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C8orf51 Gene

RNA gene   GIFtS: 27

GC08M139702
chromosome 8 open reading frame 51
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
chromosome 8 open reading frame 511 2
MGC31131 2

External Ids:    HGNC: 284571   Entrez Gene: 789982   Ensembl: ENSG000002543897   UniProtKB: Q9BWJ23   

Export aliases for C8orf51 gene to outside databases

Previous GC identifers: GC08M144521 GC08M144448


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C8orf51 gene promoter:
         CUTL1   RFX1   ISGF-3   CREB   deltaCREB   Nkx2-2   ATF-2   XBP-1   c-Myb   p53   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for C8orf51

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

C8orf51 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C8orf51 gene location

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M139702:  view genomic region     (about GC identifiers)

Start:
139,702,289 bp from pter
End:
139,704,301 bp from pter
Size:
2,013 bases
Orientation:
minus strand

1 alternative location:
Chr8- 144,448,801-144,450,718     
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CH051_HUMAN, Q9BWJ2 (See protein sequence)
Recommended Name: Putative uncharacterized protein C8orf51  
Size: 59 amino acids; 6658 Da
Caution: Product of a dubious gene prediction

Explore the universe of human proteins at neXtProt for C8orf51: NX_Q9BWJ2 


Human Recombinant Proteins 

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Assays for C8orf51: 
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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9BWJ2


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for C8orf51
Sigma-Aldrich shRNA for C8orf51
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): C8orf51
OriGene shRNA RFP (see all 2): C8orf51
OriGene basic RS shRNA (see all 2): C8orf51
Browse OriGene siRNA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of C8orf51 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of C8orf51 
Search SABiosciences for Assays for microRNAs that regulate C8orf51

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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OriGene untagged cDNA clones in CMV expression vector: C8orf51
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Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for C8orf51 


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for C8orf51 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8orf51

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C8orf51


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for C8orf51
Sigma-Aldrich shRNA for C8orf51
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): C8orf51
OriGene shRNA RFP (see all 2): C8orf51
OriGene basic RS shRNA (see all 2): C8orf51
Browse OriGene siRNA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of C8orf51 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of C8orf51 
Search SABiosciences for Assays for microRNAs that regulate C8orf51
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene untagged cDNA clones in CMV expression vector: C8orf51
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for C8orf51 
Primers: OriGene genome-wide validated SYBR primer pairs: C8orf51
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for C8orf51: PPH14926A

Additional cDNA sequence: 

AK026503.1 BC000203.1 

1 DOTS entry:

DT.97838211 

19 AceView cDNA sequences:

BE256583 BP357787 BX283102 BE252128 BM684166 BG470720 AK026503 AW139464 
BP357653 BF516327 NM_024035 BM930735 BC000203 BI829214 BM839414 BM930586 
AI672799 BM968345 AW139092 

highest scoring ESTs for C8orf51:

AK026503 BC000203 BE252128 BE256583 BG470720 BI829214 BM839414 BX283102 AW139092 AW139464 

Unigene Cluster for C8orf51:

Chromosome 8 open reading frame 51
Hs.245886  [show with all ESTs]
Unigene Representative Sequence: BC000203


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000518049

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

C8orf51 expression in normal and diseased human tissues

1  / 2  / 3

2 probe-sets matching C8orf51 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
207458_at2, 3 U133-A 1 0.64 1.00 -- -- NM_024035 0.40 1.00 0.76 1
207458_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
C8orf51 gene expression
C8orf51 gene electronic northern expression
C8orf51 gene sage expression
About these images

CGAP SAGE TAG: TGTGACTGAA

SOURCE GeneReport for Unigene cluster: Hs.245886
Primers: OriGene genome-wide validated SYBR primer pairs: C8orf51
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for C8orf51: PPH14926A
    SABiosciences Custom PCR Arrays for C8orf51 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
ENSEMBL Gene Tree for C8orf51 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C8orf51
     1 CNV: 30299
Search QIAGEN SeqTarget long-range PCR primers for resequencing for C8orf51 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

5 PubMed articles for C8orf51 gene integrated from 7 sources:
(articles sorted by number of sources associating them with C8orf51)
  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  4. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 78998 HGNC: 28457 AceView: MGC3113 Ensembl:ENSG00000254389 euGenes: HUgn78998
ECgene: C8orf51 H-InvDB: C8orf51

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for C8orf51 gene:
Search GeneIP for patents involving C8orf51

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
 Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 Search QIAGEN SeqTarget long-range PCR primers for resequencing for C8orf51
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of C8orf51
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 Regulatory tfbs in C8orf51 promoter
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