Home
GeneCards Guide
Suite
- GeneALaCart
- GeneDecks
- GeneIP
- GeneNote
- GeneAnnot
- GeneLoc
- GeneTide
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

CCNK Gene

protein-coding GIFtS: 55

GC14P080131

cyclin K
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
cyclin K¹ ²
CPR4¹ ² ³
MGC9113²
cyclin-K²

External Ids:	HGNC: 1596¹	Entrez Gene: 8812²	Ensembl: ENSG00000090061⁷	UniProtKB: O75909³

Export aliases for CCNK gene to outside databases

Previous GC identifers: GC14P097459 GC14P093763 GC14P097937 GC14P097949 GC14P099017 GC14P099947

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNK:

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate

transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the

C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in

regulating CDK and RNA polymerase II activities. (provided by RefSeq)

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909

Function: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA

polymerase II C-terminal domain and CDK2 (CAK)

Gene Wiki entry for CCNK (Cyclin K)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNK gene promoter:
         STAT3   p53   Cart-1   RREB-1   deltaCREB   CREB   E4BP4   AREB6   HNF-1A   Pax-5
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CCNK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CCNK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32

CCNK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNK gene location

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P080131: view genomic region (about GC identifiers)

Start:	80,131,153 bp from pter
End:	80,161,252 bp from pter
Size:	30,100 bases
Orientation:	plus strand

1 alternative location:

Chr14+ 99,947,739-99,977,851

RefSeq DNA sequence:

NC_000014.8 NT_026437.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909 (See protein sequence)

Recommended Name: Cyclin-K

Size: 580 amino acids; 64240 Da

Subunit: Part of a cyclin-kinase pair in the RNA polymerase II holoenzyme. Binds to CDK9

PDB structures from and Proteopedia :

2I53 (3D)

Secondary accessions: Q59FT6 Q86U16 Q96B63 Q9NNY9

Alternative splicing: 4 isoforms: O75909-3 O75909-2 O75909-1 O75909-4

Explore the universe of human proteins at neXtProt for CCNK: NX_O75909

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001092872.1

ENSEMBL proteins:

ENSP00000369596 ENSP00000216279 ENSP00000395705 ENSP00000374529 ENSP00000398898

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for CCNK
	Novus Biologicals Protein for CCNK
	Novus Biologicals Lysate for CCNK
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

Antibodies for CCNK:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CCNK
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for CCNK
	Novus Biologicals Antibodies for CCNK
	Browse antibodies at Epitomics

Assays for CCNK:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCNK
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCNK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCNK for domains About GeneDecksing

4 InterPro domains/families:

IPR006670 Cyclin

IPR011028 Cyclin-like

IPR013763 Cyclin-related

IPR006671 Cyclin_N

Graphical View of Domain Structure for InterPro Entry O75909

ProtoNet protein and cluster: O75909

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909

Similarity: Belongs to the cyclin family. Cyclin C subfamily

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909

Function: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA

polymerase II C-terminal domain and CDK2 (CAK)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CCNK Sigma-Aldrich shRNA Panels and shRNA for CCNK
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CCNK OriGene shRNA RFP (see all 3): CCNK OriGene basic RS shRNA (see all 3): CCNK OriGene siRNA (see all 2): CCNK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCNK

miRNA:		Sigma-Aldrich microRNA Mimics for CCNK Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCNK
		8/16 SABiosciences Assays for microRNAs that regulate CCNK (see all 16):
		hsa-miR-30c hsa-miR-142-5p hsa-miR-181c hsa-miR-30d hsa-miR-30a hsa-miR-1252 hsa-miR-181b hsa-miR-27a

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): CCNK OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CCNK OriGene untagged cDNA clones in CMV expression vector (see all 3): CCNK OriGene 3'-UTR clone: CCNK Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CCNK
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for CCNK

Genatlas biochemistry entry for CCNK:

cyclin K,RNA polymerase II associated cyclin,ubiquitously expressed but most abundant in developing germ cells of adult

testis and ovary,likely involved in the regulation of basal transcription

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16713569

About this table

CCNK for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

CCNK for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for CCNK

p53 Signaling

SABiosciences Custom Pathway-Focused PCR Arrays for CCNK

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CCNK

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNK

5/16 Interacting proteins for CCNK (O75909^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253¹^,²	EBI-739806,EBI-930964 MINT-2865482 MINT-2855089
CCDC85B	Q15834²	MINT-66150
CEP76	Q8TAP6²	MINT-67109
EFEMP2	O95967²	MINT-66717
FKBP6	O75344²	MINT-66761

About this table

5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	9632813
GO:0006366	transcription from RNA polymerase II promoter	TAS	9632813
GO:0007049	cell cycle	IEA	--
GO:0007067	mitosis	IEA	--
GO:0045449	regulation of transcription	IEA	--

About this table

CCNK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCNK

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CCNK Sigma-Aldrich shRNA Panels and shRNA for CCNK
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CCNK OriGene shRNA RFP (see all 3): CCNK OriGene basic RS shRNA (see all 3): CCNK OriGene siRNA (see all 2): CCNK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCNK

miRNA:		Sigma-Aldrich microRNA Mimics for CCNK Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCNK
		8/16 SABiosciences Assays for microRNAs that regulate CCNK (see all 16):
		hsa-miR-30c hsa-miR-142-5p hsa-miR-181c hsa-miR-30d hsa-miR-30a hsa-miR-1252 hsa-miR-181b hsa-miR-27a

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): CCNK OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CCNK OriGene untagged cDNA clones in CMV expression vector (see all 3): CCNK OriGene 3'-UTR Clone: CCNK Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CCNK

Primers:		OriGene genome-wide validated SYBR primer pairs: CCNK Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CCNK: PPH19455A

REFSEQ mRNAs for CCNK gene:

NM_001099402.1

Additional cDNA sequence:

AB209373.1 AK000799.1 AK124466.1 AK311075.1 BC015935.1 BT006950.1 BX247958.1

14 DOTS entries:

DT.215479 DT.95098492 DT.100723022 DT.100812855 DT.40192993 DT.86999816 DT.91946474 DT.102830769

DT.91990905 DT.95150722 DT.120780549 DT.92445866 DT.95093600 DT.99995239

24/175 AceView cDNA sequences (see all 175):

CN484736 W74357 BQ230590 BM800386 BU171093 AW189101 CF541374 BM717996

BM508958 AA298483 BM726838 AI082525 BM505592 AA512928 AI001776 CD722655

AI937130 AW189612 NM_003858 BM504212 CA398104 AA609588 AI088693 AI935458

highest scoring ESTs for CCNK:

AA528091 AA360685 AA370112 AA421192 AA862669 AI081289 AL121493 AW020408 AW959005 BC015935

Unigene Cluster for CCNK:

Cyclin K

Hs.510409 [show with all ESTs]

Unigene Representative Sequence: AB209373

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CCNK (see all 6)

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12
SP1:											-
SP2:					-		-				-
SP3:							-				-
SP4:					-						-
SP5:

About this scheme

ECgene alternative splicing isoforms for CCNK
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380246 ENST00000216279 ENST00000437596 ENST00000389879(uc001ygi.3 uc001ygg.3)

ENST00000411691

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CCNK expression in normal and diseased human tissues

¹ / ² / ³

9 probe-sets matching CCNK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90627_at²^{, 3}	U95-E	1	0.88	1.00	0.85	0.89	AA630424	0.60	1.00	0.82	1
91009_at²^{, 3}	U95-E	1	0.75	1.00	0.70	0.43	AL121493	0.80	1.00	0.91	1
65151_at²^{, 3}	U95-C	1	0.75	1.00	-0.19	1.73	AA528091	1.00	0.90	0.95	1
82219_at²^{, 3}	U95-D	1	0.69	1.00	0.48	1.26	AA806291	0.60	1.00	0.82	1
91012_g_at²^{, 3}	U95-E	1	0.50	1.00	0.30	0.73	AL121493	0.80	1.00	0.91	1
219273_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003858	0.60	1.00	0.82	1
225824_at²^{, 3}	U133-B	1	0.73	1.00	--	--	AA528091	1.00	0.90	0.95	1
219273_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225824_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

CCNK for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CCNK gene electronic northern expression

About these images

CGAP SAGE TAG: ACACCCAGAA

SOURCE GeneReport for Unigene cluster: Hs.510409

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909

Tissue specificity: Ubiquitously expressed. Highest levels in testis

Primers:		OriGene genome-wide validated SYBR primer pairs: CCNK Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CCNK: PPH19455A

SABiosciences Custom PCR Arrays for CCNK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CCNK gene from 5/11 species (see all 11)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	CCNK¹	--	cyclin K	96.78(n) 95.92(a)	453152 XM_529650.2 XP_529650.2
cow (Bos taurus)	CCNK¹	--	cyclin K	90.51(n) 96.49(a)	530744 XM_609221.3 XP_609221.3
rat (Rattus norvegicus)	Ccnk¹	--	cyclin K	88.69(n) 95.85(a)	500715 XM_580110.2 XP_580110.2
mouse (Mus musculus)	Ccnk^{1 , 5}	12 (59.23 cM)⁵	cyclin K^{1, 5}	89.73(n)¹ 96.01(a)¹	12454¹ NM_009832.1¹ NP_033962.1¹ AF060517⁵ AK089386⁵ (see all 14)
chicken (Gallus gallus)	CCNK¹	--	cyclin K	79.15(n) 91.51(a)	423446 NM_001031209.1 NP_001026380.1

About this table Species with no ortholog for CCNK

ENSEMBL Gene Tree for CCNK (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CCNK gene

CCNL2² CCNT2² CCNC² CCNL1² FAM58A² CCNT1²

CCNK for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs941547^1,2	C,F,A,H,	99972375(-)	`CACACA/TCTACC`	1	--	int¹		8	NS NA WA	192
rs941548^1,2	C,F,A,H,	99971280(-)	`ACTTAC/TTGCTC`	1	--	int¹		19	NS EA NA WA	1180
rs2069483^1,2	C,F,	99958540(+)	`AGATGG/CTTAGT`	1	--	int¹		7	NA NS EA WA	806
rs2069484^1,2	C,F,H	99959047(+)	`CCTTCA/GGTAAC`	2	S	ref¹ syn¹		6	NA NS EA	762
rs2069485^1,2	C,F	99959737(+)	`TAATAT/CTGTTT`	1	--	int¹		2	NA NS	350
rs2069486^1,2	F	99959767(+)	`TGTTGTTG/-TGTTT`	1	--	int¹		1	NA	174
rs2069487^1,2	C,F	99960178(+)	`CTCCCG/ATGGTA`	1	--	int¹		2	NA NS	340
rs2069488^1,2	C,F,	99960261(+)	`TGTCTA/CTGCCA`	1	--	int¹		2	NA NS	354
rs2069489^1,2	C,F,	99960282(+)	`TCTTCG/AGTTAC`	1	--	int¹		2	NA NS	354
rs2069490^1,2	C,F,	99961471(+)	`CGCGGG/AACTGT`	1	--	int¹ ese³		3	NA NS WA	384

About this table

HapMap Linkage Disequilibrium images for CCNK (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNK: --

Search QIAGEN SeqTarget long-range PCR primers for resequencing for CCNK

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCNK for disorders About GeneDecksing

OMIM: 603544

4 Novoseek disease relationships for CCNK gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
kaposi sarcoma	46.3	2	15870436 (1), 15144954 (1)
lymphoma	17.1	2	20331971 (1), 16115893 (1)
tumors	0	2	12743275 (1), 11988847 (1)
cancer	0	1	16552186 (1)

About this table

Export disorders and mutations for CCNK gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/39 PubMed articles for CCNK gene, integrated from 7 sources (see all 39):
(articles sorted by number of sources associating them with CCNK)

Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. (PubMed id 9632813)^{1, 2, 3, 7} Edwards M.C.... Elledge S.J. (1998)
Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. (PubMed id 10574912)^{1, 2, 3} Fu T.J.... Flores O. (1999)
Crystal structure of human cyclin K, a positive regulator of cyclin- dependent kinase 9. (PubMed id 17169370)^{1, 2, 7} Baek K.... Ladias J.A. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{1, 2} Beausoleil S.A....Gygi S.P. (2004)
Cyclin K as a direct transcriptional target of the p53 tumor suppressor. (PubMed id 11988847)^{1, 7} Mori T....Arakawa H. (2002)
P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. (PubMed id 11884399)^{1, 7} Lin X....Peterlin B.M. (2002)
Cyclin K and cyclin D1b are oncogenic in myeloma cell s. (PubMed id 20459741)¹ Marsaud V....Sola B. (2010)
Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)² Oppermann F.S.... Daub H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8812	HGNC: 1596	AceView: CCNK	Ensembl:ENSG00000090061	euGenes: HUgn8812
ECgene: CCNK	H-InvDB: CCNK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CCNK	Genetics and Cytogenetics in Oncology and Haematology
NIEHS SNPs	http://egp.gs.washington.edu/data/ccnk/

Intellectual Property for CCNK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for CCNK gene:
Search GeneIP for patents involving CCNK

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CCNK		Antibodies for CCNK
	Super-pooled esiRNAs for CCNK		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CCNK		microRNA Mimics for CCNK
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CCNK
	Search QIAGEN SeqTarget long-range PCR primers for resequencing for CCNK
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CCNK
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CCNK

	GenScript Custom Purified and Recombinant Proteins Services for CCNK		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CCNK
	GenScript Custom Assay Services for CCNK		GenScript Custom Superior Antibodies Services for CCNK
	GenScript Custom overexpressing Cell Line Services for CCNK		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CCNK promoter
	Search Chromatin IP Primers for CCNK
	RT² qPCR Primer Assay for CCNK
	GNC Network for CCNK
	Assays for microRNAs that regulate CCNK
	SABiosciences Custom PCR Arrays for CCNK

Search Tocris compounds for CCNK

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for CCNK
	Proteins for CCNK
	Lysates for CCNK

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for CCNK

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

View Random Gene

Category
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

CCNK gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

Advanced Search

Export list of displayed genes

CCNK Gene

protein-coding GIFtS: 55

Aliases &
Descriptions
for CCNK gene

Summaries
for CCNK gene

Genomic Views
for CCNK gene

Proteins
for CCNK gene

Protein Domains/
Families
for CCNK gene

Gene Function
for CCNK gene

Pathways & Interactions
for CCNK gene

Drugs & Compounds
for CCNK gene

Transcripts
for CCNK gene

Expression
for CCNK gene

Orthologs
for CCNK gene

Paralogs
for CCNK gene

Genomic Variants
for CCNK gene

Disorders & Mutations
for CCNK gene

Medical News
for CCNK gene

Publications
for CCNK gene

External Searches for CCNK gene

Genome Databases showing CCNK gene

Other Databases showing CCNK gene

Specialized Databases showing CCNK gene

Intellectual Property
for CCNK gene

Products
for CCNK gene

View Random Gene

Advanced Search

Export list of displayed genes

CCNK Gene

protein-coding GIFtS: 55

Aliases & Descriptionsfor CCNK gene

Summariesfor CCNK gene

Genomic Viewsfor CCNK gene

Proteinsfor CCNK gene

Protein Domains/Familiesfor CCNK gene

Gene Functionfor CCNK gene

Pathways & Interactionsfor CCNK gene

Drugs & Compoundsfor CCNK gene

Transcriptsfor CCNK gene

Expression for CCNK gene

Orthologsfor CCNK gene

Paralogsfor CCNK gene

Genomic Variantsfor CCNK gene

Disorders & Mutationsfor CCNK gene

Medical Newsfor CCNK gene

Publicationsfor CCNK gene

External Searches for CCNK gene

Genome Databases showing CCNK gene

Other Databases showing CCNK gene

Specialized Databases showing CCNK gene

Intellectual Propertyfor CCNK gene

Productsfor CCNK gene

View Random Gene

Aliases &
Descriptions
for CCNK gene

Summaries
for CCNK gene

Genomic Views
for CCNK gene

Proteins
for CCNK gene

Protein Domains/
Families
for CCNK gene

Gene Function
for CCNK gene

Pathways & Interactions
for CCNK gene

Drugs & Compounds
for CCNK gene

Transcripts
for CCNK gene

Expression
for CCNK gene

Orthologs
for CCNK gene

Paralogs
for CCNK gene

Genomic Variants
for CCNK gene

Disorders & Mutations
for CCNK gene

Medical News
for CCNK gene

Publications
for CCNK gene

Intellectual Property
for CCNK gene

Products
for CCNK gene