Aliases &
Descriptions
for BIN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| bridging integrator 31 2 | | MGC149782 |
Export aliases for BIN3 gene to outside databasesPrevious GC identifers: GC08P022082 GC08M022831 GC08M022298 GC08M022499 GC08M022533 |
Summaries
for BIN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BIN3:
The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BARdomain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and inducemembrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellulartransport, and a diverse set of other processes. (provided by RefSeq)
UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0Function: Involved in cytokinesis and septation where it has a role in the localization of F-actin
Gene Wiki entry for BIN3 |
Genomic Views
for BIN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BIN3 gene promoter:
SRY GCNF-1 GCNF-2 GATA-2 GATA-3 GATA-1 AREB6 Sox9 MEF-2A HOXA9B
Other transcription factors
Search SABiosciences Chromatin IP Primers for BIN3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for BIN3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21.3 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21.2BIN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M021021: view genomic region
(about GC identifiers)
Start:
|
21,021,078 bp from pter |
End:
|
21,070,156 bp from pter |
Size:
|
49,079 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr8- 22,477,931-22,526,661 |
RefSeq DNA sequence:- NC_000008.10 NT_167187.1
|
Proteins
for BIN3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0 (See
protein sequence)Recommended Name: Bridging integrator 3 Size: 253 amino acids; 29665 Da
Subcellular location: Cytoplasm, cytoskeleton
Sequence caution: Sequence=AAH01223.1; Type=Erroneous initiation;
Secondary accessions: Q9BVG2 Q9NVY9Alternative splicing: 2 isoforms: Q9NQY0-1 Q9NQY0-2 Explore the universe of human proteins at neXtProt for BIN3: NX_Q9NQY0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061158.1
ENSEMBL proteins: ENSP00000428768 ENSP00000429660 ENSP00000276416 ENSP00000382859 ENSP00000430423 ENSP00000430546
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
BIN3 for ontologies About GeneDecksing
Antibodies for BIN3:
Assays for BIN3: |
Protein
Domains/
Families
for BIN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BIN3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NQY0ProtoNet protein and cluster: Q9NQY0 UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0Similarity: Contains 1 BAR domain |
Gene Function
for BIN3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0Function: Involved in cytokinesis and septation where it has a role in the localization of F-actin
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
BIN3 for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bin3):
BIN3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for BIN3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for BIN3
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BIN3
1 Interacting protein for BIN3 (Q9NQY01) via UniProtKB, MINT, and/or STRINGAbout this table
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): About this table
BIN3 for ontologies About GeneDecksing
|
Drugs & Compounds
for BIN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for BIN3
|
Transcripts
for BIN3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for BIN3 gene: NM_018688.4 Additional cDNA sequence: AF271732.1 AK001289.1 AK023980.1 AK124486.1 AK222470.1 BC001223.1 BC009824.2 BC050314.1 CR591250.1 CR596305.1 CR600556.1 CR607748.1 CR611814.1 CR612252.1 CR619432.1 CR619792.1 CR620938.1 CR623018.1 CR625006.1 CR626268.1 17 DOTS entries: DT.454185 DT.91738811 DT.100848059 DT.307907 DT.100028655 DT.40114938 DT.121471422 DT.91969078 DT.95104538 DT.121471418 DT.92016419 DT.95137166 DT.97800537 DT.97845467 DT.100867432 DT.121471393 DT.95257484 24/278 AceView cDNA sequences (see all 278): BQ953290 BF850372 Z43219 BF726984 NM_018688 AI961825 BQ679827 BE796954 BU554043 AK023980 F03866 AI276477 CR623018 CB115901 AI358211 AW516118 AI581845 BX112274 CR625006 CR591250 AW237835 BU634482 AA744592 BE550579
 highest scoring ESTs for BIN3:AK001289 AU126217 AI498450 AK124486 AL704157 AW001726 BC050314 BF966895 BG743151 BI763694 Unigene Cluster for BIN3: Bridging integrator 3 Hs.654720 [show with all ESTs]Unigene Representative Sequence: BC050314
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for BIN3 (see all 10)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for BIN3
11 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000520489 ENST00000522268 ENST00000520292 ENST00000276416(uc003xck.2 uc003xcl.2 uc010ltw.2)
ENST00000521140 ENST00000519335 ENST00000399977 ENST00000519863 ENST00000518366
ENST00000519513 ENST00000522687
|
Expression
for BIN3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| BIN3 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching BIN3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 87953_s_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
0.67 |
1.53 |
AW005016 |
0.60 |
0.60 |
0.60 |
1 |
| 54073_at2, 3
|
U95-B |
1 |
0.44 |
1.00 |
0.76 |
0.48 |
AI983752 |
0.60 |
0.75 |
0.68 |
1 |
| 222199_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AK001289 |
0.80 |
0.88 |
0.84 |
1 |
| 222199_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1557582_at*2
|
U133Plus2 |
NULL |
0.00 |
0.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
BIN3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CGTTGTGGGC
SOURCE GeneReport for Unigene cluster: Hs.654720
UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0Tissue specificity: Ubiquitously expressed except in brain
SABiosciences Custom PCR Arrays for BIN3
|
Orthologs
for BIN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BIN3 gene from 5/12 species (see all 12)
About this table Species with no ortholog for BIN3
ENSEMBL Gene Tree for BIN3 (if available) |
Paralogs
for BIN3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for BIN3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for BIN3
2 CNVs: 2746 3726 | | QIAGEN SeqTarget long-range PCR primers for resequencing BIN3 |
|
Disorders & Mutations
for BIN3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BIN3 for disorders About GeneDecksing
OMIM: 606396
Export disorders and mutations for BIN3 gene to outside databases
|
Medical News
for BIN3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for BIN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for BIN3 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with BIN3)- Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. (PubMed id 11274158)1, 2, 7 Routhier E.L....Prendergast G.C. (2001)
- The BAR domain proteins: molding membranes in fission, fusion, and phagy. (PubMed id 16524918)1, 3 Ren G....Munn A.L. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The BAR-domain family of proteins: a case of bending and binding? (PubMed id 14993925)1 Habermann B. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for BIN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BIN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BIN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BIN3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BIN3 gene:
Search GeneIP for patents involving BIN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BIN3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for BIN3 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for BIN3 |
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