Aliases &
Descriptions
for CBX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| chromobox homolog 11 2 | | chromobox homolog 1 (Drosophila HP1 beta)1 | | M311 2 3 | | OTTHUMP000001973162 | | CBX1 2 3 | | chromobox protein homolog 12 | | HP1Hs-beta1 2 | | heterochromatin protein 1-beta2 | | HP1-BETA1 2 | | HP1 beta homolog2 | | MOD11 2 | | chromobox homolog 1 (HP1 beta homolog Drosophila )2 | | Heterochromatin protein 1 homolog beta2 3 | | heterochromatin protein p25 beta2 | | Modifier 1 protein2 3 | | OTTHUMP000001973152 | | p25beta2 3 | | Heterochromatin protein p253 | | HP1Hsbeta2 3 | | HP1 beta3 |
Export aliases for CBX1 gene to outside databasesPrevious GC identifers: GC17M045852 GC17M048627 GC17M046489 GC17M046622 GC17M043502 GC17M046147 |
Summaries
for CBX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CBX1:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . Theprotein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminalchromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain(CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistoneproteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression.Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encodingthe same protein, have been identified. (provided by RefSeq)
UniProtKB/Swiss-Prot: CBX1_HUMAN, P83916Function: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading toepigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of theheterochromatin with the inner nuclear membrane
Gene Wiki entry for CBX1 |
Genomic Views
for CBX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CBX1 gene promoter:
NF-kappaB NF-kappaB1 Egr-3 Egr-2 c-Myb Egr-1 CUTL1 SREBP-1c SREBP-1a SREBP-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for CBX1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CBX1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32CBX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M041515: view genomic region
(about GC identifiers)
Start:
|
41,515,771 bp from pter |
End:
|
41,548,743 bp from pter |
Size:
|
32,973 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 46,147,414-46,178,883 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for CBX1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CBX1_HUMAN, P83916 (See
protein sequence)Recommended Name: Chromobox protein homolog 1 Size: 185 amino acids; 21418 Da
Subunit: Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via thechromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts withSUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6. Interacts with POGZ
Subcellular location: Nucleus. Note=Unassociated with chromosomes during mitosis
PDB structure from  and Proteopedia  :2FMM (3D)
3F2U (3D)
Secondary accessions: P23197Explore the universe of human proteins at neXtProt for CBX1: NX_P83916
Post-translational modifications:
Not phosphorylated1
Ubiquitinated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001120700.1 NP_006798.1
ENSEMBL proteins: ENSP00000393179 ENSP00000377060 ENSP00000391494 ENSP00000225603 ENSP00000385413
Human Recombinant Proteins
5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10): About this table
CBX1 for ontologies About GeneDecksing
Antibodies for CBX1:
Assays for CBX1: |
Protein
Domains/
Families
for CBX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CBX1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P83916ProtoNet protein and cluster: P83916 1 Blocks protein family: IPB008251 Chromo shadow
UniProtKB/Swiss-Prot: CBX1_HUMAN, P83916Similarity: Contains 2 chromo domains |
Gene Function
for CBX1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CBX1_HUMAN, P83916Function: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading toepigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of theheterochromatin with the inner nuclear membrane
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
CBX1 for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Cbx1):
CBX1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CBX1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CBX1 for pathways About GeneDecksing
1  Millipore Pathway for CBX1
SABiosciences Pathway-Focused PCR Array including CBX1: PAHS-086A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CBX1
5/18 Interacting proteins for CBX1 (P839161, 2 ENSP000002256033) via UniProtKB, MINT, and/or STRING (see all 18)About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006333 | chromatin assembly or disassembly |
IEA | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
-- | -- |
About this table
CBX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CBX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CBX1 for compounds About GeneDecksing
 Browse Tocris compounds for CBX1
1  Novoseek chemical compound relationship for CBX1 gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
13.7 |
1 |
17038565 (1) |
About this table
|
Transcripts
for CBX1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CBX1 gene (2 alternative transcripts): NM_001127228.1 NM_006807.4 Additional cDNA sequence: AK312615.1 BC002609.1 BC021302.2 CR456766.1 CR611707.1 CR617932.1 U35451.1 10 DOTS entries: DT.100792093 DT.119761 DT.100792090 DT.91763852 DT.91763848 DT.100044420 DT.121004469 DT.95218046 DT.121004449 DT.121004466 24/507 AceView cDNA sequences (see all 507): CR617932 AA136464 BE772751 C00060 N73001 AA814435 AI199442 BE731753 BM126009 BE223025 AI081602 AA832516 BG249202 AA513283 CB157802 BU737173 AI193109 BM126279 NM_006807 AA112180 BU686692 BU950954 AW273464 BM726192
 highest scoring ESTs for CBX1:U35451 AI816499 AL046741 AL558607 AU076653 AU099430 AU127845 AU134517 BC002609 BC021302 Unigene Cluster for CBX1: Chromobox homolog 1 Hs.77254 [show with all ESTs]Unigene Representative Sequence: NM_006807
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CBX1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CBX1
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000444685 ENST00000393408(uc002ind.3) ENST00000442683 ENST00000495350
ENST00000225603(uc002ine.3) ENST00000402583
|
Expression
for CBX1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CBX1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching CBX1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37304_at2, 3
|
U95-A |
1 |
0.62 |
1.00 |
1.00 |
1.00 |
U35451 |
1.00 |
0.90 |
0.95 |
1 |
| 201518_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
NM_006807 |
0.60 |
1.00 |
0.82 |
1 |
| 201518_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CBX1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGTTAGATTT
SOURCE GeneReport for Unigene cluster: Hs.77254
Expression variation in blood from EXPOLDB for CBX1 UniProtKB/Swiss-Prot: CBX1_HUMAN, P83916Tissue specificity: Expressed in all adult and embryonic tissues
SABiosciences Expression via Pathway-Focused PCR Array including CBX1: PAHS-086A
|
Orthologs
for CBX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CBX1 gene from 5/12 species (see all 12)
About this table Species with no ortholog for CBX1
ENSEMBL Gene Tree for CBX1 (if available) |
Paralogs
for CBX1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CBX1 gene
- MPHOSPH82 CBX32 MIR31982
CBX1 for paralogs About GeneDecksing
|
Genomic Variants
for CBX1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CBX1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CBX1
3 CNVs: 77651 88517 102471
2 Indels: 88518 77652 | | QIAGEN SeqTarget long-range PCR primers for resequencing CBX1 |
|
Disorders & Mutations
for CBX1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CBX1 for disorders About GeneDecksing
OMIM: 604511
1 PharmGKB disease relationship for CBX1 geneAbout this table
Export disorders and mutations for CBX1 gene to outside databases
|
Medical News
for CBX1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CBX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/83 PubMed articles for CBX1 gene, integrated from 7 sources (see all 83):
(articles sorted by number of sources associating them with CBX1)- Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis. (PubMed id 9169582)1, 2, 3, 7 Furuta K....Tan E.M. (1997)
- Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. (PubMed id 15947784)1, 2, 7 Ekblad C.M.S.... Itzhaki L.S. (2005)
- Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PubMed id 10460410)1, 2, 7 Minc E.... Buendia B. (1999)
- In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. (PubMed id 15899859)1, 2, 7 Verschure P.J.... van Driel R. (2005)
- Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PubMed id 20498703)1, 2 Chaturvedi P. and Parnaik V.K. (2010)
- Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding. (PubMed id 16615912)1, 2 Huang Y.... Xu R.-M. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. (PubMed id 14651845)1, 2 Hughes-Davies L.... Kouzarides T. (2003)
- Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. (PubMed id 10202156)1, 2 Aagaard L....Jenuwein T. (1999)
|
External Searches for CBX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CBX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CBX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CBX1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Heterochromatin_Protein_1 |
|
| | |
About This Section
| Patent Information for CBX1 gene:
Search GeneIP for patents involving CBX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CBX1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |
| | | |
 |
 |
| | |
 |  |  |  | |
 | Antibodies & Assays for CBX1
(HP1 beta) |
| | | | Search Tocris compounds for CBX1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for CBX1 |
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