Aliases &
Descriptions
for CCL28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| chemokine (C-C motif) ligand 281 2 | | chemokine (C-C motif) ligand 28 splice variant chi2 | | MEC1 2 3 | | C-C motif chemokine 282 | | SCYA281 2 3 | | CC chemokine CCL282 | | CCK11 2 | | OTTHUMP000002216292 | | Small-inducible cytokine A282 3 | | small inducible cytokine A282 | | Mucosae-associated epithelial chemokine2 3 | | MGC719022 | | small inducible cytokine subfamily A (Cys-Cys), member 282 | | Protein CCK13 |
Export aliases for CCL28 gene to outside databasesPrevious GC identifers: GC05M043684 GC05M044553 GC05M043376 GC05M043422 GC05M043229 |
Summaries
for CCL28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCL28:
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved inimmunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines.The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. Theproduct of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology ofextracutaneous epithelial tissues, including diverse mucosal organs. (provided by RefSeq)
UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and inducescalcium mobilization in a dose-dependent manner
|
Genomic Views
for CCL28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCL28 gene promoter:
STAT1alpha STAT1 STAT1beta p53
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCL28
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p12 Ensembl cytogenetic band: 5p12 HGNC cytogenetic band: 5p12CCL28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M043332: view genomic region
(about GC identifiers)
Start:
|
43,332,397 bp from pter |
End:
|
43,363,621 bp from pter |
Size:
|
31,225 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr5- 43,376,747-43,412,493 |
RefSeq DNA sequence:- NC_000005.9 NT_006576.16
|
Proteins
for CCL28 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3 (See
protein sequence)Recommended Name: C-C motif chemokine 28 precursor Size: 127 amino acids; 14280 Da
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for CCL28: NX_Q9NRJ3
REFSEQ proteins: NP_683513.1
ENSEMBL proteins: ENSP00000422369 ENSP00000426424 ENSP00000354416
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
About this table
CCL28 for ontologies About GeneDecksing
Antibodies for CCL28:
Assays for CCL28: |
Protein
Domains/
Families
for CCL28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCL28 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NRJ3ProtoNet protein and cluster: Q9NRJ3 1 Blocks protein family: IPB000827 Small chemokine
UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3Similarity: Belongs to the intercrine beta (chemokine CC) family |
Gene Function
for CCL28 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3Function: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and inducescalcium mobilization in a dose-dependent manner
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
CCL28 for ontologies About GeneDecksing
|
Pathways & Interactions
for CCL28 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CCL28 for pathways About GeneDecksing
3  Kegg Pathways (Kegg details for CCL28):  | hsa04060 Cytokine-cytokine receptor interaction | | hsa04062 Chemokine signaling pathway | | hsa04672 Intestinal immune network for IgA production |
SABiosciences Pathway-Focused PCR Array including CCL28: PAHS-3803A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL28
1 Interacting protein for CCL28 (Q9NRJ32) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
CCL28 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCL28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CCL28 for compounds About GeneDecksing
 Browse Tocris compounds for CCL28
4  Novoseek chemical compound relationships for CCL28 gene
About this table
|
Transcripts
for CCL28 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CCL28 gene: NM_148672.2 Additional cDNA sequence: AF220210.1 AF266504.1 AK307307.1 AK312120.1 BC062668.1 BC069532.1 HM067700.1 5 DOTS entries: DT.100795712 DT.91667792 DT.99983119 DT.40110226 DT.92044042 24/35 AceView cDNA sequences (see all 35): BE463561 NM_019846 AI880389 CB984769 AF266504 CB068281 BQ423222 BF034600 NM_148672 CB068400 CD671712 N63913 BX108072 BG682175 BC062668 BG530240 BX486632 AF110384 AW469978 N98285 AW083576 N20300 CD685600 BG532385
 highest scoring ESTs for CCL28:AF220210 AF266504 BC069532 BE088415 CB984769 AF110384 BC062668 BE004103 BX108072 BX486632 Unigene Cluster for CCL28: Chemokine (C-C motif) ligand 28 Hs.656904 [show with all ESTs]Unigene Representative Sequence: AK307307
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514421 ENST00000513525(uc010ivn.2) ENST00000489442(uc003jns.2 uc003jnt.2)
ENST00000361115(uc003jnu.2)
|
Expression
for CCL28 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CCL28 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching CCL28 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 52449_at2, 3
|
U95-B |
1 |
0.81 |
1.00 |
0.82 |
1.21 |
R70255 |
0.60 |
1.00 |
0.82 |
1 |
| 44210_at2, 3
|
U95-B |
1 |
0.50 |
1.00 |
0.87 |
0.83 |
N63913 |
0.40 |
1.00 |
0.76 |
1 |
| 224240_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AF266504 |
0.80 |
1.00 |
0.91 |
1 |
| 224027_at2, 3
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
AF110384 |
0.60 |
1.00 |
0.82 |
1 |
| 238750_at2, 3
|
U133-B |
1 |
0.64 |
1.00 |
-- |
-- |
AW083576 |
0.20 |
1.00 |
0.72 |
1 |
| 224240_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 224027_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 238750_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CCL28 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TAATCATTAA
SOURCE GeneReport for Unigene cluster: Hs.656904
UniProtKB/Swiss-Prot: CCL28_HUMAN, Q9NRJ3Tissue specificity: Preferentially expressed by epithelial cells of diverse tissues including normal and pathologicalcolon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin andin lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin
SABiosciences Expression via Pathway-Focused PCR Array including CCL28: PAHS-3803A
|
Orthologs
for CCL28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CCL28 gene from 5 species
About this table Species with no ortholog for CCL28
ENSEMBL Gene Tree for CCL28 (if available) |
Paralogs
for CCL28 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CCL28 gene
- CCL272
CCL28 for paralogs About GeneDecksing
|
Genomic Variants
for CCL28 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing CCL28 |
|
Disorders & Mutations
for CCL28 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCL28 for disorders About GeneDecksing
OMIM: 605240
4 Novoseek disease relationships for CCL28 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: CCL28 (5 documents)
Export disorders and mutations for CCL28 gene to outside databases
|
Medical News
for CCL28 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CCL28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/66 PubMed articles for CCL28 gene, integrated from 7 sources (see all 66):
(articles sorted by number of sources associating them with CCL28)- Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). (PubMed id 10781587)1, 2, 3, 7 Wang W.... Zlotnik A. (2000)
- A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PubMed id 10975800)1, 2, 7 Pan J.... Soler D. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a novel beta-chemokine, MEC, down-regulated in primary breast tumors. (PubMed id 11295038)1, 3 Mickanin C.S....Labow M. (2001)
- Serum mucosa-associated epithelial chemokine (MEC/CCL 28) in atopic dermatitis: a specific marker for severity. (PubMed id 19659860)1, 7 Ezzat M.H....Shaheen K.Y. (2009)
- CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. (PubMed id 12538707)1, 7 Hieshima K....Yoshie O. (2003)
- Human IgA-secreting cells induced by intestinal, but not systemic, immunization respond to CCL25 (TECK) and CCL28 (MEC). (PubMed id 19003934)1, 7 Sundstrom P....Quiding-Jarbrink M. (2008)
- IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFkappaB-dependent pathway. (PubMed id 16581045)1, 7 O'Gorman M.T....Mahon B.P. (2005)
- The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection. (PubMed id 17912348)1, 7 Castelletti E....Clerici M. (2007)
- Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. (PubMed id 16785557)1, 7 Eksteen B....Adams D.H. (2006)
|
External Searches for CCL28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCL28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCL28 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCL28 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/CCL28 |
|
| | |
About This Section
| Patent Information for CCL28 gene:
Search GeneIP for patents involving CCL28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCL28 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for CCL28 |
| |  |  |  |  | | | | | | Recombinant Protein for CCL28 |
|
 | | |
|
|
