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BIRC3 Gene

protein-coding GIFtS: 66

GC11P098114

baculoviral IAP repeat-containing 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: API2)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
baculoviral IAP repeat-containing 3¹ ²		hiap-1¹
RNF49¹ ² ³		cIAP2¹
MIHC¹ ² ³		mammalian IAP homolog C²
API2² ³ ⁵		baculoviral IAP repeat-containing protein 3²
MALT2¹ ²		HIAP1²
c-IAP2¹ ²		AIP1²
Apoptosis inhibitor 2² ³		TNFR2-TRAF signaling complex protein²
Inhibitor of apoptosis protein 1² ³		CIAP2²
IAP-1² ³		hIAP-1³
IAP homolog C² ³		hIAP1³
TNFR2-TRAF-signaling complex protein 1² ³		C-IAP2³
RING finger protein 49² ³		IAP1³
HAIP1² ⁵

External Ids:	HGNC: 591¹	Entrez Gene: 330²	Ensembl: ENSG00000023445⁷	UniProtKB: Q13489³

Export aliases for BIRC3 gene to outside databases

Previous GC identifers: GC11P104381 GC11P103545 GC11P102222 GC11P101725 GC11P101693

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BIRC3:

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor

necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like

proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting

from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP

repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified. (provided

by RefSeq)

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489

Function: Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and

TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)

Gene Wiki entry for BIRC3 (Baculoviral IAP repeat-containing protein 3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BIRC3 gene promoter:
         deltaCREB   CREB   AP-1   c-Jun   c-Fos   p53   c-Rel   YY1   RelA   NF-kappaB1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for BIRC3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22

BIRC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC3 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P098114: view genomic region (about GC identifiers)

Start:	98,114,751 bp from pter
End:	98,135,033 bp from pter
Size:	20,283 bases
Orientation:	plus strand

1 alternative location:

Chr11+ 102,188,194-102,208,448

RefSeq DNA sequence:

NC_000011.9 NT_033899.8

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489 (See protein sequence)

Recommended Name: Baculoviral IAP repeat-containing protein 3

Size: 604 amino acids; 68372 Da

Subunit: Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity

Subcellular location: Cytoplasm (Potential)

PDB structures from and Proteopedia :

2UVL (3D)

3EB5 (3D)

3EB6 (3D)

3M0A (3D)

3M0D (3D)

Secondary accessions: Q16628 Q9HC27 Q9UP46

Explore the universe of human proteins at neXtProt for BIRC3: NX_Q13489

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001156.1 NP_892007.1

ENSEMBL proteins:

ENSP00000391182 ENSP00000376897 ENSP00000263464

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for BIRC3 (cIAP-2/HIAP-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): BIRC3 OriGene Protein Over-expression Lysate (see all 2): BIRC3
	GenScript Custom Purified and Recombinant Proteins Services for BIRC3
	Novus Biologicals Proteins for BIRC3
	Novus Biologicals Lysates for BIRC3
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	16123224
GO:0005737	cytoplasm	IDA	16123224
GO:0043234	protein complex	IEA	--
GO:0045121	membrane raft	IEA	--

About this table

BIRC3 for ontologies About GeneDecksing

Antibodies for BIRC3:

	Millipore Mono- and Polyclonal Antibodies for the study of BIRC3
	Sigma-Aldrich Antibodies for BIRC3
	R&D Systems Antibodies for BIRC3 (cIAP-2/HIAP-1)
	Cell Signaling Technology (CST) Antibodies for BIRC3 (c-IAP2)
	OriGene Antibodies: BIRC3
	GenScript Custom Superior Antibodies Services for BIRC3
	Novus Biologicals Antibodies for BIRC3
	Epitomics antibodies for BIRC3

Assays for BIRC3:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for BIRC3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BIRC3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BIRC3 for domains About GeneDecksing

5 InterPro domains/families:

IPR001841 Znf_RING

IPR011029 DEATH-like

IPR013083 Znf_RING/FYVE/PHD

IPR001370 BIR

IPR001315 CARD

Graphical View of Domain Structure for InterPro Entry Q13489

ProtoNet protein and cluster: Q13489

3 Blocks protein families:

IPB001315 CARD interaction domain

IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)

IPB001841 Zn-finger

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489

Similarity: Belongs to the IAP family

Similarity: Contains 3 BIR repeats

Similarity: Contains 1 CARD domain

Similarity: Contains 1 RING-type zinc finger

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489

Function: Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and

TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for BIRC3 Sigma-Aldrich shRNA Panels and shRNA for BIRC3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): BIRC3 OriGene shRNA RFP (see all 2): BIRC3 OriGene basic RS shRNA (see all 2): BIRC3 OriGene siRNA (see all 2): BIRC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BIRC3

miRNA:		Sigma-Aldrich microRNA Mimics for BIRC3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BIRC3
		1 SABiosciences Assays for microRNA that regulate BIRC3:
		hsa-miR-561

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): BIRC3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): BIRC3 OriGene untagged cDNA clones in CMV expression vector (see all 2): BIRC3 OriGene 3'-UTR clone (see all 2): BIRC3 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): BIRC3
		Sino Biological Human cDNA Clone for BIRC3

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for BIRC3

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	16395405
GO:0005515	protein binding	IPI	11907583
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

BIRC3 for ontologies About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Birc3):

hematopoietic system

immune system

BIRC3 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

BIRC3 for pathways About GeneDecksing

2 Millipore Pathways for BIRC3

	Apoptosis and survival TNFR1 signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

5/11 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for BIRC3 (see all 11)

	Death Receptor Signaling
	RANK Signaling in Osteoclasts
	TWEAK Signaling
	Amyotrophic Lateral Sclerosis Signaling
	TNFR2 Signaling

5/7 Kegg Pathways (Kegg details for BIRC3) (see all 7):

	hsa04120 Ubiquitin mediated proteolysis
	hsa04210 Apoptosis
	hsa04510 Focal adhesion
	hsa04621 NOD-like receptor signaling pathway
	hsa05145 Toxoplasmosis

SABiosciences Pathway-Focused PCR Arrays including BIRC3 (see all 6): PAHS-012A PAHS-014A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for BIRC3

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BIRC3

5/33 Interacting proteins for BIRC3 (ENSP00000263464³ Q13489¹) via UniProtKB, MINT, and/or STRING (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DIABLO	Q9NR28¹	STRING: ENSP00000267169 EBI-517709,EBI-517508
TRAF2	Q12933¹	STRING: ENSP00000352685 EBI-517709,EBI-355744
APAF1	ENSP00000353059³	STRING: ENSP00000353059
BID	ENSP00000318822³	STRING: ENSP00000318822
BIRC2	ENSP00000227758³	STRING: ENSP00000227758

About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006916	anti-apoptosis	TAS	8552191
GO:0007166	cell surface receptor linked signaling pathway	TAS	8548810
GO:0007283	spermatogenesis	IEA	--
GO:0042981	regulation of apoptosis	IEA	--
GO:0051291	protein heterooligomerization	IEA	--

About this table

BIRC3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

BIRC3 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BIRC3
10/33 Novoseek chemical compound relationships for BIRC3 gene (see all 33)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ciap2	95.4	64	17972100 (7), 20385093 (7), 16115895 (4), 16144937 (4) (see all 16)
ciap1	93.7	38	15265700 (8), 20097753 (4), 18570872 (3), 17972100 (2) (see all 12)
pdtc	49.7	5	12269771 (2), 14527959 (1)
curcumin	44.5	5	16243823 (1), 17640567 (1), 16219905 (1), 15911101 (1) (see all 5)
ly294002	43.8	2	14762343 (1), 19051078 (1)
mg 132	41.9	1	14527959 (1)
parthenolide	41.6	1	11588049 (1)
triptolide	40.8	2	15972136 (1), 10224110 (1)
etoposide	40.2	3	15050749 (1), 12243753 (1), 9384571 (1)
doxorubicin	39.9	8	12926068 (2), 17311258 (1), 18434593 (1), 19746155 (1) (see all 6)

About this table

2 PharmGKB drug compound relationships for BIRC3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
dexamethasone	FA	12239098
glucocorticoids	FA	12239098

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for BIRC3 Sigma-Aldrich shRNA Panels and shRNA for BIRC3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): BIRC3 OriGene shRNA RFP (see all 2): BIRC3 OriGene basic RS shRNA (see all 2): BIRC3 OriGene siRNA (see all 2): BIRC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BIRC3

miRNA:		Sigma-Aldrich microRNA Mimics for BIRC3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BIRC3
		1 SABiosciences Assays for microRNA that regulate BIRC3:
		hsa-miR-561

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): BIRC3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): BIRC3 OriGene untagged cDNA clones in CMV expression vector (see all 2): BIRC3 OriGene 3'-UTR Clone (see all 2): BIRC3 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): BIRC3

Primers:		OriGene genome-wide validated SYBR primer pairs: BIRC3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for BIRC3: PPH00326A

REFSEQ mRNAs for BIRC3 gene (2 alternative transcripts):

NM_001165.3 NM_182962.1

Additional cDNA sequence:

AF070674.1 BC027485.2 BC037420.1 L43346.1 L49432.1 U45878.1

6 DOTS entries:

DT.442857 DT.100813069 DT.92421251 DT.95177781 DT.92425948 DT.100690941

24/228 AceView cDNA sequences (see all 228):

AI950126 AA962737 BU665537 AI581499 AV716229 AA761368 BM956105 AI678800

AI978668 AA252610 AW590487 BF339660 BU663067 BQ004306 AI827488 BU685791

BM476485 AW085885 AA534507 AW576258 AW591294 BU663663 BU662287 AI354462

highest scoring ESTs for BIRC3:

U45878 AA243387 AA252610 AA314209 AA534507 AA582034 AA582044 AA808391 AA828467 AF070674

Unigene Cluster for BIRC3:

Baculoviral IAP repeat-containing 3

Hs.127799 [show with all ESTs]

Unigene Representative Sequence: NM_001165

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC3

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b
SP1:											-		-		-								-
SP2:																							-
SP3:
SP4:
SP5:							-

About this scheme

ECgene alternative splicing isoforms for BIRC3
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000439863 ENST00000393201 ENST00000263464(uc001pgx.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

BIRC3 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching BIRC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1717_s_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.98	U45878	1.00	0.90	0.95	1
91017_at²^{, 3}	U95-E	1	0.56	1.00	0.36	0.80	U54711	0.80	0.88	0.84	1
63769_at²^{, 3}	U95-C	1	0.44	1.00	0.93	1.25	AI749656	0.80	0.88	0.84	1
210538_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U37546	0.60	0.83	0.73	1
210538_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

BIRC3 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

BIRC3 gene electronic northern expression

About these images

CGAP SAGE TAG: GTGTTTTTAT

SOURCE GeneReport for Unigene cluster: Hs.127799

Expression variation in blood from EXPOLDB for BIRC3

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489

Tissue specificity: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid

tissues, including spleen, thymus and peripheral blood lymphocytes

Primers:		OriGene genome-wide validated SYBR primer pairs: BIRC3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for BIRC3: PPH00326A

SABiosciences Expression via Pathway-Focused PCR Arrays including BIRC3 (see all 6): PAHS-012A PAHS-014A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BIRC3 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BIRC3¹	--	baculoviral IAP repeat-containing 3	76.38(n) 74.5(a)	489433 XM_546551.2 XP_546551.2
chimpanzee (Pan troglodytes)	BIRC3¹	--	baculoviral IAP repeat-containing 3	99.12(n) 99.01(a)	451507 XM_001151914.1 XP_001151914.1
cow (Bos taurus)	BIRC3¹	--	baculoviral IAP repeat-containing 3	88.69(n) 85.76(a)	514386 NM_001035293.1 NP_001030370.1
rat (Rattus norvegicus)	Birc3¹	--	baculoviral IAP repeat-containing 3	76.91(n) 74.25(a)	78971 NM_023987.2 NP_076477.2
mouse (Mus musculus)	Birc3^{1 , 5}	9 (2.46 cM)⁵	baculoviral IAP repeat-containing 3^{1, 5}	77.11(n)¹ 74.33(a)¹	11796¹ NM_007464.2¹ NP_031490.1¹ AI606357⁵ AK154721⁵ (see all 15)

About this table Species with no ortholog for BIRC3

ENSEMBL Gene Tree for BIRC3 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BIRC3 gene

BIRC7² XIAP² BIRC2² BIRC8²

BIRC3 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs3460^1,2	C,F,O,A,	102208390(+)	`TGAATG/CACATT`	2	--	ut3¹		110		NS MN EA PA EU CA WA NA	8134
rs546019^1,2	--	102198242(-)	`aggtgC/Tatgcc`	2	--	int¹		0	--	--	--	--
rs546021^1,2	--	102198241(-)	`ggtgtA/Ctgcca`	2	--	int¹		0	--	--	--	--
rs693746^1,2	H	102193449(-)	`CTGCAG/AACTTC`	2	--	int¹ ut5¹ ese³		6		EA MN NS	614
rs1055078^1,2	--	102195369(+)	`GGGGTC/TCCTGT`	4	V	syn¹ ref¹ ese³		0	--	--	--	--
rs1055079^1,2	--	102195396(+)	`GCTCGC/TGCTGG`	4	R	syn¹ ref¹ ese³		0	--	--	--	--
rs1055088^1,2	C,F,A,	102207851(+)	`ACATCA/GTCTAA`	2	--	ut3¹		19		MN EA NA NS WA	1218
rs1055093^1,2	--	102207899(+)	`ACTTTC/TATCCT`	2	--	ut3¹		0	--	--	--	--
rs1802410^1,2	--	102195084(+)	`AGAATC/TTCCAT`	2	--	ut5¹ int¹		0	--	--	--	--
rs2276113^1,2	C,F,O	102196019(+)	`CTTTAA/GAACAT`	4	K R	ref¹ mis¹		25		EA NA NS MN	3538

About this table

HapMap Linkage Disequilibrium images for BIRC3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BIRC3: --

QIAGEN SeqTarget long-range PCR primers for resequencing BIRC3

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BIRC3 for disorders About GeneDecksing

OMIM: 601721

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489

Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue

(MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of

cytogenetically abnormal low-grade MALT lymphoma

10/38 Novoseek disease relationships for BIRC3 gene (see all 38)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malt lymphoma	75.1	17	10797525 (1), 11162514 (1), 19234489 (1), 11159207 (1) (see all 15)
necrosis	61.1	22	10657935 (2), 11106668 (1), 17011514 (1), 16291753 (1) (see all 17)
tumors	54.8	42	16983704 (3), 11484955 (3), 10657935 (2), 10815900 (2) (see all 26)
lymphoma b-cell	50.5	8	11066071 (1), 16983704 (1), 14652825 (1)
leukemia	44.2	6	16638183 (2), 16983704 (1)
cancer	42	18	18570872 (3), 15856013 (2), 15265700 (1), 18992220 (1) (see all 13)
lymphoma	39.8	4	16983704 (2), 10751367 (1)
leukemia t-cell	39.1	1	19564891 (1)
burkitt lymphoma	36.9	3	16983704 (1), 18503581 (1)
muscular atrophy spinal	27.9	1	11397650 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: BIRC3 (11 documents)

Export disorders and mutations for BIRC3 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/388 PubMed articles for BIRC3 gene, integrated from 7 sources (see all 388):
(articles sorted by number of sources associating them with BIRC3)

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)^{1, 2, 3} Liston P.... Korneluk R.G. (1996)
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PubMed id 8548810)^{1, 2, 3} Rothe M.... Goeddel D.V. (1995)
Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. (PubMed id 11066071)^{1, 2, 7} Baens M.... Marynen P. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)^{1, 2} Horrevoets A.J.G.... Pannekoek H. (1999)
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. (PubMed id 8643514)^{1, 2} Uren A.G.... Vaux D.L. (1996)
Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia. (PubMed id 12393423)^{1, 7} Hasegawa T....Kitagawa S. (2003)
Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. (PubMed id 14527959)^{1, 7} Wang Q....Evers B.M. (2003)
Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. (PubMed id 20385093)^{1, 7} Zheng C....Wu H. (2010)
Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis. (PubMed id 15856013)^{1, 7} Yuan H....Liu X. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 330	HGNC: 591	AceView: BIRC3	Ensembl:ENSG00000023445	euGenes: HUgn330
ECgene: BIRC3	Kegg: 330	H-InvDB: BIRC3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for BIRC3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/birc3/

Intellectual Property for BIRC3 gene
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BIRC3 Gene

protein-coding GIFtS: 66

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BIRC3 (Gene Symbol)
baculoviral IAP repeat-containing 3
RNF49
MIHC
API2
MALT2
c-IAP2
Apoptosis inhibitor 2
Inhibitor of apoptosis protein 1
IAP-1
IAP homolog C
TNFR2-TRAF-signaling complex protein 1
RING finger protein 49
HAIP1
hiap-1
cIAP2
mammalian IAP homolog C
baculoviral IAP repeat-containing protein 3
HIAP1
AIP1
TNFR2-TRAF signaling complex protein
CIAP2
hIAP-1
hIAP1
C-IAP2
IAP1

Gastric Cancer
Leukemia T-Cell
Colon Cancer
Leukemia Lymphocytic Chronic
atherosclerotic plaque
Waldenstrom Macroglobulinemia
Carcinoma
Hodgkin Disease
ACUTE LEUKEMIA
COLON CARCINOMA
LUNG CARCINOMA
Myeloid Leukemia Chronic
Leukemia
Alzheimers Disease
Lymphoma Follicular
Breast Cancer
NSCLC
Adenocarcinoma
Cancer
Carcinoma Renal Cell
Pancreatic Cancer
Cancer Lung
Lymphoma
Shock
Lymphoma B-Cell
MALT Lymphoma
Colorectal Cancer
Burkitt Lymphoma
Inflammation
Carcinoma Squamous Cell
MYELOMA
Chromosomal Aberrations
prostate cancer
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Lymphoma Non-Hodgkins
Necrosis
Muscular Atrophy Spinal

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BIRC3 Gene

protein-coding GIFtS: 66

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