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CCKBR Gene

protein-coding GIFtS: 68

GC11P005940

cholecystokinin B receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
cholecystokinin B receptor¹ ²		CCK2R²
Cholecystokinin-2 receptor² ³		gastrin receptor²
CCK-BR² ³		gastrin/cholecystokinin type B receptor²
CCK-B receptor² ³		cholecystokinin-B receptor/gastrin receptor²
CCK2-R² ³		CCK2 receptor²
GASR² ⁵		CCKRB³
CCK-B²

External Ids:	HGNC: 1571¹	Entrez Gene: 887²	Ensembl: ENSG00000110148⁷	UniProtKB: P32239³

Export aliases for CCKBR gene to outside databases

Previous GC identifers: GC11P007024 GC11P006741 GC11P006240 GC11P006245 GC11P006237

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCKBR:

This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain

and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and

nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A

misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.

(provided by RefSeq)

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239

Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system

where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by

association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent

mechanism

summary for CCKBR:

The cholecystokinin2 receptor (CCK1 receptor, CCK-B receptor) is a member of the cholecystokinin receptor

group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain,

spinal cord and stomach where they play a role in anxiety, nociception, neuroleptic activity, gastric acid

release, gastric mucosal cell growth and histamine release. The human CCK2 receptor gene has been localized

to chromosome 11 (11p15.4).

Gene Wiki entry for CCKBR (Cholecystokinin B receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCKBR gene promoter:
         NF-kappaB1   Egr-1   GR-alpha   GR-beta   NF-kappaB   STAT3   GATA-1   Pax-2   PPAR-gamma2   PPAR-gamma1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CCKBR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

CCKBR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCKBR gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P005940: view genomic region (about GC identifiers)

Start:	5,940,913 bp from pter
End:	5,953,261 bp from pter
Size:	12,349 bases
Orientation:	plus strand

1 alternative location:

Chr11+ 6,280,966-6,293,357

RefSeq DNA sequence:

NC_000011.9 NT_009237.18

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239 (See protein sequence)

Recommended Name: Gastrin/cholecystokinin type B receptor

Size: 447 amino acids; 48419 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1L4T (3D)

Secondary accessions: A8K7P9 O75824 Q16144 Q92492 Q96LC6 Q9NYK7 Q9UBV1

Alternative splicing: 3 isoforms: P32239-1 P32239-2 P32239-3

Explore the universe of human proteins at neXtProt for CCKBR: NX_P32239

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_795344.1

ENSEMBL proteins:

ENSP00000335544

Human Recombinant Proteins

	Millipore Purified and/or Recombinant CCKBR Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for CCKBR
	Novus Biologicals Proteins for CCKBR
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IC	10913157

About this table

CCKBR for ontologies About GeneDecksing

Antibodies for CCKBR:

	Millipore Mono- and Polyclonal Antibodies for the study of CCKBR
	Sigma-Aldrich Antibodies for CCKBR
	Browse R&D Systems for Antibodies
	OriGene Antibodies: CCKBR
	GenScript Custom Superior Antibodies Services for CCKBR
	Novus Biologicals Antibodies for CCKBR
	Epitomics antibodies for CCKBR

Assays for CCKBR:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript CCKBR-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCKBR

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCKBR for domains About GeneDecksing

4 InterPro domains/families:

IPR000314 Gastrin_rcpt

IPR017452 GPCR_Rhodpsn_supfam

IPR009126 Cholcskin_rcpt

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P32239

ProtoNet protein and cluster: P32239

1 Blocks protein family: IPB000314 Gastrin receptor signature

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239

Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system

where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by

association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent

mechanism

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CCKBR Sigma-Aldrich shRNA Panels and shRNA for CCKBR
		OriGene 29mer shRNA kits in GFP-retroviral vector: CCKBR OriGene shRNA RFP: CCKBR OriGene basic RS shRNA: CCKBR OriGene siRNA: CCKBR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCKBR

miRNA:		Sigma-Aldrich microRNA Mimics for CCKBR Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCKBR
		5 SABiosciences Assays for microRNAs that regulate CCKBR:
		hsa-miR-152 hsa-miR-1294 hsa-miR-148b hsa-miR-512-3p hsa-miR-148a

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Millipore Clones for the Expression of CCKBR
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: CCKBR OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CCKBR OriGene untagged cDNA clones in CMV expression vector: CCKBR OriGene 3'-UTR clone: CCKBR Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: CCKBR
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript CCKBR-overexpressing Cell Line for Assay

Genatlas biochemistry entry for CCKBR:

cholecystokinin B/gastrin receptor, G protein coupled receptor superfamily,stimulating the phosphatidylinositol

cycle,expressed in brain,pancreas and stomach

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphoinositide phospholipase C activity	TAS	7681836
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004951	cholecystokinin receptor activity	TAS	7681836
GO:0005515	protein binding	IPI	17474147

About this table

CCKBR for ontologies About GeneDecksing

Animal Models: 11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cckbr):

behavior/neurological	cardiovascular system	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	immune system	liver/biliary system	nervous system	renal/urinary system
touch/vibrissae

CCKBR for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

CCKBR for pathways About GeneDecksing

1 Millipore Pathway for CCKBR

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for CCKBR

Cholecystokinin/Gastrin-mediated Signaling

3 Kegg Pathways (Kegg details for CCKBR):

	hsa04020 Calcium signaling pathway
	hsa04080 Neuroactive ligand-receptor interaction
	hsa04971 Gastric acid secretion

SABiosciences Pathway-Focused PCR Arrays including CCKBR: PAHS-060A PAHS-3009A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CCKBR

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCKBR

5/15 Interacting proteins for CCKBR (ENSP00000335544³ P32239^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹^,²	EBI-1753137,EBI-375543 MINT-7244458
FYN	P06241¹^,²	EBI-1753137,EBI-515315 MINT-7247506
NCK1	P16333¹^,²	EBI-1753137,EBI-389883 MINT-7248742
GRB2	P62993¹	EBI-1753137,EBI-401755
PTPN11	Q06124²	MINT-3381410 MINT-3381756 MINT-3381499 MINT-3381872 MINT-8037752

About this table

5/19 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 19):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001821	histamine secretion	IEA	--
GO:0002209	behavioral defense response	IEA	--
GO:0006915	apoptosis	IEA	--
GO:0007166	cell surface receptor linked signaling pathway	NAS	10913157
GO:0007186	G-protein coupled receptor protein signaling pathway	--	--

About this table

CCKBR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

CCKBR for compounds About GeneDecksing

Sigma-Aldrich Small Molecules for CCKBR:

Small Molecule - Antagonist

Browse drugs & compounds from Enzo Life Sciences

Compounds for CCKBR available from Tocris Bioscience

Compound	Action	CAS number
L-365,260	Selective CCK2 antagonist	[118101-09-0]
YM 022	Highly potent, selective non-peptide CCK2 antagonist	[145084-28-2]
CI 988	Potent and selective CCK2 antagonist	[130332-27-3]
LY 225910	Potent CCK2 antagonist	[133040-77-4]
PD 135158	Potent and selective CCK2 antagonist	[130325-35-8]

About this table

10/78 Novoseek chemical compound relationships for CCKBR gene (see all 78)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastrin 17	92.6	8	15128280 (2), 16143134 (2), 11551823 (1), 10477091 (1)
ym022	90.3	16	8886928 (3), 9296353 (2), 9792209 (2), 8698625 (2) (see all 9)
minigastrin	90.3	5	12658727 (1), 11965605 (1), 16204724 (1), 11713969 (1)
gv 150013	88	1	17208221 (1)
l365260	87.6	11	9834332 (2), 18310296 (1), 8208791 (1), 8663021 (1) (see all 9)
pro-gastrin	86.6	15	19652364 (5), 10931047 (3), 10190738 (2), 12353842 (1) (see all 6)
pd 134308	85.5	6	1628146 (1), 9489608 (1), 1881533 (1), 8914862 (1) (see all 5)
benzotript	85.3	1	11408175 (1)
devazepide	84.5	10	1893248 (1), 1611514 (1), 9885794 (1), 8216742 (1) (see all 9)
pd 135158	82.7	2	7890609 (1), 1679211 (1)

About this table

1 PharmGKB drug compound relationship for CCKBR gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
xenobiotics	FA GN	11773861

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CCKBR Sigma-Aldrich shRNA Panels and shRNA for CCKBR
		OriGene 29mer shRNA kits in GFP-retroviral vector: CCKBR OriGene shRNA RFP: CCKBR OriGene basic RS shRNA: CCKBR OriGene siRNA: CCKBR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCKBR

miRNA:		Sigma-Aldrich microRNA Mimics for CCKBR Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCKBR
		5 SABiosciences Assays for microRNAs that regulate CCKBR:
		hsa-miR-152 hsa-miR-1294 hsa-miR-148b hsa-miR-512-3p hsa-miR-148a

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: CCKBR OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CCKBR OriGene untagged cDNA clones in CMV expression vector: CCKBR OriGene 3'-UTR Clone: CCKBR Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: CCKBR

Primers:		OriGene genome-wide validated SYBR primer pairs: CCKBR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CCKBR: PPH02678A

REFSEQ mRNAs for CCKBR gene:

NM_176875.2

Additional cDNA sequence:

AF239668.1 AF441129.1 AK226020.1 AK292064.1 AK314266.1 AY029770.1 AY322551.1 BC000740.2

BT006789.1 D13305.1 DQ335648.1 DQ335649.1 DQ335650.1 DQ335651.1 L04473.1 L07746.1

L08112.1 S70057.1 S76072.1 Y13464.1

5 DOTS entries:

DT.110406 DT.91756568 DT.120703403 DT.91756569 DT.95365965

24/28 AceView cDNA sequences (see all 28):

AU125231 Y13464 L08112 BM709271 BF725652 CB155083 AY322551 S76072

AY029770 AA626526 AF441129 AF239668 BE279525 BC000740 AI791122 AU132610

AI734207 S70057 NM_176875 D13305 BT006789 AI655414 BI554078 CD013884

highest scoring ESTs for CCKBR:

D13305 AA626526 AF239668 AF441129 AI655414 AI734207 AI791122 AU125231 AY029770 AY322551

Unigene Cluster for CCKBR:

Cholecystokinin B receptor

Hs.203 [show with all ESTs]

Unigene Representative Sequence: AF239668

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CCKBR

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c
SP1:									-						-
SP2:									-		-		-		-
SP3:									-						-
SP4:
SP5:									-

About this scheme

ECgene alternative splicing isoforms for CCKBR
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000334619(uc001mct.1 uc001mcp.2 uc001mcq.2 uc001mcr.2 uc001mcs.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CCKBR expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching CCKBR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2083_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.73	L10822	0.20	1.00	0.72	1
35923_at²^{, 3}	U95-A	1	1.00	1.00	0.81	1.29	D13305	1.00	1.00	1.00	1
210381_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000740	0.80	1.00	0.91	1
234475_x_at²	U133-B	1	0.46	1.00	--	--	--	--	--	--	--
210381_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234475_x_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

About this table

CCKBR for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CCKBR gene electronic northern expression

About these images

CGAP SAGE TAG: ACACTGACCT

SOURCE GeneReport for Unigene cluster: Hs.203

Expression variation in blood from EXPOLDB for CCKBR

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239

Tissue specificity: Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the

T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell

line AGS. Expressed at high levels in the small cell lung cancer cell line H510, at lower levels in H345, H69 and

GLC28, not expressed in GLC19. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at

low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells,

but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer

cell line AGS and the colon cancer cell line LoVo

Primers:		OriGene genome-wide validated SYBR primer pairs: CCKBR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CCKBR: PPH02678A

SABiosciences Expression via Pathway-Focused PCR Arrays including CCKBR: PAHS-060A PAHS-3009A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CCKBR gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CCKBR¹	--	cholecystokinin B receptor	87.49(n) 90.77(a)	485333 NM_001013846.1 NP_001013868.1
chimpanzee (Pan troglodytes)	CCKBR¹	--	cholecystokinin B receptor	94.03(n) 92.79(a)	466414 XM_521813.2 XP_521813.1
cow (Bos taurus)	CCKBR¹	--	cholecystokinin B receptor	87.99(n) 92.17(a)	281665 NM_174262.3 NP_776687.2
rat (Rattus norvegicus)	Cckbr¹	--	cholecystokinin B receptor	85.62(n) 90.11(a)	25706 NM_013165.2 NP_037297.1
mouse (Mus musculus)	Cckbr^{1 , 5}	7 (55.86 cM)⁵	cholecystokinin B receptor^{1, 5}	85.54(n)¹ 89.66(a)¹	12426¹ NM_007627.3¹ NP_031653.1¹ AF019371⁵ AI840117⁵ (see all 12)

About this table Species with no ortholog for CCKBR

ENSEMBL Gene Tree for CCKBR (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CCKBR gene

TACR3² GPR83² PROKR2² TACR2² TACR1² PROKR1² CCKAR²

CCKBR for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs906895^1,2	C,F,O,A,	6280248(-)	`TTGGGA/GGTGGT`	1	--	ng5¹ tfbs³		10		MN NS EA NA WA	1658
rs1042043^1,2	C	6281170(+)	`CTGCTA/CAAGCT`	2	L	ref¹ syn¹ ese³		0	--	--	--	--
rs1042045^1,2	--	6292365(+)	`GCTCCA/TGGGCC`	2	P	syn¹ ref¹ ese³		0	--	--	--	--
rs1042047^1,2	C,F,A,H,	6293182(+)	`CAGTGA/CCCCTT`	1	--	ut3¹		14		EA MN NS NA WA	2046
rs1042048^1,2	C,F,H,	6293210(+)	`ATACCA/GTCAGG`	1	--	ut3¹		21		MN NS EA NA WA	1564
rs1042049^1,2	--	6293290(+)	`GACCGA/TGGCCC`	1	--	ut3¹ ese³		0	--	--	--	--
rs1112715^1,2	C,	6286162(-)	`tgataT/Ctggct`	1	--	int¹		7		NA WA	132
rs1112716^1,2	C,F,	6286156(-)	`tggctC/Tataaa`	1	--	int¹		12		NS EA NA WA	606
rs1396860^1,2	C,F,A,	6283452(-)	`tttccA/Gcctca`	1	--	int¹		12		MN NS EA NA WA	730
rs1799721^1,2	--	6280943(+)	`ACTGGA/CGGGAC`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CCKBR (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCKBR: --

QIAGEN SeqTarget long-range PCR primers for resequencing CCKBR

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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CCKBR for disorders About GeneDecksing

OMIM: 118445

10/70 Novoseek disease relationships for CCKBR gene (see all 70)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian stromal cancer	89	6	12658727 (1), 11965605 (1), 9102227 (1), 9553173 (1) (see all 5)
panic attacks	70.2	6	8455720 (1), 15991924 (1), 17546345 (1), 9160564 (1) (see all 6)
thyroid carcinoma medullary	68.7	23	8782652 (3), 11713969 (3), 16832634 (2), 12658724 (1) (see all 14)
panic disorder	64.5	31	7786960 (3), 11803530 (3), 11515749 (3), 11244486 (2) (see all 18)
panic	62.5	10	8985712 (2), 8955527 (1), 8580227 (1), 8879478 (1) (see all 8)
gastrinoma	56.4	4	18194935 (2), 9071943 (1)
colon cancer	56.3	45	16998832 (6), 15694043 (4), 15951156 (3), 11059789 (2) (see all 24)
pancreatic cancer	56.1	34	10931047 (3), 10228846 (2), 11444473 (2), 19131241 (2) (see all 21)
gastric cancer	52	28	15040018 (4), 17064598 (2), 8844981 (2), 20150185 (1) (see all 19)
neuroendocrine tumors	51.6	7	12658724 (1), 12658727 (1), 19853977 (1), 11965605 (1) (see all 6)

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1 PharmGKB disease relationship for CCKBR gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
diabete metillus	FA GN	11773861

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Human Gene Mutation Database (HGMD): CCKBR
Genetic Association Database (GAD): CCKBR
Human Genome Epidemiology (HuGE) Navigator: CCKBR (21 documents)

Export disorders and mutations for CCKBR gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/522 PubMed articles for CCKBR gene, integrated from 7 sources (see all 522):
(articles sorted by number of sources associating them with CCKBR)

Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization. (PubMed id 1280419)^{1, 2, 3, 7} Pisegna J.R.... Wank S.A. (1992)
Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder. (PubMed id 11515749)^{1, 4, 7} Yamada K....Yoshikawa T. (2001)
Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth. (PubMed id 10913157)^{1, 2, 7} Hellmich M.R....Townsend C.M. Jr. (2000)
A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon. (PubMed id 7887934)^{1, 2, 7} Miyake A. (1995)
The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. (PubMed id 7681836)^{1, 2, 7} Lee Y.-M....Kopin A.S. (1993)
Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor. (PubMed id 11926817)^{1, 2, 7} Giragossian C. and Mierke D.F. (2002)
No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. (PubMed id 11244486)^{1, 4, 7} Hamilton S.P....Knowles J.A. (2001)
Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. (PubMed id 15313848)^{1, 4, 7} Goldman J.G....Zhou L. (2004)
Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)^{1, 4, 7} Okubo T....Matsushita S. (2002)
Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene. (PubMed id 7848914)^{1, 2, 7} Ito M.... Matsui T. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 887	HGNC: 1571	AceView: CCKBR	Ensembl:ENSG00000110148	euGenes: HUgn887
ECgene: CCKBR	Kegg: 887	H-InvDB: CCKBR

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CCKBR	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Cholecystokinin_receptor

Intellectual Property for CCKBR gene
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Patent Information for CCKBR gene:
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protein-coding GIFtS: 68

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