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BLK Gene

protein-coding   GIFtS: 68

GC08P010282
B lymphoid tyrosine kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
B lymphoid tyrosine kinase1 2     MODY112 5
MGC104421 2     BLK nonreceptor tyrosine kinase2
B lymphocyte kinase2 3     tyrosine-protein kinase Blk2
p55-Blk2 3     EC 2.7.10.23

External Ids:    HGNC: 10571   Entrez Gene: 6402   Ensembl: ENSG000001365737   UniProtKB: P514513   

Export aliases for BLK gene to outside databases

Previous GC identifers: GC08P011414 GC08P011222 GC08P011388


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BLK:
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in
cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development.
The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of
several pancreatic beta-cell transcription factors. (provided by RefSeq)

UniProtKB/Swiss-Prot: BLK_HUMAN, P51451
Function: Modulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent
stimulation of insulin secretion in response to glucose

Gene Wiki entry for BLK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BLK gene promoter:
         NF-kappaB1   NF-kappaB   PPAR-gamma1   PPAR-gamma2   GCNF-1   GCNF-2   IRF-1   ER-alpha   NF-Y   NF-YA   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for BLK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23-p22   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23-p22

BLK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BLK gene location

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P010282:  view genomic region     (about GC identifiers)

Start:
10,282,885 bp from pter
End:
10,353,426 bp from pter
Size:
70,542 bases
Orientation:
plus strand

1 alternative location:
Chr8+ 11,351,510-11,422,113     
RefSeq DNA sequence:
NC_000008.10  NT_077531.4  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: BLK_HUMAN, P51451 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Blk  
Size: 505 amino acids; 57706 Da
Secondary accessions: Q16291

Explore the universe of human proteins at neXtProt for BLK: NX_P51451 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001706.2  

    ENSEMBL proteins: 
    ENSP00000406620 ENSP00000259089 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant BLK Protein
    Sigma-Aldrich Proteins for BLK
    R&D Systems Recombinant & Natural Proteins for BLK
    Enzo Life Sciences proteins for BLK
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Purified and Recombinant Proteins for BLK 
    Novus Biologicals Proteins for BLK
    Novus Biologicals Lysate for BLK
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins


    Antibodies for BLK: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BLK
    R&D Systems Antibodies for BLK
    Cell Signaling Technology (CST) Antibodies for BLK 
    OriGene Antibodies: BLK
    GenScript Custom Superior Antibodies Services for BLK 
    Novus Biologicals Antibodies for BLK
    Browse antibodies at Epitomics

    Assays for BLK: 
    Millipore Kits and Assays for the Analysis of BLK
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript BLK-Activity-based Kinase Assay for Compound Screening 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BLK 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    BLK for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_cat_dom
     IPR020750 Tyr_kinase_non-rcpt_Blk

    Graphical View of Domain Structure for InterPro Entry P51451

    ProtoNet protein and cluster: P51451

    3 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: BLK_HUMAN, P51451
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: BLK_HUMAN, P51451
    Function: Modulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent
    stimulation of insulin secretion in response to glucose
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme Number (IUBMB): EC 2.7.10.2 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for BLK
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for BLK
    Sigma-Aldrich shRNA Panels and shRNA for BLK
    OriGene 29mer shRNA kits in GFP-retroviral vector: BLK
    OriGene shRNA RFP: BLK
    OriGene basic RS shRNA: BLK
    OriGene siRNA: BLK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BLK 
    miRNA:Sigma-Aldrich microRNA Mimics for BLK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BLK 
    Search SABiosciences for Assays for microRNAs that regulate BLK

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: BLK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: BLK
    OriGene untagged cDNA clones in CMV expression vector (see all 4): BLK
    OriGene 3'-UTR clone: BLK 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: BLK 
    Sino Biological Human cDNA Clone for BLK

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for BLK 

    Genatlas biochemistry entry for BLK:
    lymphoid non receptor tyrosine kinase (58kDa),homologous to mouse Blk,SRC family

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity ----
    GO:0004713 protein tyrosine kinase activity TAS7845672
    GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA--
    About this table

    BLK for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Blk):

    hematopoietic systemimmune systemnormal

    BLK for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    BLK for pathways           About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  BLK
        PI3K Signaling in B Lymphocytes
    Reelin Signaling in Neurons

    2 Cell Signaling Technology (CST) Pathways for BLK
        Translational Control: Regulation of eIF4E and p70 S6 Kinase
    Protein Acetylation

        SABiosciences Custom Pathway-Focused PCR Arrays for BLK 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for BLK
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BLK

    5/50 Interacting proteins for BLK (ENSP000002590893 P514512) via UniProtKB, MINT, and/or STRING (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226812STRING: ENSP00000264033 MINT-15657
    EGFRP005332STRING: ENSP00000275493 MINT-74484
    ERBB2P046262MINT-74485
    ABL1ENSP000003614233STRING: ENSP00000361423
    BLNKENSP000002243373STRING: ENSP00000224337
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation IEA--
    GO:0007243 intracellular protein kinase cascade TAS2404338
    GO:0032024 positive regulation of insulin secretion IMP19667185
    About this table

    BLK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    BLK for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for BLK:
    Small Molecule - Substrate
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BLK
    6 Novoseek chemical compound relationships for BLK gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 70 49 7845672 (2), 8226767 (2), 7524079 (2), 7514299 (2) (see all 30)
    phosphotyrosine 56.3 1 9219519 (1)
    digitonin 49 1 1506682 (1)
    imatinib 25.8 1 17093930 (1)
    phosphatidylinositol 22.5 1 1397843 (1)
    calcium 3.33 1 9881695 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for BLK
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for BLK
    Sigma-Aldrich shRNA Panels and shRNA for BLK
    OriGene 29mer shRNA kits in GFP-retroviral vector: BLK
    OriGene shRNA RFP: BLK
    OriGene basic RS shRNA: BLK
    OriGene siRNA: BLK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BLK 
    miRNA: Sigma-Aldrich microRNA Mimics for BLK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BLK 
    Search SABiosciences for Assays for microRNAs that regulate BLK
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: BLK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: BLK
    OriGene untagged cDNA clones in CMV expression vector (see all 4): BLK
    OriGene 3'-UTR Clone: BLK 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: BLK 
    Primers: OriGene genome-wide validated SYBR primer pairs: BLK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BLK: PPH00085A

    REFSEQ mRNAs for BLK gene: 

    NM_001715.2  

    Additional cDNA sequence: 

    AK131319.1 AK313751.1 AL832875.1 BC004473.2 BC007371.2 BC018703.1 BC032413.1 BC038555.1 
    CR625422.1 S76617.1 Z33998.1 

    10 DOTS entries:

    DT.453246  DT.100019437  DT.91707407  DT.40106270  DT.91750791  DT.120648337  DT.40310138  DT.95163770 
    DT.75131135  DT.91707406 

    24/83 AceView cDNA sequences (see all 83):

    AL832875 BI224882 NM_001715 CR625422 BC018703 BC007371 BM465722 BC032413 
    BM458538 BM923839 BQ049022 AW406482 AA465318 AU141286 AI379972 BE676148 
    CD693037 BE268133 AA465545 BG388319 BI521453 BM458517 BX400483 BI521577 

    highest scoring ESTs for BLK:

    S76617 AA278447 AA465174 AA465545 AA769033 AI014559 AI084074 AI379972 AI453244 AI475734 

    Unigene Cluster for BLK:

    B lymphoid tyrosine kinase
    Hs.146591  [show with all ESTs]
    Unigene Representative Sequence: AK131319


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BLK (see all 7)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:                    -           -                             -                                                     -                     
    SP2:                    -     -     -                             -                                                                           
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                      -                                                   

    About this scheme

    ECgene alternative splicing isoforms for BLK
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427279 ENST00000259089(uc003wtx.2 uc003wty.2 uc003wtz.2 uc003wua.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    BLK expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching BLK gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    854_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 S76617 1.00 1.00 1.00 1
    206255_at2, 3 U133-A 1 0.91 1.00 -- -- NM_001715 0.60 1.00 0.82 1
    210934_at2, 3 U133-A 1 0.36 1.00 -- -- BC004473 0.60 1.00 0.82 1
    206255_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    210934_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    About this table

    BLK for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    BLK gene expression
    BLK gene electronic northern expression
    BLK gene sage expression
    About these images

    CGAP SAGE TAG: CCGCGCCCCG

    SOURCE GeneReport for Unigene cluster: Hs.146591

    Expression variation in blood from EXPOLDB for BLK

    UniProtKB/Swiss-Prot: BLK_HUMAN, P51451
    Tissue specificity: Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands
    and hair follicles

    Primers: OriGene genome-wide validated SYBR primer pairs: BLK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BLK: PPH00085A
        SABiosciences Custom PCR Arrays for BLK 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for BLK gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BLK1   -- B lymphoid tyrosine kinase 87.47(n)
    88.8(a)
    486080  XM_543206.2  XP_543206.2 
    cow
    (Bos taurus)
    BLK1   -- B lymphoid tyrosine kinase 87(n)
    88.2(a)
    532587  NM_001075968.1  NP_001069436.1 
    rat
    (Rattus norvegicus)
    Blk1   -- B lymphoid tyrosine kinase 85.57(n)
    87.98(a)
    364403  NM_001025751.1  NP_001020922.1 
    mouse
    (Mus musculus)
    Blk1 , 5 14 (33.25 cM)5
    B lymphoid kinase1, 5 84.97(n)1
    87.17(a)1
    121431  NM_007549.21  NP_031575.21 
     AA2042655  AK0898885  (see all 10)
    chicken
    (Gallus gallus)
    BLK1   -- B lymphoid tyrosine kinase 73.01(n)
    74.94(a)
    422035  XM_420040.2  XP_420040.2 
    About this table        Species with no ortholog for BLK

    ENSEMBL Gene Tree for BLK (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for BLK gene
    FRK2  LCK2  LYN2  FGR2  HCK2  YES12  SRC2  FYN2  

    BLK for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 19 variations for BLK
         3 CNVs: 6592 47971 53411
         15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306
    QIAGEN SeqTarget long-range PCR primers for resequencing BLK 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BLK for disorders           About GeneDecksing

    OMIM: 191305   disorders: 613375  

    UniProtKB/Swiss-Prot: BLK_HUMAN, P51451

  • Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11) [MIM:613375]. MODY11 is a
  • form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early
    adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at
    the beginning of the disease

    3 Novoseek disease relationships for BLK gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 33.6 2 19180478 (1)
    lymphoma 14.1 2 8349295 (1), 19351960 (1)
    necrosis 0 1 16907856 (1)
    About this table

    1 PharmGKB disease relationship for BLK gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Human Gene Mutation Database (HGMD): BLK
    Human Genome Epidemiology (HuGE) Navigator: BLK (17 documents)
    Tumor Gene Database (TGDB): BLK

    Export disorders and mutations for BLK gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/76 PubMed articles for BLK gene, integrated from 7 sources (see all 76):
    (articles sorted by number of sources associating them with BLK)
    1. Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). (PubMed id 7845672)1, 2, 3, 7 Drebin J.A....Niederhuber J.E. (1995)
    2. Mutations at the BLK locus linked to maturity onset d iabetes of the young and beta-cell dysfunction. (PubMed id 19667185)1, 2, 7 Borowiec M....Doria A. (2009)
    3. Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk. (PubMed id 7822795)1, 2, 7 Islam K.B.... Smith C.I. (1995)
    4. Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma. (PubMed id 19351960)1, 7 Krejsgaard T....A9dum N. (2009)
    5. Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. (PubMed id 9525867)1, 7 Hegde R....Alnemri E.S. (1998)
    6. Reconstitution of the B cell antigen receptor signaling components in COS cells. (PubMed id 7592958)1, 7 Saouaf S.J....Mahajan S. (1995)
    7. Transcription of the blk gene in human B lymphocytes is controlled by two promoters. (PubMed id 7592787)1, 7 Lin Y.H....Niederhuber J.E. (1995)
    8. In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. (PubMed id 8756631)1, 7 Bewarder N....Frey J. (1996)
    9. Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. (PubMed id 14970218)1, 7 Cho J.-Y.... Libermann T.A. (2004)
    10. Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate. (PubMed id 9177269)1, 7 Saouaf S.J....Bolen J.B. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 640 HGNC: 1057 AceView: BLK Ensembl:ENSG00000136573 euGenes: HUgn640
    ECgene: BLK H-InvDB: BLK

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for BLK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for BLK gene:
    Search GeneIP for patents involving BLK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for BLK Antibodies for BLK
     Super-pooled esiRNAs for BLK Proteins for BLK
     Lentivirus-delivered shRNAs for BLK microRNA Mimics for BLK
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Nano Scale siRNA for BLK
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Small molecules for BLK
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
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     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for BLK (Blk)  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
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     miRNA Primers for qPCR Assays
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BLK
     SeqTarget long-range PCR primers for resequencing BLK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BLK
     GenScript Purified and Recombinant Proteins for BLK GenScript cDNA clones with any tag delivered in your preferred vector for BLK
     GenScript BLK-Activity-based Kinase Assay for Compound Screening GenScript Custom Superior Antibodies Services for BLK
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     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for BLK 

     Regulatory tfbs in BLK promoter
     Search Chromatin IP Primers for BLK
     RT2 qPCR Primer Assay for BLK
     GNC Network for BLK
     Search for Assays for microRNAs that regulate BLK
     SABiosciences Custom PCR Arrays for BLK
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     Browse Sino Biological Proteins and Antibodies
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     Antibodies/Proteins Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for BLK
     Proteins for BLK
     Lysates for BLK
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for BLK
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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