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CCNK Gene

protein-coding   GIFtS: 55

GC14P080131
cyclin K
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
cyclin K1 2
CPR41 2 3
MGC91132
cyclin-K2

External Ids:    HGNC: 15961   Entrez Gene: 88122   Ensembl: ENSG000000900617   UniProtKB: O759093   

Export aliases for CCNK gene to outside databases

Previous GC identifers: GC14P097459 GC14P093763 GC14P097937 GC14P097949 GC14P099017 GC14P099947


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNK:
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate
transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the
C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in
regulating CDK and RNA polymerase II activities. (provided by RefSeq)

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
Function: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA
polymerase II C-terminal domain and CDK2 (CAK)

Gene Wiki entry for CCNK (Cyclin K)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNK gene promoter:
         STAT3   p53   Cart-1   RREB-1   deltaCREB   CREB   E4BP4   AREB6   HNF-1A   Pax-5   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CCNK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CCNK 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32

CCNK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNK gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P080131:  view genomic region     (about GC identifiers)

Start:
80,131,153 bp from pter
End:
80,161,252 bp from pter
Size:
30,100 bases
Orientation:
plus strand

1 alternative location:
Chr14+ 99,947,739-99,977,851     
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909 (See protein sequence)
Recommended Name: Cyclin-K  
Size: 580 amino acids; 64240 Da
Subunit: Part of a cyclin-kinase pair in the RNA polymerase II holoenzyme. Binds to CDK9
PDB structures from and Proteopedia :
2I53 (3D)    
Secondary accessions: Q59FT6 Q86U16 Q96B63 Q9NNY9
Alternative splicing: 4 isoforms:  O75909-3   O75909-2   O75909-1   O75909-4   

Explore the universe of human proteins at neXtProt for CCNK: NX_O75909 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001092872.1  

    ENSEMBL proteins: 
    ENSP00000369596 ENSP00000216279 ENSP00000395705 ENSP00000374529 ENSP00000398898 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for CCNK 
    Novus Biologicals Protein for CCNK
    Novus Biologicals Lysate for CCNK
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins


    Antibodies for CCNK: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for CCNK
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for CCNK 
    Novus Biologicals Antibodies for CCNK
    Browse antibodies at Epitomics

    Assays for CCNK: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCNK 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCNK 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CCNK for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006670 Cyclin
     IPR011028 Cyclin-like
     IPR013763 Cyclin-related
     IPR006671 Cyclin_N

    Graphical View of Domain Structure for InterPro Entry O75909

    ProtoNet protein and cluster: O75909

    1 Blocks protein family: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
    Function: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA
    polymerase II C-terminal domain and CDK2 (CAK)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CCNK
    Sigma-Aldrich shRNA Panels and shRNA for CCNK
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CCNK
    OriGene shRNA RFP (see all 3): CCNK
    OriGene basic RS shRNA (see all 3): CCNK
    OriGene siRNA (see all 2): CCNK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCNK 
    miRNA:Sigma-Aldrich microRNA Mimics for CCNK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCNK 
    8/16 SABiosciences Assays for microRNAs that regulate CCNK (see all 16):
    hsa-miR-30c hsa-miR-142-5p hsa-miR-181c hsa-miR-30d hsa-miR-30a hsa-miR-1252 hsa-miR-181b hsa-miR-27a

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): CCNK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CCNK
    OriGene untagged cDNA clones in CMV expression vector (see all 3): CCNK
    OriGene 3'-UTR clone: CCNK 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CCNK 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CCNK 

    Genatlas biochemistry entry for CCNK:
    cyclin K,RNA polymerase II associated cyclin,ubiquitously expressed but most abundant in developing germ cells of adult
    testis and ovary,likely involved in the regulation of basal transcription

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI16713569
    About this table

    CCNK for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CCNK for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  CCNK
        p53 Signaling

        SABiosciences Custom Pathway-Focused PCR Arrays for CCNK 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CCNK
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNK

    5/16 Interacting proteins for CCNK (O759091, 2) via UniProtKB, MINT, and/or STRING (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2EBI-739806,EBI-930964 MINT-2865482 MINT-2855089
    CCDC85BQ158342MINT-66150
    CEP76Q8TAP62MINT-67109
    EFEMP2O959672MINT-66717
    FKBP6O753442MINT-66761
    About this table

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079 regulation of cyclin-dependent protein kinase activity TAS9632813
    GO:0006366 transcription from RNA polymerase II promoter TAS9632813
    GO:0007049 cell cycle IEA--
    GO:0007067 mitosis IEA--
    GO:0045449 regulation of transcription IEA--
    About this table

    CCNK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNK


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CCNK
    Sigma-Aldrich shRNA Panels and shRNA for CCNK
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CCNK
    OriGene shRNA RFP (see all 3): CCNK
    OriGene basic RS shRNA (see all 3): CCNK
    OriGene siRNA (see all 2): CCNK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCNK 
    miRNA: Sigma-Aldrich microRNA Mimics for CCNK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCNK 
    8/16 SABiosciences Assays for microRNAs that regulate CCNK (see all 16):
    hsa-miR-30c hsa-miR-142-5p hsa-miR-181c hsa-miR-30d hsa-miR-30a hsa-miR-1252 hsa-miR-181b hsa-miR-27a
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): CCNK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CCNK
    OriGene untagged cDNA clones in CMV expression vector (see all 3): CCNK
    OriGene 3'-UTR Clone: CCNK 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CCNK 
    Primers: OriGene genome-wide validated SYBR primer pairs: CCNK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CCNK: PPH19455A

    REFSEQ mRNAs for CCNK gene: 

    NM_001099402.1  

    Additional cDNA sequence: 

    AB209373.1 AK000799.1 AK124466.1 AK311075.1 BC015935.1 BT006950.1 BX247958.1 

    14 DOTS entries:

    DT.215479  DT.95098492  DT.100723022  DT.100812855  DT.40192993  DT.86999816  DT.91946474  DT.102830769 
    DT.91990905  DT.95150722  DT.120780549  DT.92445866  DT.95093600  DT.99995239 

    24/175 AceView cDNA sequences (see all 175):

    CN484736 W74357 BQ230590 BM800386 BU171093 AW189101 CF541374 BM717996 
    BM508958 AA298483 BM726838 AI082525 BM505592 AA512928 AI001776 CD722655 
    AI937130 AW189612 NM_003858 BM504212 CA398104 AA609588 AI088693 AI935458 

    highest scoring ESTs for CCNK:

    AA528091 AA360685 AA370112 AA421192 AA862669 AI081289 AL121493 AW020408 AW959005 BC015935 

    Unigene Cluster for CCNK:

    Cyclin K
    Hs.510409  [show with all ESTs]
    Unigene Representative Sequence: AB209373


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CCNK (see all 6)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                -                                                               
    SP2:              -     -           -                                                               
    SP3:                    -           -                                                               
    SP4:              -                 -                                                               
    SP5:                                                                                                

    About this scheme

    ECgene alternative splicing isoforms for CCNK
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380246 ENST00000216279 ENST00000437596 ENST00000389879(uc001ygi.3 uc001ygg.3)
    ENST00000411691

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CCNK expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching CCNK gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    90627_at2, 3 U95-E 1 0.88 1.00 0.85 0.89 AA630424 0.60 1.00 0.82 1
    91009_at2, 3 U95-E 1 0.75 1.00 0.70 0.43 AL121493 0.80 1.00 0.91 1
    65151_at2, 3 U95-C 1 0.75 1.00 -0.19 1.73 AA528091 1.00 0.90 0.95 1
    82219_at2, 3 U95-D 1 0.69 1.00 0.48 1.26 AA806291 0.60 1.00 0.82 1
    91012_g_at2, 3 U95-E 1 0.50 1.00 0.30 0.73 AL121493 0.80 1.00 0.91 1
    219273_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003858 0.60 1.00 0.82 1
    225824_at2, 3 U133-B 1 0.73 1.00 -- -- AA528091 1.00 0.90 0.95 1
    219273_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    225824_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    CCNK for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CCNK gene expression
    CCNK gene electronic northern expression
    CCNK gene sage expression
    About these images

    CGAP SAGE TAG: ACACCCAGAA

    SOURCE GeneReport for Unigene cluster: Hs.510409

    UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
    Tissue specificity: Ubiquitously expressed. Highest levels in testis

    Primers: OriGene genome-wide validated SYBR primer pairs: CCNK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CCNK: PPH19455A
        SABiosciences Custom PCR Arrays for CCNK 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CCNK gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    CCNK1   -- cyclin K 96.78(n)
    95.92(a)
    453152  XM_529650.2  XP_529650.2 
    cow
    (Bos taurus)
    CCNK1   -- cyclin K 90.51(n)
    96.49(a)
    530744  XM_609221.3  XP_609221.3 
    rat
    (Rattus norvegicus)
    Ccnk1   -- cyclin K 88.69(n)
    95.85(a)
    500715  XM_580110.2  XP_580110.2 
    mouse
    (Mus musculus)
    Ccnk1 , 5 12 (59.23 cM)5
    cyclin K1, 5 89.73(n)1
    96.01(a)1
    124541  NM_009832.11  NP_033962.11 
     AF0605175  AK0893865  (see all 14)
    chicken
    (Gallus gallus)
    CCNK1   -- cyclin K 79.15(n)
    91.51(a)
    423446  NM_001031209.1  NP_001026380.1 
    About this table        Species with no ortholog for CCNK

    ENSEMBL Gene Tree for CCNK (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CCNK gene
    CCNL22  CCNT22  CCNC2  CCNL12  FAM58A2  CCNT12  

    CCNK for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/217 NCBI SNPs in CCNK are shown (see all 217)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs9415471,2
    C,F,A,H,99972375(-) CACACA/TCTACC 1 -- int18Minor allele frequency- T:0.03NS NA WA 192
    rs9415481,2
    C,F,A,H,99971280(-) ACTTAC/TTGCTC 1 -- int119Minor allele frequency- T:0.02NS EA NA WA 1180
    rs20694831,2
    C,F,99958540(+) AGATGG/CTTAGT 1 -- int17Minor allele frequency- C:0.01NA NS EA WA 806
    rs20694841,2
    C,F,H99959047(+) CCTTCA/GGTAAC 2 S ref1 syn16Minor allele frequency- G:0.00NA NS EA 762
    rs20694851,2
    C,F99959737(+) TAATAT/CTGTTT 1 -- int12Minor allele frequency- C:0.01NA NS 350
    rs20694861,2
    F99959767(+) TGTTGTTG/-TGTTT 1 -- int11Minor allele frequency- -:0.01NA 174
    rs20694871,2
    C,F99960178(+) CTCCCG/ATGGTA 1 -- int12Minor allele frequency- A:0.01NA NS 340
    rs20694881,2
    C,F,99960261(+) TGTCTA/CTGCCA 1 -- int12Minor allele frequency- C:0.02NA NS 354
    rs20694891,2
    C,F,99960282(+) TCTTCG/AGTTAC 1 -- int12Minor allele frequency- A:0.02NA NS 354
    rs20694901,2
    C,F,99961471(+) CGCGGG/AACTGT 1 -- int1 ese33Minor allele frequency- A:0.05NA NS WA 384
    About this table

    HapMap Linkage Disequilibrium images for CCNK (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCNK: --

    Search QIAGEN SeqTarget long-range PCR primers for resequencing for CCNK 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCNK for disorders           About GeneDecksing

    OMIM: 603544

    4 Novoseek disease relationships for CCNK gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kaposi sarcoma 46.3 2 15870436 (1), 15144954 (1)
    lymphoma 17.1 2 20331971 (1), 16115893 (1)
    tumors 0 2 12743275 (1), 11988847 (1)
    cancer 0 1 16552186 (1)
    About this table


    Export disorders and mutations for CCNK gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/39 PubMed articles for CCNK gene, integrated from 7 sources (see all 39):
    (articles sorted by number of sources associating them with CCNK)
    1. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. (PubMed id 9632813)1, 2, 3, 7 Edwards M.C.... Elledge S.J. (1998)
    2. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. (PubMed id 10574912)1, 2, 3 Fu T.J.... Flores O. (1999)
    3. Crystal structure of human cyclin K, a positive regulator of cyclin- dependent kinase 9. (PubMed id 17169370)1, 2, 7 Baek K.... Ladias J.A. (2007)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    7. Cyclin K as a direct transcriptional target of the p53 tumor suppressor. (PubMed id 11988847)1, 7 Mori T....Arakawa H. (2002)
    8. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. (PubMed id 11884399)1, 7 Lin X....Peterlin B.M. (2002)
    9. Cyclin K and cyclin D1b are oncogenic in myeloma cell s. (PubMed id 20459741)1 Marsaud V....Sola B. (2010)
    10. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Disorders
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8812 HGNC: 1596 AceView: CCNK Ensembl:ENSG00000090061 euGenes: HUgn8812
    ECgene: CCNK H-InvDB: CCNK

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CCNK Genetics and Cytogenetics in Oncology and Haematology
    NIEHS SNPshttp://egp.gs.washington.edu/data/ccnk/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for CCNK gene:
    Search GeneIP for patents involving CCNK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
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     Predesigned and custom siRNAs for CCNK Antibodies for CCNK
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     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
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     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCNK
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     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CCNK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCNK
     GenScript Custom Purified and Recombinant Proteins Services for CCNK GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CCNK
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     GenScript Custom overexpressing Cell Line Services for CCNK CloneReady with Over 120,000 Genes
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     Search for Antibodies & Assays

     Regulatory tfbs in CCNK promoter
     Search Chromatin IP Primers for CCNK
     RT2 qPCR Primer Assay for CCNK
     GNC Network for CCNK
     Assays for microRNAs that regulate CCNK
     SABiosciences Custom PCR Arrays for CCNK
     Search Tocris compounds for CCNK
     Browse Sino Biological Proteins and Antibodies
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     Antibodies/Proteins Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for CCNK
     Proteins for CCNK
     Lysates for CCNK
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for CCNK
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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