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C1QTNF9 Gene

protein-coding   GIFtS: 40

GC13P005695
C1q and tumor necrosis factor related protein 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
C1q and tumor necrosis factor related protein 91 2     AQL11 2
C1QTNF9A1 2 3     Complement C1q tumor necrosis factor-related protein 92 3
CTRP91 2     complement C1q tumor necrosis factor-related protein 9A2
MGC489151 2     OTTHUMP000000181252

External Ids:    HGNC: 287321   Entrez Gene: 3388722   Ensembl: ENSG000002406547   UniProtKB: P0C8623   

Export aliases for C1QTNF9 gene to outside databases

Previous GC identifers: GC13P023779 GC13P024881


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862
Function: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways (By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C1QTNF9 gene promoter:
         CUTL1   ER-alpha   SREBP-1b   SREBP-1a   SREBP-1c   POU2F1   E47   E2F-1   E2F   NRSF form 2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for C1QTNF9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for C1QTNF9 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.12   Ensembl cytogenetic band:  13q12.12   HGNC cytogenetic band: 13q12.12

C1QTNF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C1QTNF9 gene location

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P005695:  view genomic region     (about GC identifiers)

Start:
5,695,414 bp from pter
End:
5,708,613 bp from pter
Size:
13,200 bases
Orientation:
plus strand

1 alternative location:
Chr13+ 24,881,304-24,896,673     
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862 (See protein sequence)
Recommended Name: Complement C1q tumor necrosis factor-related protein 9A precursor  
Size: 333 amino acids; 34681 Da
Subunit: Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex
(By similarity). Interacts with CTRP9B. Forms heterotrimers and heterooligomeric complexes with CTRP9B
Subcellular location: Secreted (By similarity)
Secondary accessions: A2A3T6 Q0VGC5 Q5VX65 Q5VX66 Q8IUU4

Explore the universe of human proteins at neXtProt for C1QTNF9: NX_P0C862 

REFSEQ proteins: NP_848635.2  

ENSEMBL proteins: 
ENSP00000371498 ENSP00000333737 ENSP00000371503 


Human Recombinant Proteins 
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1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
About this table

C1QTNF9 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C1QTNF9 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR008983 Tumour_necrosis_fac-like
 IPR008160 Collagen
 IPR001073 C1q

Graphical View of Domain Structure for InterPro Entry P0C862

ProtoNet protein and cluster: P0C862

UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862
Similarity: Contains 1 C1q domain
Similarity: Contains 3 collagen-like domains


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862
Function: Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways (By similarity)

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich esiRNA and siRNA for C1QTNF9
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OriGene 29mer shRNA kits in GFP-retroviral vector: C1QTNF9
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OriGene siRNA: C1QTNF9
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Search SABiosciences for Assays for microRNAs that regulate C1QTNF9

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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OriGene GFP tagged cDNA clones in CMV expression vector: C1QTNF9
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: C1QTNF9
OriGene untagged cDNA clones in CMV expression vector: C1QTNF9
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Cell
Lines:
  
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2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005179 hormone activity IEA--
GO:0005515 protein binding IEA--
About this table

C1QTNF9 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for C1QTNF9 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C1QTNF9

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C1QTNF9


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for C1QTNF9
Sigma-Aldrich shRNA for C1QTNF9
OriGene 29mer shRNA kits in GFP-retroviral vector: C1QTNF9
OriGene shRNA RFP: C1QTNF9
OriGene basic RS shRNA: C1QTNF9
OriGene siRNA: C1QTNF9
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of C1QTNF9 
miRNA: Sigma-Aldrich microRNA Mimics for C1QTNF9
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of C1QTNF9 
Search SABiosciences for Assays for microRNAs that regulate C1QTNF9
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: C1QTNF9
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: C1QTNF9
OriGene untagged cDNA clones in CMV expression vector: C1QTNF9
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: C1QTNF9 
Primers: OriGene genome-wide validated SYBR primer pairs: C1QTNF9
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for C1QTNF9: PPH00034A

REFSEQ mRNAs for C1QTNF9 gene: 

NM_178540.3  

Additional cDNA sequence: 

AY358145.1 BC040438.1 

1 DOTS entry:

DT.95304754 

24/228 AceView cDNA sequences (see all 228):

AK123225 AL707817 BQ717547 CD723650 BE735417 AW206404 AK092759 AK055770 
AA360954 BX644087 CD678459 BE502293 AL699742 AA253426 AK097217 R78453 
CK905109 D79329 BM728412 CB215619 BX283763 AA159751 AI435823 AA007146 

highest scoring ESTs for C1QTNF9:

AY358145 BC040438 BI833629 BQ023266 NM_178540 AW983590 DB520946 XM_370715 CA425716 AW983589 

Unigene Cluster for C1QTNF9:

C1q and tumor necrosis factor related protein 9
Hs.362854  [show with all ESTs]
Unigene Representative Sequence: NM_178540


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000382066 ENST00000332018(uc001upj.2) ENST00000382071

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

C1QTNF9 expression in normal and diseased human tissues

1  / 2  / 3

1 probe-set matching C1QTNF9 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1554233_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
C1QTNF9 gene expression
C1QTNF9 gene electronic northern expression
C1QTNF9 gene sage expression
About these images

CGAP SAGE TAG: CATTAGCTAT

SOURCE GeneReport for Unigene cluster: Hs.362854

UniProtKB/Swiss-Prot: C1T9A_HUMAN, P0C862
Tissue specificity: Expressed predominantly in adipose tissue

Primers: OriGene genome-wide validated SYBR primer pairs: C1QTNF9
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for C1QTNF9: PPH00034A
    SABiosciences Custom PCR Arrays for C1QTNF9 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C1QTNF9 gene from 5/7 species (see all 7)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
C1QTNF91   -- C1q and tumor necrosis factor related protein 9 86.85(n)
89.76(a)
609026  XM_846206.1  XP_851299.1 
chimpanzee
(Pan troglodytes)
C1QTNF91   -- C1q and tumor necrosis factor related protein 9 98.9(n)
98.5(a)
467230  XM_001152983.1  XP_001152983.1 
cow
(Bos taurus)
C1QTNF91   -- C1q and tumor necrosis factor related protein 9 81.53(n)
85.24(a)
523616  NM_001075846.1  NP_001069314.1 
rat
(Rattus norvegicus)
C1qtnf91   -- C1q and tumor necrosis factor related protein 9 83.03(n)
84.55(a)
364395  XM_344414.3  XP_344415.3 
mouse
(Mus musculus)
C1qtnf91 , 5 14 (31.93 cM)5
C1q and tumor necrosis factor related protein 91, 5 82.03(n)1
84.94(a)1
2391261  NM_183175.31  NP_898998.21 
 AK0336735  AV3768305  (see all 8)
About this table        Species with no ortholog for C1QTNF9

ENSEMBL Gene Tree for C1QTNF9 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for C1QTNF9 gene
C1QB2  COL10A12  C1QTNF9B2  COL8A22  COL8A12  C1QTNF72  C1QC2  C1QTNF22  
ADIPOQ2  

C1QTNF9 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/216 NCBI SNPs in C1QTNF9 are shown (see all 216)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 13 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs13206171,2
--24896055(+) ATTCTA/GTGTAA 1 -- ut310--------
rs18156801,2
F24895921(+) GTTTAA/TAAATC 1 -- ut311Minor allele frequency- T:0.18MN 184
rs18156811,2
--24895927(+) AAATCC/TGCCAC 1 -- ut310--------
rs18156821,2
--24895932(+) CGCCAC/GACCAT 1 -- ut310--------
rs19619931,2
C,F,H,24891017(+) AGGGTA/CACATA 1 -- int112Minor allele frequency- C:0.21NS EA NA WA 586
rs19743321,2
C,F,O,A24890157(+) GGTGGC/TTTCTG 2 L F ref1 mis13Minor allele frequency- T:0.50NA WA 6
rs19743331,2
C,A,H,24881867(+) TAGGAG/CACAGT 1 -- ng518Minor allele frequency- C:0.17NA WA 64
rs21482361,2
--24892662(+) CCCCAC/TTGCAC 1 -- int10--------
rs21536611,2
--24891938(+) CAGGGA/GAACAA 1 -- int10--------
rs21536621,2
--24891983(+) CCAGTA/Ggaggg 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for C1QTNF9 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for C1QTNF9
     4 CNVs: 8747 5317 5315 9216

QIAGEN SeqTarget long-range PCR primers for resequencing C1QTNF9 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

7 PubMed articles for C1QTNF9 gene integrated from 7 sources:
(articles sorted by number of sources associating them with C1QTNF9)
  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
  2. Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. (PubMed id 18787108)1, 3 Wong G.W....Lodish H.F. (2009)
  3. CTRP8 and CTRP9B are novel proteins that hetero-oligo merize with C1q/TNF family members. (PubMed id 19666007)2 Peterson J.M....Wong G.W. (2009)
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 338872 HGNC: 28732 AceView: SPATA13andMGC48915 Ensembl:ENSG00000240654 euGenes: HUgn338872
ECgene: C1QTNF9 H-InvDB: C1QTNF9

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for C1QTNF9 gene:
Search GeneIP for patents involving C1QTNF9

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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