Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



CCKBR Gene

protein-coding   GIFtS: 68

GC11P005940
cholecystokinin B receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
cholecystokinin B receptor1 2     CCK2R2
Cholecystokinin-2 receptor2 3     gastrin receptor2
CCK-BR2 3     gastrin/cholecystokinin type B receptor2
CCK-B receptor2 3     cholecystokinin-B receptor/gastrin receptor2
CCK2-R2 3     CCK2 receptor2
GASR2 5     CCKRB3
CCK-B2     

External Ids:    HGNC: 15711   Entrez Gene: 8872   Ensembl: ENSG000001101487   UniProtKB: P322393   

Export aliases for CCKBR gene to outside databases

Previous GC identifers: GC11P007024 GC11P006741 GC11P006240 GC11P006245 GC11P006237


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCKBR:
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain
and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and
nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A
misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.
(provided by RefSeq)

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239
Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system
where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by
association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent
mechanism

summary for CCKBR:
The cholecystokinin2 receptor (CCK1 receptor, CCK-B receptor) is a member of the cholecystokinin receptor
group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain,
spinal cord and stomach where they play a role in anxiety, nociception, neuroleptic activity, gastric acid
release, gastric mucosal cell growth and histamine release. The human CCK2 receptor gene has been localized
to chromosome 11 (11p15.4).

Gene Wiki entry for CCKBR (Cholecystokinin B receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCKBR gene promoter:
         NF-kappaB1   Egr-1   GR-alpha   GR-beta   NF-kappaB   STAT3   GATA-1   Pax-2   PPAR-gamma2   PPAR-gamma1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CCKBR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

CCKBR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCKBR gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P005940:  view genomic region     (about GC identifiers)

Start:
5,940,913 bp from pter
End:
5,953,261 bp from pter
Size:
12,349 bases
Orientation:
plus strand

1 alternative location:
Chr11+ 6,280,966-6,293,357     
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239 (See protein sequence)
Recommended Name: Gastrin/cholecystokinin type B receptor  
Size: 447 amino acids; 48419 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structures from and Proteopedia :
1L4T (3D)    
Secondary accessions: A8K7P9 O75824 Q16144 Q92492 Q96LC6 Q9NYK7 Q9UBV1
Alternative splicing: 3 isoforms:  P32239-1   P32239-2   P32239-3   

Explore the universe of human proteins at neXtProt for CCKBR: NX_P32239 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_795344.1  

    ENSEMBL proteins: 
    ENSP00000335544 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant CCKBR Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for CCKBR 
    Novus Biologicals Proteins for CCKBR
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction IEA--
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005886 plasma membrane TAS--
    GO:0005887 integral to plasma membrane IC10913157
    About this table

    CCKBR for ontologies           About GeneDecksing



    Antibodies for CCKBR: 
    Millipore Mono- and Polyclonal Antibodies for the study of CCKBR
    Sigma-Aldrich Antibodies for CCKBR
    Browse R&D Systems for Antibodies
    OriGene Antibodies: CCKBR
    GenScript Custom Superior Antibodies Services for CCKBR 
    Novus Biologicals Antibodies for CCKBR
    Epitomics antibodies for CCKBR

    Assays for CCKBR: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript CCKBR-overexpressing Cell Line for Assay 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCKBR 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CCKBR for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000314 Gastrin_rcpt
     IPR017452 GPCR_Rhodpsn_supfam
     IPR009126 Cholcskin_rcpt
     IPR000276 7TM_GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32239

    ProtoNet protein and cluster: P32239

    1 Blocks protein family: IPB000314 Gastrin receptor signature

    UniProtKB/Swiss-Prot: GASR_HUMAN, P32239
    Similarity: Belongs to the G-protein coupled receptor 1 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: GASR_HUMAN, P32239
    Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system
    where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by
    association with G proteins that activate a phosphatidylinositol-calcium second messenger system
    Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent
    mechanism

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CCKBR
    Sigma-Aldrich shRNA Panels and shRNA for CCKBR
    OriGene 29mer shRNA kits in GFP-retroviral vector: CCKBR
    OriGene shRNA RFP: CCKBR
    OriGene basic RS shRNA: CCKBR
    OriGene siRNA: CCKBR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCKBR 
    miRNA:Sigma-Aldrich microRNA Mimics for CCKBR
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCKBR 
    5 SABiosciences Assays for microRNAs that regulate CCKBR:
    hsa-miR-152 hsa-miR-1294 hsa-miR-148b hsa-miR-512-3p hsa-miR-148a

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Millipore Clones for the Expression of CCKBR
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CCKBR
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CCKBR
    OriGene untagged cDNA clones in CMV expression vector: CCKBR
    OriGene 3'-UTR clone: CCKBR 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: CCKBR 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript CCKBR-overexpressing Cell Line for Assay 

    Genatlas biochemistry entry for CCKBR:
    cholecystokinin B/gastrin receptor, G protein coupled receptor superfamily,stimulating the phosphatidylinositol
    cycle,expressed in brain,pancreas and stomach

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435 phosphoinositide phospholipase C activity TAS7681836
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity IEA--
    GO:0004951 cholecystokinin receptor activity TAS7681836
    GO:0005515 protein binding IPI17474147
    About this table

    CCKBR for ontologies           About GeneDecksing

    Animal Models: 11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cckbr):

    behavior/neurologicalcardiovascular systemdigestive/alimentaryendocrine/exocrine glandgrowth/size
    homeostasis/metabolismimmune systemliver/biliary systemnervous systemrenal/urinary system
    touch/vibrissae

    CCKBR for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CCKBR for pathways           About GeneDecksing

    1 Millipore Pathway for CCKBR
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  CCKBR
        Cholecystokinin/Gastrin-mediated Signaling

    3 Kegg Pathways  (Kegg details for CCKBR):
        hsa04020 Calcium signaling pathway
    hsa04080 Neuroactive ligand-receptor interaction
    hsa04971 Gastric acid secretion

        SABiosciences Pathway-Focused PCR Arrays including CCKBR: PAHS-060A PAHS-3009A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CCKBR
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCKBR

    5/15 Interacting proteins for CCKBR (ENSP000003355443 P322391, 2) via UniProtKB, MINT, and/or STRING (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2EBI-1753137,EBI-375543 MINT-7244458
    FYNP062411, 2EBI-1753137,EBI-515315 MINT-7247506
    NCK1P163331, 2EBI-1753137,EBI-389883 MINT-7248742
    GRB2P629931EBI-1753137,EBI-401755
    PTPN11Q061242MINT-3381410 MINT-3381756 MINT-3381499 MINT-3381872 MINT-8037752
    About this table

    5/19 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 19):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001821 histamine secretion IEA--
    GO:0002209 behavioral defense response IEA--
    GO:0006915 apoptosis IEA--
    GO:0007166 cell surface receptor linked signaling pathway NAS10913157
    GO:0007186 G-protein coupled receptor protein signaling pathway ----
    About this table

    CCKBR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CCKBR for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for CCKBR:
    Small Molecule - Antagonist
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CCKBR available from Tocris Bioscience
    CompoundAction CAS number
    L-365,260 Selective CCK2 antagonist[118101-09-0]
    YM 022 Highly potent, selective non-peptide CCK2 antagonist [145084-28-2]
    CI 988Potent and selective CCK2 antagonist[130332-27-3]
    LY 225910Potent CCK2 antagonist[133040-77-4]
    PD 135158Potent and selective CCK2 antagonist[130325-35-8]
    About this table


    10/78 Novoseek chemical compound relationships for CCKBR gene (see all 78)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrin 17 92.6 8 15128280 (2), 16143134 (2), 11551823 (1), 10477091 (1)
    ym022 90.3 16 8886928 (3), 9296353 (2), 9792209 (2), 8698625 (2) (see all 9)
    minigastrin 90.3 5 12658727 (1), 11965605 (1), 16204724 (1), 11713969 (1)
    gv 150013 88 1 17208221 (1)
    l365260 87.6 11 9834332 (2), 18310296 (1), 8208791 (1), 8663021 (1) (see all 9)
    pro-gastrin 86.6 15 19652364 (5), 10931047 (3), 10190738 (2), 12353842 (1) (see all 6)
    pd 134308 85.5 6 1628146 (1), 9489608 (1), 1881533 (1), 8914862 (1) (see all 5)
    benzotript 85.3 1 11408175 (1)
    devazepide 84.5 10 1893248 (1), 1611514 (1), 9885794 (1), 8216742 (1) (see all 9)
    pd 135158 82.7 2 7890609 (1), 1679211 (1)
    About this table

    1 PharmGKB drug compound relationship for CCKBR gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    xenobioticsFA  GN  11773861
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CCKBR
    Sigma-Aldrich shRNA Panels and shRNA for CCKBR
    OriGene 29mer shRNA kits in GFP-retroviral vector: CCKBR
    OriGene shRNA RFP: CCKBR
    OriGene basic RS shRNA: CCKBR
    OriGene siRNA: CCKBR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCKBR 
    miRNA: Sigma-Aldrich microRNA Mimics for CCKBR
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCKBR 
    5 SABiosciences Assays for microRNAs that regulate CCKBR:
    hsa-miR-152 hsa-miR-1294 hsa-miR-148b hsa-miR-512-3p hsa-miR-148a
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CCKBR
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CCKBR
    OriGene untagged cDNA clones in CMV expression vector: CCKBR
    OriGene 3'-UTR Clone: CCKBR 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: CCKBR 
    Primers: OriGene genome-wide validated SYBR primer pairs: CCKBR
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CCKBR: PPH02678A

    REFSEQ mRNAs for CCKBR gene: 

    NM_176875.2  

    Additional cDNA sequence: 

    AF239668.1 AF441129.1 AK226020.1 AK292064.1 AK314266.1 AY029770.1 AY322551.1 BC000740.2 
    BT006789.1 D13305.1 DQ335648.1 DQ335649.1 DQ335650.1 DQ335651.1 L04473.1 L07746.1 
    L08112.1 S70057.1 S76072.1 Y13464.1 

    5 DOTS entries:

    DT.110406  DT.91756568  DT.120703403  DT.91756569  DT.95365965 

    24/28 AceView cDNA sequences (see all 28):

    AU125231 Y13464 L08112 BM709271 BF725652 CB155083 AY322551 S76072 
    AY029770 AA626526 AF441129 AF239668 BE279525 BC000740 AI791122 AU132610 
    AI734207 S70057 NM_176875 D13305 BT006789 AI655414 BI554078 CD013884 

    highest scoring ESTs for CCKBR:

    D13305 AA626526 AF239668 AF441129 AI655414 AI734207 AI791122 AU125231 AY029770 AY322551 

    Unigene Cluster for CCKBR:

    Cholecystokinin B receptor
    Hs.203  [show with all ESTs]
    Unigene Representative Sequence: AF239668


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCKBR

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                          -                 -                                 
    SP2:                          -     -     -     -                                 
    SP3:                          -                 -                                 
    SP4:                                                                              
    SP5:                          -                                                   

    About this scheme

    ECgene alternative splicing isoforms for CCKBR
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334619(uc001mct.1 uc001mcp.2 uc001mcq.2 uc001mcr.2 uc001mcs.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CCKBR expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching CCKBR gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    2083_at2, 3 U95-A 1 1.00 1.00 0.95 0.73 L10822 0.20 1.00 0.72 1
    35923_at2, 3 U95-A 1 1.00 1.00 0.81 1.29 D13305 1.00 1.00 1.00 1
    210381_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC000740 0.80 1.00 0.91 1
    234475_x_at2 U133-B 1 0.46 1.00 -- -- -- -- -- -- --
    210381_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    234475_x_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    CCKBR for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CCKBR gene expression
    CCKBR gene electronic northern expression
    CCKBR gene sage expression
    About these images

    CGAP SAGE TAG: ACACTGACCT

    SOURCE GeneReport for Unigene cluster: Hs.203

    Expression variation in blood from EXPOLDB for CCKBR

    UniProtKB/Swiss-Prot: GASR_HUMAN, P32239
    Tissue specificity: Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the
    T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell
    line AGS. Expressed at high levels in the small cell lung cancer cell line H510, at lower levels in H345, H69 and
    GLC28, not expressed in GLC19. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at
    low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells,
    but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer
    cell line AGS and the colon cancer cell line LoVo

    Primers: OriGene genome-wide validated SYBR primer pairs: CCKBR
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CCKBR: PPH02678A
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCKBR: PAHS-060A PAHS-3009A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CCKBR gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CCKBR1   -- cholecystokinin B receptor 87.49(n)
    90.77(a)
    485333  NM_001013846.1  NP_001013868.1 
    chimpanzee
    (Pan troglodytes)
    CCKBR1   -- cholecystokinin B receptor 94.03(n)
    92.79(a)
    466414  XM_521813.2  XP_521813.1 
    cow
    (Bos taurus)
    CCKBR1   -- cholecystokinin B receptor 87.99(n)
    92.17(a)
    281665  NM_174262.3  NP_776687.2 
    rat
    (Rattus norvegicus)
    Cckbr1   -- cholecystokinin B receptor 85.62(n)
    90.11(a)
    25706  NM_013165.2  NP_037297.1 
    mouse
    (Mus musculus)
    Cckbr1 , 5 7 (55.86 cM)5
    cholecystokinin B receptor1, 5 85.54(n)1
    89.66(a)1
    124261  NM_007627.31  NP_031653.11 
     AF0193715  AI8401175  (see all 12)
    About this table        Species with no ortholog for CCKBR

    ENSEMBL Gene Tree for CCKBR (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CCKBR gene
    TACR32  GPR832  PROKR22  TACR22  TACR12  PROKR12  CCKAR2  

    CCKBR for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/217 NCBI SNPs in CCKBR are shown (see all 217)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs9068951,2
    C,F,O,A,6280248(-) TTGGGA/GGTGGT 1 -- ng51 tfbs310Minor allele frequency- G:0.37MN NS EA NA WA 1658
    rs10420431,2
    C6281170(+) CTGCTA/CAAGCT 2 L ref1 syn1 ese30--------
    rs10420451,2
    --6292365(+) GCTCCA/TGGGCC 2 P syn1 ref1 ese30--------
    rs10420471,2
    C,F,A,H,6293182(+) CAGTGA/CCCCTT 1 -- ut3114Minor allele frequency- C:0.44EA MN NS NA WA 2046
    rs10420481,2
    C,F,H,6293210(+) ATACCA/GTCAGG 1 -- ut3121Minor allele frequency- G:0.26MN NS EA NA WA 1564
    rs10420491,2
    --6293290(+) GACCGA/TGGCCC 1 -- ut31 ese30--------
    rs11127151,2
    C,6286162(-) tgataT/Ctggct 1 -- int17Minor allele frequency- C:0.17NA WA 132
    rs11127161,2
    C,F,6286156(-) tggctC/Tataaa 1 -- int112Minor allele frequency- T:0.05NS EA NA WA 606
    rs13968601,2
    C,F,A,6283452(-) tttccA/Gcctca 1 -- int112Minor allele frequency- G:0.17MN NS EA NA WA 730
    rs17997211,2
    --6280943(+) ACTGGA/CGGGAC 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for CCKBR (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCKBR: --

    QIAGEN SeqTarget long-range PCR primers for resequencing CCKBR 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCKBR for disorders           About GeneDecksing

    OMIM: 118445

    10/70 Novoseek disease relationships for CCKBR gene (see all 70)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian stromal cancer 89 6 12658727 (1), 11965605 (1), 9102227 (1), 9553173 (1) (see all 5)
    panic attacks 70.2 6 8455720 (1), 15991924 (1), 17546345 (1), 9160564 (1) (see all 6)
    thyroid carcinoma medullary 68.7 23 8782652 (3), 11713969 (3), 16832634 (2), 12658724 (1) (see all 14)
    panic disorder 64.5 31 7786960 (3), 11803530 (3), 11515749 (3), 11244486 (2) (see all 18)
    panic 62.5 10 8985712 (2), 8955527 (1), 8580227 (1), 8879478 (1) (see all 8)
    gastrinoma 56.4 4 18194935 (2), 9071943 (1)
    colon cancer 56.3 45 16998832 (6), 15694043 (4), 15951156 (3), 11059789 (2) (see all 24)
    pancreatic cancer 56.1 34 10931047 (3), 10228846 (2), 11444473 (2), 19131241 (2) (see all 21)
    gastric cancer 52 28 15040018 (4), 17064598 (2), 8844981 (2), 20150185 (1) (see all 19)
    neuroendocrine tumors 51.6 7 12658724 (1), 12658727 (1), 19853977 (1), 11965605 (1) (see all 6)
    About this table

    1 PharmGKB disease relationship for CCKBR gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    diabete metillus FA  GN  11773861
    About this table

    Human Gene Mutation Database (HGMD): CCKBR
    Genetic Association Database (GAD): CCKBR
    Human Genome Epidemiology (HuGE) Navigator: CCKBR (21 documents)

    Export disorders and mutations for CCKBR gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/522 PubMed articles for CCKBR gene, integrated from 7 sources (see all 522):
    (articles sorted by number of sources associating them with CCKBR)
    1. Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization. (PubMed id 1280419)1, 2, 3, 7 Pisegna J.R.... Wank S.A. (1992)
    2. Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder. (PubMed id 11515749)1, 4, 7 Yamada K....Yoshikawa T. (2001)
    3. Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth. (PubMed id 10913157)1, 2, 7 Hellmich M.R....Townsend C.M. Jr. (2000)
    4. A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon. (PubMed id 7887934)1, 2, 7 Miyake A. (1995)
    5. The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. (PubMed id 7681836)1, 2, 7 Lee Y.-M....Kopin A.S. (1993)
    6. Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor. (PubMed id 11926817)1, 2, 7 Giragossian C. and Mierke D.F. (2002)
    7. No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. (PubMed id 11244486)1, 4, 7 Hamilton S.P....Knowles J.A. (2001)
    8. Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. (PubMed id 15313848)1, 4, 7 Goldman J.G....Zhou L. (2004)
    9. Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)1, 4, 7 Okubo T....Matsushita S. (2002)
    10. Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene. (PubMed id 7848914)1, 2, 7 Ito M.... Matsui T. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 887 HGNC: 1571 AceView: CCKBR Ensembl:ENSG00000110148 euGenes: HUgn887
    ECgene: CCKBR Kegg: 887 H-InvDB: CCKBR

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CCKBR Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Cholecystokinin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for CCKBR gene:
    Search GeneIP for patents involving CCKBR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for CCKBR Antibodies for CCKBR
     Super-pooled esiRNAs for CCKBR Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CCKBR microRNA Mimics for CCKBR
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Small molecules for CCKBR
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCKBR
     SeqTarget long-range PCR primers for resequencing CCKBR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCKBR
     GenScript Custom Purified and Recombinant Proteins Services for CCKBR GenScript cDNA clones with any tag delivered in your preferred vector for CCKBR
     GenScript CCKBR-overexpressing Cell Line for Assay GenScript Custom Superior Antibodies Services for CCKBR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CCKBR promoter
     Search Chromatin IP Primers for CCKBR
     RT2 qPCR Primer Assay for CCKBR
     GNC Network for CCKBR
     Assays for microRNAs that regulate CCKBR
     SABiosciences PCR Arrays including CCKBR
     Tocris compounds for CCKBR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for CCKBR
     Proteins for CCKBR
     Antibodies for CCKBR
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for CCKBR
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    CCKBR gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4