Aliases &
Descriptions
for CD101 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| CD101 molecule1 2 | | leukocyte surface protein2 | | V71 2 3 | | immunoglobulin superfamily member 22 | | immunoglobulin superfamily, member 21 2 | | OTTHUMP000000138172 | | Cell surface glycoprotein V72 3 | | CD101 antigen3 | | Glu-Trp-Ile EWI motif-containing protein 1012 3 | | IgSF23 | | IGSF22 3 | | EWI1013 | | EWI-1012 3 | | |
Export aliases for CD101 gene to outside databasesPrevious GC identifers: GC01P117345 GC01P117545 |
Summaries
for CD101 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IGSF2_HUMAN, Q93033Function: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activatedT-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellularproliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes inintracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Playsa role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker ofCD4(+) CD56(+) leukemic tumor cells
Gene Wiki entry for CD101 (IGSF2) |
Genomic Views
for CD101 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CD101
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD101
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13 Ensembl cytogenetic band: 1p13.1 HGNC cytogenetic band: 1p13CD101 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P115403: view genomic region
(about GC identifiers)
Start:
|
115,403,033 bp from pter |
End:
|
115,437,667 bp from pter |
Size:
|
34,635 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr1+ 117,544,382-117,579,167 |
RefSeq DNA sequence:- NC_000001.10 NT_032977.9
|
Proteins
for CD101 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: IGSF2_HUMAN, Q93033 (See
protein sequence)Recommended Name: Immunoglobulin superfamily member 2 precursor Size: 1021 amino acids; 115109 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q15856Explore the universe of human proteins at neXtProt for CD101: NX_Q93033
Post-translational modifications:
N-glycosylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004249.2
ENSEMBL proteins: ENSP00000358482 ENSP00000256652 ENSP00000408903
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CD101 for ontologies About GeneDecksing
Antibodies for CD101:
Assays for CD101: |
Protein
Domains/
Families
for CD101 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD101 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q93033ProtoNet protein and cluster: Q93033 1 Blocks protein family: IPB002195 Dihydroorotase
UniProtKB/Swiss-Prot: IGSF2_HUMAN, Q93033Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains |
Gene Function
for CD101 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: IGSF2_HUMAN, Q93033Function: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activatedT-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellularproliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes inintracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Playsa role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker ofCD4(+) CD56(+) leukemic tumor cells
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
IEA | -- |
About this table
CD101 for ontologies About GeneDecksing
|
Pathways & Interactions
for CD101 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for CD101
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD101
5 Interacting proteins for CD101 (Q930332) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007166 | cell surface receptor linked signaling pathway |
TAS | 7722300 |
About this table
CD101 for ontologies About GeneDecksing
|
Drugs & Compounds
for CD101 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CD101
|
Transcripts
for CD101 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CD101 gene: NM_004258.3 Additional cDNA sequence: AK298237.1 AK307542.1 BC130327.1 BC136484.1 BC171768.1 Z33642.1 3 DOTS entries: DT.100669655 DT.200957 DT.95153918 11 AceView cDNA sequences: BG504603 Z33642 NM_004258 BX283362 BE746215 AI732666 AI791963 AI698289 BM069664 AA594805 BG980559 Unigene Cluster for CD101: CD101 molecule Hs.654598 [show with all ESTs]Unigene Representative Sequence: NM_004258
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CD101
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CD101
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369470 ENST00000467588 ENST00000460180 ENST00000256652(uc010oxb.1 uc009whd.2 uc010oxc.1 uc010oxd.1)
ENST00000437666
|
Expression
for CD101 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CD101 expression in normal and diseased human tissues
1 / 2 3 probe-sets matching CD101 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33983_at2
|
U95-A |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
| 207167_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 207167_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CD101 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CACCAATGCA
SOURCE GeneReport for Unigene cluster: Hs.654598
UniProtKB/Swiss-Prot: IGSF2_HUMAN, Q93033Tissue specificity: Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activatedT-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in someleukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cellhistiocytosis) patients
SABiosciences Custom PCR Arrays for CD101
|
Orthologs
for CD101 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CD101 gene from 5 species
About this table Species with no ortholog for CD101
ENSEMBL Gene Tree for CD101 (if available) |
Paralogs
for CD101 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CD101 gene
- IGSF82 IGSF32 PTGFRN2
CD101 for paralogs About GeneDecksing
|
Genomic Variants
for CD101 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CD101 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD101
1 Indel: 48095 | | QIAGEN SeqTarget long-range PCR primers for resequencing CD101 |
|
Disorders & Mutations
for CD101 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CD101 for disorders About GeneDecksing
OMIM: 604516
Human Genome Epidemiology (HuGE) Navigator: CD101 (1 document)
Export disorders and mutations for CD101 gene to outside databases
|
Medical News
for CD101 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CD101 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/24 PubMed articles for CD101 gene, integrated from 7 sources (see all 24):
(articles sorted by number of sources associating them with CD101)- V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene. (PubMed id 7722300)1, 2, 3 Ruegg C.L.... Engleman E.G. (1995)
- CD4+ CD56+ blastic tumor cells express CD101 molecules. (PubMed id 15737213)1, 2 Meyer N.... Bagot M. (2005)
- EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PubMed id 11504738)1, 2 Stipp C.S.... Hemler M.E. (2001)
- CD101 expression by Langerhans cell histiocytosis cells. (PubMed id 10692025)1, 2 Bouloc A....Bagot M. (2000)
- Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production. (PubMed id 11093127)1, 2 Bouloc A.... Boumsell L. (2000)
- V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation. (PubMed id 9647226)1, 2 Soares L.R.B.... Engleman E.G. (1998)
- Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism. (PubMed id 9233604)1, 2 Soares L.R.B.... Engleman E.G. (1997)
- CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation. (PubMed id 9389317)1, 2 Bagot M.... Boumsell L. (1997)
- V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies. (PubMed id 7722299)1, 2 Rivas A....Engleman E.G. (1995)
- Genetic variants at CD28, PRDM1 and CD2/CD58 are asso ciated with rheumatoid arthritis risk. (PubMed id 19898481)1 Raychaudhuri S....Plenge R.M. (2009)
|
External Searches for CD101 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CD101 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD101 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD101 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CD101 gene:
Search GeneIP for patents involving CD101
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CD101 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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