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Aliases & Descriptionsfor BTN3A3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions butyrophilin, subfamily 3, member A31 2 BTF31 2 3 butyrophilin subfamily 3 member A32 OTTHUMP000002145392 butyrophilin 32
Export aliases for BTN3A3 gene to outside databases Previous GC identifers: GC06P026498 GC06P026427 GC06P026548 GC06P026441
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Summariesfor BTN3A3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for BTN3A3 : The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 (PubMed 20208008)).(supplied by OMIM) Gene Wiki entry for BTN3A3
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Genomic Viewsfor BTN3A3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the BTN3A3 gene promoter: GR-alpha GR-beta RP58 SRF STAT5A MRF-2 MEF-2A YY1 ATF6 NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for BTN3A3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1 BTN3A3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P026384: view genomic region
(about GC identifiers )
Start:
26,383,366 bp from pter
End:
26,396,309 bp from pter
Size:
12,944 bases
Orientation:
plus strand
1 alternative location : Chr 6+ 26,440,700-26,453,643
RefSeq DNA sequence: NC_000006.11 NT_007592.15
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Proteinsfor BTN3A3 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: BT3A3_HUMAN, O00478 (See
protein sequence )Recommended Name: Butyrophilin subfamily 3 member A3 precursor Size : 584 amino acids; 65002 Da
Subcellular location : Membrane; Single-pass type I membrane protein (By similarity)Explore the universe of human proteins at neXtProt for BTN3A3: NX_O00478
REFSEQ proteins (2 alternative transcripts):
NP_008925.1 NP_932078.2 ENSEMBL proteins: ENSP00000402706 ENSP00000344968 ENSP00000420147 ENSP00000419736 ENSP00000419445 ENSP00000380127 ENSP00000420339 ENSP00000417717 ENSP00000244519 ENSP00000419312 ENSP00000355238 ENSP00000420290 ENSP00000417234 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table
BTN3A3 for ontologies About GeneDecksing Antibodies for BTN3A3: Assays for BTN3A3:
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Protein
Domains/ Familiesfor BTN3A3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
BTN3A3 for domains About GeneDecksing 5/10 InterPro domains/families (see all 10 ):
Graphical View of Domain Structure for InterPro Entry O00478 ProtoNet protein and cluster: O00478
4 Blocks protein families : IPB003599 Immunoglobulin subtype IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain IPB013106 Immunoglobulin V-set UniProtKB/Swiss-Prot: BT3A3_HUMAN, O00478 Similarity : Belongs to the immunoglobulin superfamily. BTN/MOG familySimilarity : Contains 1 B30.2/SPRY domainSimilarity : Contains 2 Ig-like V-type (immunoglobulin-like) domains
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Gene Functionfor BTN3A3 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section Genatlas biochemistry entry for BTN3A3 :butyrophilin subfamily 3,member A3,B box family of proteins,involved in cell proliferation and development 1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IEA --
About this table
BTN3A3 for ontologies About GeneDecksing
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Pathways & Interactionsfor BTN3A3 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for BTN3A3 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BTN3A3
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Drugs & Compoundsfor BTN3A3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for BTN3A3
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Transcriptsfor BTN3A3 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for BTN3A3 gene (2 alternative transcripts): NM_006994.4 NM_197974.2
Additional cDNA sequence: AB209581.1 AK223279.1 AK223301.1 AK291722.1 AK301553.1 BC015815.2 BT007251.1 CR618410.1 U90548.1
16 DOTS entries : DT.91838414 DT.100800862 DT.100799407 DT.91845984 DT.91719140 DT.121381011 DT.121381034 DT.121381117
DT.65285590 DT.92381252 DT.121381024 DT.121381057 DT.422538 DT.87017064 DT.87017066 DT.95160541 24/107 AceView cDNA sequences (see all 107 ):
BQ082601 AA825832 AA731296 CR618410 BP345297 AA402951 AW338105 BQ646764 CO400795 AI335723 AA505847 BM820421 BC015815 BF907202 BX095674 CO392914 AI571622 BM769467 BM905265 AA234051 AW779191 AA479322 BX362684 AA478585
highest scoring ESTs for BTN3A3 :U90548 AW368686 BF908066 H45341 AA234051 AA401962 AA402025 AA402951 AA478585 AA479322 Unigene Cluster for BTN3A3:
Butyrophilin, subfamily 3, member A3 Hs.167741 [show with all ESTs ] Unigene Representative Sequence: AB209581 GeneLoc Exon Structure 18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19 ): ENST00000457225 ENST00000339789 ENST00000467524 ENST00000480110 ENST00000496719 ENST00000477388 ENST00000490254 ENST00000487272 ENST00000396921 ENST00000487627 ENST00000471353 ENST00000244519 (uc003nhz.2 uc003nia.2 uc011dkn.1 )ENST00000482451 ENST00000474790 ENST00000361232 ENST00000476281 ENST00000483179 ENST00000497681
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Expression for BTN3A3 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section BTN3A3 expression in normal and diseased human tissues 1 / 2 / 3
7 probe-sets matching BTN3A3 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
38241_at2 , 3
U133-A
2
1.00
0.88
1.00
1.00
U90548
1.00
0.87
0.94
1
204821_at2 , 3
U133-A
1
1.00
1.00
--
--
NM_006994
0.60
0.78
0.69
1
38241_at2 , 3
U133-A
2
1.00
0.88
--
--
U90548
1.00
0.87
0.94
1
204820_s_at2 , 3
U133-A
2
1.00
0.64
--
--
NM_006994
0.60
0.78
0.69
1
204821_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
38241_at2
U133Plus2
2
1.00
0.88
--
--
--
--
--
--
--
204820_s_at2
U133Plus2
2
1.00
0.64
--
--
--
--
--
--
--
About this table
BTN3A3 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGGCACAGAT SOURCE GeneReport for Unigene cluster: Hs.167741 Expression variation in blood from EXPOLDB for BTN3A3
SABiosciences Custom PCR Arrays for BTN3A3
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Orthologsfor BTN3A3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for BTN3A3 gene from 1 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
chimpanzee (Pan troglodytes)
BTN3A31
--
butyrophilin, subfamily 3, member A3
99.03(n) 99.32(a)
462498 XM_001173277.1 XP_001173277.1
About this table Species with no ortholog for BTN3A3 ENSEMBL Gene Tree for BTN3A3 (if available)
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Paralogsfor BTN3A3 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for BTN3A3 gene BTN2A1 2 BTN3A2 2 ERMAP 2 BTN3A1 2 BTN2A2 2 BTN1A1 2
BTN3A3 for paralogs About GeneDecksing
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Genomic Variantsfor BTN3A3 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 6 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for BTN3A3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for BTN3A3: --
QIAGEN SeqTarget long-range PCR primers for resequencing BTN3A3
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Disorders & Mutationsfor BTN3A3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
BTN3A3 for disorders About GeneDecksing
OMIM: 613595 Export disorders and mutations for BTN3A3 gene to outside databases
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Medical Newsfor BTN3A3 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor BTN3A3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/11 PubMed articles for BTN3A3 gene, integrated from 7 sources (see all 11 ): (articles sorted by number of sources associating them with BTN3A3) A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PubMed id 9149941) 1 , 2 , 3 Ruddy D.A.... Feder J.N. (1997) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 Zhang Z. and Henzel W.J. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 Mungall A.J.... Beck S. (2003) Structure and evolution of the extended B7 family. (PubMed id 10354554) 1 , 3 Henry J....Pontarotti P. (1999) BTN1A1, the mammary gland butyrophilin, and BTN2A2 ar e both inhibitors of T cell activation. (PubMed id 20208008) 1 Smith I.A....Trowsdale J. (2010 Apr 1) Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973) 2 Wollscheid B.... Watts J.D. (2009) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) The cluster of BTN genes in the extended major histocompatibility complex. (PubMed id 11170752) 1 Rhodes D.A.... Trowsdale J. (2001) Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149) 1 Suzuki Y.... Sugano S. (1997)
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External Searches for BTN3A3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing BTN3A3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing BTN3A3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing BTN3A3 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for BTN3A3 gene: Search GeneIP for patents involving BTN3A3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor BTN3A3 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for BTN3A3
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