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BTG3 Gene

protein-coding   GIFtS: 55

GC21M004351
BTG family, member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for BTG3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
About This Section
Aliases & Descriptions
BTG family, member 31 2     TOB552
ANA1 2 3 5     protein BTG32
TOB52 3 5     MGC89282
Abundant in neuroepithelium area protein2 3     TOFA2
Protein Tob52 3     BTG family member 33
tob551     B-cell translocation gene9
B-cell translocation gene 32     

External Ids:    HGNC: 11321   Entrez Gene: 109502   Ensembl: ENSG000001546407   UniProtKB: Q142013   

Export aliases for BTG3 gene to outside databases

Previous GC identifers: GC21M015630 GC21M017887 GC21M018965


Summaries
for BTG3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BTG3:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that
appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central
nervous system. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq)

UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201
Function: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase

Gene Wiki entry for BTG3

Genomic Views
for BTG3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BTG3 gene promoter:
         GR-beta   GR-alpha   NF-kappaB   NF-kappaB1   Bach1   RREB-1   RSRFC4   GATA-1   MEF-2A   Nkx2-2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for BTG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for BTG3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q21.1
Nature(405: 311-319) cytogenetic band:   21q21.1
BTG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTG3 gene location
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M004351:   GeneLoc Nature:405,311-319
Start:
 4,351,708 bp from pter       4,630,458 bp from centromere
End:
 4,371,005 bp from pter 4,649,509 bp from centromere
Size:
 19,298 bases 19,052 bases
Orientation:
 minus strand minus strand

1 alternative location:
Chr21- 18,965,971-18,985,265     
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  

Whole chromosome sequencing:
cDNA sequence: D64110
genomic clones: R877L16 R396A17


Proteins
for BTG3 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201 (See protein sequence)
Recommended Name: Protein BTG3  
Size: 252 amino acids; 29116 Da
Developmental stage: Expression is cell cycle dependent with the highest levels at the end of G1 phase, peaking at the
G1-S transition
Secondary accessions: Q53XV1 Q96ET7
Alternative splicing: 2 isoforms:  Q14201-1   Q14201-2   

Explore the universe of human proteins at neXtProt for BTG3: NX_Q14201 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001124386.1  NP_006797.3  


    ENSEMBL proteins: 
    ENSP00000413799 ENSP00000284879 ENSP00000344609 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: BTG3
    GenScript Custom Purified and Recombinant Proteins Services for BTG3 
    Novus Biologicals Protein for BTG3
    Novus Biologicals Lysate for BTG3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA9632145
    About this table

    BTG3 for ontologies           About GeneDecksing



    Antibodies for BTG3: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BTG3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for BTG3 
    Browse antibodies at Epitomics

    Assays for BTG3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BTG3 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BTG3 

    Protein Domains/
    Families
    for BTG3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BTG3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002087 Anti_prolifrtn

    Graphical View of Domain Structure for InterPro Entry Q14201

    ProtoNet protein and cluster: Q14201

    1 Blocks protein family: IPB002087 Anti-proliferative protein

    UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201
    Similarity: Belongs to the BTG family


    Gene Function
    for BTG3 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201
    Function: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for BTG3
    Sigma-Aldrich shRNA for BTG3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): BTG3
    OriGene shRNA RFP (see all 2): BTG3
    OriGene basic RS shRNA (see all 2): BTG3
    OriGene siRNA (see all 2): BTG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BTG3 
    miRNA:Sigma-Aldrich microRNA Mimics for BTG3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BTG3 
    8/20 SABiosciences Assays for microRNAs that regulate BTG3 (see all 20):
    hsa-miR-548j hsa-miR-448 hsa-miR-548i hsa-miR-106a hsa-miR-139-5p hsa-miR-371-5p hsa-miR-410 hsa-miR-519a

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: BTG3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): BTG3
    OriGene untagged cDNA clones in CMV expression vector: BTG3
    OriGene 3'-UTR clone (see all 2): BTG3 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for BTG3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for BTG3 

    Genatlas biochemistry entry for BTG3:
    B cell transcription gene 3,antiproliferative,predominantly expressed in ovary,testis,prostate,thymus,lung,putatively
    involved in neurogenesis in the central nervous system,Tob/BTG1 family
    Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Btg3):
    skeletontumorigenesis

    BTG3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BTG3 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for BTG3 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTG3

    2 Interacting proteins for BTG3 (Q142012) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1Q010942MINT-5226290 MINT-5226306 MINT-5226261
    ATXN1P542532MINT-2868836 MINT-2868855
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979 response to oxidative stress ----
    GO:0008285 negative regulation of cell proliferation TAS9632145
    GO:0045930 negative regulation of mitotic cell cycle IDA9632145
    About this table

    BTG3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BTG3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BTG3


    Transcripts
    for BTG3 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for BTG3
    Sigma-Aldrich shRNA for BTG3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): BTG3
    OriGene shRNA RFP (see all 2): BTG3
    OriGene basic RS shRNA (see all 2): BTG3
    OriGene siRNA (see all 2): BTG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of BTG3 
    miRNA: Sigma-Aldrich microRNA Mimics for BTG3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of BTG3 
    8/20 SABiosciences Assays for microRNAs that regulate BTG3 (see all 20):
    hsa-miR-548j hsa-miR-448 hsa-miR-548i hsa-miR-106a hsa-miR-139-5p hsa-miR-371-5p hsa-miR-410 hsa-miR-519a
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: BTG3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): BTG3
    OriGene untagged cDNA clones in CMV expression vector: BTG3
    OriGene 3'-UTR Clone (see all 2): BTG3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for BTG3 
    Primers: OriGene genome-wide validated SYBR primer pairs: BTG3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BTG3: PPH10050A

    REFSEQ mRNAs for BTG3 gene (2 alternative transcripts): 

    NM_001130914.1  NM_006806.4  

    Additional cDNA sequence: 

    AK289408.1 BC011957.1 BT007276.1 CR457061.1 CR590787.1 CR593770.1 CR598696.1 CR600061.1 
    CR602342.1 CR604425.1 CR607894.1 CR608349.1 CR618065.1 CR618737.1 CR620760.1 D64110.1 

    10 DOTS entries:

    DT.215678  DT.100757082  DT.100814202  DT.100814204  DT.40242889  DT.97846043  DT.121139656  DT.100028740 
    DT.91820940  DT.95174003 

    10 AceView cDNA sequences:

    BX101397 AI648620 BU674227 BC028229 AI830363 CB960723 AW665615 BG255148 
    BX404773 BI912970 

    highest scoring ESTs for BTG3:

    D64110 AL523247 BC011957 BE896159 BE906747 BG675997 BG743348 AA039702 AA398442 AA620290 

    Unigene Cluster for BTG3:

    BTG family, member 3
    Hs.473420  [show with all ESTs]
    Unigene Representative Sequence: NM_001130914


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BTG3 (see all 7)

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
    SP1:                    -     -                       -                 -                                 
    SP2:                                                  -                 -                                 
    SP3:                                                  -           -     -                                 
    SP4:                                                                                                      
    SP5:                                                  -     -     -     -                                 

    About this scheme

    ECgene alternative splicing isoforms for BTG3
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457956 ENST00000464058 ENST00000496601 ENST00000348354(uc002ykk.2)
    ENST00000339775(uc002ykl.2) ENST00000471860

    Expression
    for BTG3 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    BTG3 expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching BTG3 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37218_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D64110 1.00 1.00 1.00 1
    32568_at*2, 3 U95-A 1 -- -- 0.32 0.21 AL049332 0.60 1.00 0.82 1
    205548_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006806 0.60 1.00 0.82 1
    213134_x_at2, 3 U133-A 1 1.00 1.00 -- -- AI765445 0.60 1.00 0.82 1
    215425_at*2, 3 U133-A NULL 0.00 0.00 -- -- AL049332 0.60 1.00 0.82 1
    205548_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    213134_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1556213_a_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    215425_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    About this table

    BTG3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    BTG3 gene expression
    BTG3 gene electronic northern expression
    BTG3 gene sage expression
    About these images

    CGAP SAGE TAG: TAGTTGCAAA

    SOURCE GeneReport for Unigene cluster: Hs.473420

    Expression variation in blood from EXPOLDB for BTG3

    UniProtKB/Swiss-Prot: BTG3_HUMAN, Q14201
    Tissue specificity: Ubiquitous. High expression in the ventricular zone of the developing central nervous system. High
    in ovary, testis, prostate, thymus and lung

    Primers: OriGene genome-wide validated SYBR primer pairs: BTG3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for BTG3: PPH10050A
        SABiosciences Custom PCR Arrays for BTG3 


    Orthologs
    for BTG3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for BTG3 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 BTG31   -- BTG family, member 3 94.05(n)
    97.62(a)    		 487695  XM_544819.2  XP_544819.2 
    chimpanzee
    (Pan troglodytes)    		 BTG31   -- BTG family, member 3 99.47(n)
    99.21(a)    		 749692  XM_001170879.1  XP_001170879.1 
    cow
    (Bos taurus)    		 BTG31   -- BTG family, member 3 92.59(n)
    94.84(a)    		 541054  NM_001034722.1  NP_001029894.1 
    rat
    (Rattus norvegicus)    		 Btg31   -- B-cell translocation gene 3 91.01(n)
    92.06(a)    		 54230  NM_019290.1  NP_062163.1 
    mouse
    (Mus musculus)    		 Btg31 , 5 16 (45.36 cM)5
    		 B-cell translocation gene 31, 5 91.53(n)1
    94.05(a)1    		 122281  NM_009770.21  NP_033900.11 
     AK1444155  AW8234065  (see all 11)
    About this table        Species with no ortholog for BTG3

    ENSEMBL Gene Tree for BTG3 (if available)

    Paralogs
    for BTG3 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for BTG3 gene
    BTG42  TOB12  BTG12  TOB22  BTG22  

    BTG3 for paralogs           About GeneDecksing



    Genomic Variants
    for BTG3 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/172 NCBI SNPs in BTG3 are shown (see all 172)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 21 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs154591,2
    		C,F18966136(-) GTTGGC/ATACGA 2 -- ut31 ese32Minor allele frequency- A:0.50MN 372
    rs9282481,2
    		C,F,18986727(+) AAAAAA/GTACAG 2 -- ng5118Minor allele frequency- G:0.17NS EA NA 1376
    rs28243861,2
    		C,F,O,18966089(+) TAAATT/GCTCAA 2 -- ut3110Minor allele frequency- G:0.06NA NS EA 658
    rs28243871,2
    		C,F,O,18966783(+) TCAGGT/GCTAAA 2 -- int115Minor allele frequency- G:0.08NA NS EA 1804
    rs28243881,2
    		C,F,18977367(+) ATAAAC/TGCCGT 2 -- int115Minor allele frequency- T:0.06NA NS EA 779
    rs28243891,2
    		C,F,O,18978176(+) TCCTAG/CTATTT 2 -- int115Minor allele frequency- C:0.31NA NS EA WA 1058
    rs28243901,2
    		F,O18978416(+) TAATAT/ATaaca 2 -- int11Minor allele frequency- A:0.25NA 12
    rs28243911,2
    		C,F,O,18978690(+) TTAGCG/ATCACC 2 -- int119Minor allele frequency- A:0.06NA NS EA 1200
    rs28243921,2
    		C,F,O,18979555(+) TTTAAA/GTATTT 2 -- int114Minor allele frequency- G:0.06NA NS EA 1094
    rs28243931,2
    		C,F,O,18979637(+) AGTTAA/TATCAG 2 -- int197Minor allele frequency- T:0.07NA NS EA PA EU CA WA 5556
    About this table

    HapMap Linkage Disequilibrium images for BTG3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BTG3: --

    QIAGEN SeqTarget long-range PCR primers for resequencing BTG3 

    Disorders & Mutations
    for BTG3 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BTG3 for disorders           About GeneDecksing

    OMIM: 605674

    1 Novoseek disease relationship for BTG3 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 8.26 3 19221000 (2), 19885928 (1)
    About this table


    Export disorders and mutations for BTG3 gene to outside databases

    Medical News
    for BTG3 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for BTG3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/17 PubMed articles for BTG3 gene, integrated from 7 sources (see all 17):
    (articles sorted by number of sources associating them with BTG3)
    1. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. (PubMed id 9632145)1, 2, 3 Yoshida Y.... Yamamoto T. (1998)
    2. Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. (PubMed id 9067576)1, 2, 7 Guehenneux F....Rouault J.-P. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PubMed id 11429045)1, 7 Yoshida Y....Yamamoto T. (2001)
    5. BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. (PubMed id 19221000)1, 7 Majid S....Dahiya R. (2009)
    6. Methylation-mediated downregulation of the B-cell translocation gene 3 (BTG3) in breast cancer cells. (PubMed id 18590053)1 Yu J....Patterson D. (2008)
    7. The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1. (PubMed id 17690688)1 Ou Y.H....Shieh S.Y. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for BTG3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing BTG3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10950 HGNC: 1132 AceView: BTG3.1 Ensembl:ENSG00000154640 euGenes: HUgn10950
    ECgene: BTG3 H-InvDB: BTG3

    Other Databases showing BTG3 gene

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    Specialized Databases showing BTG3 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for BTG3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
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     ELISAs and CLIAs for BTG3
           

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