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BGN Gene

protein-coding   GIFtS: 56

GC0XP141428
biglycan
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
biglycan1 2     biglycan proteoglycan2
SLRR1A1 2 3     OTTHUMP000000259302
DSPG11 2     small leucine-rich protein 1A2
Bone/cartilage proteoglycan I2 3     bone/cartilage proteoglycan-I2
PG-S12 3     PGI2
dermatan sulphate proteoglycan I2     

External Ids:    HGNC: 10441   Entrez Gene: 6332   Ensembl: ENSG000001824927   UniProtKB: P218103   

Export aliases for BGN gene to outside databases

Previous GC identifers: GC0XP146898 GC0XP149215 GC0XP150346 GC0XP151228 GC0XP152285 GC0XP152413 GC0XP152762


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BGN:
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in
structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to
be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein
probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly
of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy,
including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the
dystrophin-associated protein complex. (provided by RefSeq)

UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
Function: May be involved in collagen fiber assembly (By similarity)

Gene Wiki entry for BGN (Biglycan)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BGN gene promoter:
         NF-kappaB1   NF-kappaB   MyoD   GR-alpha   PPAR-gamma2   PPAR-gamma1   Elk-1   GR-beta   NF-kappaB2   FOXD1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for BGN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

BGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BGN gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP141428:  view genomic region     (about GC identifiers)

Start:
141,428,414 bp from pter
End:
141,433,357 bp from pter
Size:
4,944 bases
Orientation:
plus strand

1 alternative location:
ChrX+ 152,760,397-152,775,012     
RefSeq DNA sequence:
NC_000023.10  NT_167198.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810 (See protein sequence)
Recommended Name: Biglycan precursor  
Size: 368 amino acids; 41654 Da
Subunit: Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: P13247

Explore the universe of human proteins at neXtProt for BGN: NX_P21810 

Post-translational modifications:

  • The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate (By similarity)1


  • REFSEQ proteins: NP_001702.1  

    ENSEMBL proteins: 
    ENSP00000392412 ENSP00000402525 ENSP00000359223 ENSP00000399515 ENSP00000408051 ENSP00000327336 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    R&D Systems Recombinant & Natural Proteins for BGN (Biglycan)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: BGN
    GenScript Custom Purified and Recombinant Proteins Services for BGN 
    Novus Biologicals Protein for BGN
    Novus Biologicals Lysate for BGN
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix NAS1860845
    GO:0009986 cell surface IEA--
    GO:0030133 transport vesicle IDA11256614
    GO:0031012colocalizes with extracellular matrix IDA--
    About this table

    BGN for ontologies           About GeneDecksing



    Antibodies for BGN: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BGN
    R&D Systems Antibodies for BGN (Biglycan)
    OriGene Antibodies (see all 2): BGN
    GenScript Custom Superior Antibodies Services for BGN 
    Novus Biologicals Antibodies for BGN
    Epitomics antibodies for BGN

    Assays for BGN: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BGN 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BGN 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    BGN for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001611 Leu-rich_rpt
     IPR000372 LRR-contain_N
     IPR016352 SLRP_I_decor/aspor/byglycan

    Graphical View of Domain Structure for InterPro Entry P21810

    ProtoNet protein and cluster: P21810

    2 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily
    Similarity: Contains 12 LRR (leucine-rich) repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
    Function: May be involved in collagen fiber assembly (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for BGN
    Sigma-Aldrich shRNA Panels and shRNA for BGN
    OriGene 29mer shRNA kits in GFP-retroviral vector: BGN
    OriGene shRNA RFP: BGN
    OriGene basic RS shRNA: BGN
    OriGene siRNA: BGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BGN 
    miRNA:Sigma-Aldrich microRNA Mimics for BGN
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BGN 
    Search SABiosciences for Assays for microRNAs that regulate BGN

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: BGN
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: BGN
    OriGene untagged cDNA clones in CMV expression vector: BGN
    OriGene 3'-UTR clone: BGN 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for BGN 
    Sino Biological Human cDNA Clone for BGN

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for BGN 

    Genatlas biochemistry entry for BGN:
    biglycan (small interstitial proteoglycan),leucine-rich repeat (LRR) family

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201 extracellular matrix structural constituent NAS1860845
    GO:0005515 protein binding IEA--
    GO:0005539 glycosaminoglycan binding IEA--
    GO:0050840 extracellular matrix binding IEA--
    About this table

    BGN for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bgn):

    behavior/neurologicalgrowth/sizeimmune systemlimbs/digits/tailmuscle
    skeleton

    BGN for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Arrays including BGN: PAHS-026A PAHS-095A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BGN

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001974 blood vessel remodeling IEA--
    GO:0008150 biological_process ND--
    GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA--
    About this table

    BGN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    BGN for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BGN
    3 Novoseek chemical compound relationships for BGN gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 68.4 1 1863601 (1)
    leucine 35.6 1 1870448 (1)
    dexamethasone 27.8 7 7988427 (6)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for BGN
    Sigma-Aldrich shRNA Panels and shRNA for BGN
    OriGene 29mer shRNA kits in GFP-retroviral vector: BGN
    OriGene shRNA RFP: BGN
    OriGene basic RS shRNA: BGN
    OriGene siRNA: BGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BGN 
    miRNA: Sigma-Aldrich microRNA Mimics for BGN
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BGN 
    Search SABiosciences for Assays for microRNAs that regulate BGN
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: BGN
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: BGN
    OriGene untagged cDNA clones in CMV expression vector: BGN
    OriGene 3'-UTR Clone: BGN 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for BGN 
    Primers: OriGene genome-wide validated SYBR primer pairs: BGN
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BGN: PPH01899A

    REFSEQ mRNAs for BGN gene: 

    NM_001711.4  

    Additional cDNA sequence: 

    AK092954.1 AK093023.1 AK094059.1 AK222484.1 AK223302.1 AK291955.1 AK293268.1 AK293289.1 
    AK297966.1 AK298756.1 BC002416.2 BC004244.1 BT007323.1 CR595264.1 CR618469.1 CR624916.1 
    J04599.1 U11686.1 

    24/49 DOTS entries (see all 49):

    DT.100877240  DT.455904  DT.86995097  DT.100877223  DT.100804711  DT.99943230  DT.100877226  DT.97860449 
    DT.95122348  DT.100031288  DT.97860448  DT.100877237  DT.121287231  DT.85103514  DT.121287285  DT.91657188 
    DT.121287209  DT.91761196  DT.100877242  DT.121287265  DT.100877233  DT.91816029  DT.100877231  DT.95122339 

    24/767 AceView cDNA sequences (see all 767):

    BQ067023 AU103050 BQ181055 BQ708510 AU141292 BU736310 BP372124 BP372343 
    AA336870 CD612580 BQ882271 CN484687 AA348703 BT007323 AA554050 R32372 
    BU185997 BP372907 BQ883638 BP372385 BQ942694 NM_001711 BQ182092 AU142113 

    highest scoring ESTs for BGN:

    AW007442 J04599 R77227 AA317049 AA336870 AA348703 AA348704 AA359111 AA401265 AA404245 

    Unigene Cluster for BGN:

    Biglycan
    Hs.821  [show with all ESTs]
    Unigene Representative Sequence: NM_001711


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for BGN (see all 11)

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^
    SP1:                                                                          -                                                                                 
    SP2:              -     -                                                     -                                                                                 
    SP3:              -     -                                               -     -     -     -                                                                     
    SP4:              -     -                 -     -                             -                                                                                 
    SP5:                                                                          -                                                                                 

    ExUns: 12a · 12b · 12c · 12d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        

    About this scheme

    ECgene alternative splicing isoforms for BGN
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418899 ENST00000480756 ENST00000431891 ENST00000370204 ENST00000431270
    ENST00000492658 ENST00000472615 ENST00000430380 ENST00000331595(uc004fhq.1 uc004fhr.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    BGN expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching BGN gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38126_at2, 3 U95-A 1 1.00 1.00 0.98 0.93 J04599 1.00 0.90 0.95 1
    74989_at2, 3 U95-D 1 1.00 1.00 0.98 1.02 AW007442 1.00 0.90 0.95 1
    89603_at2, 3 U95-E 1 0.81 1.00 1.00 1.06 R77227 1.00 0.90 0.95 1
    201262_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001711 0.60 1.00 0.82 1
    201261_x_at2, 3 U133-A 3 0.91 0.93 -- -- BC002416 0.80 1.00 0.91 1
    213905_x_at2, 3 U133-A 1 0.73 1.00 -- -- AA845258 0.40 1.00 0.76 1
    201262_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    201261_x_at2 U133Plus2 3 0.91 0.93 -- -- -- -- -- -- --
    213905_x_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    BGN for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    BGN gene expression
    BGN gene electronic northern expression
    BGN gene sage expression
    About these images

    CGAP SAGE TAG: GCCTGTCCCT

    SOURCE GeneReport for Unigene cluster: Hs.821

    Expression variation in blood from EXPOLDB for BGN

    UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
    Tissue specificity: Found in several connective tissues, especially in articular cartilages

    Primers: OriGene genome-wide validated SYBR primer pairs: BGN
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BGN: PPH01899A
        SABiosciences Expression via Pathway-Focused PCR Arrays including BGN: PAHS-026A PAHS-095A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for BGN gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BGN1   -- biglycan 91.85(n)
    94.84(a)
    403905  NM_001003229.1  NP_001003229.1 
    chimpanzee
    (Pan troglodytes)
    BGN1   -- biglycan 99.23(n)
    100(a)
    473829  XM_529202.2  XP_529202.2 
    cow
    (Bos taurus)
    BGN1   -- biglycan 90.85(n)
    94.84(a)
    280733  NM_178318.3  NP_847888.2 
    rat
    (Rattus norvegicus)
    Bgn1   -- biglycan 88.59(n)
    95.65(a)
    25181  NM_017087.1  NP_058783.1 
    mouse
    (Mus musculus)
    Bgn1 , 5 X (37.33 cM)5
    biglycan1, 5 88.59(n)1
    95.92(a)1
    121111  NM_007542.31  NP_031568.21 
     AK0869205  AK1354965  (see all 19)
    About this table        Species with no ortholog for BGN

    ENSEMBL Gene Tree for BGN (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for BGN gene
    OGN2  DCN2  PODNL12  PODN2  OPTC2  EPYC2  ECM22  LOC1005073522  
    ASPN2  

    BGN for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/149 NCBI SNPs in BGN are shown (see all 149)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs48331,2
    C,F,H,152770230(+) ACCTCG/AGGCGT 4 /S syn1 ref18Minor allele frequency- A:0.38MN EA NS NA 746
    rs176781,2
    C152774727(-) GTTTTG/TTGGGC 2 -- ut31 ese30--------
    rs7436411,2
    C,F,A,H152774154(+) CTCCCA/TCCACA 2 -- ut31 ese39Minor allele frequency- T:0.27MN EA NS NA 846
    rs7436421,2
    C,F,O,A152774221(+) CCAAGG/TCTCCA 2 -- ut31 ese317Minor allele frequency- T:0.22EA NA MN NS 1378
    rs8804141,2
    --152767813(+) GCAGGA/GGCATC 1 -- int10--------
    rs10421031,2
    C,F,A152774031(+) ACCTCG/AGGTCC 2 -- ut315Minor allele frequency- A:0.14NS EA NA 419
    rs10425701,2
    --152774931(+) TCCTTC/TTGGTC 2 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs10426141,2
    --152774958(+) TGCTTC/TTGAGG 2 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs11264991,2
    C,F,A,152771509(+) TTCAGC/TGGGCT 4 S ref1 syn1 ese312Minor allele frequency- T:0.31NS EA NA 847
    rs11265981,2
    --152774517(+) tctctC/G/Ttctgt 2 -- ut310--------
    About this table

    HapMap Linkage Disequilibrium images for BGN (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BGN: --

    QIAGEN SeqTarget long-range PCR primers for resequencing BGN 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BGN for disorders           About GeneDecksing

    OMIM: 301870

    Locus Specific Mutation Databases (LSDB): BGN
    Human Genome Epidemiology (HuGE) Navigator: BGN (4 documents)

    Export disorders and mutations for BGN gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/83 PubMed articles for BGN gene, integrated from 7 sources (see all 83):
    (articles sorted by number of sources associating them with BGN)
    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PubMed id 10854409)1, 2 Mallon A.-M....Brown S.D.M. (2000)
    3. Dinucleotide repeat polymorphism at the human biglycan (BGN) locus. (PubMed id 7881444)1, 2 Just W.... Vogel W. (1994)
    4. Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. (PubMed id 1612609)1, 3 Traupe H....Ropers H.H. (1992)
    5. Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. (PubMed id 1860845)1, 2 Fisher L.W.... Young M.F. (1991)
    6. Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. (PubMed id 2590169)1, 2 Roughley P.J. and White R.J. (1989)
    7. Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. (PubMed id 2647739)1, 2 Fisher L.W.... Young M.F. (1989)
    8. Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. (PubMed id 3597437)1, 2 Fisher L.W.... Termine J.D. (1987)
    9. Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. (PubMed id 12140283)1, 7 Chen W.B....Ungefroren H. (2002)
    10. Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling. (PubMed id 12538652)1, 7 Ungefroren H....Kalthoff H. (2003)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 633 HGNC: 1044 AceView: BGN Ensembl:ENSG00000182492 euGenes: HUgn633
    ECgene: BGN H-InvDB: BGN

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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