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CABIN1 Gene

protein-coding GIFtS: 62

GC22P007355

calcineurin binding protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
calcineurin binding protein 1¹ ²		Calcineurin inhibitor² ³
KIAA0330¹ ² ³		calcineurin binding protein cabin 1²
CAIN² ³ ⁵		OTTHUMP00000198541²
PPP3IN¹ ²		calcineurin-binding protein cabin-1²

External Ids:	HGNC: 24187¹	Entrez Gene: 23523²	Ensembl: ENSG00000099991⁷	UniProtKB: Q9Y6J0³

Export aliases for CABIN1 gene to outside databases

Previous GC identifers: GC22P021103 GC22P022732 GC22P024407

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CABIN1:

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by

this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal

transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST

motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results

in multiple transcript variants. (provided by RefSeq)

UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0

Function: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell

receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC

and calcium signals

Gene Wiki entry for CABIN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CABIN1 gene promoter:
         STAT1   NF-1   STAT3   CREB   deltaCREB   p53   AML1a
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CABIN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CABIN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23

CABIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CABIN1 gene location

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P007355: view genomic region (about GC identifiers)

Start:	7,355,977 bp from pter
End:	7,523,706 bp from pter
Size:	167,730 bases
Orientation:	plus strand

1 alternative location:

Chr22+ 24,407,642-24,574,596

RefSeq DNA sequence:

NC_000022.10 NT_011520.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0 (See protein sequence)

Recommended Name: Calcineurin-binding protein cabin-1

Size: 2220 amino acids; 246352 Da

Subunit: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with

calcineurin. Interacts with MEF2B

Subcellular location: Nucleus

Sequence caution: Sequence=BAA20788.2; Type=Erroneous initiation;

PDB structures from and Proteopedia :

1N6J (3D)

Secondary accessions: Q9Y460

Explore the universe of human proteins at neXtProt for CABIN1: NX_Q9Y6J0

Post-translational modifications:

Activated through PKC-mediated hyperphosphorylation. Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001186210.1 NP_036427.1

ENSEMBL proteins:

ENSP00000384729 ENSP00000394209 ENSP00000381364 ENSP00000412389 ENSP00000336991 ENSP00000384694

ENSP00000263119

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for CABIN1
	Novus Biologicals Protein for CABIN1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--

About this table

CABIN1 for ontologies About GeneDecksing

Antibodies for CABIN1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CABIN1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for CABIN1
	Novus Biologicals Antibodies for CABIN1
	Browse antibodies at Epitomics

Assays for CABIN1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CABIN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CABIN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CABIN1 for domains About GeneDecksing

4 InterPro domains/families:

IPR011990 TPR-like_helical

IPR015134 MEF2_binding

IPR013026 TPR-contain

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry Q9Y6J0

ProtoNet protein and cluster: Q9Y6J0

UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0

Similarity: Contains 6 TPR repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0

Function: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell

receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC

and calcium signals

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for CABIN1 Sigma-Aldrich shRNA for CABIN1
		OriGene 29mer shRNA kits in GFP-retroviral vector: CABIN1 OriGene shRNA RFP: CABIN1 OriGene basic RS shRNA: CABIN1 OriGene siRNA: CABIN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CABIN1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CABIN1
		4 SABiosciences Assays for microRNAs that regulate CABIN1:
		hsa-miR-376b hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-376a

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: CABIN1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CABIN1 OriGene untagged cDNA clones in CMV expression vector: CABIN1 OriGene 3'-UTR clone: CABIN1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: CABIN1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for CABIN1

Genatlas biochemistry entry for CABIN1:

calcineurin binding protein 1,cDNA sequence,expressed in brain,>100kDa,related to murine procollagen alpha

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004864	phosphoprotein phosphatase inhibitor activity	NAS	9655484
GO:0005488	binding	--	--
GO:0005515	protein binding	IEA	--
GO:0030346	protein phosphatase 2B binding	IEA	--

About this table

CABIN1 for ontologies About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cabin1):

immune system

lethality-prenatal/perinatal

CABIN1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

CABIN1 for pathways About GeneDecksing

1 Millipore Pathway for CABIN1

Immune response Function of MEF2 in T lymphocytes

5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for CABIN1

	Nur77 Signaling in T Lymphocytes
	Role of NFAT in Cardiac Hypertrophy
	Calcium Signaling
	Calcium-induced T Lymphocyte Apoptosis
	Role of NFAT in Regulation of the Immune Response

SABiosciences Custom Pathway-Focused PCR Arrays for CABIN1

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CABIN1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CABIN1

5/16 Interacting proteins for CABIN1 (ENSP00000263119³ Q9Y6J0²) via UniProtKB, MINT, and/or STRING (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAQ	P27348²	STRING: ENSP00000371267 MINT-8007070
LOC729991	ENSP00000162023³	STRING: ENSP00000162023
MEF2D	ENSP00000271555³	STRING: ENSP00000271555
CREBBP	ENSP00000371502³	STRING: ENSP00000371502
EP300	ENSP00000263253³	STRING: ENSP00000263253

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007166	cell surface receptor linked signaling pathway	NAS	9655484
GO:0016568	chromatin modification	IEA	--

About this table

CABIN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

CABIN1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CABIN1
10/12 Novoseek chemical compound relationships for CABIN1 gene (see all 12)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rapamycin	80	24	18793727 (2), 16975081 (1), 17713429 (1), 19923086 (1) (see all 18)
mycophenolate mofetil	76.3	8	19775321 (1), 18282242 (1), 18992054 (1), 12709080 (1) (see all 6)
tacrolimus	75.4	15	11150994 (1), 16182764 (1), 11558493 (1), 15619640 (1) (see all 10)
thymoglobulin	75.4	2	18657156 (1), 16110819 (1)
cyclosporin a	70.1	15	18574772 (1), 11150994 (1), 16182764 (1), 11558493 (1) (see all 10)
mycophenolic acid	66.5	1	14508385 (1)
basiliximab	63.1	1	18282242 (1)
alemtuzumab	48.1	2	16974888 (1), 16110819 (1)
steroid	34.9	4	16974888 (1), 12717217 (1), 16975489 (1), 16249744 (1)
azathioprine	11.2	1	12709080 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for CABIN1 Sigma-Aldrich shRNA for CABIN1
		OriGene 29mer shRNA kits in GFP-retroviral vector: CABIN1 OriGene shRNA RFP: CABIN1 OriGene basic RS shRNA: CABIN1 OriGene siRNA: CABIN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CABIN1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CABIN1
		4 SABiosciences Assays for microRNAs that regulate CABIN1:
		hsa-miR-376b hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-376a

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: CABIN1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CABIN1 OriGene untagged cDNA clones in CMV expression vector: CABIN1 OriGene 3'-UTR Clone: CABIN1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: CABIN1

Primers:		OriGene genome-wide validated SYBR primer pairs: CABIN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CABIN1: PPH01508A

REFSEQ mRNAs for CABIN1 gene (2 alternative transcripts):

NM_001199281.1 NM_012295.3

Additional cDNA sequence:

AB002328.2 AF072441.1 AK127950.1 AK307522.1 AL390166.1 BC013099.1 BC021929.1 BC028969.1

BC041659.1 BC054497.1

14 DOTS entries:

DT.95310233 DT.447375 DT.97838462 DT.92062145 DT.92450991 DT.95286036 DT.97847423 DT.95310218

DT.91669963 DT.120672683 DT.86854770 DT.86854771 DT.95134074 DT.95148167

24/245 AceView cDNA sequences (see all 245):

BM684175 CK299251 BQ432007 BC041659 BQ688962 AF072441 NM_012295 AI075184

BQ425586 AA322823 AW071541 BQ951397 BM685136 BQ184002 BQ425780 BC054497

CA416329 BX644449 BM556693 BG106330 BM791822 CB852081 BF929368 BC021929

highest scoring ESTs for CABIN1:

AB002328 AA206547 AA235085 AA235496 AA424585 AA626489 AA687740 AA769343 AA815445 AA858218

Unigene Cluster for CABIN1:

Calcineurin binding protein 1

Hs.517478 [show with all ESTs]

Unigene Representative Sequence: AB002328

GeneLoc Exon Structure

5/26 Alternative Splicing Database (ASD) splice patterns (SP) for CABIN1 (see all 26)

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	·	18c	^
SP1:							-
SP2:							-								-
SP3:
SP4:
SP5:

ExUns:	19a	·	19b	^	20a	·	20b	^	21a	·	21b	^	22a	·	22b	^	23	^	24	^	25a	·	25b	^	26a	·	26b	^	27	^	28	^	29	^	30a	·	30b	^	31	^	32a	·	32b	·	32c	^	33	^	34	^	35	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	36a	·	36b	^	37a	·	37b	·	37c	^	38a	·	38b	^	39	^	40	^	41	^	42	^	43a	·	43b	·	43c	^	44a	·	44b	^	45	^	46	^	47	^	48	^	49a	·	49b	^	50
SP1:
SP2:
SP3:															-		-
SP4:																																					-
SP5:

About this scheme

ECgene alternative splicing isoforms for CABIN1
15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000474981 ENST00000487946 ENST00000403176 ENST00000459824 ENST00000454754

ENST00000398319(uc002zzk.1 uc002zzl.1) ENST00000445422 ENST00000337989(uc002zzm.1)

ENST00000484593 ENST00000485008 ENST00000467937 ENST00000495121 ENST00000496016

ENST00000405822 ENST00000263119(uc010guk.1 uc002zzi.1 uc002zzj.1 uc010gul.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CABIN1 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching CABIN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37652_at²^{, 3}	U133-A	1	1.00	1.00	0.69	1.22	AB002328	1.00	1.00	1.00	1
56078_at²^{, 3}	U95-C	1	0.44	1.00	-0.08	0.78	AI953154	0.60	1.00	0.82	1
37652_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB002328	1.00	1.00	1.00	1
202624_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012295	0.60	1.00	0.82	1
37652_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202624_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

CABIN1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CABIN1 gene electronic northern expression

About these images

CGAP SAGE TAG: TGAAGGTGGA

SOURCE GeneReport for Unigene cluster: Hs.517478

Expression variation in blood from EXPOLDB for CABIN1

UniProtKB/Swiss-Prot: CABIN_HUMAN, Q9Y6J0

Tissue specificity: Widely expressed in different tissues

Primers:		OriGene genome-wide validated SYBR primer pairs: CABIN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CABIN1: PPH01508A

SABiosciences Custom PCR Arrays for CABIN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CABIN1 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CABIN1¹	--	calcineurin binding protein 1	89.78(n) 92.27(a)	486403 XM_543529.2 XP_543529.2
chimpanzee (Pan troglodytes)	CABIN1¹	--	calcineurin binding protein 1	99.4(n) 99.41(a)	458709 XM_001170576.1 XP_001170576.1
rat (Rattus norvegicus)	Cabin1¹	--	calcineurin binding protein 1	87.06(n) 89.51(a)	94165 NM_053575.1 NP_446027.1
mouse (Mus musculus)	Cabin1^{1 , 5}	10 (38.56 cM)⁵	calcineurin binding protein 1^{1, 5}	86.93(n)¹ 90.07(a)¹	104248¹ NM_172549.3¹ NP_766137.2¹ AI427692⁵ AK039606⁵ (see all 26)
chicken (Gallus gallus)	CABIN1¹	--	calcineurin binding protein 1	72(n) 76.96(a)	416938 XM_415231.2 XP_415231.2

About this table Species with no ortholog for CABIN1

ENSEMBL Gene Tree for CABIN1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs112272^1,2	C,F,A,	24510620(+)	`AAACGC/TTGGTG`	1	--	int¹		17		MN NS EA NA WA	1410
rs140319^1,2	--	24538353(+)	`ATGAC-/TGGGAAT`	1	--	int¹		0	--	--	--	--
rs140320^1,2	C,A	24548785(+)	`GGTGGC/TGTGTG`	1	--	int¹		3		NA WA	6
rs176154^1,2		24497916(+)	`AGGTGC/TCTGCA`	1	--	int¹		0	--	--	--	--
rs176155^1,2	C,F,A,H,	24499204(+)	`ATGCGG/ATGGGG`	1	--	int¹		7		NA EA MN WA	538
rs176156^1,2	C,F,O,A,	24500866(+)	`CACAAG/CCATAC`	1	--	int¹		21		EA MN NS NA WA	2608
rs176157^1,2	C,F,O,	24503987(+)	`GCCATC/TGGTGT`	1	--	int¹		99		NS MN EA PA EU CA WA NA	6507
rs176158^1,2	C,A,	24513337(+)	`tttttT/Aaattt`	1	--	int¹		3		EA NA WA	254
rs176159^1,2	C,F,O,A,H,	24514352(+)	`GGCTTC/TGACTT`	1	--	int¹		18		NA NS EA WA	1470
rs176160^1,2	C,F,	24514910(+)	`CACTGA/CGCAGG`	1	--	int¹		4		NS EA	408

About this table

HapMap Linkage Disequilibrium images for CABIN1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CABIN1
5 CNVs: 0235 0688 36015 5180 36016

QIAGEN SeqTarget long-range PCR primers for resequencing CABIN1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CABIN1 for disorders About GeneDecksing

OMIM: 604251

9 Novoseek disease relationships for CABIN1 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
purpura thrombotic thrombocytopenic	44.3	2	18671673 (1), 18398793 (1)
renal disease	42.2	5	15919481 (2), 17112881 (1), 12883183 (1), 18585837 (1)
proteinuria	39.1	3	17900463 (2), 16975081 (1)
cmv infection	37.7	1	18202507 (1)
renal failure	37.2	6	11558493 (2), 17262720 (2), 19923086 (1), 15780099 (1)
hypertension arterial	0.113	1	17333201 (1)
atherosclerosis	0	1	18202507 (1)
histopathology	0	1	16932468 (1)
edema	0	1	17199798 (1)

About this table

Human Gene Mutation Database (HGMD): CABIN1
Genetic Association Database (GAD): CABIN1
Human Genome Epidemiology (HuGE) Navigator: CABIN1 (6 documents)

Export disorders and mutations for CABIN1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/120 PubMed articles for CABIN1 gene, integrated from 7 sources (see all 120):
(articles sorted by number of sources associating them with CABIN1)

Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. (PubMed id 9655484)^{1, 2, 3} Sun L.... Liu J.O. (1998)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2, 3} Nagase T.... Ohara O. (1997)
Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. (PubMed id 12700764)^{1, 2, 7} Han A.... Chen L. (2003)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. (PubMed id 14718166)^{1, 2} Tagami H.... Nakatani Y. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. (PubMed id 15902271)^{1, 7} Pan F....Liu J.O. (2005)
Cabin1 restrains p53 activity on chromatin. (PubMed id 19668210)^{1, 7} Jang H....Youn H.D. (2009)
Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1. (PubMed id 17172641)^{1, 7} Jang H....Youn H.D. (2007)
The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT. (PubMed id 15671033)^{1, 7} Rodriguez A....Redondo J.M. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23523	HGNC: 24187	AceView: CABIN1	Ensembl:ENSG00000099991	euGenes: HUgn23523
ECgene: CABIN1	H-InvDB: CABIN1

(According to HUGE)
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HUGE: KIAA0330

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for CABIN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for CABIN1 gene:
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