Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



CABIN1 Gene

protein-coding   GIFtS: 62

GC22P007355
calcineurin binding protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
calcineurin binding protein 11 2     Calcineurin inhibitor2 3
KIAA03301 2 3     calcineurin binding protein cabin 12
CAIN2 3 5     OTTHUMP000001985412
PPP3IN1 2     calcineurin-binding protein cabin-12

External Ids:    HGNC: 241871   Entrez Gene: 235232   Ensembl: ENSG000000999917   UniProtKB: Q9Y6J03   

Export aliases for CABIN1 gene to outside databases

Previous GC identifers: GC22P021103 GC22P022732 GC22P024407


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CABIN1:
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by
this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal
transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST
motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results
in multiple transcript variants. (provided by RefSeq)

UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0
Function: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell
receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC
and calcium signals

Gene Wiki entry for CABIN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CABIN1 gene promoter:
         STAT1   NF-1   STAT3   CREB   deltaCREB   p53   AML1a   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CABIN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CABIN1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

CABIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CABIN1 gene location

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P007355:  view genomic region     (about GC identifiers)

Start:
7,355,977 bp from pter
End:
7,523,706 bp from pter
Size:
167,730 bases
Orientation:
plus strand

1 alternative location:
Chr22+ 24,407,642-24,574,596     
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0 (See protein sequence)
Recommended Name: Calcineurin-binding protein cabin-1  
Size: 2220 amino acids; 246352 Da
Subunit: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with
calcineurin. Interacts with MEF2B
Subcellular location: Nucleus
Sequence caution: Sequence=BAA20788.2; Type=Erroneous initiation;
PDB structures from and Proteopedia :
1N6J (3D)    
Secondary accessions: Q9Y460

Explore the universe of human proteins at neXtProt for CABIN1: NX_Q9Y6J0 

Post-translational modifications:

  • Activated through PKC-mediated hyperphosphorylation. Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001186210.1  NP_036427.1  


    ENSEMBL proteins: 
    ENSP00000384729 ENSP00000394209 ENSP00000381364 ENSP00000412389 ENSP00000336991 ENSP00000384694 
    ENSP00000263119 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for CABIN1 
    Novus Biologicals Protein for CABIN1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS--
    About this table

    CABIN1 for ontologies           About GeneDecksing



    Antibodies for CABIN1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for CABIN1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for CABIN1 
    Novus Biologicals Antibodies for CABIN1
    Browse antibodies at Epitomics

    Assays for CABIN1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CABIN1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CABIN1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CABIN1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR015134 MEF2_binding
     IPR013026 TPR-contain
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q9Y6J0

    ProtoNet protein and cluster: Q9Y6J0

    UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0
    Similarity: Contains 6 TPR repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0
    Function: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell
    receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC
    and calcium signals

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for CABIN1
    Sigma-Aldrich shRNA for CABIN1
    OriGene 29mer shRNA kits in GFP-retroviral vector: CABIN1
    OriGene shRNA RFP: CABIN1
    OriGene basic RS shRNA: CABIN1
    OriGene siRNA: CABIN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CABIN1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CABIN1 
    4 SABiosciences Assays for microRNAs that regulate CABIN1:
    hsa-miR-376b hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-376a

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CABIN1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CABIN1
    OriGene untagged cDNA clones in CMV expression vector: CABIN1
    OriGene 3'-UTR clone: CABIN1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: CABIN1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CABIN1 

    Genatlas biochemistry entry for CABIN1:
    calcineurin binding protein 1,cDNA sequence,expressed in brain,>100kDa,related to murine procollagen alpha

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864 phosphoprotein phosphatase inhibitor activity NAS9655484
    GO:0005488 binding ----
    GO:0005515 protein binding IEA--
    GO:0030346 protein phosphatase 2B binding IEA--
    About this table

    CABIN1 for ontologies           About GeneDecksing

    Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cabin1):

    immune systemlethality-prenatal/perinatal

    CABIN1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CABIN1 for pathways           About GeneDecksing

    1 Millipore Pathway for CABIN1
        Immune response Function of MEF2 in T lymphocytes

    5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  CABIN1
        Nur77 Signaling in T Lymphocytes
    Role of NFAT in Cardiac Hypertrophy
    Calcium Signaling
    Calcium-induced T Lymphocyte Apoptosis
    Role of NFAT in Regulation of the Immune Response

        SABiosciences Custom Pathway-Focused PCR Arrays for CABIN1 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CABIN1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CABIN1

    5/16 Interacting proteins for CABIN1 (ENSP000002631193 Q9Y6J02) via UniProtKB, MINT, and/or STRING (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAQP273482STRING: ENSP00000371267 MINT-8007070
    LOC729991ENSP000001620233STRING: ENSP00000162023
    MEF2DENSP000002715553STRING: ENSP00000271555
    CREBBPENSP000003715023STRING: ENSP00000371502
    EP300ENSP000002632533STRING: ENSP00000263253
    About this table

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166 cell surface receptor linked signaling pathway NAS9655484
    GO:0016568 chromatin modification IEA--
    About this table

    CABIN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CABIN1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CABIN1
    10/12 Novoseek chemical compound relationships for CABIN1 gene (see all 12)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 80 24 18793727 (2), 16975081 (1), 17713429 (1), 19923086 (1) (see all 18)
    mycophenolate mofetil 76.3 8 19775321 (1), 18282242 (1), 18992054 (1), 12709080 (1) (see all 6)
    tacrolimus 75.4 15 11150994 (1), 16182764 (1), 11558493 (1), 15619640 (1) (see all 10)
    thymoglobulin 75.4 2 18657156 (1), 16110819 (1)
    cyclosporin a 70.1 15 18574772 (1), 11150994 (1), 16182764 (1), 11558493 (1) (see all 10)
    mycophenolic acid 66.5 1 14508385 (1)
    basiliximab 63.1 1 18282242 (1)
    alemtuzumab 48.1 2 16974888 (1), 16110819 (1)
    steroid 34.9 4 16974888 (1), 12717217 (1), 16975489 (1), 16249744 (1)
    azathioprine 11.2 1 12709080 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for CABIN1
    Sigma-Aldrich shRNA for CABIN1
    OriGene 29mer shRNA kits in GFP-retroviral vector: CABIN1
    OriGene shRNA RFP: CABIN1
    OriGene basic RS shRNA: CABIN1
    OriGene siRNA: CABIN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CABIN1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CABIN1 
    4 SABiosciences Assays for microRNAs that regulate CABIN1:
    hsa-miR-376b hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-376a
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CABIN1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CABIN1
    OriGene untagged cDNA clones in CMV expression vector: CABIN1
    OriGene 3'-UTR Clone: CABIN1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: CABIN1 
    Primers: OriGene genome-wide validated SYBR primer pairs: CABIN1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CABIN1: PPH01508A

    REFSEQ mRNAs for CABIN1 gene (2 alternative transcripts): 

    NM_001199281.1  NM_012295.3  

    Additional cDNA sequence: 

    AB002328.2 AF072441.1 AK127950.1 AK307522.1 AL390166.1 BC013099.1 BC021929.1 BC028969.1 
    BC041659.1 BC054497.1 

    14 DOTS entries:

    DT.95310233  DT.447375  DT.97838462  DT.92062145  DT.92450991  DT.95286036  DT.97847423  DT.95310218 
    DT.91669963  DT.120672683  DT.86854770  DT.86854771  DT.95134074  DT.95148167 

    24/245 AceView cDNA sequences (see all 245):

    BM684175 CK299251 BQ432007 BC041659 BQ688962 AF072441 NM_012295 AI075184 
    BQ425586 AA322823 AW071541 BQ951397 BM685136 BQ184002 BQ425780 BC054497 
    CA416329 BX644449 BM556693 BG106330 BM791822 CB852081 BF929368 BC021929 

    highest scoring ESTs for CABIN1:

    AB002328 AA206547 AA235085 AA235496 AA424585 AA626489 AA687740 AA769343 AA815445 AA858218 

    Unigene Cluster for CABIN1:

    Calcineurin binding protein 1
    Hs.517478  [show with all ESTs]
    Unigene Representative Sequence: AB002328


    GeneLoc Exon Structure

    5/26 Alternative Splicing Database (ASD) splice patterns (SP) for CABIN1 (see all 26)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^
    SP1:                    -                                                                                                                                       
    SP2:                    -                       -                                                                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34 ^ 35 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 36a · 36b ^ 37a · 37b · 37c ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b · 43c ^ 44a · 44b ^ 45 ^ 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:                                            -     -                                                                                       
    SP4:                                                                                                              -                           
    SP5:                                                                                                                                          

    About this scheme

    ECgene alternative splicing isoforms for CABIN1
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474981 ENST00000487946 ENST00000403176 ENST00000459824 ENST00000454754
    ENST00000398319(uc002zzk.1 uc002zzl.1) ENST00000445422 ENST00000337989(uc002zzm.1)
    ENST00000484593 ENST00000485008 ENST00000467937 ENST00000495121 ENST00000496016
    ENST00000405822 ENST00000263119(uc010guk.1 uc002zzi.1 uc002zzj.1 uc010gul.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CABIN1 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching CABIN1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37652_at2, 3 U133-A 1 1.00 1.00 0.69 1.22 AB002328 1.00 1.00 1.00 1
    56078_at2, 3 U95-C 1 0.44 1.00 -0.08 0.78 AI953154 0.60 1.00 0.82 1
    37652_at2, 3 U133-A 1 1.00 1.00 -- -- AB002328 1.00 1.00 1.00 1
    202624_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_012295 0.60 1.00 0.82 1
    37652_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    202624_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    CABIN1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CABIN1 gene expression
    CABIN1 gene electronic northern expression
    CABIN1 gene sage expression
    About these images

    CGAP SAGE TAG: TGAAGGTGGA

    SOURCE GeneReport for Unigene cluster: Hs.517478

    Expression variation in blood from EXPOLDB for CABIN1

    UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0
    Tissue specificity: Widely expressed in different tissues

    Primers: OriGene genome-wide validated SYBR primer pairs: CABIN1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CABIN1: PPH01508A
        SABiosciences Custom PCR Arrays for CABIN1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CABIN1 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CABIN11   -- calcineurin binding protein 1 89.78(n)
    92.27(a)
    486403  XM_543529.2  XP_543529.2 
    chimpanzee
    (Pan troglodytes)
    CABIN11   -- calcineurin binding protein 1 99.4(n)
    99.41(a)
    458709  XM_001170576.1  XP_001170576.1 
    rat
    (Rattus norvegicus)
    Cabin11   -- calcineurin binding protein 1 87.06(n)
    89.51(a)
    94165  NM_053575.1  NP_446027.1 
    mouse
    (Mus musculus)
    Cabin11 , 5 10 (38.56 cM)5
    calcineurin binding protein 11, 5 86.93(n)1
    90.07(a)1
    1042481  NM_172549.31  NP_766137.21 
     AI4276925  AK0396065  (see all 26)
    chicken
    (Gallus gallus)
    CABIN11   -- calcineurin binding protein 1 72(n)
    76.96(a)
    416938  XM_415231.2  XP_415231.2 
    About this table        Species with no ortholog for CABIN1

    ENSEMBL Gene Tree for CABIN1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1264 NCBI SNPs in CABIN1 are shown (see all 1264)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 22 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122721,2
    C,F,A,24510620(+) AAACGC/TTGGTG 1 -- int117Minor allele frequency- T:0.40MN NS EA NA WA 1410
    rs1403191,2
    --24538353(+) ATGAC-/TGGGAAT 1 -- int10--------
    rs1403201,2
    C,A24548785(+) GGTGGC/TGTGTG 1 -- int13Minor allele frequency- T:0.50NA WA 6
    rs1761541,2
    24497916(+) AGGTGC/TCTGCA 1 -- int10--------
    rs1761551,2
    C,F,A,H,24499204(+) ATGCGG/ATGGGG 1 -- int17Minor allele frequency- A:0.29NA EA MN WA 538
    rs1761561,2
    C,F,O,A,24500866(+) CACAAG/CCATAC 1 -- int121Minor allele frequency- C:0.42EA MN NS NA WA 2608
    rs1761571,2
    C,F,O,24503987(+) GCCATC/TGGTGT 1 -- int199Minor allele frequency- T:0.08NS MN EA PA EU CA WA NA 6507
    rs1761581,2
    C,A,24513337(+) tttttT/Aaattt 1 -- int13Minor allele frequency- A:0.01EA NA WA 254
    rs1761591,2
    C,F,O,A,H,24514352(+) GGCTTC/TGACTT 1 -- int118Minor allele frequency- T:0.11NA NS EA WA 1470
    rs1761601,2
    C,F,24514910(+) CACTGA/CGCAGG 1 -- int14Minor allele frequency- C:0.00NS EA 408
    About this table

    HapMap Linkage Disequilibrium images for CABIN1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for CABIN1
         5 CNVs: 0235 0688 36015 5180 36016

    QIAGEN SeqTarget long-range PCR primers for resequencing CABIN1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CABIN1 for disorders           About GeneDecksing

    OMIM: 604251

    9 Novoseek disease relationships for CABIN1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    purpura thrombotic thrombocytopenic 44.3 2 18671673 (1), 18398793 (1)
    renal disease 42.2 5 15919481 (2), 17112881 (1), 12883183 (1), 18585837 (1)
    proteinuria 39.1 3 17900463 (2), 16975081 (1)
    cmv infection 37.7 1 18202507 (1)
    renal failure 37.2 6 11558493 (2), 17262720 (2), 19923086 (1), 15780099 (1)
    hypertension arterial 0.113 1 17333201 (1)
    atherosclerosis 0 1 18202507 (1)
    histopathology 0 1 16932468 (1)
    edema 0 1 17199798 (1)
    About this table

    Human Gene Mutation Database (HGMD): CABIN1
    Genetic Association Database (GAD): CABIN1
    Human Genome Epidemiology (HuGE) Navigator: CABIN1 (6 documents)

    Export disorders and mutations for CABIN1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/120 PubMed articles for CABIN1 gene, integrated from 7 sources (see all 120):
    (articles sorted by number of sources associating them with CABIN1)
    1. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. (PubMed id 9655484)1, 2, 3 Sun L.... Liu J.O. (1998)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. (PubMed id 12700764)1, 2, 7 Han A.... Chen L. (2003)
    4. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
    5. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. (PubMed id 14718166)1, 2 Tagami H.... Nakatani Y. (2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    7. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. (PubMed id 15902271)1, 7 Pan F....Liu J.O. (2005)
    8. Cabin1 restrains p53 activity on chromatin. (PubMed id 19668210)1, 7 Jang H....Youn H.D. (2009)
    9. Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1. (PubMed id 17172641)1, 7 Jang H....Youn H.D. (2007)
    10. The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT. (PubMed id 15671033)1, 7 Rodriguez A....Redondo J.M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23523 HGNC: 24187 AceView: CABIN1 Ensembl:ENSG00000099991 euGenes: HUgn23523
    ECgene: CABIN1 H-InvDB: CABIN1

    (According to HUGE)
    About This Section
    HUGE: KIAA0330

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for CABIN1 gene:
    Search GeneIP for patents involving CABIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for CABIN1 Antibodies for CABIN1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CABIN1 Browse microRNA Mimics at Sigma-Aldrich
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CABIN1
     SeqTarget long-range PCR primers for resequencing CABIN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CABIN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CABIN1
     GenScript Custom Purified and Recombinant Proteins Services for CABIN1 GenScript cDNA clones with any tag delivered in your preferred vector for CABIN1
     GenScript Custom Assay Services for CABIN1 GenScript Custom Superior Antibodies Services for CABIN1
     GenScript Custom overexpressing Cell Line Services for CABIN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CABIN1 promoter
     Search Chromatin IP Primers for CABIN1
     RT2 qPCR Primer Assay for CABIN1
     GNC Network for CABIN1
     Assays for microRNAs that regulate CABIN1
     SABiosciences Custom PCR Arrays for CABIN1
     Search Tocris compounds for CABIN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for CABIN1
     Proteins for CABIN1
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for CABIN1
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    CABIN1 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4