Aliases &
Descriptions
for BTBD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| BTB (POZ) domain containing 21 2 | | BTB/POZ domain-containing protein 22 |
Export aliases for BTBD2 gene to outside databasesPrevious GC identifers: GC19M002048 GC19M001925 GC19M001936 GC19M001934 GC19M001985 |
Summaries
for BTBD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BTBD2:
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich regionand a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typicallyinvolved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. (provided byRefSeq)
Gene Wiki entry for BTBD2 |
Genomic Views
for BTBD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BTBD2 gene promoter:
NF-1 AREB6 LCR-F1 YY1 Elk-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BTBD2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for BTBD2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3-p12BTBD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M001757: view genomic region
(about GC identifiers)
Start:
|
1,757,711 bp from pter |
End:
|
1,787,607 bp from pter |
Size:
|
29,897 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr19- 1,985,447-2,015,702 |
RefSeq DNA sequence:- NC_000019.9 NT_011255.14
|
Proteins
for BTBD2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: BTBD2_HUMAN, Q9BX70 (See
protein sequence)Recommended Name: BTB/POZ domain-containing protein 2 Size: 525 amino acids; 55931 Da
Subunit: Interacts with topoisomerase 1 and with TRIM5 isoform Delta
Subcellular location: Cytoplasm, P-body. Note=Cytoplasmic bodies
Sequence caution: Sequence=AAC16070.1; Type=Erroneous gene model prediction; Sequence=BAB55143.1; Type=Erroneousinitiation;
PDB structures from  and Proteopedia  :3NO8 (3D)
Secondary accessions: O60418 O75248 Q4VBZ1 Q6IAC5 Q7Z5W0 Q96SX8 Q9NPS1 Q9NX81Alternative splicing: 2 isoforms: Q9BX70-1 Q9BX70-2 Explore the universe of human proteins at neXtProt for BTBD2: NX_Q9BX70
REFSEQ proteins: NP_060267.2
ENSEMBL proteins: ENSP00000255608
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000932 | cytoplasmic mRNA processing body |
IEA | -- | | GO:0005737 | cytoplasm |
IEA | -- |
About this table
BTBD2 for ontologies About GeneDecksing
Antibodies for BTBD2:
Assays for BTBD2: |
Protein
Domains/
Families
for BTBD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BTBD2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9BX70ProtoNet protein and cluster: Q9BX70 3 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated IPB012983 PHR
UniProtKB/Swiss-Prot: BTBD2_HUMAN, Q9BX70Similarity: Contains 1 BTB (POZ) domain |
Gene Function
for BTBD2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
BTBD2 for ontologies About GeneDecksing
|
Pathways & Interactions
for BTBD2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for BTBD2
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTBD2
5/20 Interacting proteins for BTBD2 (Q9BX701, 2) via UniProtKB, MINT, and/or STRING (see all 20)About this table
|
Drugs & Compounds
for BTBD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for BTBD2
|
Transcripts
for BTBD2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for BTBD2 gene: NM_017797.3 Additional cDNA sequence: AF355797.1 AK027481.1 AK056818.1 AK225831.1 AL360275.1 AY007116.1 BC000564.2 BC008035.2 BC053986.1 BC069199.1 BC094820.1 CR457230.1 CR622857.1 10 DOTS entries: DT.115191 DT.95360692 DT.100789822 DT.100724241 DT.95360691 DT.121478488 DT.95360690 DT.100789823 DT.91771828 DT.95360708 24/352 AceView cDNA sequences (see all 352): BM745125 BC000564 BQ924946 BQ420960 BC069199 BG336099 BF527106 CB156525 BM912486 BQ083309 CR622857 AI284908 BM711980 BM560061 BE794401 BM547284 BM770365 CA417435 AL360276 T51086 BU543263 CF144459 CD251497 BM741425
 highest scoring ESTs for BTBD2:AW998457 BF058865 BF059074 BF346059 BF346615 BF839380 BF850268 BF926650 BG396663 BG421222 Unigene Cluster for BTBD2: BTB (POZ) domain containing 2 Hs.465543 [show with all ESTs]Unigene Representative Sequence: AK056818
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for BTBD2
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | - | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for BTBD2
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000255608(uc002luo.1 uc002lup.1)
|
Expression
for BTBD2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| BTBD2 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching BTBD2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 35155_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.97 |
0.84 |
AC005306 |
0.20 |
1.00 |
0.72 |
1 |
| 35154_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.94 |
1.17 |
W68046 |
0.80 |
1.00 |
0.91 |
1 |
| 207722_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_017797 |
0.60 |
1.00 |
0.82 |
1 |
| 233358_at*2, 3
|
U133-B |
43 |
0.27 |
0.02 |
-- |
-- |
AK024373 |
0.20 |
0.01 |
0.14 |
3 |
| 207722_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 233358_at*2
|
U133Plus2 |
43 |
0.27 |
0.02 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
BTBD2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCCCCAGATG
SOURCE GeneReport for Unigene cluster: Hs.465543
Expression variation in blood from EXPOLDB for BTBD2 SABiosciences Custom PCR Arrays for BTBD2
|
Orthologs
for BTBD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BTBD2 gene from 5/8 species (see all 8)
About this table Species with no ortholog for BTBD2
ENSEMBL Gene Tree for BTBD2 (if available) |
Paralogs
for BTBD2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for BTBD2 gene
- BTBD12 BTBD62 BTBD32 BTBD192 BTBD92
BTBD2 for paralogs About GeneDecksing
|
Genomic Variants
for BTBD2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for BTBD2
4 CNVs: 30062 7191 73279 30063 | | QIAGEN SeqTarget long-range PCR primers for resequencing BTBD2 |
|
Disorders & Mutations
for BTBD2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BTBD2 for disorders About GeneDecksing
OMIM: 608531
Human Genome Epidemiology (HuGE) Navigator: BTBD2 (1 document)
Export disorders and mutations for BTBD2 gene to outside databases
|
Medical News
for BTBD2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for BTBD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/19 PubMed articles for BTBD2 gene, integrated from 7 sources (see all 19):
(articles sorted by number of sources associating them with BTBD2)- Characterization of BTBD1 and BTBD2, two similar BTB-domain- containing Kelch-like proteins that interact with topoisomerase I. (PubMed id 11818025)1, 2, 7 Xu L....D'Arpa P. (2002)
- BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. (PubMed id 12878161)1, 2, 7 Xu L.... D'Arpa P. (2003)
- Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24. (PubMed id 11179693)1, 3, 7 Carim-Todd L.... Escarceller M. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Gamma-radiation sensitivity and polymorphisms in RAD5 1L1 modulate glioma risk. (PubMed id 20610542)1 Liu Y....Bondy M.L. (2010)
- Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma surviva l. (PubMed id 20368557)1 Liu Y....Bondy M. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Search for cellular partners of human papillomavirus type 16 E2 protein. (PubMed id 18305892)1 Olejnik-Schmidt A.K....Gozdzicka-Jozefiak A. (2008)
|
External Searches for BTBD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BTBD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BTBD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BTBD2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BTBD2 gene:
Search GeneIP for patents involving BTBD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BTBD2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for BTBD2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for BTBD2 |
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