27)
    cisplatin 58.4 126 16331250 (5), 17848273 (5), 17275076 (4), 16020667 (4) (see all 57)
    About this table



    Transcripts
    for BCL2L1 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for BCL2L1
    Sigma-Aldrich shRNA Panels and shRNA for BCL2L1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): BCL2L1
    OriGene shRNA RFP (see all 2): BCL2L1
    OriGene basic RS shRNA (see all 2): BCL2L1
    OriGene siRNA (see all 2): BCL2L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BCL2L1 
    miRNA: Sigma-Aldrich microRNA Mimics for BCL2L1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BCL2L1 
    6 SABiosciences Assays for microRNAs that regulate BCL2L1:
    hsa-miR-140-5p hsa-miR-513b hsa-miR-1276 hsa-miR-342-5p hsa-miR-184 hsa-miR-342-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): BCL2L1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): BCL2L1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): BCL2L1
    OriGene 3'-UTR Clone (see all 2): BCL2L1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): BCL2L1 
    Primers: OriGene genome-wide validated SYBR primer pairs: BCL2L1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BCL2L1: PPH00082A

    REFSEQ mRNAs for BCL2L1 gene (2 alternative transcripts): 

    NM_001191.2  NM_138578.1  

    Additional cDNA sequence: 

    AK290968.1 AY263335.1 AY263336.1 AY263337.1 BC019307.1 BT007208.1 BX647525.1 CR936637.1 
    Z23115.1 Z23116.1 

    24 DOTS entries:

    DT.101984602  DT.100824803  DT.100033618  DT.92454063  DT.95322400  DT.95277896  DT.101959134  DT.97857304 
    DT.100824812  DT.100824811  DT.100824816  DT.100824805  DT.92454059  DT.97860277  DT.91851155  DT.120812879 
    DT.95277878  DT.100824807  DT.100033609  DT.100824814  DT.120812945  DT.100033608  DT.100680697  DT.92454062 

    24/550 AceView cDNA sequences (see all 550):

    BX441570 BQ892066 BM905690 BU190798 BQ883146 BM554265 BQ932013 BQ070711 
    BQ646866 BE900510 BQ636684 BU168531 BU859465 BU185884 BU553275 BQ689630 
    BM928004 AI672672 AA323426 BM985334 BU157566 BX647525 BM811650 BU931878 

    highest scoring ESTs for BCL2L1:

    AY263335 AY263336 BC019307 BE788685 BF128036 BG752203 BG764073 BI022254 BI824161 BM543578 

    Unigene Cluster for BCL2L1:

    BCL2-like 1
    Hs.516966  [show with all ESTs]
    Unigene Representative Sequence: CR936637


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L1 (see all 8)

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:        -     -     -     -     -     -                             -     -                                       
    SP2:                    -     -     -                                   -     -                                       
    SP3:                    -     -     -     -                             -     -                                       
    SP4:                                                                    -                                             
    SP5:                                -                                                                                 

    About this scheme

    ECgene alternative splicing isoforms for BCL2L1
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376055 ENST00000376062 ENST00000450273 ENST00000422920 ENST00000420488
    ENST00000307677(uc002wwk.2 uc002wwl.2 uc002wwm.2 uc002wwn.2)
    ENST00000456404(uc002wwo.1) ENST00000434194 ENST00000376060 ENST00000439267
    ENST00000420653

    Expression
    for BCL2L1 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    BCL2L1 expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching BCL2L1 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    65477_at2, 3 U95-C 1 1.00 1.00 0.92 1.41 T15735 0.60 1.00 0.82 1
    34742_at2, 3 U95-A 1 1.00 1.00 0.95 0.81 Z23115 0.80 1.00 0.91 1
    1615_at2, 3 U95-A 1 0.88 1.00 0.80 0.78 Z23115 0.80 1.00 0.91 1
    215037_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    212312_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    206665_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001191 0.60 1.00 0.82 1
    215037_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212312_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    206665_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    BCL2L1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    BCL2L1 gene expression
    BCL2L1 gene electronic northern expression
    BCL2L1 gene sage expression
    About these images

    CGAP SAGE TAG: CCTGTCCAGC

    SOURCE GeneReport for Unigene cluster: Hs.516966

    Expression variation in blood from EXPOLDB for BCL2L1

    UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817
    Tissue specificity: Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as
    developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as
    adult brain

    Primers: OriGene genome-wide validated SYBR primer pairs: BCL2L1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BCL2L1: PPH00082A
        SABiosciences Expression via Pathway-Focused PCR Arrays including BCL2L1 (see all 16): PAHS-003A PAHS-004A  


    Orthologs
    for BCL2L1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for BCL2L1 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 BCL2L11   -- BCL2-like 1 96.57(n)
    100(a)    		 403618  NM_001003072.1  NP_001003072.1 
    chimpanzee
    (Pan troglodytes)    		 BCL2L11   -- BCL2-like 1 99.86(n)
    100(a)    		 458156  XM_514565.2  XP_514565.2 
    cow
    (Bos taurus)    		 BCL2L11   -- BCL2-like 1 94.99(n)
    97.85(a)    		 282152  NM_001077486.1  NP_001070954.1 
    rat
    (Rattus norvegicus)    		 Bcl2l11   -- Bcl2-like 1 93.85(n)
    97.85(a)    		 24888  NM_001033670.1  NP_001028842.1 
    mouse
    (Mus musculus)    		 Bcl2l11 , 5 2 (75.41 cM)5
    		 BCL2-like 11, 5 93.56(n)1
    97.85(a)1    		 120481  NM_009743.41  NP_033873.31 
     AF0889045  AK1464615  (see all 26)
    About this table        Species with no ortholog for BCL2L1

    ENSEMBL Gene Tree for BCL2L1 (if available)

    Paralogs
    for BCL2L1 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for BCL2L1 gene
    BAK12  BCL2L22  BCL22  BAX2  

    BCL2L1 for paralogs           About GeneDecksing



    Genomic Variants
    for BCL2L1 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/473 NCBI SNPs in BCL2L1 are shown (see all 473)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs108611,2
    		--30253600(-) TGCAGC/TTAGTT 2 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs3660011,2
    		--30271352(-) tcaggG/Tgatcc 2 -- int10--------
    rs3853941,2
    		--30271440(-) ggcccC/Gccacc 2 -- int10--------
    rs3912811,2
    		--30284847(-) agataA/Gagtct 2 -- int10--------
    rs3939461,2
    		--30271467(-) aacctC/Tttgag 2 -- int10--------
    rs4034161,2
    		--30271445(-) acaggG/Tgcccc 2 -- int10--------
    rs4042901,2
    		--30271525(-) gcgcaA/Gcctcg 2 -- int10--------
    rs4316861,2
    		C,A,H,30303687(-) actgcA/Gctcca 2 -- int17Minor allele frequency- G:0.00NA WA 14
    rs4522951,2
    		H30274040(-) CTTGAG/ACAAGT 2 -- int17Minor allele frequency- A:0.00EA NA NS 474
    rs7298381,2
    		C,F,A,H,30263528(-) CCCACC/TCATAC 2 -- int17Minor allele frequency- T:0.06EA NA NS 520
    About this table

    HapMap Linkage Disequilibrium images for BCL2L1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for BCL2L1
         1 Indel: 102948

    QIAGEN SeqTarget long-range PCR primers for resequencing BCL2L1 

    Disorders & Mutations
    for BCL2L1 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BCL2L1 for disorders           About GeneDecksing

    OMIM: 600039

    10/93 Novoseek disease relationships for BCL2L1 gene (see all 93)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 69 352 19209227 (6), 9060818 (5), 8909234 (4), 17699103 (4) (see all 99)
    cancer 65.1 136 14613034 (4), 19883274 (4), 12915656 (3), 12120204 (3) (see all 91)
    leukemia 60 37 11961058 (2), 10516758 (2), 11523242 (2), 16219908 (2) (see all 30)
    necrosis 56.8 42 11292287 (2), 19331832 (2), 9209397 (2), 17011514 (1) (see all 36)
    colon cancer 54.6 31 17534896 (4), 18200666 (2), 15314290 (2), 15205359 (2) (see all 23)
    prostate cancer 52.9 61 11929841 (4), 16794010 (3), 18196538 (3), 12633850 (3) (see all 30)
    myeloid leukemia 50.1 9 9204972 (2), 11410409 (1), 14726688 (1), 19676104 (1) (see all 7)
    lymphoma 49.4 54 11869534 (4), 8616083 (3), 12969962 (3), 17096886 (3) (see all 28)
    myeloma 49.3 21 10583232 (4), 9163609 (2), 15970928 (1), 9664139 (1) (see all 15)
    pancreatic cancer 49.1 26 16258364 (4), 10658530 (2), 15841044 (2), 15781649 (2) (see all 15)
    About this table

    Genetic Association Database (GAD): BCL2L1
    Human Genome Epidemiology (HuGE) Navigator: BCL2L1 (13 documents)
    Tumor Gene Database (TGDB): BCL2L1

    Export disorders and mutations for BCL2L1 gene to outside databases

    Medical News
    for BCL2L1 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for BCL2L1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/2019 PubMed articles for BCL2L1 gene, integrated from 7 sources (see all 2019):
    (articles sorted by number of sources associating them with BCL2L1)
    1. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. (PubMed id 8358789)1, 2, 3 Boise L.H.... Thompson C.B. (1993)
    2. Bax-independent inhibition of apoptosis by Bcl-XL. (PubMed id 8596636)1, 2, 7 Cheng E.H.-Y....Korsmeyer S.J. (1996)
    3. Investigation of bax, bcl-2, bcl-x and p53 gene polymorphisms in multiple sclerosis. (PubMed id 12161031)1, 4, 7 Kuhlmann T....Bruck W. (2002)
    4. BCL-XL dimerization by three-dimensional domain swapping. (PubMed id 16368107)1, 2 O'Neill J.W.... Hockenbery D.M. (2006)
    5. PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. (PubMed id 17046835)1, 2 Lo S.-C. and Hannink M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. (PubMed id 12011449)1, 2 Xue L.... Prasad K.V.S. (2002)
    8. PUMA induces the rapid apoptosis of colorectal cancer cells. (PubMed id 11463391)1, 2 Yu J.... Vogelstein B. (2001)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    10. Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. (PubMed id 11206074)1, 2 Petros A.M....Fesik S.W. (2000)

    External Searches for BCL2L1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BCL2L1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 598 HGNC: 992 AceView: BCL2L1 Ensembl:ENSG00000171552 euGenes: HUgn598
    ECgene: BCL2L1 Kegg: 598 H-InvDB: BCL2L1

    Other Databases showing BCL2L1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BCL2L1 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for BCL2L1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BCL2L1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for BCL2L1 gene:
    Search GeneIP for patents involving BCL2L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for BCL2L1 gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for BCL2L1 Antibodies for BCL2L1
     Super-pooled esiRNAs for BCL2L1 Proteins for BCL2L1
     Lentivirus-delivered shRNAs for BCL2L1 microRNA Mimics for BCL2L1
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies for BCL2L1 (Bcl-x)   Cell Culture Products  
     ELISAs for BCL2L1 (Bcl-xL)   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for BCL2L1 (Bcl-xL)  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BCL2L1
     SeqTarget long-range PCR primers for resequencing BCL2L1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for BCL2L1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BCL2L1
     GenScript Custom Purified and Recombinant Proteins Services for BCL2L1 GenScript cDNA clones with any tag delivered in your preferred vector for BCL2L1
     GenScript Custom Assay Services for BCL2L1 GenScript Custom Superior Antibodies Services for BCL2L1
     GenScript Custom overexpressing Cell Line Services for BCL2L1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for BCL2L1  (Bcl-XL)

     Regulatory tfbs in BCL2L1 promoter
     Search Chromatin IP Primers for BCL2L1
     RT2 qPCR Primer Assay for BCL2L1
     GNC Network for BCL2L1
     Assays for microRNAs that regulate BCL2L1
     SABiosciences PCR Arrays including BCL2L1
     Tocris compounds for BCL2L1
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for BCL2L1
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for BCL2L1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for BCL2L1
     Proteins for BCL2L1
     Lysates for BCL2L1
     Antibodies for BCL2L1
     Browse ProSpec Recombinant Proteins

     Browse ELISAs and CLIAs at Uscn
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    BCL2L1 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4