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C2CD2L Gene

protein-coding GIFtS: 41

GC11P114917

C2CD2-like
(Previous name: transmembrane protein 24 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TMEM24)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
C2CD2-like¹ ²
Transmembrane protein 24¹ ² ³
KIAA0285¹ ² ³
TMEM24² ³
C2 domain-containing protein 2-like²

External Ids:	HGNC: 29000¹	Entrez Gene: 9854²	Ensembl: ENSG00000172375⁷	UniProtKB: O14523³

Export aliases for C2CD2L gene to outside databases

Previous GC identifers: GC11P118484 GC11P118978

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for C2CD2L
Other transcription factors

Search SABiosciences Chromatin IP Primers for C2CD2L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

C2CD2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C2CD2L gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P114917: view genomic region (about GC identifiers)

Start:	114,917,539 bp from pter
End:	114,927,267 bp from pter
Size:	9,729 bases
Orientation:	plus strand

1 alternative location:

Chr11+ 118,978,093-118,987,826

RefSeq DNA sequence:

NC_000011.9 NT_033899.8

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: C2C2L_HUMAN, O14523 (See protein sequence)

Recommended Name: C2 domain-containing protein 2-like

Size: 706 amino acids; 76181 Da

Subcellular location: Membrane; Single-pass membrane protein (By similarity)

Sequence caution: Sequence=AAH10071.2; Type=Erroneous initiation; Sequence=AAH21254.2; Type=Erroneous initiation;

Secondary accessions: Q86UT7 Q86V04 Q8N522 Q8TBN4 Q96G10

Alternative splicing: 2 isoforms: O14523-1 O14523-2

Explore the universe of human proteins at neXtProt for C2CD2L: NX_O14523

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055622.3

ENSEMBL proteins:

ENSP00000412032 ENSP00000338885

Human Recombinant Proteins

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3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

C2CD2L for ontologies About GeneDecksing

Antibodies for C2CD2L:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C2CD2L for domains About GeneDecksing

1 InterPro domain/family:

IPR008973 C2_Ca/lipid-bd_dom_CaLB

Graphical View of Domain Structure for InterPro Entry O14523

ProtoNet protein and cluster: O14523

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for C2CD2L Sigma-Aldrich shRNA for C2CD2L
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miRNA:		Sigma-Aldrich microRNA Mimics for C2CD2L Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of C2CD2L
		1 SABiosciences Assays for microRNA that regulate C2CD2L:
		hsa-miR-558

Gene
Editing:

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Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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Cell
Lines:

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1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

C2CD2L for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for C2CD2L

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C2CD2L

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

About this table

C2CD2L for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C2CD2L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for C2CD2L Sigma-Aldrich shRNA for C2CD2L
		OriGene 29mer shRNA kits in GFP-retroviral vector: C2CD2L OriGene shRNA RFP: C2CD2L OriGene basic RS shRNA: C2CD2L OriGene siRNA: C2CD2L
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of C2CD2L

miRNA:		Sigma-Aldrich microRNA Mimics for C2CD2L Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of C2CD2L
		1 SABiosciences Assays for microRNA that regulate C2CD2L:
		hsa-miR-558

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: C2CD2L OriGene Myc/DDK tagged cDNA clones in CMV expression vector: C2CD2L OriGene untagged cDNA clones in CMV expression vector: C2CD2L OriGene 3'-UTR Clone: C2CD2L Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: C2CD2L

Primers:		OriGene genome-wide validated SYBR primer pairs: C2CD2L Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for C2CD2L: PPH08709A

REFSEQ mRNAs for C2CD2L gene:

NM_014807.3

Additional cDNA sequence:

AB006623.2 AB094094.1 AK025223.1 BC003598.1 BC010071.2 BC021254.2 BC022219.1 BC033083.1

BC040131.1 BC052246.1 BC075832.1 CR615888.1

10 DOTS entries:

DT.95200692 DT.455487 DT.100845813 DT.101982557 DT.120710433 DT.91831681 DT.92426179 DT.455486

DT.100785092 DT.95370586

24/128 AceView cDNA sequences (see all 128):

BM692996 AI160178 CK903758 CR615888 CD242710 AI146585 AI399936 BC003598

BE504023 D31407 BC033083 BE312719 AW105306 BC052246 CD242553 BU727518

BC075832 BQ051620 BU623225 BC010071 AI871543 AA872837 D81760 BM721292

Unigene Cluster for C2CD2L:

C2CD2-like

Hs.26899 [show with all ESTs]

Unigene Representative Sequence: NM_014807

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for C2CD2L

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for C2CD2L
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000425549(uc001pvo.2) ENST00000336702(uc001pvn.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

C2CD2L expression in normal and diseased human tissues

¹ / ²

2 probe-sets matching C2CD2L gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
204757_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204757_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

C2CD2L gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.26899

Primers:		OriGene genome-wide validated SYBR primer pairs: C2CD2L Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for C2CD2L: PPH08709A

SABiosciences Custom PCR Arrays for C2CD2L

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C2CD2L gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	C2CD2L¹	--	C2CD2-like	91.32(n) 93.07(a)	610622 XM_848159.1 XP_853252.1
chimpanzee (Pan troglodytes)	C2CD2L¹	--	C2CD2-like	99.72(n) 99.72(a)	451603 XM_001164505.1 XP_001164505.1
cow (Bos taurus)	C2CD2L¹	--	C2CD2-like	91.37(n) 92.93(a)	511966 XM_589395.3 XP_589395.2
rat (Rattus norvegicus)	Tmem24¹	--	transmembrane protein 24	87.91(n) 91.08(a)	300666 NM_001011996.1 NP_001011996.1
mouse (Mus musculus)	C2cd2l^{1 , 5}	9 (24.84 cM)⁵	C2 calcium-dependent domain containing 2-like^{1, 5}	88.24(n)¹ 90.79(a)¹	71764¹ NM_027909.2¹ NP_082185.2¹ AI447952⁵ AK004920⁵ (see all 23)

About this table Species with no ortholog for C2CD2L

ENSEMBL Gene Tree for C2CD2L (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for C2CD2L gene

C2CD2²

C2CD2L for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs510435^1,2	C,F,A,	118980039(-)	`AGTGCG/AGACAC`	1	--	int¹		14		NA MN NS EA WA	1004
rs554589^1,2	C,A,H,	118982670(-)	`CCTCCA/CA /G/TGTGAAG`	1	--	int¹		0	--	--	--	--
rs571445^1,2	C,F,A,H,	118987971(+)	`GCAGGA/GAAGAA`	1	--	ng3¹		12		NS EA NA WA	588
rs574266^1,2	--	118984290(-)	`GCTGGG/CAGGTG`	1	--	int¹		2		NA	36
rs588539^1,2	C,A,H,	118982671(+)	`TTCATA/GGAGGA`	1	--	int¹		6		NA EA WA	216
rs595782^1,2	C,F,A,	118985151(+)	`GCCAGT/CGTGCC`	1	--	int¹		10		MN NS EA NA WA	698
rs597614^1,2	--	118985510(+)	`ctgggC/Ggtagt`	1	--	int¹		0	--	--	--	--
rs597642^1,2	--	118985527(+)	`cacctG/Ttaatc`	1	--	int¹		1		MN	184
rs608444^1,2	C,F,A,H,	118986630(+)	`AGCCTA/GGCTTC`	1	--	int¹		10		MN NA EA WA	516
rs608793^1,2	C,A,H,	118986659(+)	`CTGTCT/CACATC`	1	--	int¹		7		MN NA WA	314

About this table

HapMap Linkage Disequilibrium images for C2CD2L (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C2CD2L: --

QIAGEN SeqTarget long-range PCR primers for resequencing C2CD2L

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/12 PubMed articles for C2CD2L gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with C2CD2L)

Identification and characterization of TMEM24 family genes in silico. (PubMed id 15289880)^{1, 3, 7} Katoh M. and Katoh M. (2004)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)^{1, 2} Ohara O....Nomura N. (1997)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. (PubMed id 16368544)¹ Calinisan V....Gascard P. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9854	HGNC: 29000	AceView: TMEM24	Ensembl:ENSG00000172375	euGenes: HUgn9854
ECgene: C2CD2L	H-InvDB: C2CD2L

(According to HUGE)
About This Section

HUGE: KIAA0285

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for C2CD2L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for C2CD2L gene:
Search GeneIP for patents involving C2CD2L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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C2CD2L Gene

protein-coding GIFtS: 41

Aliases &
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for C2CD2L gene

Summaries
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Genomic Views
for C2CD2L gene

Proteins
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Protein Domains/
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Gene Function
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Pathways & Interactions
for C2CD2L gene

Drugs & Compounds
for C2CD2L gene

Transcripts
for C2CD2L gene

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C2CD2L Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor C2CD2L gene

Summariesfor C2CD2L gene

Genomic Viewsfor C2CD2L gene

Proteinsfor C2CD2L gene

Protein Domains/Familiesfor C2CD2L gene

Gene Functionfor C2CD2L gene

Pathways & Interactionsfor C2CD2L gene

Drugs & Compoundsfor C2CD2L gene

Transcriptsfor C2CD2L gene

Expression for C2CD2L gene

Orthologsfor C2CD2L gene

Paralogsfor C2CD2L gene

Genomic Variantsfor C2CD2L gene

Disorders & Mutationsfor C2CD2L gene

Medical Newsfor C2CD2L gene

Publicationsfor C2CD2L gene

External Searches for C2CD2L gene

Genome Databases showing C2CD2L gene

Other Databases showing C2CD2L gene

Specialized Databases showing C2CD2L gene

Intellectual Propertyfor C2CD2L gene

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Aliases &
Descriptions
for C2CD2L gene

Summaries
for C2CD2L gene

Genomic Views
for C2CD2L gene

Proteins
for C2CD2L gene

Protein Domains/
Families
for C2CD2L gene

Gene Function
for C2CD2L gene

Pathways & Interactions
for C2CD2L gene

Drugs & Compounds
for C2CD2L gene

Transcripts
for C2CD2L gene

Expression
for C2CD2L gene

Orthologs
for C2CD2L gene

Paralogs
for C2CD2L gene

Genomic Variants
for C2CD2L gene

Disorders & Mutations
for C2CD2L gene

Medical News
for C2CD2L gene

Publications
for C2CD2L gene

Intellectual Property
for C2CD2L gene

Products
for C2CD2L gene