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BMP10 Gene

protein-coding   GIFtS: 52

GC02M068828
bone morphogenetic protein 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
bone morphogenetic protein 101 2
BMP-102 3
MGC1267832

External Ids:    HGNC: 208691   Entrez Gene: 273022   Ensembl: ENSG000001632177   UniProtKB: O953933   

Export aliases for BMP10 gene to outside databases

Previous GC identifers: GC02M069104 GC02M069290 GC02M069067 GC02M069004 GC02M069092


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BMP10:
The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar
protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal
through receptor serine/threonine kinases. (provided by RefSeq)

UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393
Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature
activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of
cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading
to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP10 gene promoter:
         Sox9   MEF-2A   SRF   STAT1beta   STAT5A   STAT1alpha   STAT3   STAT1   STAT4   STAT5B   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for BMP10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.2

BMP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP10 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M068828:  view genomic region     (about GC identifiers)

Start:
68,828,848 bp from pter
End:
68,834,901 bp from pter
Size:
6,054 bases
Orientation:
minus strand

1 alternative location:
Chr2- 69,092,613-69,098,649     
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393 (See protein sequence)
Recommended Name: Bone morphogenetic protein 10 precursor  
Size: 424 amino acids; 48047 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: Q53R17 Q6NTE0

Explore the universe of human proteins at neXtProt for BMP10: NX_O95393 

REFSEQ proteins: NP_055297.1  

ENSEMBL proteins: 
ENSP00000295379 


Human Recombinant Proteins 
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4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005615 extracellular space IEA--
GO:0009986 cell surface IDA17921333
GO:0030018 Z disc IDA17921333
About this table

BMP10 for ontologies           About GeneDecksing



Antibodies for BMP10: 
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Uscn ELISAs and CLIAs for BMP10 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BMP10 for domains           About GeneDecksing

5 InterPro domains/families:
 IPR001111 TGF-b_N
 IPR015615 TGF-beta-rel
 IPR002405 Inhibin_asu
 IPR001839 TGF-b_C
 IPR017948 TGFb_CS

Graphical View of Domain Structure for InterPro Entry O95393

ProtoNet protein and cluster: O95393

3 Blocks protein families:
IPB001111 Transforming growth factor beta (TGFb)
IPB001839 Transforming growth factor beta (TGFb)
IPB002400 Growth factor cystine knot superfamily signature


UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393
Similarity: Belongs to the TGF-beta family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393
Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature
activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of
cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading
to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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Gene
Editing:
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Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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Cell
Lines:
  
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4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005125 cytokine activity IEA--
GO:0005515 protein binding IPI17921333
GO:0008083 growth factor activity IEA--
GO:0033612 receptor serine/threonine kinase binding IDA17068149
About this table

BMP10 for ontologies           About GeneDecksing

Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bmp10):

cardiovascular systemlethality-prenatal/perinatalmuscle

BMP10 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


BMP10 for pathways           About GeneDecksing

5/9 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  BMP10 (see all 9)
    Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
Cardiomyocyte Differentiation via BMP Receptors
Human Embryonic Stem Cell Pluripotency
Molecular Mechanisms of Cancer
Basal Cell Carcinoma Signaling

    SABiosciences Pathway-Focused PCR Array including BMP10: PAHS-041A 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for BMP10
    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMP10

5/22 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 22):

GO IDQualified GO termEvidencePubMed IDs
GO:0007219 Notch signaling pathway ISS10072785
GO:0007275 multicellular organismal development IEA--
GO:0007507 heart development ----
GO:0007512 adult heart development ISS10072785
GO:0010596 negative regulation of endothelial cell migration IDA17068149
About this table

BMP10 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BMP10


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for BMP10
Sigma-Aldrich shRNA for BMP10
OriGene 29mer shRNA kits in GFP-retroviral vector: BMP10
OriGene shRNA RFP: BMP10
OriGene basic RS shRNA: BMP10
OriGene siRNA: BMP10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BMP10 
miRNA: Sigma-Aldrich microRNA Mimics for BMP10
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BMP10 
Search SABiosciences for Assays for microRNAs that regulate BMP10
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: BMP10
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: BMP10
OriGene untagged cDNA clones in CMV expression vector: BMP10
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: BMP10 
Primers: OriGene genome-wide validated SYBR primer pairs: BMP10
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for BMP10: PPH01913A

REFSEQ mRNAs for BMP10 gene: 

NM_014482.1  

Additional cDNA sequence: 

AF101441.1 BC069080.1 BC101734.1 BC105063.1 

1 DOTS entry:

DT.92044941 

4 AceView cDNA sequences:

NM_014482 AF101441 BC069080 BM755159 

highest scoring ESTs for BMP10:

AF101441 BC069080 BM755159 NM_014482 BC101734 BC105063 AI872435 

Unigene Cluster for BMP10:

Bone morphogenetic protein 10
Hs.158317
Unigene Representative Sequence: AF101441


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000295379(uc002sez.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

BMP10 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching BMP10 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
31399_at2, 3 U95-A 1 0.75 1.00 1.00 1.00 AF101441 1.00 1.00 1.00 1
208292_at2, 3 U133-A 1 0.73 1.00 -- -- NM_014482 0.60 1.00 0.82 1
208292_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
About this table

BMP10 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
BMP10 gene expression
BMP10 gene electronic northern expression
BMP10 gene sage expression
About these images

CGAP SAGE TAG: GCCGTCTCCG

SOURCE GeneReport for Unigene cluster: Hs.158317

Expression variation in blood from EXPOLDB for BMP10

Primers: OriGene genome-wide validated SYBR primer pairs: BMP10
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for BMP10: PPH01913A
    SABiosciences Expression via Pathway-Focused PCR Array including BMP10: PAHS-041A 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BMP10 gene from 5/7 species (see all 7)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
BMP101   -- bone morphogenetic protein 10 87.5(n)
91.51(a)
481408  XM_538528.2  XP_538528.2 
chimpanzee
(Pan troglodytes)
BMP101   -- bone morphogenetic protein 10 99.61(n)
99.76(a)
470391  XM_525772.2  XP_525772.1 
cow
(Bos taurus)
BMP101   -- bone morphogenetic protein 10 87.74(n)
89.86(a)
538874  XM_583418.2  XP_583418.2 
rat
(Rattus norvegicus)
Bmp101   -- bone morphogenetic protein 10 82.9(n)
86.46(a)
500245  NM_001031824.1  NP_001026994.1 
mouse
(Mus musculus)
Bmp101 , 5 6 (37.96 cM)5
bone morphogenetic protein 101, 5 83.33(n)1
85.48(a)1
121541  NM_009756.11  NP_033886.11 
 AF1010335  BC1450445  (see all 6)
About this table        Species with no ortholog for BMP10

ENSEMBL Gene Tree for BMP10 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for BMP10 gene
GDF52  NODAL2  GDF62  GDF72  GDF22  

BMP10 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/81 NCBI SNPs in BMP10 are shown (see all 81)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs22313371,2
H69098745(-) ATAGAA/CACAAA 1 -- ng514Minor allele frequency- C:0.00NS EA 420
rs22313381,2
H69098496(-) CGAGCG/AGAGTC 1 -- ut51 ese34Minor allele frequency- A:0.00NS EA 420
rs22313391,2
H69098350(-) CAAGAC/TGGTGT 2 D ref1 syn1 ese34Minor allele frequency- T:0.00NS EA 420
rs22313401,2
C,F,69098078(-) TGATAT/CAGGTA 1 -- int14Minor allele frequency- C:0.01NS EA 420
rs22313411,2
--69093769(-) TTACAG/TAAATA 1 -- int10--------
rs22313421,2
C,F69093439(-) GGAGAC/GTTTTG 2 T S ref1 mis1 ese39Minor allele frequency- G:0.01NS EA NA 894
rs22313431,2
--69093354(-) AAACAC/TGATGA 2 H ref1 syn1 ese30--------
rs22313441,2
C,F,A,69093312(-) ATAGAT/CACCAG 2 /D syn1 ref1 ese316Minor allele frequency- C:0.10NS EA NA 2098
rs22313451,2
C,F,69093288(-) CATAAC/ACCTTT 2 /K /N mis1 ref15Minor allele frequency- A:0.02NS EA NA 480
rs22313461,2
--69093255(-) CAAAGC/TAGTGA 2 S ref1 syn1 ese30--------
About this table

HapMap Linkage Disequilibrium images for BMP10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for BMP10: --

Search QIAGEN SeqTarget long-range PCR primers for resequencing for BMP10 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BMP10 for disorders           About GeneDecksing

OMIM: 608748

Human Gene Mutation Database (HGMD): BMP10
Human Genome Epidemiology (HuGE) Navigator: BMP10 (5 documents)

Export disorders and mutations for BMP10 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/17 PubMed articles for BMP10 gene, integrated from 7 sources (see all 17):
(articles sorted by number of sources associating them with BMP10)
  1. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. (PubMed id 17068149)1, 2 David L.... Bailly S. (2007)
  2. Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. (PubMed id 16049014)1, 2 Mazerbourg S....Hsueh A.J.W. (2005)
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. (PubMed id 10072785)1, 3 Neuhaus H....Thies R.S. (1999)
  6. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. (PubMed id 17921333)1, 7 Nakano N....Kimura A. (2007)
  7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
  8. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
  9. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1 He C....Hunter D.J. (2010)
  10. Bone morphogenetic protein-10 (BMP-10) inhibits aggre ssiveness of breast cancer cells and correlates with poor prognosis in breast c ancer. (PubMed id 20608934)1 Ye L....Jiang W.G. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 27302 HGNC: 20869 AceView: BMP10 Ensembl:ENSG00000163217 euGenes: HUgn27302
ECgene: BMP10 H-InvDB: BMP10

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_10

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for BMP10 gene:
Search GeneIP for patents involving BMP10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
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 Antibodies for BMP10
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 ELISAs and CLIAs for BMP10
       

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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