Aliases &
Descriptions
for CAMK1D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| calcium/calmodulin-dependent protein kinase ID1 2 | | CaM kinase ID2 3 | | CKLiK1 2 3 | | CaMKID2 | | CaMKI delta2 3 | | CaM-K12 | | CaMKI-like protein kinase2 3 | | calcium/calmodulin-dependent protein kinase type 1D2 | | CaM kinase I delta2 3 | | EC 2.7.11.173 | | CaM-KI delta2 3 | | |
Export aliases for CAMK1D gene to outside databasesPrevious GC identifer: GC10P012431 |
Summaries
for CAMK1D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CAMK1D:
This gene encodes a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of serine/threonine kinases. Theencoded protein may be involved in the regulation of granulocyte function through the chemokine signal transductionpathway. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.(provided by RefSeq)
UniProtKB/Swiss-Prot: KCC1D_HUMAN, Q8IU85Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. Mayregulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. Activates MAPkinase MAPK3 (By similarity). In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1
|
Genomic Views
for CAMK1D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CAMK1D gene promoter:
Chx10 RORalpha2 c-Rel Pax-2 COUP-TF1 HNF-4alpha2 PPAR-gamma1 PPAR-gamma2 Arnt AhR
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAMK1D
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CAMK1D  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13CAMK1D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P012395: view genomic region
(about GC identifiers)
Start:
|
12,307,786 bp from pter |
End:
|
12,877,545 bp from pter |
Size:
|
569,760 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.10 NT_008705.16
|
Proteins
for CAMK1D gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: KCC1D_HUMAN, Q8IU85 (See
protein sequence)Recommended Name: Calcium/calmodulin-dependent protein kinase type 1D Size: 385 amino acids; 42914 Da
Subcellular location: Cytoplasm (Probable). Nucleus (Probable). Note=Predominantly cytoplasmic (Probable). Also nuclearupon activation (Probable)
PDB structures from  and Proteopedia  :2JC6 (3D)
Secondary accessions: B0YIY0 Q9HD31Alternative splicing: 2 isoforms: Q8IU85-1 Q8IU85-2 Explore the universe of human proteins at neXtProt for CAMK1D: NX_Q8IU85
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_065130.1 NP_705718.1
ENSEMBL proteins: ENSP00000368122 ENSP00000368124
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CAMK1D for ontologies About GeneDecksing
Antibodies for CAMK1D:
Assays for CAMK1D: |
Protein
Domains/
Families
for CAMK1D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAMK1D for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q8IU85ProtoNet protein and cluster: Q8IU85 UniProtKB/Swiss-Prot: KCC1D_HUMAN, Q8IU85Domain: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive foldedstate with the catalytic domain as a pseudosubstrate (By similarity)Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamilySimilarity: Contains 1 protein kinase domain |
Gene Function
for CAMK1D gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: KCC1D_HUMAN, Q8IU85Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. Mayregulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. Activates MAPkinase MAPK3 (By similarity). In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin is thought to result in a conformationalchange and can lead to subsequent activation through phosphorylation by CAMKK1 and CAMKK2. At least in part, can alsobe activated by CAMKK1 in a calcium-independent mannerInduction: Expression increases upon treatment of EC cells with DMSO and retinoic acidEnzyme Number (IUBMB): EC 2.7.11.17
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
-- | -- | | GO:0004683 | calmodulin-dependent protein kinase activity |
IEA | -- | | GO:0005516 | calmodulin binding |
IEA | -- |
About this table
CAMK1D for ontologies About GeneDecksing
|
Pathways & Interactions
for CAMK1D gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CAMK1D for pathways About GeneDecksing
5/9  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for CAMK1D (see all 9)
SABiosciences Custom Pathway-Focused PCR Arrays for CAMK1D
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CAMK1D
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAMK1D
2 Interacting proteins for CAMK1D (ENSP000003681243) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
IEA | -- | | GO:0042981 | regulation of apoptosis |
IEA | -- |
About this table
CAMK1D for ontologies About GeneDecksing
|
Drugs & Compounds
for CAMK1D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CAMK1D for compounds About GeneDecksing
 Browse Tocris compounds for CAMK1D
1  Novoseek chemical compound relationship for CAMK1D gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ionomycin |
58.3 |
1 |
12935886 (1) |
About this table
|
Transcripts
for CAMK1D gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CAMK1D gene (2 alternative transcripts): NM_020397.2 NM_153498.2 Additional cDNA sequence: AB081726.1 AF286366.1 AK289393.1 BC035745.1 CR616818.1 5 DOTS entries: DT.91893789 DT.75154235 DT.121247871 DT.95156581 DT.100650925 24/54 AceView cDNA sequences (see all 54): CR616818 BU542765 AA366780 BM919261 W39588 AI923704 W44938 BQ059621 BF447614 AW248435 BM714694 CF136419 BI463145 AL708492 BC035745 AF286366 AL560091 BX108255 AA835485 AA480174 CB268236 AW005054 CA431549 AW501047
 highest scoring ESTs for CAMK1D:AW005054 AA366780 AA480174 AA515024 AA835485 AI306553 AI582866 AI821714 AI887873 BE503756 Unigene Cluster for CAMK1D: Calcium/calmodulin-dependent protein kinase ID Hs.659517 [show with all ESTs]Unigene Representative Sequence: NM_153498
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000487696 ENST00000378845(uc001iln.2) ENST00000378847(uc001ilo.2 uc001ilp.3)
|
Expression
for CAMK1D gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CAMK1D expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching CAMK1D gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 51085_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AW005054 |
1.00 |
1.00 |
1.00 |
1 |
| 235626_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AA835485 |
0.80 |
1.00 |
0.91 |
1 |
| 220246_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_020397 |
0.60 |
1.00 |
0.82 |
1 |
| 235626_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 220246_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CAMK1D for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTGCCCCTTC
SOURCE GeneReport for Unigene cluster: Hs.659517
UniProtKB/Swiss-Prot: KCC1D_HUMAN, Q8IU85Tissue specificity: Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic andeosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes
SABiosciences Custom PCR Arrays for CAMK1D
|
Orthologs
for CAMK1D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CAMK1D gene from 5/13 species (see all 13)
About this table Species with no ortholog for CAMK1D
ENSEMBL Gene Tree for CAMK1D (if available) |
Paralogs
for CAMK1D gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CAMK1D gene
- CAMK1G2 PNCK2 CAMKV2 CAMK12
CAMK1D for paralogs About GeneDecksing
|
Genomic Variants
for CAMK1D gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 10 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CAMK1D (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 25 variations for CAMK1D
15/21 CNVs (see all 21): 65591 75116 85114 43787 5577 85111 43470 85112 23378 75115 70923 85113 75117 75118 100868
4 Indels: 24358 42528 44678 100867 | | QIAGEN SeqTarget long-range PCR primers for resequencing CAMK1D |
|
Disorders & Mutations
for CAMK1D gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CAMK1D for disorders About GeneDecksing
OMIM: 607957
Human Genome Epidemiology (HuGE) Navigator: CAMK1D (25 documents)
Export disorders and mutations for CAMK1D gene to outside databases
|
Medical News
for CAMK1D gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CAMK1D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/37 PubMed articles for CAMK1D gene, integrated from 7 sources (see all 37):
(articles sorted by number of sources associating them with CAMK1D)- Identification and characterization of CKLiK, a novel granulocyte Ca++/calmodulin-dependent protein kinase. (PubMed id 11050006)1, 2, 3, 7 Verploegen S.... Coffer P.J. (2000)
- Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PubMed id 12935886)1, 2, 7 Ishikawa Y....Kobayashi R. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. (PubMed id 15840691)1, 7 Verploegen S....Coffer P.J. (2005)
- CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer. (PubMed id 19383354)1, 7 Bergamaschi A....Pollack J.R. (2008)
- Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1 Fontaine-Bisson B....Franks P.W. (2010)
- Gene variants in the novel type 2 diabetes loci CDC12 3/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancre atic beta-cell function. (PubMed id 19833888)1 Simonis-Bik A.M....'t Hart L.M. (2010)
- Impact of single nucleotide polymorphisms and of clin ical risk factors on newa89onset diabetes mellitus in HIVa89infected individuals. (PubMed id 20879858)1 Rotger M....Tarr P.E. (2010 Nov 1)
- Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. (PubMed id 20161779)1 Wen J....Hu R. (2010)
|
External Searches for CAMK1D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CAMK1D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CAMK1D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CAMK1D gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CAMK1D gene:
Search GeneIP for patents involving CAMK1D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAMK1D gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 | Antibodies & Assays for CAMK1D (CamK1-delta) |
| | | | Search Tocris compounds for CAMK1D |
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