Aliases &
Descriptions
for CASP14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| caspase 14, apoptosis-related cysteine peptidase1 2 | | MICE1 | | MGC1190781 2 | | caspase-142 | | MGC1190791 2 | | apoptosis-related cysteine protease2 | | caspase 14, apoptosis-related cysteine protease1 2 | | EC 3.4.22.-3 | | CASP-142 3 | | |
Export aliases for CASP14 gene to outside databasesPrevious GC identifers: GC19P015542 GC19P015008 GC19P015024 GC19P015160 |
Summaries
for CASP14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CASP14:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspasesplays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergoproteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to formthe active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, andby anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of thiscaspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skinbarrier. (provided by RefSeq)
UniProtKB/Swiss-Prot: CASPE_HUMAN, P31944Function: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a rolein keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolyticallyprocessing filaggrin (By similarity)
 summary
for CASP14: Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of
apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and
effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,
upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector
caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the
executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase
Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors
such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For
example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form
part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by
inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of
many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory
disease.
Gene Wiki entry for CASP14 |
Genomic Views
for CASP14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CASP14 gene promoter:
NF-kappaB1 NF-kappaB GATA-1 C/EBPbeta POU2F1 FOXO1a FOXF2 C/EBPalpha FOXO4 Nkx3-1 v4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CASP14
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.1CASP14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P014730: view genomic region
(about GC identifiers)
Start:
|
14,730,590 bp from pter |
End:
|
14,734,478 bp from pter |
Size:
|
3,889 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19+ 15,160,195-15,169,104 |
RefSeq DNA sequence:- NC_000019.9 NT_011295.11
|
Proteins
for CASP14 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CASPE_HUMAN, P31944 (See
protein sequence)Recommended Name: Caspase-14 precursor Size: 242 amino acids; 27680 Da
Subunit: Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: O95823 Q3SYC9Explore the universe of human proteins at neXtProt for CASP14: NX_P31944
REFSEQ proteins: NP_036246.1
ENSEMBL proteins: ENSP00000221740 ENSP00000393417
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CASP14 for ontologies About GeneDecksing
Antibodies for CASP14:
Assays for CASP14: |
Protein
Domains/
Families
for CASP14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CASP14 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P31944ProtoNet protein and cluster: P31944 1 Blocks protein family: IPB002398 Interleukin-1B converting enzyme signature
UniProtKB/Swiss-Prot: CASPE_HUMAN, P31944Similarity: Belongs to the peptidase C14A family |
Gene Function
for CASP14 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CASPE_HUMAN, P31944Function: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a rolein keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolyticallyprocessing filaggrin (By similarity)Induction: In undifferentiated keratinocytes under postconfluency growth conditions (in vitro)Enzyme Number (IUBMB): EC 3.4.22.-
Genatlas biochemistry entry for CASP14:caspase 14,cysteine containing aspartate-specific protease,stored in the mitochondrial intermembrane space and releasedinto cytosol after appropriate apoptotic stimuli,promoting apoptosis,homolog to murine CASP14 expressed in embryo andin adult skin3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004197 | cysteine-type endopeptidase activity |
IEA | -- | | GO:0008233 | peptidase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
-- | -- |
About this table
CASP14 for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Casp14):
CASP14 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CASP14 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CASP14 for pathways About GeneDecksing
4  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for CASP14
SABiosciences Pathway-Focused PCR Arrays including CASP14: PAHS-012A PAHS-3012A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CASP14
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CASP14
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
CASP14 for ontologies About GeneDecksing
|
Drugs & Compounds
for CASP14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CASP14 for compounds About GeneDecksing
Compounds for CASP14 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Ac-DEVD-AFC | Fluorogenic caspase substrate | [201608-14-2] | | Ac-LEHD-AFC | Fluorogenic caspase substrate | [210345-03-2] | | Z-VAD-FMK | Cell-permeable, irreversible caspase inhibitor | -- |
About this table
6  Novoseek chemical compound relationships for CASP14 gene
About this table
|
Transcripts
for CASP14 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CASP14 gene: NM_012114.2 Additional cDNA sequence: AF097874.1 AK313992.1 BC069541.1 BC103868.1 BC103869.1 EU262664.1 EU502748.1 6 DOTS entries: DT.91716894 DT.91756482 DT.91716891 DT.121486669 DT.121470661 DT.91730497 16 AceView cDNA sequences: NM_012114 AF097874 BC069541 BF739066 BF843203 BF380910 BF093917 BE940739 BF914944 AW796525 BF737240 BE939716 AW796661 BF916315 BQ300908 BF380585
 highest scoring ESTs for CASP14:AF097874 AW796525 BC069541 BF093917 BF380585 BF739066 BF843203 BF914944 BE939716 BE940739 Unigene Cluster for CASP14: Caspase 14, apoptosis-related cysteine peptidase Hs.466057 [show with all ESTs]Unigene Representative Sequence: EU502748
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000221740 ENST00000427043(uc010dzv.1 uc002naf.2)
|
Expression
for CASP14 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CASP14 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching CASP14 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 231722_at2, 3
|
U133-B |
1 |
0.55 |
1.00 |
-- |
-- |
NM_012114 |
0.60 |
1.00 |
0.82 |
1 |
| 231722_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AATTCACTCT
SOURCE GeneReport for Unigene cluster: Hs.466057
UniProtKB/Swiss-Prot: CASPE_HUMAN, P31944Tissue specificity: Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratumgranulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (atprotein level). In psoriatic skin only expressed at very low levels
SABiosciences Expression via Pathway-Focused PCR Arrays including CASP14: PAHS-012A PAHS-3012A
|
Orthologs
for CASP14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CASP14 gene from 4 species
About this table Species with no ortholog for CASP14
ENSEMBL Gene Tree for CASP14 (if available) |
Paralogs
for CASP14 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CASP14 gene
- CASP22 CARD172 CASP14L2 LOC6437332 CASP52 CASP122 CASP92 CASP42
CASP14 for paralogs About GeneDecksing
|
Genomic Variants
for CASP14 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CASP14 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CASP14
5 CNVs: 89128 4068 78111 89125 89126 | | QIAGEN SeqTarget long-range PCR primers for resequencing CASP14 |
|
Disorders & Mutations
for CASP14 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CASP14 for disorders About GeneDecksing
OMIM: 605848
7 Novoseek disease relationships for CASP14 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| psoriasis |
14 |
3 |
15619438 (1), 15556625 (1) |
| carcinoma squamous cell |
7.65 |
4 |
15537824 (1), 16061209 (1), 17366476 (1) |
| breast cancer |
0.0455 |
1 |
16061209 (1) |
| necrosis |
0 |
1 |
16907856 (1) |
| inflammation |
0 |
2 |
17558860 (1), 16061862 (1) |
| tumors |
0 |
10 |
16061862 (2), 19846913 (2), 15537824 (1), 16061209 (1) |
| cancer |
0 |
14 |
17558860 (2), 16061862 (2), 19846913 (1), 17436577 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: CASP14 (7 documents)
Export disorders and mutations for CASP14 gene to outside databases
|
Medical News
for CASP14 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CASP14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/67 PubMed articles for CASP14 gene, integrated from 7 sources (see all 67):
(articles sorted by number of sources associating them with CASP14)- Expression and transcriptional regulation of caspase-14 in simple and complex epithelia. (PubMed id 12181750)1, 2, 7 Pistritto G.... Alnemri E.S. (2002)
- Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation. (PubMed id 12200134)1, 2, 7 Chien A.J.... Kuechle M.K. (2002)
- Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing. (PubMed id 11175259)1, 2, 7 Lippens S.... Declercq W. (2000)
- Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation. (PubMed id 11062009)1, 2, 7 Eckhart L.... Tschachler E. (2000)
- Identification of a new caspase homologue: caspase-14. (PubMed id 10203698)1, 3, 7 Van de Craen M....Vandenabeele P. (1998)
- Caspase-14 is a novel developmentally regulated protease. (PubMed id 9792675)1, 3, 7 Hu S....Dixit V.M. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
- Tumor-associated alterations in caspase-14 expression in epithelial malignancies. (PubMed id 16061862)1, 7 Krajewska M....Krajewski S. (2005)
- Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures. (PubMed id 15331408)1, 7 Lippens S....Declercq W. (2004)
|
External Searches for CASP14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CASP14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CASP14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CASP14 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CASP14 gene:
Search GeneIP for patents involving CASP14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CASP14 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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