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Aliases & Descriptionsfor BMP10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions bone morphogenetic protein 101 2 BMP-102 3 MGC1267832
Export aliases for BMP10 gene to outside databases Previous GC identifers: GC02M069104 GC02M069290 GC02M069067 GC02M069004 GC02M069092
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Summariesfor BMP10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for BMP10 : The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. (provided by RefSeq) UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393 Function : Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing prematureactivation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth
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Genomic Viewsfor BMP10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the BMP10 gene promoter: Sox9 MEF-2A SRF STAT1beta STAT5A STAT1alpha STAT3 STAT1 STAT4 STAT5B Other transcription factors Search SABiosciences Chromatin IP Primers for BMP10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p13.3 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p13.2 BMP10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M068828: view genomic region
(about GC identifiers )
Start:
68,828,848 bp from pter
End:
68,834,901 bp from pter
Size:
6,054 bases
Orientation:
minus strand
1 alternative location : Chr 2- 69,092,613-69,098,649
RefSeq DNA sequence: NC_000002.11 NT_022184.15
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Proteinsfor BMP10 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393 (See
protein sequence )Recommended Name: Bone morphogenetic protein 10 precursor Size : 424 amino acids; 48047 Da
Subunit : Homodimer; disulfide-linked (By similarity)
Subcellular location : Secreted (By similarity)
Secondary accessions : Q53R17 Q6NTE0Explore the universe of human proteins at neXtProt for BMP10: NX_O95393
REFSEQ proteins: NP_055297.1 ENSEMBL proteins: ENSP00000295379 Human Recombinant Proteins 4 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
BMP10 for ontologies About GeneDecksing Antibodies for BMP10: Assays for BMP10:
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Protein
Domains/ Familiesfor BMP10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
BMP10 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O95393 ProtoNet protein and cluster: O95393
3 Blocks protein families : IPB001111 Transforming growth factor beta (TGFb) IPB001839 Transforming growth factor beta (TGFb) IPB002400 Growth factor cystine knot superfamily signature UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393 Similarity : Belongs to the TGF-beta family
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Gene Functionfor BMP10 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393 Function : Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing prematureactivation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
About this table
BMP10 for ontologies About GeneDecksing Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bmp10) :
BMP10 for phenotypes About GeneDecksing
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Pathways & Interactionsfor BMP10 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
BMP10 for pathways About GeneDecksing 5/9 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for BMP10 (see all 9 ) SABiosciences Pathway-Focused PCR Array including BMP10 : PAHS-041A Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for BMP10 SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMP10 5/22 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 22 ):
About this table
BMP10 for ontologies About GeneDecksing
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Drugs & Compoundsfor BMP10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for BMP10
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Transcriptsfor BMP10 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for BMP10 gene: NM_014482.1
Additional cDNA sequence: AF101441.1 BC069080.1 BC101734.1 BC105063.1
1 DOTS entry : DT.92044941
4 AceView cDNA sequences :
NM_014482 AF101441 BC069080 BM755159
highest scoring ESTs for BMP10 :AF101441 BC069080 BM755159 NM_014482 BC101734 BC105063 AI872435 Unigene Cluster for BMP10:
Bone morphogenetic protein 10 Hs.158317 Unigene Representative Sequence: AF101441 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000295379 (uc002sez.1 )
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Expression for BMP10 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section BMP10 expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching BMP10 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
31399_at2 , 3
U95-A
1
0.75
1.00
1.00
1.00
AF101441
1.00
1.00
1.00
1
208292_at2 , 3
U133-A
1
0.73
1.00
--
--
NM_014482
0.60
1.00
0.82
1
208292_at2
U133Plus2
1
0.73
1.00
--
--
--
--
--
--
--
About this table
BMP10 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCCGTCTCCG SOURCE GeneReport for Unigene cluster: Hs.158317 Expression variation in blood from EXPOLDB for BMP10
SABiosciences Expression via Pathway-Focused PCR Array including BMP10 : PAHS-041A
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Orthologsfor BMP10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for BMP10 gene from 5/7 species (see all 7 )
About this table Species with no ortholog for BMP10 ENSEMBL Gene Tree for BMP10 (if available)
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Paralogsfor BMP10 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for BMP10 gene GDF5 2 NODAL 2 GDF6 2 GDF7 2 GDF2 2
BMP10 for paralogs About GeneDecksing
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Genomic Variantsfor BMP10 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 2 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for BMP10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for BMP10: --
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Disorders & Mutationsfor BMP10 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
BMP10 for disorders About GeneDecksing
OMIM: 608748 Human Gene Mutation Database (HGMD) : BMP10 Human Genome Epidemiology (HuGE) Navigator: BMP10 (5 documents) Export disorders and mutations for BMP10 gene to outside databases
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Medical Newsfor BMP10 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor BMP10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/17 PubMed articles for BMP10 gene, integrated from 7 sources (see all 17 ): (articles sorted by number of sources associating them with BMP10) Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. (PubMed id 17068149) 1 , 2 David L.... Bailly S. (2007) Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. (PubMed id 16049014) 1 , 2 Mazerbourg S....Hsueh A.J.W. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 1 , 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. (PubMed id 10072785) 1 , 3 Neuhaus H....Thies R.S. (1999) Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. (PubMed id 17921333) 1 , 7 Nakano N....Kimura A. (2007) New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496) 1 Davila S....Seielstad M. (2010) Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891) 1 Jugessur A....Murray J.C. (2010) A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064) 1 He C....Hunter D.J. (2010) Bone morphogenetic protein-10 (BMP-10) inhibits aggre ssiveness of breast cancer cells and correlates with poor prognosis in breast c ancer. (PubMed id 20608934) 1 Ye L....Jiang W.G. (2010)
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External Searches for BMP10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing BMP10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing BMP10 gene
(According to HUGE )
About This Section --
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Specialized Databases showing BMP10 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_10
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About This Section Patent Information for BMP10 gene: Search GeneIP for patents involving BMP10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor BMP10 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for BMP10
ELISAs and CLIAs for BMP10
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